Shu‐Qin Ding
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View article: Metformin-associated gut microbiota remodeling correlates with reinvigorated splenic immunity in aged mice: microbiome-immune crosstalk via the gut-spleen axis
Metformin-associated gut microbiota remodeling correlates with reinvigorated splenic immunity in aged mice: microbiome-immune crosstalk via the gut-spleen axis Open
Background and aim Immunosenescence involves age-related immune decline and chronic inflammation, with the spleen serving as a critical hub for immune dysregulation. While gut microbiota influences systemic immunity, its specific role and …
View article: Developing a Student-Centred Curriculum: Insights from Anaesthetic Placement Experiences for Co-Designing in China’s Greater Bay Area
Developing a Student-Centred Curriculum: Insights from Anaesthetic Placement Experiences for Co-Designing in China’s Greater Bay Area Open
This study demonstrates the effective implementation of collaborative teaching and curriculum co-designed in anaesthesia education at a tertiary hospital in the "Greater Bay Innovative Zones of China". This curricular design model facilita…
View article: The gut microbiota in mice with erythropoietin—induced abdominal aortic aneurysm
The gut microbiota in mice with erythropoietin—induced abdominal aortic aneurysm Open
Background In recent years, a novel animal abdominal aortic aneurysm (AAA) model was established by administering erythropoietin (EPO) to wild-type (WT) mice. However, the influence of EPO on the murine fecal microbiota remains uninvestiga…
View article: Immunosuppression of spleen in mice treated with erythropoietin: transcriptomic and immunological analysis
Immunosuppression of spleen in mice treated with erythropoietin: transcriptomic and immunological analysis Open
Background and aim Long term high-dose erythropoietin (EPO) had been reported inducing the formation of abdominal aortic aneurysm (AAA) in mice. When using this model, we found that EPO treated mice showed significant splenomegaly. This is…
View article: Ezrin, a novel marker of ependymal cells, can be used to demonstrate their proliferation regulation after spinal cord injury in mice
Ezrin, a novel marker of ependymal cells, can be used to demonstrate their proliferation regulation after spinal cord injury in mice Open
Ependymal cells (EpCs), as a potential stem cell niche, have gained interest for their potential in vivo stem cell therapy for spinal cord injury (SCI). Heterogeneity of spinal EpCs may contribute to differences in the ability of spinal Ep…
View article: Collaborative Teaching and Curricular Integration in Pre-Intern Clinical Placements: Insights from the Greater Bay Area
Collaborative Teaching and Curricular Integration in Pre-Intern Clinical Placements: Insights from the Greater Bay Area Open
This study demonstrates the successful delivery of collaborative teaching and learning through medical curricular integration in China's "Global-Innovation-Hub" zones. This integration enables the development of a consistent and student-pr…
View article: A subunit vaccine based on <italic>Brucella</italic> rBP26 induces Th1 immune responses and M1 macrophage activation
A subunit vaccine based on <italic>Brucella</italic> rBP26 induces Th1 immune responses and M1 macrophage activation Open
Brucellosis is a global zoonotic infection caused by Brucella bacteria, which poses a significant burden on society. While transmission prevention is currently the most effective method, the absence of a licenced vaccine for humans necessi…
View article: Baculovirus-mediated endostatin and angiostatin activation of autophagy through the AMPK/AKT/mTOR pathway inhibits angiogenesis in hepatocellular carcinoma
Baculovirus-mediated endostatin and angiostatin activation of autophagy through the AMPK/AKT/mTOR pathway inhibits angiogenesis in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is a highly vascularized carcinoma, and targeting its neovascularization represents an effective therapeutic approach. Our previous study demonstrated that the baculovirus-mediated endostatin and angiostatin …
View article: A Microsoft-Excel Template for Identifying Mouse Myeloid Cell Types in the Central Nervous System Based on Single-cell RNA Sequencing Data
A Microsoft-Excel Template for Identifying Mouse Myeloid Cell Types in the Central Nervous System Based on Single-cell RNA Sequencing Data Open
