Shangnao Xie
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View article: Anti-tumor effects of Cinnamomum camphora essential oil in breast cancer via NOX4 modulation by (+)-2-bornanone
Anti-tumor effects of Cinnamomum camphora essential oil in breast cancer via NOX4 modulation by (+)-2-bornanone Open
The anti-tumor effects of CCEO in triple-negative breast cancer (TNBC) are principally mediated by (+)-2-Bornanone, which inhibits the MAPK/ERK pathway via NOX4 downregulation. These findings reveal a novel anti-tumor mechanism and provide…
View article: The oncolytic virus of p53-armed NDV, in combination with GM-CSF and iPD-L1, induces the Immunogenic cell death of melanoma
The oncolytic virus of p53-armed NDV, in combination with GM-CSF and iPD-L1, induces the Immunogenic cell death of melanoma Open
Melanoma is a malignant tumor that mutates from melanocytes on the skin and mucous membranes. (Long et al., 2023) Cutaneous melanoma is the most dangerous skin cancer, which causes 80% of causalities (Saeed et al., 2024). The treatment of …
View article: The oncolytic virus of p53-armed NDV, in combination with GM-CSF and iPD-L1, induces the Immunogenic cell death of melanoma
The oncolytic virus of p53-armed NDV, in combination with GM-CSF and iPD-L1, induces the Immunogenic cell death of melanoma Open
Melanoma is a malignant tumor that mutates from melanocytes on the skin and mucous membranes. (Long et al., 2023) Cutaneous melanoma is the most dangerous skin cancer, which causes 80% of causalities (Saeed et al., 2024). The treatment of …
View article: Berberine safeguards sepsis‐triggered acute gastric damage and inhibits pyroptosis in gastric epithelial cells via suppressing the ubiquitination and degradation of Nrf2
Berberine safeguards sepsis‐triggered acute gastric damage and inhibits pyroptosis in gastric epithelial cells via suppressing the ubiquitination and degradation of Nrf2 Open
Berberine (BBR), a widely recognized traditional Chinese medicine, has attracted considerable attention for its promising anti‐inflammatory effects. The activation of nuclear factor erythroid 2‐related factor 2 (Nrf2) effectively safeguard…
View article: Disparities in quality of life among patients with breast cancer based on surgical methods: a cross-sectional prospective study
Disparities in quality of life among patients with breast cancer based on surgical methods: a cross-sectional prospective study Open
To determine the impact of breast conservation on quality of life and identify treatment-related and other demographic factors associated with post-breast cancer treatment quality of life. A prospective study was conducted on 392 women who…
View article: Lateral thoracic adipofascial flaps in the reconstruction of defects after breast-conserving surgery in breasts with ptosis, mild ptosis or without ptosis
Lateral thoracic adipofascial flaps in the reconstruction of defects after breast-conserving surgery in breasts with ptosis, mild ptosis or without ptosis Open
It is reliable and effective to use the lateral thoracic adipofascial flaps to reconstruct the defects after BCS when the breast is not ptotic and the lesions are located in the lateral and central quadrants.
View article: KMT2D Regulates the NCOA6/THRB Signal Axis through Epigenetic Modification to Promote the Migration and Invasion of Papillary Thyroid Cancer
KMT2D Regulates the NCOA6/THRB Signal Axis through Epigenetic Modification to Promote the Migration and Invasion of Papillary Thyroid Cancer Open
Background: The histone lysine methyltransferase Histone-lysine N-methytransferase 2D (KMT2D) is a common mutated gene in a variety of cancers, including papillary thyroid cancer (PTC). However, the mechanism of KMT2D on the progression of…
View article: Impact of Nischarin on EMT regulators in breast cancer cell lines
Impact of Nischarin on EMT regulators in breast cancer cell lines Open
Nischarin is an integrin-binding protein, which is well known as a novel tumor suppressor. In breast cancer, Nischarin serves a critical role in breast cancer cell migration and invasion. However, the molecular mechanism underlying the rol…
View article: Papillary thyroid cancer with para-aortic lymph node metastasis discovered incidentally during work-up of metastatic colon cancer: a case report
Papillary thyroid cancer with para-aortic lymph node metastasis discovered incidentally during work-up of metastatic colon cancer: a case report Open
Background: Papillary thyroid cancer usually manifests an indolent behavior and infrequently causes rare distant metastases, with the exclusion of lung and bone metastases. Metastasis to the para-aortic lymph node from papillary thyroid ca…
View article: T Cell Factor 4 Is Involved in Papillary Thyroid Carcinoma via Regulating Long Non-Coding RNA HCP5
T Cell Factor 4 Is Involved in Papillary Thyroid Carcinoma via Regulating Long Non-Coding RNA HCP5 Open
The annual incidence of papillary thyroid carcinoma has increased dramatically. T cell factor 4 (TCF4) is an important component of Wnt signaling pathway.However, the role of TCF4 in PTC remains unknown. In this study, TCF4 was observed to…
View article: Role of surgery in patients with early stage small-cell lung cancer [Erratum]
Role of surgery in patients with early stage small-cell lung cancer [Erratum] Open
Peng A, Li G, Xiong M, et al. Cancer Manag Res. 2019;11:7089–7101.Following a review of the data post-publication, the authors found Table 2 was misaligned. This replacement of Table 2 has no impact to the findi…
View article: The genomic mutation spectrums of breast fibroadenomas in Chinese population by whole exome sequencing analysis
The genomic mutation spectrums of breast fibroadenomas in Chinese population by whole exome sequencing analysis Open
Fibroadenomas (FAs) are the most common fibroepithelial lesions and the most common benign tumors of the breast in women of reproductive age. Although MED12 mutations, an overwhelming majority of all mutations, and some other gene mutation…
View article: Erratum: Involvement of the Mitochondrial Pathway in p53-Independent Apoptosis Induced by <i>p28GANK</i> Knockdown in Hep3B Cells
Erratum: Involvement of the Mitochondrial Pathway in p53-Independent Apoptosis Induced by <i>p28GANK</i> Knockdown in Hep3B Cells Open
It is well known that TP53 may mediate apoptosis triggered by anticancer drugs. However, accumulating evidence indicates that TP53 may be inactivated by mutations and/or deletions in about 50% of human cancers and, as such, may lead to pro…
View article: Novel germline mutations and unclassified variants of BRCA1 and BRCA2 genes in Chinese women with familial breast/ovarian cancer
Novel germline mutations and unclassified variants of BRCA1 and BRCA2 genes in Chinese women with familial breast/ovarian cancer Open
BRCA1 and BRCA2 mutations accounted for a considerable proportion of hereditary breast/ovarian cancer patients from eastern China and the spectrum of the mutations of these two genes exhibited some unique features. The two BRCA1 putative f…