Shunjie Bai
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View article: The viable but non-culturable (VBNC) status of Shewanella putrefaciens (S. putrefaciens) with thermosonication (TS) treatment
The viable but non-culturable (VBNC) status of Shewanella putrefaciens (S. putrefaciens) with thermosonication (TS) treatment Open
Although thermosonication (TS) treatment has been widely used in food sterilization, the viable but non-culturable (VBNC) of bacteria with TS treatment has still concerned potential food safety and public health. The molecular mechanism of…
View article: Identification and isolation of a novel antifreeze peptide from crayfish shells
Identification and isolation of a novel antifreeze peptide from crayfish shells Open
In this study, a novel antifreeze peptide was isolated from crayfish shells and its antifreeze mechanism and activity were investigated. Firstly, the crayfish shells peptides (CSPs) were prepared by Enzymatic Hydrolysis Technology (alkalin…
View article: Peer Review #1 of "Fasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis (v0.1)"
Peer Review #1 of "Fasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis (v0.1)" Open
Alcohol dependence is a chronic, relapsing encephalopathy characterized by compulsive craving for alcohol, loss of control over alcohol use, and the presence of negative emotions and physical discomfort when alcohol is unavailable.Harmful …
View article: Peer Review #1 of "Fasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis (v0.2)"
Peer Review #1 of "Fasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis (v0.2)" Open
Alcohol dependence is a chronic, relapsing encephalopathy characterized by compulsive craving for alcohol, loss of control over alcohol use, and the presence of negative emotions and physical discomfort when alcohol is unavailable.Harmful …
View article: Peer Review #2 of "Fasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis (v0.2)"
Peer Review #2 of "Fasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis (v0.2)" Open
Alcohol dependence is a chronic, relapsing encephalopathy characterized by compulsive craving for alcohol, loss of control over alcohol use, and the presence of negative emotions and physical discomfort when alcohol is unavailable.Harmful …
View article: Peer Review #2 of "Fasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis (v0.1)"
Peer Review #2 of "Fasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis (v0.1)" Open
Alcohol dependence is a chronic, relapsing encephalopathy characterized by compulsive craving for alcohol, loss of control over alcohol use, and the presence of negative emotions and physical discomfort when alcohol is unavailable.Harmful …
View article: Associations Between Disordered Microbial Metabolites and Changes of Neurotransmitters in Depressed Mice
Associations Between Disordered Microbial Metabolites and Changes of Neurotransmitters in Depressed Mice Open
Backgrounds Many pieces of evidence demonstrated that there were close relationships between gut microbiota and depression. However, the specific molecular mechanisms were still unknown. Here, using targeted metabolomics, this study was co…
View article: Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder
Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder Open
Objective Although many works have been done, the objectively measured diagnostic biomarkers are not available. Thus, we conducted this study to identify potential biomarkers for objectively diagnosing depression and explore the role of gu…
View article: Gut Microbiota-Derived Inflammation-Related Serum Metabolites as Potential Biomarkers for Major Depressive Disorder
Gut Microbiota-Derived Inflammation-Related Serum Metabolites as Potential Biomarkers for Major Depressive Disorder Open
These findings suggested that the disturbance of phyla Firmicutes might be involved in the onset of depression by regulating host's inflammatory response, and these potential biomarkers could be useful for future investigating the objectiv…
View article: High Mobility Group Box 1/Toll-like Receptor 4 Signaling Increases GABRB3 Expression in Alcohol Exposure
High Mobility Group Box 1/Toll-like Receptor 4 Signaling Increases GABRB3 Expression in Alcohol Exposure Open
Through the reanalysis of GSE123114 microarray profile, we found that Gabrb3 is a key gene associated with alcohol exposure. In further experiments, our findings suggest that alcohol exposure modulates Gabrb3 expression through the HMGB1/T…
View article: Absence of gut microbiota affects lipid metabolism in the prefrontal cortex of mice
Absence of gut microbiota affects lipid metabolism in the prefrontal cortex of mice Open
Objectives: Lipid metabolism is closely associated with many important biological functions. Here, we conducted this study to explore the effects of gut microbiota on the lipid metabolism in the prefrontal cortex of mice. Methods: Germ-fre…
View article: Absence of gut microbiota affects lipid metabolism in the prefrontal cortex of mice
Absence of gut microbiota affects lipid metabolism in the prefrontal cortex of mice Open
Objectives: Lipid metabolism is closely associated with many important biological functions. Here, we conducted this study to explore the effects of gut microbiota on the lipid metabolism in the prefrontal cortex of mice. Methods: Germ-fre…
View article: Potential Biomarkers for Diagnosing Major Depressive Disorder Patients with Suicidal Ideation
Potential Biomarkers for Diagnosing Major Depressive Disorder Patients with Suicidal Ideation Open
These results showed that these potential biomarkers could facilitate the development of an objective method for diagnosing MDD patients with SI, and the decreased AAT levels in MDD patients might lead to the appearance of SI by resulting …
View article: CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice
CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice Open
View article: Alpha 1-antitrypsin as a Potential Biomarker for Diagnosing Major Depressive Disorder
Alpha 1-antitrypsin as a Potential Biomarker for Diagnosing Major Depressive Disorder Open
Background: Despite decades of intensive research on major depressive disorder (MDD), the pathogenesis of MDD is still unclear and the objectively diagnostic method remains unavailable. Therefore, we conducted this study to assess whether …
View article: Extracellular Matrix and Oxidative Phosphorylation: Important Role in the Regulation of Hypothalamic Function by Gut Microbiota
Extracellular Matrix and Oxidative Phosphorylation: Important Role in the Regulation of Hypothalamic Function by Gut Microbiota Open
In summary, our findings suggested that regulation of ECM is a key mechanism shared by different gut microbiota and that inhibition of energy metabolism in the hypothalamus by gut microbiota derived from MDD patients is a potential mechani…
View article: Circulating microRNA 134 sheds light on the diagnosis of major depressive disorder
Circulating microRNA 134 sheds light on the diagnosis of major depressive disorder Open
View article: <p>Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways</p>
Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways Open
These findings provide novel insight into the mechanisms underlying the antidepressant action of DG, and should help advance the development of new therapeutic strategies for depression.
