Shusen Zheng
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View article: AFP/PIVKA-II double-positive status indicates a high-risk subtype of hepatocellular carcinoma in liver transplantation: retrospective cohort study and phosphoproteome evaluation
AFP/PIVKA-II double-positive status indicates a high-risk subtype of hepatocellular carcinoma in liver transplantation: retrospective cohort study and phosphoproteome evaluation Open
Introduction: Liver transplantation (LT) is one of the therapeutic options for hepatocellular carcinoma (HCC). α-fetoprotein (AFP) and Protein Induced by Vitamin K Absence or Antagonist II (PIVKA-II) serologic levels are commonly used in m…
View article: Immune-related adverse events are a potent predictor of post-transplant rejection in HCC: a multicentre retrospective cohort study
Immune-related adverse events are a potent predictor of post-transplant rejection in HCC: a multicentre retrospective cohort study Open
Background Immune checkpoint inhibitors (ICIs) enable successful hepatocellular carcinoma (HCC) downstaging or bridging for liver transplantation (LT) but increase allograft rejection risk. Although immune-related adverse events (irAEs) re…
View article: Risk modeling of delayed postoperative bleeding after endoscopic submucosal dissection for early colorectal cancer and precancerous lesions
Risk modeling of delayed postoperative bleeding after endoscopic submucosal dissection for early colorectal cancer and precancerous lesions Open
BACKGROUND As a minimally invasive technique, endoscopic submucosal dissection (ESD) is widely used in treating early colorectal cancer (ECRC) and precancerous lesions (PCLs). However, a common postoperative complication - delayed postoper…
View article: A Case of Combined Hepatocellular‐Cholangiocarcinoma Diagnosis and Treatment With Literature Review
A Case of Combined Hepatocellular‐Cholangiocarcinoma Diagnosis and Treatment With Literature Review Open
This report presents a rare case of a 43‐year‐old man with unresectable combined hepatocellular‐cholangiocarcinoma who, after undergoing transarterial chemoembolization, systemic chemotherapy, and stereotactic body radiation therapy, accep…
View article: Advanced omics approaches in liver transplant settings: current applications and future prospectives
Advanced omics approaches in liver transplant settings: current applications and future prospectives Open
Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST), as advanced omics technologies, have addressed critical challenges in liver transplantation (LT), the most effective treatment for end-stage liver disease. This revie…
View article: Redistribution of super-enhancers promotes malignancy in human hepatocellular carcinoma
Redistribution of super-enhancers promotes malignancy in human hepatocellular carcinoma Open
The dysregulated SE landscape of HCC promoted the malignancy phenotype by the upregulation of oncogenes, and SE-regulatory network might be potential drug targets for HCC treatment. Our study deepened the insight of epigenetic dysregulatio…
View article: Artesunate-mycophenolate Mofetil Dimer Micelles Alleviate Allogeneic Skin Graft Rejection by Inhibiting the TLR-4 Pathway in Macrophages
Artesunate-mycophenolate Mofetil Dimer Micelles Alleviate Allogeneic Skin Graft Rejection by Inhibiting the TLR-4 Pathway in Macrophages Open
Background: Organ transplantation continues to be an essential therapeutic option for patients afflicted with end-stage organ failure. However, long-term administration of immunosuppressive agents has the potential to trigger severe advers…
View article: Advancing immunomodulation in organ transplantation: the therapeutic potential of self-assembled rapamycin nanoparticles in allograft rejection
Advancing immunomodulation in organ transplantation: the therapeutic potential of self-assembled rapamycin nanoparticles in allograft rejection Open
This study highlights sRNP's superiority over oral RAPA in managing allograft rejection by enhancing immune regulation, reducing T cell differentiation, and decreasing inflammation. These effects extend graft survival, underscoring sRNP's …
View article: Advances and challenges in the application of donor-derived cell-free DNA for diagnosis and treatment in liver transplantation: a narrative review
Advances and challenges in the application of donor-derived cell-free DNA for diagnosis and treatment in liver transplantation: a narrative review Open
In the field of liver disease treatment, liver transplantation (LT) has become an effective option for end-stage liver disease. However, issues such as immune rejection and graft damage remain important factors influencing the success rate…
View article: Research on the Practice of Ideological and Political Education in Holiday Universities A Case Study of Jingdezhen Vocational University of Art
Research on the Practice of Ideological and Political Education in Holiday Universities A Case Study of Jingdezhen Vocational University of Art Open
This article takes the summer ideological and political education practice of the School of Economics and Law at Jingdezhen Vocational University of Art as the research object, and explores the mode innovation and optimization path of ideo…
View article: Impact of COVID‐19 Vaccination and Infection on Anti‐Triple‐Knockout (TKO) Pig Antibody Production: A Study in Patients With End‐Stage Liver Disease and Liver Transplant Recipients
Impact of COVID‐19 Vaccination and Infection on Anti‐Triple‐Knockout (TKO) Pig Antibody Production: A Study in Patients With End‐Stage Liver Disease and Liver Transplant Recipients Open
This study investigates the impact of COVID‐19 vaccination, with a focus on inactivated vaccines, on the production of anti‐triple‐knockout (TKO) pig antibodies, crucial for xenotransplantation. Although it is known that vaccination influe…
View article: Adipose-Derived Stem Cells for Cartilage Tissue Engineering: A Bibliometric Analysis of Trends and Themes
Adipose-Derived Stem Cells for Cartilage Tissue Engineering: A Bibliometric Analysis of Trends and Themes Open
This bibliometric analysis provides valuable guidance for researchers, clinicians, and policymakers, emphasizing the necessity of addressing translational challenges and fostering global collaboration to develop clinically effective soluti…
View article: Four-dimensional model analysis of the hidden barriers to the first promotion of college graduates and their breakthroughs
Four-dimensional model analysis of the hidden barriers to the first promotion of college graduates and their breakthroughs Open
The first career promotion of college graduates is the most important step in the early stage of their career development. In order to help graduates break through the hidden barriers to initial promotion, this paper uses Porter and Shephe…
View article: Stimulation of regulatory dendritic cells suppresses cytotoxic T cell function and alleviates DEN-induced liver injury, fibrosis and hepatocellular carcinoma
Stimulation of regulatory dendritic cells suppresses cytotoxic T cell function and alleviates DEN-induced liver injury, fibrosis and hepatocellular carcinoma Open
Background Dendritic cells (DCs) are versatile professional antigen-presenting cells and play an instrumental role in the generation of antigen-specific T-cell responses. Modulation of DC function holds promise as an effective strategy to …