Sai Ma
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View article: Trajectory classes of suicidal ideation and anhedonia among Chinese vocational school students: Links with childhood trauma, school bullying victimization, and emotion regulation
Trajectory classes of suicidal ideation and anhedonia among Chinese vocational school students: Links with childhood trauma, school bullying victimization, and emotion regulation Open
Chinese vocational school students exhibit a higher prevalence of suicidal ideation (SI) than the general adolescent population. Given anhedonia's transdiagnostic nature, its predictive value for SI, influence on recovery, and shared neuro…
View article: Population Genetics of an Endemic Species <scp> <i>Mongoloniscus sinensis</i> </scp> (Isopoda: Oniscidea) and Diversification Dynamics Across Northern China
Population Genetics of an Endemic Species <span> <i>Mongoloniscus sinensis</i> </span> (Isopoda: Oniscidea) and Diversification Dynamics Across Northern China Open
Endemic to temperate northern China, Mongoloniscus sinensis is a soil‐dwelling isopod that provides a powerful system for investigating how Pleistocene climatic fluctuations and mountainous barriers have shaped genetic divergence and regio…
View article: A single-cell spatial transcriptomic census of human skin anatomy
A single-cell spatial transcriptomic census of human skin anatomy Open
The skin is the largest human organ and a site of significant disease burden, yet its cellular and molecular organization across the body are largely undefined. Here, we construct a spatially-resolved single-cell atlas of 1.2 million cells…
View article: Predictive value of multiparametric magnetic resonance imaging combined with pathological biomarkers for axillary lymph node metastasis of breast cancer
Predictive value of multiparametric magnetic resonance imaging combined with pathological biomarkers for axillary lymph node metastasis of breast cancer Open
Combining MRI parameters (lesion margin, D, Ktrans) with pathological biomarker PD-L1 significantly improves prediction accuracy for ALN metastasis in breast cancer. This integrated model has considerable clinical potential, enabling preci…
View article: [Efficacy of ruxolitinib and prognostic factors in patients with myelofibrosis stratified by age].
[Efficacy of ruxolitinib and prognostic factors in patients with myelofibrosis stratified by age]. Open
Objective: To explore differences in the efficacy and safety of ruxolitinib in patients with myelofibrosis by age and to identify prognostic factors by analyzing clinical features and characteristics of chromosomes and gene mutations. Meth…
View article: Identification of Immune Candidate Genes in Post-Sepsis Syndrome: Linking Innate Immunity to Long-Term Autoimmune Responses
Identification of Immune Candidate Genes in Post-Sepsis Syndrome: Linking Innate Immunity to Long-Term Autoimmune Responses Open
Introduction: Post-sepsis syndrome (PSS) is marked by persistent immune dysregulation, leading to long-term complications that overlap with autoimmune responses. Uncovering key immune-related candidate genes during PSS recovery can enhance…
View article: Effects of long-term care insurance on health: a study of the middle-aged and older adult in pilot cities in China
Effects of long-term care insurance on health: a study of the middle-aged and older adult in pilot cities in China Open
Background China established a trial long-term care insurance program in 15 cities in 2016 to address the country’s aging population; however, the policy’s impacts must be confirmed. Methods Panel data from the China Health and Retirement …
View article: Multi-scale footprinting
Multi-scale footprinting Open
Data associated with the multi-scale footprinting project. (1) Tn5_NN_model.h5 Pre-trained CNN-based Tn5 bias model implemented with Keras. Takes local DNA sequence context as input and predicts Tn5 insertion bias. See tutorial for how to …
View article: Effectiveness of the Information–Motivation–Behavioral Skills Model-Based Nursing Intervention on Maternal and Neonatal Outcomes in Women with Gestational Diabetes Mellitus: A Randomized Controlled Trial
Effectiveness of the Information–Motivation–Behavioral Skills Model-Based Nursing Intervention on Maternal and Neonatal Outcomes in Women with Gestational Diabetes Mellitus: A Randomized Controlled Trial Open
The IMB model-based nursing intervention was more effective in managing blood glucose levels, reducing the need for insulin therapy, and improving both maternal and neonatal outcomes compared to traditional health education. This intervent…
View article: Expanding GABAergic Neuronal Diversity in iPSC-Derived Disease Models
Expanding GABAergic Neuronal Diversity in iPSC-Derived Disease Models Open
GABAergic interneurons play a critical role in maintaining neural circuit function, and their dysfunction is implicated in various neurodevelopmental and psychiatric disorders. Traditional approaches for differentiating human pluripotent s…
View article: Salary satisfaction of acute critical care nurses in Hunan Province: a mixed study
Salary satisfaction of acute critical care nurses in Hunan Province: a mixed study Open