View article: Age-specific differential changes on gut microbiota composition in patients with major depressive disorder
Age-specific differential changes on gut microbiota composition in patients with major depressive disorder Open
Emerging evidence has shown the age-related changes in gut microbiota, but few studies were conducted to explore the effects of age on the gut microbiota in patients with major depressive disorder (MDD). This study was performed to identif…
View article: Dl-3-n-butylphthalide attenuates mouse behavioral deficits to chronic social defeat stress by regulating energy metabolism via AKT/CREB signaling pathway
Dl-3-n-butylphthalide attenuates mouse behavioral deficits to chronic social defeat stress by regulating energy metabolism via AKT/CREB signaling pathway Open
View article: Age-specific urinary metabolite signatures and functions in patients with major depressive disorder
Age-specific urinary metabolite signatures and functions in patients with major depressive disorder Open
Major depressive disorder (MDD) patients in different age ranges might have different urinary metabolic phenotypes, because age could significantly affect the physiological and psychological status of person. Therefore, it was very importa…
View article: Randomized controlled trials of serotonin-norepinephrine reuptake inhibitor in treating major depressive disorder in children and adolescents: a meta-analysis of efficacy and acceptability
Randomized controlled trials of serotonin-norepinephrine reuptake inhibitor in treating major depressive disorder in children and adolescents: a meta-analysis of efficacy and acceptability Open
New generation antidepressant therapies, including serotonin-norepinephrine reuptake inhibitor (SNRIs), were introduced in the late 1980s; however, few comprehensive studies have compared the benefits and risks of various contemporary trea…
View article: Diterpene Ginkgolides Exert an Antidepressive Effect Through the NT3-TrkA and Ras-MAPK Pathways
Diterpene Ginkgolides Exert an Antidepressive Effect Through the NT3-TrkA and Ras-MAPK Pathways Open
View article: Urinary biomarker panel for diagnosing patients with depression and anxiety disorders
Urinary biomarker panel for diagnosing patients with depression and anxiety disorders Open
Available data indicate that patients with depression and anxiety disorders are likely to be at greater risk for suicide. Therefore, it is important to correctly diagnose patients with depression and anxiety disorders. However, there are s…
View article: Ginkgo biloba extract and its diterpene ginkgolide constituents ameliorate the metabolic disturbances caused by recombinant tissue plasminogen activator in rat prefrontal cortex
Ginkgo biloba extract and its diterpene ginkgolide constituents ameliorate the metabolic disturbances caused by recombinant tissue plasminogen activator in rat prefrontal cortex Open
Our results provide important novel mechanistic insights into the adverse effects of rtPA and offer directions for future exploration on the thrombolytic effects of rtPA combined with the administration of DG or GBE for the treatment of ac…
View article: Correction: Dietary cholesterol intake and stroke risk: a meta-analysis
Correction: Dietary cholesterol intake and stroke risk: a meta-analysis Open
[This corrects the article DOI: 10.18632/oncotarget.23933.].
View article: Metabolite-related antidepressant action of diterpene ginkgolides in the prefrontal cortex
Metabolite-related antidepressant action of diterpene ginkgolides in the prefrontal cortex Open
These findings demonstrate that DG has antidepressant-like, but not anxiolytic-like, effects in mice, suggesting that it might have therapeutic potential for the treatment of major depressive disorder.
View article: An adenosine�A1R-A2aR imbalance regulates low glucose/hypoxia-induced microglial activation, thereby contributing to oligodendrocyte damage through NF-κB and CREB phosphorylation
An adenosine�A1R-A2aR imbalance regulates low glucose/hypoxia-induced microglial activation, thereby contributing to oligodendrocyte damage through NF-κB and CREB phosphorylation Open
Microglial activation-mediated inflammatory damage to oligodendrocytes is a key step in the etiology of ischemic white matter lesions. The adenosine A1 receptor (A1R) and adenosine A2a receptor (A2aR) have been reported to regulate the act…
View article: Dietary cholesterol intake and stroke risk: a meta-analysis
Dietary cholesterol intake and stroke risk: a meta-analysis Open
Higher cholesterol intake has no association with the overall stroke risk. Age and body mass index affect the relationship between dietary cholesterol intake and stroke risk. However, the association between higher dietary cholesterol and …
View article: Proteomic and network analysis of human serum albuminome by integrated use of quick crosslinking and two-step precipitation
Proteomic and network analysis of human serum albuminome by integrated use of quick crosslinking and two-step precipitation Open
Affinity- and chemical-based methods are usually employed to prepare human serum albuminome; however, these methods remain technically challenging. Herein, we report the development of a two-step precipitation (TSP) method by combined use …