Shuohua Wu
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View article: Mapping Resting‐State Brain Functional Specialization to Neurotransmitter Profiles in Autism Spectrum Disorder
Mapping Resting‐State Brain Functional Specialization to Neurotransmitter Profiles in Autism Spectrum Disorder Open
Background Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder. However, its diagnosis and effective treatment present challenges. Understanding neurotransmitter impairments may offer new perspectives into the …
View article: Multimodal data fusion reveals functional and neurochemical correlates of Parkinson's disease
Multimodal data fusion reveals functional and neurochemical correlates of Parkinson's disease Open
Our results revealed abnormal brain activity patterns and specific neurotransmitter deficits in patients with PD, which may provide new insights into the mechanisms and potential targets for pharmacotherapy.
View article: Repurposing of the PET Probe Prototype PiB for Label and Radiation-Free CEST MRI Molecular Imaging of Amyloid
Repurposing of the PET Probe Prototype PiB for Label and Radiation-Free CEST MRI Molecular Imaging of Amyloid Open
Positron emission tomography (PET) probes are specific and sensitive while suffering from radiation risk. It is worthwhile to explore the chemical emission saturation transfer (CEST) effects of the probe prototypes and repurpose them for C…
View article: Alteration of intracerebral metabolites and subjective sleepiness by acute caffeine administration in adults
Alteration of intracerebral metabolites and subjective sleepiness by acute caffeine administration in adults Open
Higher caffeine consumption had a significant impact on brain metabolites. Magnetic resonance spectroscopy was sensitive in measuring brain metabolite fluctuations after caffeine intake, particularly the levels of GABA+ in the thalamus, wh…
View article: γ-Aminobutyric acid as a biomarker of the lateralizing and monitoring drug effect in patients with magnetic resonance imaging-negative temporal lobe epilepsy
γ-Aminobutyric acid as a biomarker of the lateralizing and monitoring drug effect in patients with magnetic resonance imaging-negative temporal lobe epilepsy Open
Introduction Despite verifying proton magnetic resonance spectroscopy ( 1 H-MRS) for focal localization in magnetic resonance imaging (MRI)-negative temporal lobe epilepsy (TLE), it is necessary to illustrate metabolic changes and screen f…