Explanipedia

Clinical Characteristics of Extrapulmonary Nontuberculous Mycobacterial Diseases in Japanese Adult Patients without HIV: A Multicenter Retrospective Study Open

Shuhei Azekawa, Takanori Asakura, Shunsuke Uno, Yosuke Nakanishi, Eriko Morino , et al. · 2025

Most extrapulmonary NTM cases respond to antimicrobial therapy and source control. RGM infections involving prosthetic devices without source control remain challenging, warranting further research into optimized management.

Tropheryma whipplei Endocarditis Diagnosed by Tissue 16S rRNA Gene Sequencing: A Case Report Open

Takashi Maeda, Shun Kohsaka, Nozomi Niimi, Shunsuke Uno, Yoshifumi Uwamino , et al. · 2025

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases Open

Youngjune Bhak, Vasilis Raptis, Yunye He, Tomoko Nakanishi, Erin Macdonald-Dunlop , et al. · 2025

Males and females exhibit differences in proteome profiles associated with disease risk. However, sex-dimorphic protein quantitative trait loci (SD-pQTL) and their effects on sex differences in health disorders have not been thoroughly inv…

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution Open

Go Sato, Ryunosuke Saiki, Kyuto Sonehara, Yoshihiko Tomofuji, Kenichi Yamamoto , et al. · 2025

Cefiderocol susceptibility of Stenotrophomonas maltophilia species complex and carbapenem-resistant Pseudomonas aeruginosa isolates from blood cultures at a university hospital in Tokyo, Japan Open

Wataru Aoki, Yoshifumi Uwamino, Nagi Niida, Hiroaki Kubota, Yuka Kamoshita , et al. · 2025

A Simulated Interprofessional Team Conference Using Cross-Training for Junior Healthcare Students in Interprofessional Education: a Qualitative Content Analysis Open

Etsuko Tomisaki, Junji Haruta, Takashi Horiguchi, Tomoko Arahata, Rika Fukui , et al. · 2025

Simulated interprofessional team conferences using cross-training effectively taught junior students to understand the essence of a good healthcare team and the importance of a patient-centered approach. Cross-training significantly enhanc…

Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity Open

Kyuto Sonehara, Yoshifumi Uwamino, Ryunosuke Saiki, Masaru Takeshita, Shinichi Namba , et al. · 2025

Direct analysis of hepatic stellate cells with flow cytometry in specimens derived from the human liver Open

Toshiaki Bando, Hajime Morita, Lynn Zreka, Shuhe Ma, Mouna Khan , et al. · 2024

Background & Aims: Hepatic stellate cells (HSCs) play a crucial role in liver fibrosis. However, the methodology to directly assess the biology of primary HSCs in human liver specimens is yet to be established. In this study, we aimed to e…

Trends in the integration of medical corporation hospitals in Japan: a national wide longitudinal study between 2017 and 2021 Open

Satoshi Funada, Yan Luo, Hirotaka Kato, Takashi Yoshioka, Shunsuke Uno , et al. · 2024

This longitudinal study revealed a gradual downward trend in the number of hospitals and hospital beds owned by medical corporations, while horizontal and vertical integration gradually progressed without any particular medical corporation…

Factors associated with lifetime use of commercial sex work services among Japanese men aged 20–49: findings from a quasi-representative national survey, 2022 Open

Cyrus Ghaznavi, Peter Ueda, Shuhei Nomura, Masahiro Ishikane, Shunsuke Uno , et al. · 2024

Objectives Approximately half of Japanese men aged 20–49 years have purchased sexual services, but data concerning the use of commercial sex work (CSW) in Japan remain scarce. Methods We used online survey data from the National Inventory …

Trends in the integration of medical corporation hospitals in Japan: a national wide longitudinal study between 2017 and 2021 Open

Satoshi Funada, Yan Luo, Hirotaka Kato, Takashi Yoshioka, Shunsuke Uno , et al. · 2024

Background Medical corporations, which aim to operate hospitals, clinics, or long-term care facilities, account for more than half of all hospital beds and play a central role in the health care system in Japan. However, limited analysis o…

Factors affecting motivation for receiving a booster dose of the COVID-19 vaccine among Japanese university students and staff: a cross-sectional questionnaire survey Open

Sho Uchida, Shunsuke Uno, Masahiro Kondo, Yoshifumi Uwamino, Ho Namkoong , et al. · 2024

Understanding the factors that influence people’s decisions regarding vaccination is essential to promote vaccination. We aimed to clarify the motivations for receiving booster vaccines. We conducted a paper-based questionnaire distributed…

Age and Infusion Rate Adjusted Body Weight (Mg/Min/Kg) as Risk Factor for Vancomycin Infusion Reaction: A Retrospective Study Open

Osamu Iketani, Shunsuke Uno, Masayoshi Shinjoh, Ryo Takemura, Shogo Fukuda , et al. · 2024

Analysis of Risk Factors for Developing Tuberculosis in Patients Who Received Prophylactic Latent Tuberculosis Infection Treatment with Experience of Biologic Medications Open

Marina Itagaki, Osamu Iketani, Yuki Enoki, Victor Tuan Giam Chuang, Kazuaki Taguchi , et al. · 2023

Biologic medications have dramatically improved the treatment outcomes of immunological inflammatory diseases, but their immunosuppressive effects put patients at risk for tuberculosis (TB). We investigated the risk factors for developing …

Cost-Effectiveness of Universal Asymptomatic Preoperative SARS-CoV-2 Polymerase Chain Reaction Screening: A Cost-Utility Analysis Open

