Shuya Zhang
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View article: Study on the Empowerment of Women's Participation in Rural Tourism Under the Background of Rural Revitalization —— Take the Rural Revitalization Demonstration Area of Mount Tai Jiunu Peak as an Example
Study on the Empowerment of Women's Participation in Rural Tourism Under the Background of Rural Revitalization —— Take the Rural Revitalization Demonstration Area of Mount Tai Jiunu Peak as an Example Open
With continuous socioeconomic development, rural tourism has not only become a vital component of China's tourism industry system but also serves as a key mechanism to implement national development strategies and empower rural revitalizat…
View article: Deciphering structure-composition-efficacy transformation in processed Fuzi: an integrated SEM, XRD, metabolomics, and pharmacodynamics approach
Deciphering structure-composition-efficacy transformation in processed Fuzi: an integrated SEM, XRD, metabolomics, and pharmacodynamics approach Open
Background Aconiti Lateralis Radix Praeparata (Fuzi), a vital yet toxic herbal medicine, faces significant challenges in standardization due to varied processing methods that undermine detoxification efficacy and hinder therapeutic optimiz…
View article: Understanding mechanisms of Polygonatum sibiricum-derived exosome-like nanoparticles against breast cancer through an integrated metabolomics and network pharmacology analysis
Understanding mechanisms of Polygonatum sibiricum-derived exosome-like nanoparticles against breast cancer through an integrated metabolomics and network pharmacology analysis Open
Background Polygonatum sibiricum has a long history of medicinal and edible usages, and has attracted widespread attention from researchers due to its rich pharmacological activities. Research has found that plant-derived exosome-like nano…
View article: Towards equitable carbon responsibility: Integrating trade-related emissions and carbon sinks in urban decarbonization
Towards equitable carbon responsibility: Integrating trade-related emissions and carbon sinks in urban decarbonization Open
Cities play a pivotal role in global decarbonization, acting as a critical driver of carbon emissions. Accurately allocating carbon mitigation responsibility (CMR) is essential for designing effective and equitable climate policies. How ci…
View article: Application of lipidomics in the study of traditional Chinese medicine
Application of lipidomics in the study of traditional Chinese medicine Open
View article: Establishing Salvia miltiorrhiza-Derived Exosome-like Nanoparticles and Elucidating Their Role in Angiogenesis
Establishing Salvia miltiorrhiza-Derived Exosome-like Nanoparticles and Elucidating Their Role in Angiogenesis Open
Exosomes are multifunctional, cell-derived nanoscale membrane vesicles. Exosomes derived from certain mammalian cells have been developed as angiogenesis promoters for the treatment of myocardial ischemia–reperfusion injury, as they posses…
View article: Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification
Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification Open
Cell-free RNAs (cfRNAs) offer an opportunity to detect diseases from a transcriptomic perspective, however, existing techniques have fallen short in generating a comprehensive cell-free transcriptome profile. We develop a sensitive library…
View article: A Modified Method for the Isolation and Purification of Liver Sinusoidal Endothelial Cells from Mice
A Modified Method for the Isolation and Purification of Liver Sinusoidal Endothelial Cells from Mice Open
View article: A Novel Apolipoprotein E Mutation in a Boy and His Mother with Lipoprotein Glomerulopathy
A Novel Apolipoprotein E Mutation in a Boy and His Mother with Lipoprotein Glomerulopathy Open
View article: Metabolomic Analysis of Trehalose Alleviating Oxidative Stress in Myoblasts
Metabolomic Analysis of Trehalose Alleviating Oxidative Stress in Myoblasts Open
Trehalose, a naturally occurring non-toxic disaccharide, has attracted considerable attention for its potential in alleviating oxidative stress in skeletal muscle. In this study, our aim was to elucidate the metabolic mechanisms underlying…
View article: Single-cell RNA-seq analysis reveals that immune cells induce human nucleus pulposus ossification and degeneration
Single-cell RNA-seq analysis reveals that immune cells induce human nucleus pulposus ossification and degeneration Open
Background and aims Determining the transcriptomes and molecular mechanism underlying human degenerative nucleus pulposus (NP) is of critical importance for treating intervertebral disc degeneration (IDD). Here, we aimed to elucidate the d…
View article: Anti-glioma effect of ginseng-derived exosomes-like nanoparticles by active blood–brain-barrier penetration and tumor microenvironment modulation
Anti-glioma effect of ginseng-derived exosomes-like nanoparticles by active blood–brain-barrier penetration and tumor microenvironment modulation Open
Inhibition of tumor growth and normalization of immune responses in the tumor microenvironment (TME) are critical issues for improving cancer therapy. However, in the treatment of glioma, effective nanomedicine has limited access to the br…
View article: Advice for smokers in smoking cessation clinic: a review
Advice for smokers in smoking cessation clinic: a review Open
Background: Tobacco dependence has become a global public health concern. We chose to investigate the modifiable factors and motivations during the period of smoking cessation based on the mechanism of nicotine addiction.
