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View article: Thrombospondin-1 (THBS1) is dysregulated in preeclampsia
Thrombospondin-1 (THBS1) is dysregulated in preeclampsia Open
View article: Depression in pregnancy: A multinational prospective cohort study
Depression in pregnancy: A multinational prospective cohort study Open
Within our study cohort, spanning two centres in Pakistan and South Africa, one in six women experienced depression in pregnancy. Reassuringly, depression was not associated with an increase in adverse pregnancy outcomes; spontaneous prete…
View article: Hypertensive disorders of pregnancy and childhood neurodevelopment: A systematic review and meta-analysis
Hypertensive disorders of pregnancy and childhood neurodevelopment: A systematic review and meta-analysis Open
Background Hypertensive disorders of pregnancy may be associated with an increased risk of adverse neurodevelopmental outcomes for the child, though no recent comprehensive meta-analyses exist. The aim of this study was to conduct a system…
View article: Sialic acid-binding immunoglobulin-like lectin-6 (SIGLEC6) is increased by hypoxia and inflammation; relevance to preeclampsia
Sialic acid-binding immunoglobulin-like lectin-6 (SIGLEC6) is increased by hypoxia and inflammation; relevance to preeclampsia Open
SIGLEC6, a human-specific transmembrane receptor, is highly expressed in placenta. Our team have identified elevated SIGLEC6 in maternal circulation preceding preeclampsia and in women with preeclampsia, correlating with disease severity. …
View article: The association between circulating SIGLEC6 and preeclampsia: observational studies of seven cohorts
The association between circulating SIGLEC6 and preeclampsia: observational studies of seven cohorts Open
National Health and Medical Research Council (#1065854) and the Norman Beischer Medical Research Foundation. Additional sources of funding for the biobank from South Africa was received from the Swedish Medical Society, Märta Lundqvist Fou…
View article: Diabetes in Pregnancy and School-Age Developmental Outcomes for Offspring: A Statewide Retrospective Cohort Study
Diabetes in Pregnancy and School-Age Developmental Outcomes for Offspring: A Statewide Retrospective Cohort Study Open
OBJECTIVE The impact of diabetes in pregnancy on offspring neurodevelopment is unclear. We investigate whether exposure to diabetes in utero is associated with developmental vulnerability or educational delay during primary school. RESEARC…
View article: Reduced circulating NrCAM as a biomarker for fetal growth restriction
Reduced circulating NrCAM as a biomarker for fetal growth restriction Open
View article: The Fetal Region-specific Optimized Growth Standard (FROGS)—A fetal and birthweight centile calculator validated in a national population
The Fetal Region-specific Optimized Growth Standard (FROGS)—A fetal and birthweight centile calculator validated in a national population Open
Background There is no universally agreed upon obstetric growth standard for use during pregnancy. We aimed to design a simple novel growth standard, which incorporates key beneficial features identified in prior research. Methods and find…
View article: The human placenta and its role in reproductive outcomes revisited
The human placenta and its role in reproductive outcomes revisited Open
The placenta performs many key tasks that are essential for the healthy growth and development of the human fetus. Placental dysfunction has multiple manifestations, but they share the common property of lacking a mechanistic understanding…
View article: Slowing fetal growth velocity from the mid-trimester may signal increased risks of perinatal morbidity and mortality: a retrospective cohort study
Slowing fetal growth velocity from the mid-trimester may signal increased risks of perinatal morbidity and mortality: a retrospective cohort study Open
Background Undetected fetal growth restriction is a major risk factor for stillbirth. Detecting small babies is a cornerstone of obstetric care, but we fail to detect most uteroplacental insufficiency impairing fetal growth, and most small…
View article: High-order cumulants of wolfram metal in anharmonic EXAFS theory calculated using the correlated Einstein model
High-order cumulants of wolfram metal in anharmonic EXAFS theory calculated using the correlated Einstein model Open
The anharmonic extended X-ray absorption fine structure (EXAFS) cumulants of wolfram metal (W) in expansion to the 4th order have been calculated under the influence of thermal disorder. The temperature-dependent EXAFS cumulants were calcu…
View article: Blood-brain barrier injury and neuroinflammation in pre-eclampsia and eclampsia
Blood-brain barrier injury and neuroinflammation in pre-eclampsia and eclampsia Open
View article: Cystatin 6 (CST6) and Legumain (LGMN) are potential mediators in the pathogenesis of preeclampsia
Cystatin 6 (CST6) and Legumain (LGMN) are potential mediators in the pathogenesis of preeclampsia Open
Preeclampsia results from placental insufficiency and causes maternal endothelial dysfunction and multi-organ damage. Our in-silico analysis identified Cystatin 6 (CST6), a cysteine protease inhibitor, as located on the placental surface w…
View article: Phosphoglucomutase 5 gene transcripts are expressed by the human placenta and differentially regulated in placental dysfunction
Phosphoglucomutase 5 gene transcripts are expressed by the human placenta and differentially regulated in placental dysfunction Open