Shunsuke Uno, Rei Goto, Kimiko Honda, Sho Uchida, Yoshifumi Uwamino , et al. · 2023

Background An early report has shown the clinical benefit of the asymptomatic preoperative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) screening test, and some clinical guidelines recommended this test. However, the cost-e…

Healthcare costs for hospitalized COVID-19 patients in a Japanese university hospital: a cross-sectional study Open

Shunsuke Uno, Rei Goto, Kimiko Honda, Machiko Tokuda, Hirofumi Kamata , et al. · 2023

Healthcare costs for hospitalized COVID-19 patients in a Japanese university hospital: A cross-sectional study Open

Shunsuke Uno, Rei Goto, Kimiko Honda, Machiko Tokuda, Hirofumi Kamata , et al. · 2023

Background: A health-economic evaluation related to COVID-19 is urgently needed to allocate healthcare resources efficiently; however, relevant medical cost data in Japan concerning COVID-19 are scarce. Methods: This cross-sectional study …

Association of demographics, HCV co‐infection, HIV‐1 subtypes and genetic clustering with late HIV diagnosis: a retrospective analysis from the Japanese Drug Resistance HIV‐1 Surveillance Network Open

Machiko Otani, Teiichiro Shiino, Atsuko Hachiya, Hiroyuki Gatanaga, Dai Watanabe , et al. · 2023

Introduction Late diagnosis of the human immunodeficiency virus (HIV) is a major concern epidemiologically, socially and for national healthcare systems. Although the association of certain demographics with late HIV diagnosis has been rep…

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity Open

Ryuya Edahiro, Yuya Shirai, Yusuke Takeshima, Shuhei Sakakibara, Yuta Yamaguchi , et al. · 2023

Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral blood mononu…

Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force Open

Ho Lee, Shotaro Chubachi, Ho Namkoong, Takanori Asakura, Hiromu Tanaka , et al. · 2022

Background We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant. Methods We used…

Metastatic prostate cancer with low PSA levels diagnosed after holmium laser enucleation of the prostate Open

Kosuke Ogawa, Ryota Kitabayashi, Masayuki Kurokawa, Yoshiyuki Okada, Shunsuke Uno , et al. · 2022

Contents: Eur. J. Immunol. 12'22 Open

Lorenz Kretschmer, Tal Pecht, Katja Knapp, Sabrina B. Bennstein, Niclas Flosdorf , et al. · 2022

Assessing anti‐SARS‐CoV‐2 cellular immunity in 571 vaccines by using an IFN‐γ release assay Open

Masatoshi Wakui, Yoshifumi Uwamino, Yoko Yatabe, Terumichi Nakagawa, Akiko Sakai , et al. · 2022

Memory T cell responses have been analyzed only in small cohorts of COVID‐19 vaccines. Herein, we aimed to assess anti‐SARS‐CoV‐2 cellular immunity in a large cohort using QuantiFERON assays, which are IFN‐γ release assays (IGRAs) based on…

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force Open

Qingbo S. Wang, Ryuya Edahiro, Ho Namkoong, Takanori Hasegawa, Yuya Shirai , et al. · 2022

DOCK2 is involved in the host genetics and biology of severe COVID-19 Open

Ho Namkoong, Ryuya Edahiro, Tomomi Takano, Hiroshi Nishihara, Yuya Shirai , et al. · 2022

Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge 1–5 . Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese individuals collected during …

Osteoporosis in nontuberculous mycobacterial pulmonary disease: a cross-sectional study Open

Hiromu Tanaka, Takanori Asakura, Shoji Suzuki, Satoshi Okamori, Tatsuya Kusumoto , et al. · 2022

Pro108Ser mutation of SARS-CoV-2 3CLpro reduces the enzyme activity and ameliorates the clinical severity of COVID-19 Open

Kodai Abe, Yasuaki Kabe, Susumu Uchiyama, Yuka W. Iwasaki, Hirotsugu Ishizu , et al. · 2022

Young age, female sex, and presence of systemic adverse reactions are associated with high post-vaccination antibody titer after two doses of BNT162b2 mRNA SARS-CoV-2 vaccination: An observational study of 646 Japanese healthcare workers and university staff Open

Yoshifumi Uwamino, Toshinobu Kurafuji, Yasunori Sato, Yukari Tomita, Ayako Shibata , et al. · 2022

A hemodialysis patient who developed spontaneous bladder perforation： a case report Open

Naoki Mori, M Kashiwa, Aika Hagiwara, Yasuyoshi Yamaji, Yoshinori Sato , et al. · 2022

症例は79歳女性．血液透析歴19年，関節リウマチに対して2年前からプレドニゾロン5 mg/日を内服している．下腹部痛を主訴に入院後発熱が続き，膿尿と腹・骨盤部単純CTで残尿を認めた．尿路感染症を疑い，メロペネムで加療を開始した．尿培養でEscherichia‒coli，血液培養でBacteroides thetaiotaomicronが検出，第3病日の造影CTで気泡を伴う膀胱周囲膿瘍を認めたため膀胱穿孔と診断した．手術は行わず，尿道カテーテルに加え，経皮的に膀胱周囲にドレー…

Anti-SARS-CoV-2 cellular immunity in 571 vaccinees assessed using an interferon-γ release assay Open

Yoshifumi Uwamino, Masatoshi Wakui, Yoko Yatabe, Terumichi Nakagawa, Akiko Sakai , et al. · 2021

Generation of antigen-specific memory T cells has been analyzed only for few coronavirus disease 2019 (COVID-19) vaccinees, whereas antibody titers have been serologically measured for a large number of individuals. Here, we assessed the a…

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