Shusheng Lin
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View article: Yin Yang 1 Promotes Antiprogrammed Cell Death‐1 Resistance in Hepatocellular Carcinoma through Polypeptide N‐Acetylgalactosaminyltransferase 16‐Mediated Glycosylation of Programmed Death Ligand‐1
Yin Yang 1 Promotes Antiprogrammed Cell Death‐1 Resistance in Hepatocellular Carcinoma through Polypeptide N‐Acetylgalactosaminyltransferase 16‐Mediated Glycosylation of Programmed Death Ligand‐1 Open
Immune checkpoint inhibitors (ICIs) are widely used for treating hepatocellular carcinoma (HCC), yet their efficacy remains limited, with suboptimal response rates. The predictive power of the current biomarker, programmed death ligand‐1 (…
View article: Cancer-associated fibroblast-derived stanniocalcin 1 promotes cholangiocarcinoma progression and lymph node metastasis
Cancer-associated fibroblast-derived stanniocalcin 1 promotes cholangiocarcinoma progression and lymph node metastasis Open
Cholangiocarcinoma (CCA) is a fibroblast-rich tumor. Lymph node metastasis (LNM) is the main prognostic risk factor for CCA. We determined that stanniocalcin 1 (STC1) is highly expressed in cancer-associated fibroblasts (CAFs) with LNM in …
View article: Identification of a Novel Prognostic Signature Based on N-Linked Glycosylation and Its Correlation with Immunotherapy Response in Hepatocellular Carcinoma
Identification of a Novel Prognostic Signature Based on N-Linked Glycosylation and Its Correlation with Immunotherapy Response in Hepatocellular Carcinoma Open
In this study, we establish that the risk model based on N-linked glycosylation related genes could efficiently predict the prognosis and tumor microenvironment immune state of HCC patients, and the risk score could serve as a novel indica…
View article: Cancer-Associated Fibroblasts Promote Lymphatic Metastasis in Cholangiocarcinoma <i>via</i> the PDGF-BB/PDGFR-β Mediated Paracrine Signaling Network
Cancer-Associated Fibroblasts Promote Lymphatic Metastasis in Cholangiocarcinoma <i>via</i> the PDGF-BB/PDGFR-β Mediated Paracrine Signaling Network Open
Patients with cholangiocarcinoma (CCA) with lymph node metastasis (LNM) have the worst prognosis, even after complete resection; however, the underlying mechanism remains unclear. Here, we established CAF-derived PDGF-BB as a regulator of …
View article: Bioinformatic analysis and in vitro experiments reveal that N-linked glycosylation related genes STT3A, DDOST and TMEM165 participate in the promotion of hepatocellular carcinoma and Its role in immunotherapy
Bioinformatic analysis and in vitro experiments reveal that N-linked glycosylation related genes STT3A, DDOST and TMEM165 participate in the promotion of hepatocellular carcinoma and Its role in immunotherapy Open
Background: The complex tumor microenvironment of hepatocellular carcinoma (HCC) has led to a low response to immune checkpoints inhibitors (ICIs) and a poor prognosis. PD-L1, as one of the indications for ICIs, is rich in glycosylation mo…
View article: Intermittent superior mesenteric artery occlusion for en bloc resection of the uncinate process during laparoscopic pancreaticoduodenectomy: A novel technique
Intermittent superior mesenteric artery occlusion for en bloc resection of the uncinate process during laparoscopic pancreaticoduodenectomy: A novel technique Open
Background: En bloc resection of the uncinate process of the pancreas represents the most important yet difficult step in laparoscopic pancreaticoduodenectomy (LPD), given the risk of major intraoperative bleeding which often necessitates …