Explanipedia

Effectiveness of dupilumab treatment against refractory eosinophilic chronic rhinosinusitis Open

Daiki Nakashima, Tsuguhisa Nakayama, Shunsuke Minagawa, Tetsuya Adachi, Chieko Mitsuyama , et al. · 2025

Lipogenic Lung Fibroblast-derived Extracellular Vesicles Mitigate Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease Pathologies through LAT1-mediated Alveolar Type II Cell Restoration Open

Shota Fujimoto, Yuta Hirano, Naoaki Watanabe, Sachi Matsubayashi, Shun Inukai , et al. · 2024

Emerging research has revealed specific cellular aberrations in Chronic Obstructive Pulmonary Disease (COPD), with a particular focus on alveolar type 2 (AT2) cells, which play a pivotal role in the restoration of damaged lung tissue and p…

Clinical features in patients with COVID-19 treated with biologics for severe asthma Open

Takanori Numata, Keitaro Okuda, Hanae Miyagawa, Shunsuke Minagawa, Takeo Ishikawa , et al. · 2024

Minoxidil-induced lung disease, masquerading as hypersensitivity pneumonitis Open

Daisuke Takekosh, Teruhisa Nemoto, Susumu Saito, Yuma Matsui, Shunsuke Minagawa , et al. · 2023

We report the case of a 71-year-old male with essential thrombosis who presented with ground-glass lung opacity with a mosaic pattern on computed tomography, which resolved spontaneously with hospitalization. This was confused with a case …

Long-Term Efficacy and Clinical Remission After Benralizumab Treatment in Patients with Severe Eosinophilic Asthma: A Retrospective Study Open

Takanori Numata, Jun Araya, Keitaro Okuda, Hanae Miyagawa, Shunsuke Minagawa , et al. · 2022

Takanori Numata, Jun Araya, Keitaro Okuda, Hanae Miyagawa, Shunsuke Minagawa, Takeo Ishikawa, Hiromichi Hara, Kazuyoshi Kuwano Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, J…

Real-life effectiveness of dupilumab in patients with mild to moderate bronchial asthma comorbid with CRSwNP Open

Shunsuke Minagawa, Jun Araya, Naoaki Watanabe, Shota Fujimoto, Junko Watanabe , et al. · 2022

Involvement of Parkin‐mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease‐related sarcopenia Open

Akihiko Ito, Mitsuo Hashimoto, Jun Tanihata, Sachi Matsubayashi, Ryoko Sasaki , et al. · 2022

Background Sarcopenia is characterized by the loss of skeletal muscle mass and strength and is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS) exposure, a major cause for C…

Real-life effectiveness of dupilumab in patients with mild to moderate bronchial asthma comorbid with CRSwNP Open

Shunsuke Minagawa, Jun Araya, Naoaki Watanabe, Shota Fujimoto, Junko Watanabe , et al. · 2022

( Background ) Dupilumab, an anti-IL-4α receptor antibody, is a new treatment for severe or refractory asthma, but real-world evidence is lacking for the efficacy of dupilumab in patients with mild to moderate bronchial asthma.( Methods ) …

Possible relationship between esophageal dilatation and severity of M. abscessus pulmonary disease Open

Hiromichi Hara, Keitaro Okuda, Jun Araya, Hirofumi Utsumi, Daisuke Takekoshi , et al. · 2021

Objectives Recently, incidence of Mycobacterium abscessus (Mab) pulmonary disease (Mab-PD) is increasing worldwide. We aimed to identify factors associated with severity of Mycobacterium abscessus (Mab) pulmonary disease (Mab-PD). Methods …

P7‐8: Effect of surgical mask on exercise capacity in patients with chronic obstructive pulmonary disease: A randomized controlled trial Open

Kuniaki Hirai, Akihiko Tanaka, Hiroki Sato, Yoko Sato, Yoshitaka Uchida , et al. · 2021

a periodontal pathogen) and Fusobacterium spp.detection were higher.Although the COPD state is proposed to be related to F. nucleatum, the mechanism is unclear.In this study, we investigated the effect of F. nucleatum aspiration on COPD ex…

