Explanipedia

The enigmatic role of C5aR2 in diabetic kidney disease Open

Inez Trambas, Adrienne Laskowski, Amalia Khayyira, Arpeeta Sharma, Poh‐Yi Gan , et al. · 2025

Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes Open

Inez Trambas, Lilliana Bowen, Vicki Thallas‐Bonke, Matthew Snelson, Karly C. Sourris , et al. · 2025

Proximal Tubular Deletion of Superoxide Dismutase-2 Reveals Disparate Effects on Kidney Function in Diabetes Open

Melinda T. Coughlan, Inez Trambas, Lilliana Bowen, Vicki Thallas‐Bonke, Matthew Snelson , et al. · 2025

Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitment Open

Matthew Snelson, Devy Deliyanti, Sih Min Tan, Anna M. Drake, Cassandra de Pasquale , et al. · 2024

Background Dietary-resistant starch is emerging as a potential therapeutic tool to limit the negative effects of diabetes on the kidneys. However, its metabolic and immunomodulatory effects have not yet been fully elucidated. Methods Six-w…

Therapeutic Potential of Targeting Complement C5a Receptors in Diabetic Kidney Disease Open

Inez Trambas, Melinda T. Coughlan, Sih Min Tan · 2023

Diabetic kidney disease (DKD) affects 30–40% of patients with diabetes and is currently the leading cause of end-stage renal disease (ESRD). The activation of the complement cascade, a highly conserved element of the innate immune system, …

Valproic acid attenuates cellular senescence in diabetic kidney disease through the inhibition of complement C5a receptors Open

Melinda T. Coughlan, Mark Ziemann, Adrienne Laskowski, Trent M. Woodruff, Sih Min Tan · 2022

P776: A PHASE 2, OPEN-LABEL, ASCENDING DOSE STUDY OF KER-050 FOR THE TREATMENT OF ANEMIA IN PATIENTS WITH VERY LOW, LOW, OR INTERMEDIATE RISK MYELODYSPLASTIC SYNDROMES Open

Sih Min Tan, Alejandro Arbelaez, Lynette Chee, Chun Yew Fong, Devendra Hiwase , et al. · 2022

Background: Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis; many patients develop high transfusion burden (HTB) requiring ≥4 units RBCs every 8 weeks and have high unmet medical need. KER-050, an investigati…

The Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease Open

Sih Min Tan, Matthew Snelson, Jakob Appel Østergaard, Melinda T. Coughlan · 2021

Significance: The metabolic disorder, diabetes mellitus, results in microvascular complications, including diabetic kidney disease (DKD), which is partly believe to involve disrupted energy generation in the kidney, leading t…

Thermally Processed Diet-Induced Albuminuria, Complement Activation and Intestinal Permeability Are Attenuated by Resistant Starch in Experimental Diabetes Open

Matthew Snelson, Sih Min Tan, Vicki Thallas‐Bonke, Karly C. Sourris, Mark Ziemann , et al. · 2021

Targeting Methylglyoxal in Diabetic Kidney Disease Using the Mitochondria-Targeted Compound MitoGamide Open

Sih Min Tan, Runa Lindblom, Mark Ziemann, Adrienne Laskowski, Cesare Granata , et al. · 2021

Diabetic kidney disease (DKD) remains the number one cause of end-stage renal disease in the western world. In experimental diabetes, mitochondrial dysfunction in the kidney precedes the development of DKD. Reactive 1,2-dicarbonyl compound…

Processed foods drive intestinal barrier permeability and microvascular diseases Open

Matthew Snelson, Sih Min Tan, Rachel Clarke, Cassandra de Pasquale, Vicki Thallas‐Bonke , et al. · 2021

This study shows how highly processed foods can cause innate immune inflammation that promotes chronic microvascular disease.

Thermally processed diet-induced albuminuria, Enterobacteriaceae expansion and cecal metabolome alterations are attenuated by resistant starch in diabetes Open

Matthew Snelson, Sih Min Tan, Karly C. Sourris, Runa Lindblom, Vicki Thallas‐Bonke , et al. · 2020

Background: Modern, processed diets are replete in dietary advanced glycation endproducts (AGEs) which contribute to chronic renal injury. This study investigated whether excess consumption of dietary AGEs alters gut ecology and exacerbate…

Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy Open

Matthew Snelson, Sih Min Tan, Gavin C. Higgins, Runa Lindblom, Melinda T. Coughlan · 2020

Alterations in gut homeostasis may contribute to the progression of diabetic nephropathy. There has been recent attention on the renoprotective effects of metabolite-sensing receptors in chronic renal injury, including the G protein-couple…

Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility Open

Sih Min Tan, Mark Ziemann, Vicki Thallas‐Bonke, Matthew Snelson, Vinod Kumar , et al. · 2019

