Shuting Lu
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View article: Development and Bioactivity Evaluation of a “Medicine and Food Homology” Composite Schisandra Chinensis Functional Beverage
Development and Bioactivity Evaluation of a “Medicine and Food Homology” Composite Schisandra Chinensis Functional Beverage Open
Schisandra chinensis, a “medicine and food homology” herb, is highly regarded for its medicinal and nutritional value. Composite beverages that combine Schisandra chinensis with other medicinal and edible plants are gaining popularity due …
View article: P4HA2 interacted with ATAD3A to modulate PINK1/parkin-dependent mitophagy and 125I brachytherapy sensitization in esophageal carcinoma
P4HA2 interacted with ATAD3A to modulate PINK1/parkin-dependent mitophagy and 125I brachytherapy sensitization in esophageal carcinoma Open
Interventional brachytherapy, such as iodine-125( 125 I), has improved the survival of obstructive late-stage esophageal cancer patients. However, most patients experience radioresistance after 125 I brachytherapy. It is key to decipher th…
View article: Pre-screening value of serum albumin and the glucose-lymphocyte ratio as the “transport-activation” effectors of immune checkpoint inhibitors in small cell lung cancer
Pre-screening value of serum albumin and the glucose-lymphocyte ratio as the “transport-activation” effectors of immune checkpoint inhibitors in small cell lung cancer Open
Pre-treatment serum ALB and the GLR represent cost-effective, readily accessible biomarkers for stratifying SCLC patients who may derive survival benefits from ICI-based regimens. These findings warrant validation in prospective multicente…
View article: Development of high-performance cryocoolers capable of operating from 120 K down to 5 mK
Development of high-performance cryocoolers capable of operating from 120 K down to 5 mK Open
This paper presents a review of the recent development of a variety of high-performance cryocoolers developed in the authors’ laboratory operating from 120 K down to 5 mK. Above 1.0 K, these cryocoolers involve regenerative or recuperative…
View article: Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling
Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling Open
The cKIF6 regulates lymphangiogenesis by targeting cholesterol metabolism, making it a promising therapeutic target for lymphangiogenesis-related diseases.
View article: Surface Nanotube Engineering of Iodine‐125 Seed for Combination of Chemotherapy and Brachytherapy
Surface Nanotube Engineering of Iodine‐125 Seed for Combination of Chemotherapy and Brachytherapy Open
Iodine‐125 ( 125 I) brachytherapy, in combination with chemotherapy, is extensively utilized for tumor treatment. However, the primary challenge in concurrently implementing brachy‐chemotherapy involves integrating the in situ implantation…
View article: Nanoscale CaO<sub>2</sub>‐Loaded Surface‐Engineered Iodine‐125 Seed with Sustained Self‐Oxygenation for Sensitized Tumor Brachytherapy
Nanoscale CaO<sub>2</sub>‐Loaded Surface‐Engineered Iodine‐125 Seed with Sustained Self‐Oxygenation for Sensitized Tumor Brachytherapy Open
Iodine‐125 ( 125 I) brachytherapy (BT) is renowned for its precision and effectiveness in delivering localized radiation doses to solid tumors. However, the therapeutic efficacy of traditional 125 I seed is often limited due to the inheren…
View article: Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis
Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis Open
View article: Protocol for in situ and in vivo dissection of mouse lung-draining lymph nodes
Protocol for in situ and in vivo dissection of mouse lung-draining lymph nodes Open
View article: Lymphatic‐specific methyltransferase‐like 3‐mediated m<sup>6</sup>A modification drives vascular patterning through prostaglandin metabolism reprogramming
Lymphatic‐specific methyltransferase‐like 3‐mediated m<sup>6</sup>A modification drives vascular patterning through prostaglandin metabolism reprogramming Open
Lymphangiogenesis plays a pivotal role in the pathogenesis of various vascular disorders, including ocular vascular diseases and cancers. Deregulation of N 6 ‐methyladenosine (m 6 A) modification has been identified as a key contributor to…
View article: Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis
Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis Open
Lymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Disruption of this process is implicated in diseases such as cancer, inflammation, and autoimmune disorders. In this study, we elucidate the ro…
View article: Glymphatic function and its influencing factors in different glucose metabolism states
Glymphatic function and its influencing factors in different glucose metabolism states Open
BACKGROUND Dysfunction of the glymphatic system in the brain in different stages of altered glucose metabolism and its influencing factors are not well characterized. AIM To investigate the function of the glymphatic system and its clinica…
View article: GPT Modeling for English Learning Assistance Functions in Non-Native Language Environments
GPT Modeling for English Learning Assistance Functions in Non-Native Language Environments Open
In this paper, we design an English multi-round dialogue model based on the pre-trained model GPT-2 and use Top-p and Top-k sampling instead of greedy search and cluster search sampling to optimize the decoding strategy. After that, a dial…
View article: Cover Feature: Rapid Peripheral Nerve Imaging by Fluorescent Polymer Dots for Minimizing the Risk of Intraoperative Nerve Injury (Anal. Sens. 1/2024)
Cover Feature: Rapid Peripheral Nerve Imaging by Fluorescent Polymer Dots for Minimizing the Risk of Intraoperative Nerve Injury (Anal. Sens. 1/2024) Open
The cover feature illustrates the application of high-brightness green fluorescent polymer dots (Pdots) to intraoperative neuroimaging to achieve excellent tracing effects. Through direct administration, Pdots can rapidly bind to the epine…
View article: Integrated analysis of transcription factor-mRNA-miRNA regulatory network related to immune characteristics in medullary thyroid carcinoma
