Shenghai Zhang
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View article: Longitudinal scRNA-seq of retinal organoids derived from Stargardt disease patient with ABCA4 mutation
Longitudinal scRNA-seq of retinal organoids derived from Stargardt disease patient with ABCA4 mutation Open
Stargardt disease (STGD), predominantly caused by mutations in the ABCA4 gene, is a leading cause of inherited retinal degeneration. Although several lines of mice expressing disease-causing variants have been produced, mice due to the lac…
View article: The Cytotoxic Activity of Secondary Metabolites from Marine-Derived Penicillium spp.: A Review (2018–2024)
The Cytotoxic Activity of Secondary Metabolites from Marine-Derived Penicillium spp.: A Review (2018–2024) Open
Marine-derived Penicillium spp., including Penicillium citrinum, Penicillium chrysogenum, and Penicillium sclerotiorum, have emerged as prolific producers of structurally diverse secondary metabolites with cytotoxic activity. This review s…
View article: Identification of a neural basis for energy expenditure in the arcuate hypothalamus
Identification of a neural basis for energy expenditure in the arcuate hypothalamus Open
Summary Given the evolutionary instinct for caloric intake and the tendency for weight rebound after discontinuing dietary interventions or medications, increasing energy expenditure emerges as an alternative obesity treatment. However, ne…
View article: Single-Cell Transcriptomic Dataset of RPGR-associated Retinitis Pigmentosa Patient-Derived Retinal Organoids
Single-Cell Transcriptomic Dataset of RPGR-associated Retinitis Pigmentosa Patient-Derived Retinal Organoids Open
X-linked retinitis pigmentosa (XLRP) is a severe hereditary retinal disorder marked by progressive vision loss due to photoreceptor dysfunction. The retinitis pigmentosa GTPase regulator (RPGR) gene, responsible for most XLRP cases, encode…
View article: Recent advances in the structures and bioactivities of benzopyrans derived from marine fungi: a review
Recent advances in the structures and bioactivities of benzopyrans derived from marine fungi: a review Open
Marine fungi represent a treasure trove of bioactive secondary metabolites, with benzopyran compounds emerging as a significant class of these natural products. This review delves into the structural diversity, biological activities, and s…
View article: Neuroprotective effects of apigenin on retinal ganglion cells in ischemia/reperfusion: modulating mitochondrial dynamics in in vivo and in vitro models
Neuroprotective effects of apigenin on retinal ganglion cells in ischemia/reperfusion: modulating mitochondrial dynamics in in vivo and in vitro models Open
View article: Fam96a is essential for the host control of Toxoplasma gondii infection by fine-tuning macrophage polarization via an iron-dependent mechanism
Fam96a is essential for the host control of Toxoplasma gondii infection by fine-tuning macrophage polarization via an iron-dependent mechanism Open
Background Toxoplasmosis affects a quarter of the world’s population. Toxoplasma gondii ( T . gondii ) is an intracellular parasitic protozoa. Macrophages are necessary for proliferation and spread of T . gondii by regulating immunity and …
View article: Whole genome sequencing enables new genetic diagnosis for inherited retinal diseases by identifying pathogenic variants
Whole genome sequencing enables new genetic diagnosis for inherited retinal diseases by identifying pathogenic variants Open
Inherited retinal diseases (IRDs) are a group of common primary retinal degenerative disorders. Conventional genetic testing strategies, such as panel-based sequencing and whole exome sequencing (WES), can only elucidate the genetic etiolo…
View article: Mechanism and ingredients prediction of Radix Salviae-Angelicae Sinensis Radix-Lycii Fructus-Rehmanniae Radix Praeparata-Ginkgo Folium for retinitis pigmentosa therapy using network pharmacology and molecular docking analysis
Mechanism and ingredients prediction of Radix Salviae-Angelicae Sinensis Radix-Lycii Fructus-Rehmanniae Radix Praeparata-Ginkgo Folium for retinitis pigmentosa therapy using network pharmacology and molecular docking analysis Open
