Shuo Tian
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View article: A CEBPB/TYMP/GDF15 signaling axis mediates tumor growth and cisplatin resistance in bladder cancer
A CEBPB/TYMP/GDF15 signaling axis mediates tumor growth and cisplatin resistance in bladder cancer Open
View article: A New Perspective on Regenerative Medicine: Plant-Derived Extracellular Vesicles
A New Perspective on Regenerative Medicine: Plant-Derived Extracellular Vesicles Open
Plant-derived extracellular vesicles (PDEVs) are nanoscale, phospholipid bilayer-enclosed vesicles secreted by living cells through cytokinesis under physiological and pathological conditions. Owing to their high biocompatibility and stabi…
View article: Investigation of the molecular mechanism of Xiaoluo Wan in thyroid-associated ophthalmopathy: network analysis and in vivo study
Investigation of the molecular mechanism of Xiaoluo Wan in thyroid-associated ophthalmopathy: network analysis and in vivo study Open
View article: Human iPSCs Derived MSCs‐Secreted Exosomes Modulate Senescent Nucleus Pulposus Cells Induced Macrophage Polarization via Metabolic Reprogramming to Mitigate Intervertebral Disc Degeneration
Human iPSCs Derived MSCs‐Secreted Exosomes Modulate Senescent Nucleus Pulposus Cells Induced Macrophage Polarization via Metabolic Reprogramming to Mitigate Intervertebral Disc Degeneration Open
Intervertebral disc degeneration (IDD) is a leading cause of discogenic lower back pain, yet the crosstalk between macrophage polarization and nucleus pulposus (NP) cell senescence in IDD progression remains poorly understood. Emerging the…
View article: Phytochemical profile of Pereskia aculeata Miller and its bioactive constituents for treating rheumatoid arthritis' s inflammation via inhibiting COX-2 target
Phytochemical profile of Pereskia aculeata Miller and its bioactive constituents for treating rheumatoid arthritis' s inflammation via inhibiting COX-2 target Open
Pereskia aculeata Miller (OPN), an edible plant, has the potential to treat the inflammation of rheumatoid arthritis (RA). This article aimed to characterize its phytochemical profile and to explore the key target and bioactive compounds a…
View article: Exosomes derived from MSCs exposed to hypoxic and inflammatory environments slow intervertebral disc degeneration by alleviating the senescence of nucleus pulposus cells through epigenetic modifications
Exosomes derived from MSCs exposed to hypoxic and inflammatory environments slow intervertebral disc degeneration by alleviating the senescence of nucleus pulposus cells through epigenetic modifications Open
Intervertebral disc degeneration (IDD) is the leading cause of low back pain, which places heavy burdens on society and individuals. Surgical intervention is the conventional therapy for IDD, but patients who undergo surgery face relativel…
View article: Progress in the Study of Intratumoral Microorganisms in Hepatocellular Carcinoma
Progress in the Study of Intratumoral Microorganisms in Hepatocellular Carcinoma Open
The intratumoral microbiota, an integral part of liver tumors, has garnered significant attention from researchers due to its role in tumor development regulation and impact on cancer treatment. Intratumoral microorganism not only influenc…
View article: Cellular and molecular mechanisms underlying obesity in degenerative spine and joint diseases
Cellular and molecular mechanisms underlying obesity in degenerative spine and joint diseases Open
Degenerative spine and joint diseases, including intervertebral disc degeneration (IDD), ossification of the spinal ligaments (OSL), and osteoarthritis (OA), are common musculoskeletal diseases that cause pain or disability to the patients…
View article: Noncoding RNA as a crucial epigenetic modulator in the degeneration of the ligamentum flavum
Noncoding RNA as a crucial epigenetic modulator in the degeneration of the ligamentum flavum Open
View article: Chinese herbal medicine-derived extracellular vesicles as novel biotherapeutic tools: present and future
Chinese herbal medicine-derived extracellular vesicles as novel biotherapeutic tools: present and future Open