P7‐7: Effect of periodontal pathogen <i>Fusobacterium nucleatum</i> on a COPD mouse model Open

Kazufumi Takamatsu, Kaechang Park, Yoshiaki Hirakawa, Junki Terada, Yu Nakatani , et al. · 2021

Background: COPD has been found to be caused by impairment of lung development.Preserved ratio impaired spirometry (PRISm) is thought to be a subtype of lung growth impairment and is associated with COPD.We hypothesized that the associatio…

P16‐14: Iron‐dependent mitochondrial dysfunction contributes to the pathogenesis of pulmonary fibrosis Open

Tsukasa Kadota, Yu Fujita, Jun Araya, Sachi Matsubayashi, Ryoko Sasaki , et al. · 2021

Results: A total of 1016 patients (524 with IIPs, including 145 CPFE, and 491 with COPD) were enrolled.96.8% of COPD patients and 69.9% of IIPs patients were current or former smokers.The telomerase reverse transcriptase (TERT) rs2736100 w…

Human bronchial epithelial cell‐derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF‐β‐WNT crosstalk Open

Tsukasa Kadota, Yu Fujita, Jun Araya, Naoaki Watanabe, Shota Fujimoto , et al. · 2021

Idiopathic pulmonary fibrosis (IPF) is characterized by devastating and progressive lung parenchymal fibrosis, resulting in poor patient prognosis. An aberrant recapitulation of developmental lung gene expression, including genes for trans…

Effectiveness of Switching Biologics for Severe Asthma Patients in Japan: A Single-Center Retrospective Study Open

Takanori Numata, Jun Araya, Hanae Miyagawa, Keitaro Okuda, Yu Fujita , et al. · 2021

Switching between biologics can be a promising option for severe asthma patients in whom treatment with an initial biologic is ineffective.

Characteristics of anti-IL-17/23 biologics-induced interstitial pneumonia in patients with psoriasis Open

Hanae Miyagawa, Hiromichi Hara, Jun Araya, Shunsuke Minagawa, Takanori Numata , et al. · 2021

Objectives Anti-IL-17/23 biologics are increasingly used to treat psoriasis. We aimed to elucidate characteristics of drug-induced interstitial pneumonia (DIIP) caused by anti-IL-17/23 biologics. Methods We retrospectively analyzed the cli…

Human bronchial epithelial cell-derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF-β-WNT crosstalk Open

Tsukasa Kadota, Yu Fujita, Jun Araya, Naoaki Watanabe, Shota Fujimoto , et al. · 2020

Idiopathic pulmonary fibrosis (IPF) is characterized by devastating and progressive lung parenchymal fibrosis, resulting in poor patient prognosis. An aberrant recapitulation of developmental lung gene expression, including genes for trans…

Chaperone‐mediated autophagy receptor modulates tumor growth and chemoresistance in non–small cell lung cancer Open

Akihiro Ichikawa, Yu Fujita, Yusuke Hosaka, Tsukasa Kadota, Akihiko Ito , et al. · 2020

Chaperone‐mediated autophagy (CMA) is a lysosomal degradation pathway of selective soluble proteins. Lysosome‐associated membrane protein type 2a (LAMP2A) is the key receptor protein of CMA; downregulation of LAMP2A leads to CMA blockade. …

Efficacy of benralizumab for patients with severe eosinophilic asthma: a retrospective, real-life study Open

Takanori Numata, Hanae Miyagawa, Saiko Nishioka, Keitaro Okuda, Hirofumi Utsumi , et al. · 2020

Dasatinib-induced Nonspecific Interstitial Pneumonia That Developed 7 Years after the Initiation of Dasatinib Open

Daisuke Takekoshi, Yuma Matsui, Takuya Akutsu, Ayako Nishioka, Ayu Kiritani , et al. · 2020