RALRG was found to be the main regulator for oxidative stress and PI3K/AKT signaling pathways. Luteolin, quercetin, and kaempferol were three promising complementary ingredients for RP treatment. This study may provide a theoretical basis …
View article: Treatment of autosomal dominant retinitis pigmentosa caused by RHO-P23H mutation with high-fidelity Cas13X in mice
Treatment of autosomal dominant retinitis pigmentosa caused by RHO-P23H mutation with high-fidelity Cas13X in mice Open
Mutations in Rhodopsin (RHO) gene commonly cause autosomal dominant retinitis pigmentosa (adRP) without effective therapeutic treatment so far. Compared with genomic DNA-targeting CRISPR-Cas9 system, Cas13 edits RNA for therapeutic …
View article: Development of a novel prediction model based on protein structure for identifying RPE65-associated inherited retinal disease (IRDs) of missense variants
Development of a novel prediction model based on protein structure for identifying RPE65-associated inherited retinal disease (IRDs) of missense variants Open
Purpose This study aimed to develop a prediction model to classify RPE65 -mediated inherited retinal disease (IRDs) based on protein secondary structure and to analyze phenotype-protein structure correlations of RPE65 missense variants in …
View article: Data for comprehensive effect of soil particle size composition and wind speed on dust emission efficiency
Data for comprehensive effect of soil particle size composition and wind speed on dust emission efficiency Open
The original data obtained by the wind tunnel experiments aims to investigate the comprehensive effect of soil particle size composition and wind speed on dust emission efficiency
View article: ceRNA network construction and identification of hub genes as novel therapeutic targets for age-related cataracts using bioinformatics
ceRNA network construction and identification of hub genes as novel therapeutic targets for age-related cataracts using bioinformatics Open
Background The aim of this study is to investigate the genetic and epigenetic mechanisms involved in the pathogenesis of age-related cataract (ARC). Methods We obtained the transcriptome datafile of th ree ARC samples and three healthy, ag…
View article: Construction of ceRNA network and identification of hub genes in aniridia-associated keratopathy using bioinformatics analysis
Construction of ceRNA network and identification of hub genes in aniridia-associated keratopathy using bioinformatics analysis Open
Aniridia-associated keratopathy (AAK) is characteristic at ocular surface of aniridia caused by haploinsufficiency of PAX6 . Competing endogenous RNA (ceRNA) has been reported to play an important role in various diseases, whereas its func…
View article: Genetic Characteristics and Variation Spectrum of USH2A-Related Retinitis Pigmentosa and Usher Syndrome
Genetic Characteristics and Variation Spectrum of USH2A-Related Retinitis Pigmentosa and Usher Syndrome Open
Purposes: We aimed to characterize the USH2A genotypic spectrum in a Chinese cohort and provide a detailed genetic profile for Chinese patients with USH2A-IRD. Methods: We designed a retrospective study wherein a total of 1,334 patients di…
View article: Identification of Immune Infiltration-Related ceRNAs as Novel Biomarkers for Prognosis of Patients With Primary Open-Angle Glaucoma
Identification of Immune Infiltration-Related ceRNAs as Novel Biomarkers for Prognosis of Patients With Primary Open-Angle Glaucoma Open
Glaucoma is the leading cause of irreversible blindness globally; hence, relevant clinical biomarkers are necessary to enable diagnosis, early detection, and development of novel therapies. The differentially expressed genes were annotated…
View article: Single-Cell RNA-Seq Reveals the Cellular Diversity and Developmental Characteristics of the Retinas of an Infant and a Young Child
Single-Cell RNA-Seq Reveals the Cellular Diversity and Developmental Characteristics of the Retinas of an Infant and a Young Child Open
The human retina, located in the innermost layer of the eye, plays a decisive role in visual perception. Dissecting the heterogeneity of retinal cells is essential for understanding the mechanism of visual development. Here, we performed s…
View article: Effects of acute high intraocular pressure on red-green and blue-yellow cortical color responses in non-human primates