ficult problem.5][6] Morphology mainly relies on conventional staining to identify cells through characteristic morphology under the microscope, which is very subjective.Moreover, their morphologies are very similar under pathological cond…
View article: Reflecting on Students’ Experiences of an Innovative Teaching Model During Aged Care Visit in Clinical Placements: A Qualitative Pilot Study
Reflecting on Students’ Experiences of an Innovative Teaching Model During Aged Care Visit in Clinical Placements: A Qualitative Pilot Study Open
This qualitative pilot study demonstrated through students' reflection that "Student-doctor-in-charge-of-nursing-home-round" is an innovative teaching model for clinical reasoning learning. This model extended the concepts of "cognitive-ap…
View article: Anthocyanins from Lycium ruthenicum Murray inhibit HCC tumor angiogenesis and promote autophagic apoptosis through AMPK/PI3K/AKT/mTOR pathway
Anthocyanins from Lycium ruthenicum Murray inhibit HCC tumor angiogenesis and promote autophagic apoptosis through AMPK/PI3K/AKT/mTOR pathway Open
Purpose Angiogenesis is a crucial factor in the initiation, progression and metastasis of tumor. The exploration for novel anti-angiogenic agents from natural sources has garnered significant attention. Our previous study confirmed the inh…
View article: Peer Review #1 of "The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis (v0.1)"
Peer Review #1 of "The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis (v0.1)" Open
Background.Following spinal cord injury (SCI), a large number of peripheral monocytes infiltrate into the lesion area and differentiate into macrophages (Mø).These monocyte-derived Mø are very difficult to distinguish from the local activa…
View article: Peer Review #1 of "The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis (v0.2)"
Peer Review #1 of "The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis (v0.2)" Open
Background.Following spinal cord injury (SCI), a large number of peripheral monocytes infiltrate into the lesion area and differentiate into macrophages (Mø).These monocyte-derived Mø are very difficult to distinguish from the local activa…
View article: The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis
The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis Open
Background Following spinal cord injury (SCI), a large number of peripheral monocytes infiltrate into the lesion area and differentiate into macrophages (Mø). These monocyte-derived Mø are very difficult to distinguish from the local activ…
View article: Peer Review #2 of "The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis (v0.1)"
Peer Review #2 of "The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis (v0.1)" Open
Background.Following spinal cord injury (SCI), a large number of peripheral monocytes infiltrate into the lesion area and differentiate into macrophages (Mø).These monocyte-derived Mø are very difficult to distinguish from the local activa…
View article: Proteomic Analysis of Plasma-Derived Extracellular Vesicles From Mice With Echinococcus granulosus at Different Infection Stages and Their Immunomodulatory Functions
Proteomic Analysis of Plasma-Derived Extracellular Vesicles From Mice With Echinococcus granulosus at Different Infection Stages and Their Immunomodulatory Functions Open
The globally distributed cystic echinococcosis (CE) is caused by the larval stage of Echinococcus granulosus ( E. granulosus ), a cosmopolitan and zoonotic disease with potentially life-threatening complications in humans. The emerging rol…
View article: Excel Template for Identifying Mouse Myeloid Cell-Types in the Central Nervous System Based on Single-Cell RNA Sequencing Data
Excel Template for Identifying Mouse Myeloid Cell-Types in the Central Nervous System Based on Single-Cell RNA Sequencing Data Open
Background The myeloid cells play a vital role in health and disease of central nervous system (CNS). However, how to clearly distinguish them is still a knotty problem. At present, single-cell RNA Sequencing (scRNA-Seq) technology can seq…
View article: VX-765 reduces neuroinflammation after spinal cord injury in mice
VX-765 reduces neuroinflammation after spinal cord injury in mice Open
Inflammation is a major cause of neuronal injury after spinal cord injury. We hypothesized that inhibiting caspase-1 activation may reduce neuroinflammation after spinal cord injury, thus producing a protective effect in the injured spinal…
View article: CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment
CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment Open
Background After spinal cord injury (SCI), destructive immune cell subsets are dominant in the local microenvironment, which are the important mechanism of injury. Studies have shown that inflammasomes play an important role in the inflamm…
View article: Effect of VX‑765 on the transcriptome profile of mice spinal cords with acute injury
Effect of VX‑765 on the transcriptome profile of mice spinal cords with acute injury Open
Previous studies have shown that caspase-1 plays an important role in the acute inflammatory response of spinal cord injury (SCI). VX‑765, a novel and irreversible caspase‑1 inhibitor, has been reported to effectively intervene in inflamma…
View article: CRID3 , a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment
CRID3 , a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment Open
Background: After spinal cord injury (SCI), destructive immune cell subsets are dominant in the local microenvironment, which are the important mechanism of injury. Studies have shown that inflammasomes play an important role in the inflam…
View article: Anti-Osteoporotic Activity of an Edible Traditional Chinese Medicine Cistanche deserticola on Bone Metabolism of Ovariectomized Rats Through RANKL/RANK/TRAF6-Mediated Signaling Pathways
Anti-Osteoporotic Activity of an Edible Traditional Chinese Medicine Cistanche deserticola on Bone Metabolism of Ovariectomized Rats Through RANKL/RANK/TRAF6-Mediated Signaling Pathways Open
Given the limitations of existing therapeutic agents for treatment of postmenopausal osteoporosis, there still remains a need for more options with both efficacy and less adverse effects. Cistanche deserticola Y. C. Ma is known as a popula…
View article: Neuroprotective effects of P7C3 against spinal cord injury in rats
Neuroprotective effects of P7C3 against spinal cord injury in rats Open
Spinal cord injury (SCI), a serious neurological disease, has few therapeutic interventions. A small molecule, P7C3, has been confirmed to play a role in neuroprotection of some neurological diseases. But the effect of P7C3 on acute SCI ha…
View article: Identification of serum exosomal microRNAs in acute spinal cord injured rats
Identification of serum exosomal microRNAs in acute spinal cord injured rats Open
It is important to find specific and easily detectable diagnostic markers in acute stage of spinal cord injury for guiding treatment and estimating prognosis. Although, microRNAs are attractive biomarkers, there is still no uniform standar…
View article: Novel miR-1958 Promotes Mycobacterium tuberculosis Survival in RAW264.7 Cells by Inhibiting Autophagy Via Atg5
Novel miR-1958 Promotes Mycobacterium tuberculosis Survival in RAW264.7 Cells by Inhibiting Autophagy Via Atg5 Open
Autophagy is crucial for immune defense against Mycobacterium tuberculosis (Mtb) infection. Mtb can evade host immune attack and survival within macrophages by manipulating the autophagic process. MicroRNAs (miRNAs) are small, non-coding R…
View article: Beneficial Effects of Total Phenylethanoid Glycoside Fraction Isolated from <i>Cistanche deserticola</i> on Bone Microstructure in Ovariectomized Rats
Beneficial Effects of Total Phenylethanoid Glycoside Fraction Isolated from <i>Cistanche deserticola</i> on Bone Microstructure in Ovariectomized Rats Open
The present study was designed to estimate the antiosteoporotic activity of total phenylethanoid glycoside fraction isolated from C. deserticola (CDP) on rats induced by ovariectomy (OVX) as well as the related mechanisms. After 3 months o…
View article: Effect of M2 macrophage adoptive transfer on transcriptome profile of injured spinal cords in rats
Effect of M2 macrophage adoptive transfer on transcriptome profile of injured spinal cords in rats Open
The previous studies showed that alternatively activated anti-inflammatory macrophage (M2) adoptive immunity can improve the proportion of local M2 cells and play the neuroprotective effect after spinal cord injury (SCI). Its molecular mec…
View article: Expression and localization of absent in melanoma 2 in the injured spinal cord
Expression and localization of absent in melanoma 2 in the injured spinal cord Open
In traumatic brain injury, absent in melanoma 2 (AIM2) has been demonstrated to be involved in pyroptotic neuronal cell death. Although the pathophysiological mechanism of spinal cord injury is similar to that of brain injury, the expressi…