Integrated analysis of transcription factor-mRNA-miRNA regulatory network related to immune characteristics in medullary thyroid carcinoma Open
Background Medullary thyroid carcinoma (MTC), a thyroid C cell-derived malignancy, is poorly differentiated and more aggressive than papillary, follicular and oncocytic types of thyroid cancer. The current therapeutic options are limited, …
View article: Application of artificial intelligence in the diagnosis of dry eye
Application of artificial intelligence in the diagnosis of dry eye Open
Dry eye(DE)is one of the most common eye diseases worldwide, with prevalence ranging from 5% to 50%. DE cannot be diagnosed timely and accurately due to its complex etiology and the limitations of testing equipment. In recent years, with t…
View article: Imaging of fluorescent polymer dots in relation to channels and immune cells in the lymphatic system
Imaging of fluorescent polymer dots in relation to channels and immune cells in the lymphatic system Open
Polymer dots (Pdots) have been applied to imaging lymph nodes (LNs) and lymphatic vessels (LVs) in living mice and rats. However, the mechanism of absorption, distribution, metabolism, and excretion of Pdots in LNs and LVs is still unclear…
View article: Long Non-Coding RNA PNKY Modulates the Development of Choroidal Neovascularization
Long Non-Coding RNA PNKY Modulates the Development of Choroidal Neovascularization Open
Long non-coding RNAs (lncRNAs) have been widely implicated in human diseases. Our aim was to explore the regulatory role of changes in the expression levels of PNKY and its linked signaling networks in mediating stress-induced choroidal ne…
View article: Structure and photocatalytic influence of N-doping ATO nano-tubes on antibacterial activity toward Escherichia coli
Structure and photocatalytic influence of N-doping ATO nano-tubes on antibacterial activity toward Escherichia coli Open
The photocatalytic antibacterial properties of anodic titanium oxide (ATO) nanotubes in the anatase structure derived from annealing at 450°C or 550°C or N-doping treatment were tested on Escherichia coli under UV-A, visible light illumi-n…
View article: A Hybrid Multiple Criteria Decision-Making Technique to Evaluate Regional Intellectual Capital: Evidence from China
A Hybrid Multiple Criteria Decision-Making Technique to Evaluate Regional Intellectual Capital: Evidence from China Open
With the dawn of economic globalization and the knowledge economy, intellectual capital has become the most important factor to determine economic growth. However, due to resource endowment, location conditions, policy differences, and oth…
View article: A Versatile Plant Rhabdovirus-Based Vector for Gene Silencing, miRNA Expression and Depletion, and Antibody Production
A Versatile Plant Rhabdovirus-Based Vector for Gene Silencing, miRNA Expression and Depletion, and Antibody Production Open
Plant virus vectors are ideal tools for delivery of genetic cargo into host cells for functional genomics studies and protein overexpression. Although a vast number of plant virus vectors have been developed for different purposes, the uti…
View article: Single-Component Bismuth Nanoparticles as a Theranostic Agent for Multimodal Imaging-Guided Glioma Therapy
Single-Component Bismuth Nanoparticles as a Theranostic Agent for Multimodal Imaging-Guided Glioma Therapy Open
Single-component nanomaterials such as bismuth (Bi) based on nanoparticles (NPs) intrinsically having both diagnostic and therapeutic capabilities are widely needed in biomedical fields. However, their design and fabrication still face eno…
View article: Patching a leak in an R1 university gateway STEM course
Patching a leak in an R1 university gateway STEM course Open
A cognitively intensive companion service course has been introduced to the main fall general chemistry class at Cornell University. For years 2015 and 2016, priority students (those from groups under-represented and economically disadvant…
View article: Gadolinium-chelate functionalized bismuth nanotheranostic agent for in vivo MRI/CT/PAI imaging-guided photothermal cancer therapy
Gadolinium-chelate functionalized bismuth nanotheranostic agent for in vivo MRI/CT/PAI imaging-guided photothermal cancer therapy Open
View article: MRI-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles
MRI-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles Open
In recent years, there has been increasing interest in developing a multifunctional nanoscale platform for cancer monitoring and chemotherapy. However, there is still a big challenge for current clinic contrast agents to improve their poor…
View article: Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy
Near-infrared light-triggered theranostics for tumor-specific enhanced multimodal imaging and photothermal therapy Open
The major challenge in current clinic contrast agents (CAs) and chemotherapy is the poor tumor selectivity and response. Based on the self-quench property of IR820 at high concentrations, and different contrast effect ability of Gd-DOTA be…
View article: Codelivery of doxorubicin and triptolide with reduction-sensitive lipid&ndash;polymer hybrid nanoparticles for in vitro and in vivo synergistic cancer treatment
Codelivery of doxorubicin and triptolide with reduction-sensitive lipid–polymer hybrid nanoparticles for in vitro and in vivo synergistic cancer treatment Open
Codelivery is a promising strategy to overcome the limitations of single chemotherapeutic agents in cancer treatment. Despite progress, codelivery of two or more different functional drugs to increase anticancer efficiency still remains a …
View article: Research on Photocatalytic Degradation of Methyl Orange by a &beta;-Cyclodextrin/Titanium Dioxide Composite
Research on Photocatalytic Degradation of Methyl Orange by a β-Cyclodextrin/Titanium Dioxide Composite Open
A photocatalytic composite of β-cyclodextrin/titanium dioxide (β-CD/TiO2) was synthesized via the photoinduced assembly method in this work.The morphology of the composite was characterized by scanning electron microscope (SEM) and transmi…