Extracellular vesicles (EVs) are phospholipid bilayer-enclosed biological particles that are secreted by almost all living cells including animals, plants, and microorganisms. Chinese herbal medicines (CHM) have a long history of using pla…
View article: Inhibition of primary cilia-hedgehog signaling axis triggers autophagic cell death and suppresses malignant progression of VHL wild-type ccRCC
Inhibition of primary cilia-hedgehog signaling axis triggers autophagic cell death and suppresses malignant progression of VHL wild-type ccRCC Open
View article: Mechanisms of Flavonoids and Their Derivatives in Endothelial Dysfunction Induced by Oxidative Stress in Diabetes
Mechanisms of Flavonoids and Their Derivatives in Endothelial Dysfunction Induced by Oxidative Stress in Diabetes Open
Diabetic complications pose a significant threat to life and have a negative impact on quality of life in individuals with diabetes. Among the various factors contributing to the development of these complications, endothelial dysfunction …
View article: Inhibition of primary cilia-hedgehog signaling axis triggers autophagic cell death and suppresses malignant progression of VHL wild-type ccRCC
Inhibition of primary cilia-hedgehog signaling axis triggers autophagic cell death and suppresses malignant progression of VHL wild-type ccRCC Open
Primary cilia are present on renal tubules and are implicated to play pivotal role in transducing signals during development; however, the oncogenic role of cilia in clear cell renal cell carcinoma (ccRCC) has not been examined. Here we sh…
View article: 14-3-3 binding motif phosphorylation disrupts Hdac4-organized condensates to stimulate cardiac reprogramming
14-3-3 binding motif phosphorylation disrupts Hdac4-organized condensates to stimulate cardiac reprogramming Open
View article: EIF4A3-mediated biogenesis of circSTX6 promotes bladder cancer metastasis and cisplatin resistance
EIF4A3-mediated biogenesis of circSTX6 promotes bladder cancer metastasis and cisplatin resistance Open
Background Cisplatin (CDDP)-based chemotherapy is a standard first-line treatment for metastatic bladder cancer (BCa) patients, and chemoresistance remains a major challenge in clinical practice. Circular RNAs (circRNAs) have emerged as es…
View article: Transient BRD4 degradation improves cardiac reprogramming by inhibiting macrophage/Oncostatin M induced JAK/STAT pathway
Transient BRD4 degradation improves cardiac reprogramming by inhibiting macrophage/Oncostatin M induced JAK/STAT pathway Open
Reprogramming fibroblasts into induced cardiomyocytes (iCMs) holds great potential for cardiac regeneration. However, low conversion rate both in vitro and in vivo remains a significant challenge. To address this challenge, we focused on p…
View article: 14-3-3 binding motif phosphorylation disrupts Hdac4 organized condensates to stimulate cardiac reprogramming
14-3-3 binding motif phosphorylation disrupts Hdac4 organized condensates to stimulate cardiac reprogramming Open
Cell fate conversion is associated with extensive epigenetic and post translational modifications (PTMs) and architectural changes of sub-organelles and organelles, yet how these events are interconnected remains unknown. We report here th…
View article: EIF4A3-mediated biogenesis of circSTX6 promotes bladder cancer metastasis and cisplatin resistance
EIF4A3-mediated biogenesis of circSTX6 promotes bladder cancer metastasis and cisplatin resistance Open
Background Cisplatin (CDDP)-based chemotherapy is a standard first-line treatment for metastatic bladder cancer (BCa) patients, and chemoresistance remains a major challenge in clinical practice. Circular RNAs (circRNAs) have emerged as es…
View article: Effect of SARS-CoV-2 on semen parameters: A meta-analysis of 39 articles from 15 countries
Effect of SARS-CoV-2 on semen parameters: A meta-analysis of 39 articles from 15 countries Open
View article: Robot-Assisted Laparoscopic Adrenal Metastasectomy With Prior Partial or Radical Nephrectomy: Step-by-Step Technique and 1-Year Outcomes
Robot-Assisted Laparoscopic Adrenal Metastasectomy With Prior Partial or Radical Nephrectomy: Step-by-Step Technique and 1-Year Outcomes Open