Aim:Salary satisfaction of acute and critical care nurses are of great significance to turnover rate and career development. The purpose of this study was to investigate the intrinsic motivation and salary satisfaction of acute critical ca…
View article: Expression and Significance of the GDF11 Protein in Ureteropelvic Junction Obstruction (UPJO)
Expression and Significance of the GDF11 Protein in Ureteropelvic Junction Obstruction (UPJO) Open
Background To explore the expression of growth differentiation factor 11 (GDF11), a member of the TGF-β superfamily, in pediatric ureteropelvic junction obstruction (UPJO) patients. Methods Five patients diagnosed with severe neonatal hydr…
View article: Dual-Modality Imaging for Monitoring Thrombosis via Platelet GPIIb/IIIa Receptor Targeted cyclic RGDfK Microbubbles
Dual-Modality Imaging for Monitoring Thrombosis via Platelet GPIIb/IIIa Receptor Targeted cyclic RGDfK Microbubbles Open
Backgound: Acute thrombotic events play a vital role in cardiovascular diseases. Our study aims to investigate an ultrasound microbubble fordual-modality imaging of thrombi. Methods: DID-DSPE-PEG-cRGD-Microbubbles wereprepared by mechanica…
View article: Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes
Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes Open
The genome-wide DNA methylation profile, or DNA methylome, is a critical component of the overall epigenomic landscape that modulates gene activities and cell fate. Single-cell DNA methylomic studies offer unprecedented resolution for dete…
View article: Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes
Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes Open
Genome-wide DNA methylation profile, or DNA methylome, is a critical component of the overall epigenomic landscape that modulates gene activities and cell fate. Single-cell DNA methylomic studies offer unprecedented resolution for detectin…
View article: Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens
Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens Open
The mammalian SWI/SNF (mSWI/SNF or BAF) family of chromatin remodeling complexes play critical roles in regulating DNA accessibility and gene expression. The three final-form subcomplexes-cBAF, PBAF, and ncBAF-are distinct in biochemical c…
View article: Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements
Single-cell multi-scale footprinting reveals the modular organization of DNA regulatory elements Open
Cis -regulatory elements control gene expression and are dynamic in their structure, reflecting changes to the composition of diverse effector proteins over time 1–3 . Here we sought to connect the structural changes at cis -regulatory ele…
View article: Spatial epigenome–transcriptome co-profiling of mammalian tissues
Spatial epigenome–transcriptome co-profiling of mammalian tissues Open
Emerging spatial technologies, including spatial transcriptomics and spatial epigenomics, are becoming powerful tools for profiling of cellular states in the tissue context 1–5 . However, current methods capture only one layer of omics inf…
View article: KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration
KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration Open
KDELR2 has been reported as a promotive factor for the genesis and progression of several malignancies. However, it is uncertain how it affects bladder urothelial carcinoma (BLCA). Using data extracted from online databases, an enhanced ex…
View article: Current status and progress of the development of prostate cancer vaccines
Current status and progress of the development of prostate cancer vaccines Open
At present, common treatments of prostate cancer mainly include surgery, radiotherapy, chemotherapy and hormone therapy. However, patients have high recurrence rate after treatment, and are prone to castration-resistant prostate cancer. Tu…
View article: Additional file 2 of FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation
Additional file 2 of FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation Open
Additional file 2. The sgRNA sequences. Primers sequences for plasmid construction. Primer sequences for mutation sequencing. Primer sequences for the quantitative RT-PCR. Relationship between protein overexpression and clinicopathologic p…
View article: SMARCA4 inactivation promotes lineage-specific transformation and early metastatic features in the lung
SMARCA4 inactivation promotes lineage-specific transformation and early metastatic features in the lung Open
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\n SMARCA4/BRG1 encodes for one of two mutually exclusive ATPases present in mammalian SWI/SNF chromatin remodeling complexes and is frequently mutated in human lung adenocarcinoma. However, the functional consequences of SMARCA4 m…
View article: The association of new-onset diabetes with subsequent diagnosis of pancreatic cancer—novel use of a large administrative database
The association of new-onset diabetes with subsequent diagnosis of pancreatic cancer—novel use of a large administrative database Open
Background Screening options for pancreatic ductal adenocarcinoma (PDAC) are limited. New-onset type 2 diabetes (NoD) is associated with subsequent diagnosis of PDAC in observational studies and may afford an opportunity for PDAC screening…