Shuting Han
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View article: CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer
CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer Open
Application of machine learning (ML) on cancer-specific pharmacogenomic datasets shows immense promise for identifying predictive response biomarkers to enable personalized treatment. We introduce CAN-Scan, a precision oncology platform, w…
View article: Quantitative Estimation of Iron and Fat Content in Prostate Cancer by Multiparametric <scp>MRI</scp> and Its Application in Optimizing D'Amico Score
Quantitative Estimation of Iron and Fat Content in Prostate Cancer by Multiparametric <span>MRI</span> and Its Application in Optimizing D'Amico Score Open
Background The risk of biochemical recurrence (BCR) in prostate cancer (PCa) is typically assessed using D'Amico score. However, iron and fat content in PCa are closely related to tumor cell proliferation and the risk of BCR may be estimat…
View article: Pythia: Non-random DNA repair allows predictable CRISPR/Cas9 integration and gene editing
Pythia: Non-random DNA repair allows predictable CRISPR/Cas9 integration and gene editing Open
Summary CRISPR-based genome engineering holds enormous promise for basic science and therapeutic applications. Integrating and editing DNA sequences is still challenging in many cellular contexts, largely due to insufficient control of the…
View article: The impact of short-course total neoadjuvant therapy, long-course chemoradiotherapy, and upfront surgery on the technical difficulty of total mesorectal excision: an observational study with an intraoperative perspective
The impact of short-course total neoadjuvant therapy, long-course chemoradiotherapy, and upfront surgery on the technical difficulty of total mesorectal excision: an observational study with an intraoperative perspective Open
TNT does not appear to increase the surgical difficulty of TME.
View article: A case of metastatic lymphoepithelial carcinoma of parotid gland identified on 68gallium DOTA-[Tyr3] octreotate PET CT
A case of metastatic lymphoepithelial carcinoma of parotid gland identified on 68gallium DOTA-[Tyr3] octreotate PET CT Open
The authors present the case of a 59-year-old lady diagnosed with lymphoepithelial carcinoma (LEC) of the left parotid gland. The primary tumour was identified using contrast-enhanced CT, and diagnosis was confirmed via fine needle aspirat…
View article: Pathogenesis and therapeutic implications of EBV-associated epithelial cancers
Pathogenesis and therapeutic implications of EBV-associated epithelial cancers Open
Epstein-Barr virus (EBV), one of the most common human viruses, has been associated with both lymphoid and epithelial cancers. Undifferentiated nasopharyngeal carcinoma (NPC), EBV associated gastric cancer (EBVaGC) and lymphoepithelioma-li…
View article: The distinct clinical trajectory, metastatic sites, and immunobiology of microsatellite-instability-high cancers
The distinct clinical trajectory, metastatic sites, and immunobiology of microsatellite-instability-high cancers Open
Microsatellite-instability-high (MSI-H) cancers form a spectrum of solid organ tumors collectively known as Lynch Syndrome cancers, occurring not only in a subset of colorectal, endometrial, small bowel, gastric, pancreatic, and biliary tr…
View article: Heat selection enables highly scalable methylome profiling in cell-free DNA for noninvasive monitoring of cancer patients
Heat selection enables highly scalable methylome profiling in cell-free DNA for noninvasive monitoring of cancer patients Open
Genome-wide analysis of cell-free DNA methylation profile is a promising approach for sensitive and specific detection of many cancers. However, scaling such assays for clinical translation is impractical because of the high cost of whole-…
View article: Impact of cancer diagnoses on the outcomes of patients with COVID-19: a systematic review and meta-analysis
Impact of cancer diagnoses on the outcomes of patients with COVID-19: a systematic review and meta-analysis Open
Background The COVID-19 has caused significant mortality and morbidity across the globe. Patients with cancer are especially vulnerable given their immunocompromised state. We aimed to determine the proportion of COVID-19 patients with can…
View article: Epstein–Barr Virus Epithelial Cancers—A Comprehensive Understanding to Drive Novel Therapies
