Shuwen Guan
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View article: The oral microbiome in aging: a window into health and longevity
The oral microbiome in aging: a window into health and longevity Open
Background Aging is characterized by progressive physiological decline and increased susceptibility to age-related diseases. The oral microbiome, a complex community of microorganisms, has been increasingly recognized as a potential key pl…
View article: Berberine Extends Lifespan in C. elegans Through Multi-Target Synergistic Antioxidant Effects
Berberine Extends Lifespan in C. elegans Through Multi-Target Synergistic Antioxidant Effects Open
Aging is a process of gradual functional decline in complex physiological systems and is closely related to the occurrence of various diseases. Berberine, a bioactive alkaloid derived from Coptis chinensis (Huanglian), has emerged as a pro…
View article: Identification of a novel macrophage-related prognostic signature in colorectal cancer
Identification of a novel macrophage-related prognostic signature in colorectal cancer Open
Colorectal cancer (CRC) is one of the most prevalent and deadliest illnesses all around the world. Growing proofs demonstrate that tumor-associated macrophages (TAMs) are of critical importance in CRC pathogenesis, but their mechanisms rem…
View article: Construction of Tumor Microenvironment‐Responsive Gene Carriers
Construction of Tumor Microenvironment‐Responsive Gene Carriers Open
Peptide‐ and polypeptide‐based self‐assembling gene delivery systems have received considerable attention owing to their inherent biocompatibility and bioactivity. Gene carriers based on elastin‐like polypeptides (ELPs) have been extensive…
View article: Identification of a Novel Macrophage-Related Prognostic Signature in Colorectal cancer
Identification of a Novel Macrophage-Related Prognostic Signature in Colorectal cancer Open
Colorectal cancer (CRC) is one of the most prevalent and deadliest illnesses all around the world. Growing proofs demonstrate that tumor-associated macrophages (TAMs) are of critical importance in CRC pathogenesis, but their mechanisms rem…
View article: Design of Cyclic Peptide-Based Nanospheres and the Delivery of siRNA
Design of Cyclic Peptide-Based Nanospheres and the Delivery of siRNA Open
In recent years, cyclic peptides have attracted much attention due to their chemical and enzymatic stability, low toxicity, and easy modification. In general, the self-assembled nanostructures of cyclic peptides tend to form nanotubes in a…
View article: Accurate Identification of Cysteine by a Nucleophilic-Reaction-Induced Conversion of an Open-Shell Luminescent Radical into Closed-Shell Molecule
Accurate Identification of Cysteine by a Nucleophilic-Reaction-Induced Conversion of an Open-Shell Luminescent Radical into Closed-Shell Molecule Open
View article: The Influencing Factors of The Social Environment of Public Psychological Crisis In COVID-19
The Influencing Factors of The Social Environment of Public Psychological Crisis In COVID-19 Open
The COVID-19 epidemic spreads around the world early in 2020. As a public emergency, the COVID-19 epidemic has caused a public psychological crisis such as panic, anxiety and worry. Government trust and social support are considered social…
View article: Ginsenoside Prolongs the Lifespan of C. elegans via Lipid Metabolism and Activating the Stress Response Signaling Pathway
Ginsenoside Prolongs the Lifespan of C. elegans via Lipid Metabolism and Activating the Stress Response Signaling Pathway Open
Panax ginseng is a valuable traditional Chinese medicine in Northeast China. Ginsenoside, the active component of ginseng, has not been investigated much for its effects on aging and its underlying mechanism(s) of action. Here, we investig…
View article: Ferulic Acid Supplementation Increases Lifespan and Stress Resistance via Insulin/IGF-1 Signaling Pathway in C. elegans
Ferulic Acid Supplementation Increases Lifespan and Stress Resistance via Insulin/IGF-1 Signaling Pathway in C. elegans Open
Ferulic acid (FA) is a naturally-occurring well-known potent antioxidant and free radical scavenger. FA supplementation is an effective strategy to delay aging, but the underlying mechanism remains unknown. In the present study, we examine…
View article: Creep properties and microstructure of a Mg-6Al-1Nd-1.5Gd alloy at temperatures above 150 °C
Creep properties and microstructure of a Mg-6Al-1Nd-1.5Gd alloy at temperatures above 150 °C Open
Compressive creep behavior of a Mg-Al alloy containing a small amount of Nd and Gd (Mg-6Al-1Nd-1.5Gd) was investigated at temperatures from 150 °C to 200 °C under a constant applied stress of 90 MPa, and its microstructure before and after…
View article: A Novel Peroxidase Mimics and Ameliorates Alzheimer’s Disease-Related Pathology and Cognitive Decline in Mice
A Novel Peroxidase Mimics and Ameliorates Alzheimer’s Disease-Related Pathology and Cognitive Decline in Mice Open
Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly, which is characterized by the accumulation of amyloid β (Aβ) plaques, oxidative stress, and neuronal loss. Therefore, clearing Aβ aggregates and reducin…