The placenta plays an essential role facilitating nutrient, gas and waste exchange between the maternal and fetal systems for optimal fetal growth. When placental development is impaired and the placenta dysfunctional, serious pregnancy co…
View article: School-age outcomes among IVF and ICSI-conceived children: a causal inference analysis using linked population-wide data
School-age outcomes among IVF and ICSI-conceived children: a causal inference analysis using linked population-wide data Open
View article: Prophylactic Aspirin Dose and Preeclampsia
Prophylactic Aspirin Dose and Preeclampsia Open
Importance It is unclear whether a higher dose (150-160 mg) or a lower dose (75 mg) of aspirin should be used to prevent preeclampsia. Objectives To compare the risk of preeclampsia and bleeding complications between women using 150 to 160…
View article: Trend-Aware Structure Relearning Framework for Water Quality Prediction with Coupled Noise Governance
Trend-Aware Structure Relearning Framework for Water Quality Prediction with Coupled Noise Governance Open
View article: Circulating concentrations of pro-inflammatory cytokines in preeclampsia with varying disease severity
Circulating concentrations of pro-inflammatory cytokines in preeclampsia with varying disease severity Open
Plasma concentrations of IL-6 and VCAM-1, but not CRP, were increased among women with preeclampsia and end-organ complications, compared with women without end-organ complications. IL-6 and VCAM-1 could be drivers of disease in preeclamps…
View article: Cerebral infarcts, edema, hypoperfusion, and vasospasm in preeclampsia and eclampsia
Cerebral infarcts, edema, hypoperfusion, and vasospasm in preeclampsia and eclampsia Open
Eclampsia was associated with cerebral infarcts, vasogenic cerebral edema, vasospasm, and decreased perfusion, which are not usually evident on standard clinical imaging. This finding may explain why some patients have cerebral symptoms an…
View article: Senescent Syncytiotrophoblast Secretion During Early Onset Preeclampsia
Senescent Syncytiotrophoblast Secretion During Early Onset Preeclampsia Open
BACKGROUND: Preeclampsia is a severe hypertensive disorder in pregnancy that causes preterm delivery, maternal and fetal morbidity, mortality, and life-long sequelae. Understanding the pathogenesis of preeclampsia is a critical first step …
View article: Metformin use and preeclampsia risk in women with diabetes: a two-country cohort analysis
Metformin use and preeclampsia risk in women with diabetes: a two-country cohort analysis Open
View article: Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is reduced with preeclampsia and small for gestational aged fetuses
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is reduced with preeclampsia and small for gestational aged fetuses Open
View article: Trophoblast Side-Population Markers are Dysregulated in Preeclampsia and Fetal Growth Restriction
Trophoblast Side-Population Markers are Dysregulated in Preeclampsia and Fetal Growth Restriction Open
View article: Does metformin prolong pregnancy in preterm pre-eclampsia? A study protocol for a South African, hospital-based double-blind, randomised, placebo-controlled trial
Does metformin prolong pregnancy in preterm pre-eclampsia? A study protocol for a South African, hospital-based double-blind, randomised, placebo-controlled trial Open
Introduction Preterm pre-eclampsia is a leading cause of maternal morbidity and mortality. The Pre-eclampsia Intervention 2 (PI 2) trial suggested that metformin sustained release (XR) may prolong gestation by a week in pregnant women unde…
View article: Preeclampsia and the Risk of Young-Onset Dementia
Preeclampsia and the Risk of Young-Onset Dementia Open
Valérie Olié, PhD; Grégory Lailler, MD; Marion J. Torres, PhD; Nolwenn Regnault, PhD; Laure Carcaillon-Bentata, PhD; Jacques Blacher, MD
View article: Metformin in pregnancy and childhood neurodevelopmental outcomes: a systematic review and meta-analysis
Metformin in pregnancy and childhood neurodevelopmental outcomes: a systematic review and meta-analysis Open
In utero exposure to metformin does not seem to be associated with adverse neurodevelopmental outcomes in children up to the age of 14 years. These findings provide reassurance to clinicians and pregnant women considering metformin use dur…
View article: Novel insights from our special issue on maternal factors during pregnancy that influence maternal, fetal and childhood outcomes
Novel insights from our special issue on maternal factors during pregnancy that influence maternal, fetal and childhood outcomes Open
View article: Front Matter
Front Matter Open
View article: Adverse outcomes of preeclampsia: From mother to baby, pregnancy to postpartum
Adverse outcomes of preeclampsia: From mother to baby, pregnancy to postpartum Open
it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed.The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge.Front…
View article: Educational Outcomes for Children at 7 to 9 Years of Age After Birth at 39 vs 40 to 42 Weeks’ Gestation
Educational Outcomes for Children at 7 to 9 Years of Age After Birth at 39 vs 40 to 42 Weeks’ Gestation Open
Importance Birth at 39 weeks’ gestation is common and thought to be safe for mother and neonate. However, findings of long-term outcomes for children born at this gestational age have been conflicting. Objective To evaluate the association…