Effects of acute high intraocular pressure on red-green and blue-yellow cortical color responses in non-human primates Open
View article: Single cell atlas for 11 non-model mammals, reptiles and birds
Single cell atlas for 11 non-model mammals, reptiles and birds Open
View article: TRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway
TRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway Open
View article: Genotypic spectrum and phenotype correlations of EYS-associated disease in a Chinese cohort
Genotypic spectrum and phenotype correlations of EYS-associated disease in a Chinese cohort Open
Background To date, certain efforts have been made to investigate the clinical and genetic characteristics of patients with EYS mutations. However, data for Chinese patients are limited. Objectives To perform a detailed phenotyping and gen…
View article: Transduction catalysis: Doxorubicin amplifies rAAV-mediated gene expression in the cortex of higher-order vertebrates
Transduction catalysis: Doxorubicin amplifies rAAV-mediated gene expression in the cortex of higher-order vertebrates Open
View article: Paeonol Induces Protective Autophagy in Retinal Photoreceptor Cells
Paeonol Induces Protective Autophagy in Retinal Photoreceptor Cells Open
Background: Retinal photoreceptor (RP) cells are widely involved in retina-related diseases, and oxidative stress plays a critical role in retinal secondary damage. Herein, we investigated the effectiveness and potential mechanisms of auto…
View article: Frequency and phenotypic characteristics of RPE65 mutations in the Chinese population
Frequency and phenotypic characteristics of RPE65 mutations in the Chinese population Open
View article: Estimating Transmissibility of Seasonal Influenza Virus by Surveillance Data
Estimating Transmissibility of Seasonal Influenza Virus by Surveillance Data Open
It is important to estimate transmissibility of influenza virus during its growing phase for understanding the propagation of the virus. The estimation procedures of the transmissibility are usually based on the data generated in flu seaso…
View article: The performance of phenomenological models in providing near-term Canadian case projections in the midst of the COVID-19 pandemic: March – April, 2020
The performance of phenomenological models in providing near-term Canadian case projections in the midst of the COVID-19 pandemic: March – April, 2020 Open
All three models have yielded qualitatively comparable near-term forecasts of cases and epidemic growth for Canada. Under or over-estimation of projected cases and epidemic growth by these models could be associated with changes in testing…
View article: The Microenvironment Combining with Immune Infiltration of Uveal Melanoma
The Microenvironment Combining with Immune Infiltration of Uveal Melanoma Open
Background: Uveal melanoma (UM) is the most common intraocular malignancy in adults. Although immunotherapy provided novel options in the disease's progression, it only benefits a minority of patients. The understanding of the UM microenvi…
View article: Prediction of Differentially Expressed miRNAs as Potential Biomarkers for Aniridia-Associated Keratopathy based on Expression Profile Analyses
Prediction of Differentially Expressed miRNAs as Potential Biomarkers for Aniridia-Associated Keratopathy based on Expression Profile Analyses Open
Background: Aniridia is a rare hereditary disorder that affects most structures of the eyes. This autosomal dominant disorder is caused by haploinsufficiency of Pax6, a critical gene for proper development of the eye. This study attempted …
View article: Novel variants of ABCA4 in Han Chinese families with Stargardt disease
Novel variants of ABCA4 in Han Chinese families with Stargardt disease Open
View article: Cell Development Deficiency and Gene Expression Dysregulation of Trisomy 21 Retina Revealed by Single-Nucleus RNA Sequencing
Cell Development Deficiency and Gene Expression Dysregulation of Trisomy 21 Retina Revealed by Single-Nucleus RNA Sequencing Open
Retina is a crucial tissue for capturing and processing light stimulus. It is critical to describe the characteristics of retina at the single-cell level for understanding its biological functions. A variety of abnormalities in terms of mo…