We report the case of a 56-year-old man with chronic myeloid leukemia (CML) who developed dasatinib-induced interstitial lung disease (ILD) 7 years after starting dasatinib, a BCR-ABL1 inhibitor. The patient presented with dyspnea. Chest i…

Successful treatment of steroid-refractory immune checkpoint inhibitor-related pneumonitis with triple combination therapy: a case report Open

Hirofumi Utsumi, Jun Araya, Keitaro Okuda, Junko Watanabe, Daisuke Takekoshi , et al. · 2020

Additional file 1 of Efficacy of benralizumab for patients with severe eosinophilic asthma: a retrospective, real-life study Open

Takanori Numata, Hanae Miyagawa, Saiko Nishioka, Keitaro Okuda, Hirofumi Utsumi , et al. · 2020

Additional file 1. Characteristics of 12 patients who received other biologics before benralizumab treatment

Predictors of the enhanced response to mepolizumab treatment for severe eosinophilic asthma: A retrospective, long-term study Open

Takanori Numata, Hanae Miyagawa, Hironori Kawamoto, Masahiro Yoshida, Hirofumi Utsumi , et al. · 2020

Mepolizumab significantly reduces the number of annual exacerbations (AEs) and the maintenance dose of systemic corticosteroids (CSs) in patients with severe eosinophilic asthma (SEA). However, there are few studies based on real life with…

Additional file 2 of Efficacy of benralizumab for patients with severe eosinophilic asthma: a retrospective, real-life study Open

Takanori Numata, Hanae Miyagawa, Saiko Nishioka, Keitaro Okuda, Hirofumi Utsumi , et al. · 2020

Additional file 2. Patients characteristics at baseline in four subgroup [male, female, AERD (−) and (+)]

Efficacy of mepolizumab for patients with severe asthma and eosinophilic chronic rhinosinusitis Open

Takanori Numata, Katsutoshi Nakayama, Hirofumi Utsumi, Kenji Kobayashi, Haruhiko Yanagisawa , et al. · 2019

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis Open

Masahiro Yoshida, Shunsuke Minagawa, Jun Araya, Taro Sakamoto, Hiromichi Hara , et al. · 2019

Prostaglandin E-Major Urinary Metabolite (PGE-MUM) as a Tumor Marker for Lung Adenocarcinoma Open

Hironori Kawamoto, Hiromichi Hara, Jun Araya, Akihiro Ichikawa, Yu Fujita , et al. · 2019

Background: Prostaglandin E2 (PGE2) is metabolized to prostaglandin E-major urinary metabolite (PGE-MUM). Enhanced cyclooxygenase-2 (COX-2) expression demonstrated in lung adenocarcinoma indicates increased PGE-MUM levels in patients with …

PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis Open

Jun Araya, Kazuya Tsubouchi, Nahoko Sato, Saburo Ito, Shunsuke Minagawa , et al. · 2018

Cigarette smoke (CS)-induced accumulation of mitochondrial damage has been widely implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. Mitophagy plays a crucial role in eliminating damaged mitochondria, and is governed …

Interstitial Pneumonia in Psoriasis Open

Hironori Kawamoto, Hiromichi Hara, Shunsuke Minagawa, Takanori Numata, Jun Araya , et al. · 2018

Risk factors of postoperative pulmonary complications in patients with asthma and COPD Open

Takanori Numata, Katsutoshi Nakayama, Satoko Fujii, Yoko Yumino, Nayuta Saito , et al. · 2018

History of smoking or severe asthma is a risk factor of PPC in patients with asthma, and age, upper abdominal surgery, or long operation time is a risk factor of PPC in patients with COPD. Adequate inhaled corticosteroids treatment in pati…

Detection of pathogens by real-time PCR in adult patients with acute exacerbation of bronchial asthma Open

Yutaka Yoshii, Kenichiro Shimizu, Miyuki Morozumi, Naoko Chiba, Kimiko Ubukata , et al. · 2017

Shunsuke Minagawa YOU? Author Swipe