Epstein–Barr Virus Epithelial Cancers—A Comprehensive Understanding to Drive Novel Therapies Open
Epstein–Barr virus (EBV) is a ubiquitous oncovirus associated with specific epithelial and lymphoid cancers. Among the epithelial cancers, nasopharyngeal carcinoma (NPC), lymphoepithelioma-like carcinoma (LELC), and EBV-associated gastric …
View article: Oncology patients with pulmonary infiltrates in the COVID-19 era: a case series
Oncology patients with pulmonary infiltrates in the COVID-19 era: a case series Open
INTRODUCTION The clinical spectrum of symptomatic coronavirus disease 2019 (COVID-19) ranges from a mild upper respiratory tract infection to severe pneumonia with respiratory failure.[1] When there is lower respiratory tract involvement, …
View article: Oncology workload in a tertiary hospital during the COVID-19 pandemic
Oncology workload in a tertiary hospital during the COVID-19 pandemic Open
Introduction Workload in oncology during a pandemic is expected to increase as manpower is shunted to other areas of need in combating the pandemic. This increased workload, coupled with the high care needs of cancer patients, can have neg…
View article: P09.06 Investigating various patient parameters as prognostic markers for patients with advance stage nasopharyngeal carcinoma undergoing induction chemotherapy followed by Epstein-Barr virus cytotoxic T-lymphocyte immunotherapy
P09.06 Investigating various patient parameters as prognostic markers for patients with advance stage nasopharyngeal carcinoma undergoing induction chemotherapy followed by Epstein-Barr virus cytotoxic T-lymphocyte immunotherapy Open
Background Previous prospective phase II study conducted by our research group at the National Cancer Centre Singapore had shown the efficacy of combined induction chemotherapy followed by cytotoxic T-lymphocyte (CTL) immunotherapy as a fi…
View article: Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition
Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition Open
As glutamine plays a central role in cancer metabolism, inhibition of glutaminolysis has become an ideal anticancer therapeutic target. However, glutaminolysis inhibition leads to activation of autophagy, which compromises its antitumor ef…
View article: A Perspective on Cell Therapy and Cancer Vaccine in Biliary Tract Cancers (BTCs)
A Perspective on Cell Therapy and Cancer Vaccine in Biliary Tract Cancers (BTCs) Open
Biliary tract cancer (BTC) is a rare, but aggressive, disease that comprises of gallbladder carcinoma, intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma, with heterogeneous molecular profiles. Advanced disease has limited…
View article: Weighted gene coexpression network analysis identifies hub genes related to KRAS mutant lung adenocarcinoma
Weighted gene coexpression network analysis identifies hub genes related to KRAS mutant lung adenocarcinoma Open
The aim of current study was to use Weighted Gene Coexpression Network Analysis (WGCNA) to identify hub genes related to the incidence and prognosis of KRAS mutant (MT) lung adenocarcinoma (LUAD). We involved 184 stage IIB to IV LUAD sampl…
View article: Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer
Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer Open
Chemoresistance remains the uppermost disincentive for cancer treatment on account of many genetic and epigenetic alterations. Long non-coding RNAs (lncRNAs) are emerging players in promoting cancer initiation and progression. However, the…
View article: Anemia is associated with poor outcomes of metastatic castration-resistant prostate cancer, a systematic review and meta-analysis.
Anemia is associated with poor outcomes of metastatic castration-resistant prostate cancer, a systematic review and meta-analysis. Open
Androgen deprivation therapy (ADT) was an important management for metastatic prostate cancer. However, patients would finally progress to the metastatic castration-resistant prostate cancer (mCRPC) and lose sensitivity to ADT. In addition…
View article: Somatostatin receptor imaging in nasopharyngeal cancer
Somatostatin receptor imaging in nasopharyngeal cancer Open
Somatostatin is a neuropeptide better known for its role in inhibiting the secretion of growth hormone, insulin and glucagon. There are five subtypes of somatostatin receptors (SSTRs) with varying tissue distribution and function. They hav…