Shu‐Tao Qi
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View article: Post-replicative initial expression of PAX6 during neuroectoderm differentiation
Post-replicative initial expression of PAX6 during neuroectoderm differentiation Open
The development of multicellular organisms requires precise coordination between cell division and differentiation. Cell division generates the necessary number of cells, while differentiation creates distinct cell identities, forming tiss…
View article: Cryo-EM structure of DNA-unbound human MCM2–7 complex reveals new disease-relevant regulation
Cryo-EM structure of DNA-unbound human MCM2–7 complex reveals new disease-relevant regulation Open
Chromatin loading of the hexameric replicative helicase MCM2–7 complex requires coordinated interactions with the origin recognition complex (ORC), CDC6, and CDT1. MCM2–7 not bound to DNA forms a single hexamer (SH) with an open DNA entry …
View article: One-pot ligation of multiple mRNA fragments on dsDNA splint advancing regional modification and translation
One-pot ligation of multiple mRNA fragments on dsDNA splint advancing regional modification and translation Open
Region-specific RNA modifications are crucial for advancing RNA research and therapeutics, including messenger RNA (mRNA)-based vaccines and immunotherapy. However, the predominant method, synthesizing regionally modified mRNAs with short …
View article: Mutual regulation mechanism of the O-GlcNAcylation enzyme pair revealed by Cryo-EM structure of human OGT–OGA complex
Mutual regulation mechanism of the O-GlcNAcylation enzyme pair revealed by Cryo-EM structure of human OGT–OGA complex Open
O-GlcNAcylation is a conserved post-translational modification that attaches N-acetyl glucosamine (GlcNAc) to myriad cellular proteins 1–4 . In response to nutritional and hormonal signals, O-GlcNAcylation regulates diverse cellular proces…
View article: TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling Open
Aneuploidy, defective differentiation, and inactivation of the tumor suppressor TP53 all occur frequently during tumorigenesis. Here, we probe the potential links among these cancer traits by inactivating TP53 in human embryonic stem cells…
View article: TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling Open
SUMMARY Aneuploidy, defective differentiation, and inactivation of the tumor suppressor TP53 all occur frequently during tumorigenesis. Here, we probe the potential links among these cancer traits by inactivating TP53 in human embryonic st…
View article: Antioxidants retard the ageing of mouse oocytes
Antioxidants retard the ageing of mouse oocytes Open
The aim of the present study was to verify the effects of heavy metal coupling agents (sodium citrate and EDTA) and antioxidants (acetyl carnitine and lipoic acid) on the number of oocytes, as well as the ageing of mitochondria, chromosome…
View article: <i>Rad9a</i>is required for spermatogonia differentiation in mice
<i>Rad9a</i>is required for spermatogonia differentiation in mice Open
Spermatogenesis in testes requires precise spermatogonia differentiation. Spermatocytes lacking the Rad9a gene are arrested in pachytene prophase, implying a possible role for RAD9A in spermatogonia differentiation. However, numerous RAD9A…
View article: N6-Methyladenosine Sequencing Highlights the Involvement of mRNA Methylation in Oocyte Meiotic Maturation and Embryo Development by Regulating Translation in Xenopus laevis
N6-Methyladenosine Sequencing Highlights the Involvement of mRNA Methylation in Oocyte Meiotic Maturation and Embryo Development by Regulating Translation in Xenopus laevis Open
During the oogenesis of Xenopus laevis, oocytes accumulate maternal materials for early embryo development. As the transcription activity of the oocyte is silenced at the fully grown stage and the global genome is reactivated only by the m…