Purpose: The purpose of this study was to elucidate the feasibility and safety of the technique of robot-assisted laparoscopic adrenal metastasectomy (RAL-AME) for adrenal metastasis (AM) originating from renal cell carcinoma (RCC) with su…
View article: Antibacterial activity mechanism of coptisine against Pasteurella multocida
Antibacterial activity mechanism of coptisine against Pasteurella multocida Open
Objective Pasteurella multocida is a widespread zoonotic pathogen that causes severe damage to the poultry industry. This study focused on the antibacterial effects and mechanism of action of coptisine against P. multocida . Methods The mi…
View article: SP1/CTR1 mediated oxidative stress-induced cuproptosis in intervertebral disk degeneration
SP1/CTR1 mediated oxidative stress-induced cuproptosis in intervertebral disk degeneration Open
Intervertebral disk degeneration (IDD) is the primary pathology responsible for lower back pain. Oxidative stress-induced cell death plays a fundamental role in IDD pathogenesis. Cuproptosis is a recently discovered form of programmed cell…
View article: Optical Genome Mapping for Comprehensive Assessment of Chromosomal Aberrations and Discovery of New Fusion Genes in Pediatric B-Acute Lymphoblastic Leukemia
Optical Genome Mapping for Comprehensive Assessment of Chromosomal Aberrations and Discovery of New Fusion Genes in Pediatric B-Acute Lymphoblastic Leukemia Open
Purpose: To assess the potential added value of Optical Genomic Mapping (OGM) for identifying chromosomal aberrations. Methods: We utilized Optical Genomic Mapping (OGM) to determine chromosomal aberrations in 46 children with B-cell Acute…
View article: Novel Ascorbic Acid Co-Crystal Formulations for Improved Stability
Novel Ascorbic Acid Co-Crystal Formulations for Improved Stability Open
A series of co-crystals of ascorbic acid were prepared with equimolar amounts of co-crystal formers (CCFs), including isonicotinic acid, nicotinic acid, 3,4-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid and m-hydroxybenzoic acid, by slo…
View article: Investigation of the Pharmacological Effect and Mechanism of Jinbei Oral Liquid in the Treatment of Idiopathic Pulmonary Fibrosis Using Network Pharmacology and Experimental Validation
Investigation of the Pharmacological Effect and Mechanism of Jinbei Oral Liquid in the Treatment of Idiopathic Pulmonary Fibrosis Using Network Pharmacology and Experimental Validation Open
Overview: Idiopathic pulmonary fibrosis (IPF) is a disease caused by many factors, eventually resulting in lung function failure. Jinbei oral liquid (JBOL) is a traditional Chinese clinical medicine used to treat pulmonary diseases. Howeve…
View article: Association of Valproic Acid Use With Post-Myocardial Infarction Heart Failure Development: A Meta-Analysis of Two Retrospective Case–Control Studies
Association of Valproic Acid Use With Post-Myocardial Infarction Heart Failure Development: A Meta-Analysis of Two Retrospective Case–Control Studies Open
Background: Despite advances in treatments, myocardial infarction (MI) remains a significant cause of morbidity and mortality worldwide. Our team has previously shown that valproic acid (VPA) is cardio-protective when administered to rats …
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View article: Author response: Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation
Author response: Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation Open
View article: Effects of Jianpi Lishi Jiedu Granules on Colorectal Adenoma Patients after Endoscopic Treatment: Study Protocol for a Randomized Controlled Trial
Effects of Jianpi Lishi Jiedu Granules on Colorectal Adenoma Patients after Endoscopic Treatment: Study Protocol for a Randomized Controlled Trial Open
BackgroundColorectal adenomas (CRAs) are precancerous lesions of the large intestine presenting as colorectal polyps. At present, the conventional treatment methods for CRA mainly include high-frequency electrocoagulation and electroexcisi…
View article: The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro
The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro Open