The sequelae of diabetes include microvascular complications such as diabetic kidney disease (DKD), which involves glucose-mediated renal injury associated with a disruption in mitochondrial metabolic agility, inflammation, and fibrosis. W…

Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy Open

Matthew Snelson, Sih Min Tan, Gavin C. Higgins, Runa Lindblom, Melinda T. Coughlan · 2019

Alterations in gut homeostasis may contribute to the progression of diabetic nephropathy. There has been recent attention on the renoprotective effects of metabolite-sensing receptors in chronic renal injury, including the G-protein-couple…

SAT-301 RESISTANT STARCH AMELIORATES ADVANCED GLYCATION ENDPRODUCT-INDUCED GUT DYSBIOSIS AND ALBUMINURIA IN A MOUSE MODEL OF TYPE 2 DIABETES Open

Matthew Snelson, Sih Min Tan, K. C. Sourris, Vicki Thallas‐Bonke, Mark Ziemann , et al. · 2019

Excess intake of dietary advanced glycation endproducts (AGEs) contributes to chronic renal injury. Recent research implicates gut dysbiosis in the progression of diabetic nephropathy, however, the role of dietary AGEs in gut dysbiosis and…

SAT-302 INHIBITION OF COMPLEMENT C5A/C5A RECEPTOR 1 DECREASES RENAL INJURY IN DIABETIC KIDNEY DISEASE VIA METABOLIC REPROGRAMMING Open

Sih Min Tan, Mark Ziemann, Elif I. Ekinci, Peter J. Meikle, Mark E. Cooper , et al. · 2019

The complement system plays a central role in the activation of innate immunity, inflammation and tissue remodelling. The complement activation fragment C5a is a potent pro-inflammatory effector molecule. We have shown complement activatio…

Use of Readily Accessible Inflammatory Markers to Predict Diabetic Kidney Disease Open

Lauren Winter, Lydia Wong, George Jerums, Jas‐mine Seah, Michele V. Clarke , et al. · 2018

Diabetic kidney disease is a common complication of type 1 and type 2 diabetes and is the primary cause of end-stage renal disease in developed countries. Early detection of diabetic kidney disease will facilitate early intervention aimed …

Lipoxins Regulate the Early Growth Response–1 Network and Reverse Diabetic Kidney Disease Open

Eoin Brennan, Muthukumar Mohan, Aaron McClelland, Christos Tikellis, Mark Ziemann , et al. · 2018

Background The failure of spontaneous resolution underlies chronic inflammatory conditions, including microvascular complications of diabetes such as diabetic kidney disease. The identification of endogenously generated molecules that prom…

Nrf2 Activation Is a Potential Therapeutic Approach to Attenuate Diabetic Retinopathy Open

Devy Deliyanti, Saeed F. Alrashdi, Sih Min Tan, Colin J. Meyer, Keith W. Ward , et al. · 2018

Our data demonstrate the ability of dh404 to protect the retina against diabetes-induced damage and potentially prevent vision loss.

Resistant starch ameliorates heat treated diet-induced gut permeability and renal dysfunction in experimental diabetes Open

Matthew Snelson, Sih Min Tan, K. C. Sourris, Gavin C. Higgins, Yu Ding , et al. · 2017

Dietary advanced glycation end products (AGEs) induce chronic kidney disease (CKD) and changes in gut homeostasis Open

Rachel Clarke, Sih Min Tan, Tuong Vi Nguyen, Sally A. Penfold, Melinda T. Coughlan · 2016

Dietary Advanced Glycation End Products and Risk Factors for Chronic Disease: A Systematic Review of Randomised Controlled Trials Open

Rachel Clarke, Aimee L. Dordevic, Sih Min Tan, Lisa Ryan, Melinda T. Coughlan · 2016

Dietary advanced glycation end-products (AGEs) form during heating and processing of food products and are widely prevalent in the modern Western diet. Recent systematic reviews indicate that consumption of dietary AGEs may promote inflamm…

Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis Open

Melinda T. Coughlan, Gavin C. Higgins, Tuong-Vi Nguyen, Sally A. Penfold, Vicki Thallas‐Bonke , et al. · 2016

Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein with dual roles in redox signaling and programmed cell death. Deficiency in AIF is known to result in defective oxidative phosphorylation (OXPHOS), via loss of complex I activ…

Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets Open

William J. Stanley, Sara A. Litwak, Hong Sheng Quah, Sih Min Tan, Thomas W. H. Kay , et al. · 2015

Type 1 diabetes (T1D) is the result of an autoimmune assault against the insulin-producing pancreatic β-cells, where chronic local inflammation (insulitis) leads to β-cell destruction. T cells and macrophages infiltrate into islets early i…

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