Methods: We sele…
View article: Transcriptomic Enrichment of Ferroptosis-Related Gene<i>ACSL4</i>in Advanced Hepatic Fibrosis/Cirrhosis: Bioinformatics Analysis and Experimental validation
Transcriptomic Enrichment of Ferroptosis-Related Gene<i>ACSL4</i>in Advanced Hepatic Fibrosis/Cirrhosis: Bioinformatics Analysis and Experimental validation Open
Background Liver fibrosis is a critical part of the clinical process of liver disease that progresses to cirrhosis and even liver cancer, and effective treatment and clinical biomarkers are urgently needed to manage liver fibrosis. Ferropt…
View article: NMR-Based Metabolic Profiling of the Effects of α-Ketoglutarate Supplementation on Energy-Deficient C2C12 Myotubes
NMR-Based Metabolic Profiling of the Effects of α-Ketoglutarate Supplementation on Energy-Deficient C2C12 Myotubes Open
Skeletal muscle is closely linked to energy metabolism, but it is inevitably deprived of energy. Cellular differentiation is an essential and energy-demanding process in skeletal muscle development. Much attention has been paid to identify…
View article: Predictive Value of Noninvasive Peripheral Atherosclerosis Measurement for Coronary Artery Disease in Patients with Long T2DM Duration
Predictive Value of Noninvasive Peripheral Atherosclerosis Measurement for Coronary Artery Disease in Patients with Long T2DM Duration Open
In patients with long T2DM duration, CPS has a higher ability to predict the occurrence and severity of CAD. However, femoral artery plaque has special value in predicting moderate to severe coronary artery disease in patients with long-te…
View article: Amelioration of colitis progression by ginseng-derived exosome-like nanoparticles through suppression of inflammatory cytokines
Amelioration of colitis progression by ginseng-derived exosome-like nanoparticles through suppression of inflammatory cytokines Open
View article: Gut microbiome sheds light on the development and treatment of abdominal aortic aneurysm
Gut microbiome sheds light on the development and treatment of abdominal aortic aneurysm Open
Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease with high disability and mortality. Its susceptible risk factors include old age, being male, smoking, hypertension, and aortic atherosclerosis. With the improvement of sc…
View article: Zr-Based Metal-Organic Frameworks for Green Biodiesel Synthesis: A Minireview
Zr-Based Metal-Organic Frameworks for Green Biodiesel Synthesis: A Minireview Open
Metal–organic frameworks (MOFs) have widespread application prospects in the field of catalysis owing to their functionally adjustable metal sites and adjustable structure. In this minireview, we summarize the current advancements in zirco…
View article: Targeting therapy and tumor microenvironment remodeling of triple-negative breast cancer by ginsenoside Rg3 based liposomes
Targeting therapy and tumor microenvironment remodeling of triple-negative breast cancer by ginsenoside Rg3 based liposomes Open
View article: Disruption of CD73-Derived and Equilibrative Nucleoside Transporter 1–Mediated Adenosine Signaling Exacerbates Oxygen-Induced Retinopathy
Disruption of CD73-Derived and Equilibrative Nucleoside Transporter 1–Mediated Adenosine Signaling Exacerbates Oxygen-Induced Retinopathy Open
View article: Quantitative Trait Loci and Transcriptome Analysis Reveal Genetic Basis of Fiber Quality Traits in CCRI70 RIL Population of Gossypium hirsutum
Quantitative Trait Loci and Transcriptome Analysis Reveal Genetic Basis of Fiber Quality Traits in CCRI70 RIL Population of Gossypium hirsutum Open
Upland cotton ( Gossypium hirsutum ) is widely planted around the world for its natural fiber, and producing high-quality fiber is essential for the textile industry. CCRI70 is a hybrid cotton plant harboring superior yield and fiber quali…
View article: Evidence for a mouse origin of the SARS-CoV-2 Omicron variant
Evidence for a mouse origin of the SARS-CoV-2 Omicron variant Open
The rapid accumulation of mutations in the SARS-CoV-2 Omicron variant that enabled its outbreak raises questions as to whether its proximal origin occurred in humans or another mammalian host. Here, we identified 45 point mutations that Om…
View article: Evidence for a mouse origin of the SARS-CoV-2 Omicron variant
Evidence for a mouse origin of the SARS-CoV-2 Omicron variant Open
View article: Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion
Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion Open
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid dispersio…
View article: Differential expression of circular RNA in patients with white matter hyperintensity and cognitive impairment.
Differential expression of circular RNA in patients with white matter hyperintensity and cognitive impairment. Open
The circRNA expression profile of patients with WMH is changed significantly. The differentially expressed circRNA may be the cause of WMH; Hsa_circ_0092222, hsa_circ_0000662, and hsa_circ_0083773 may regulate the expression of target gene…
View article: Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation
Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation Open
View article: UDP-Glucose Dehydrogenases: Identification, Expression, and Function Analyses in Upland Cotton (Gossypium hirsutum)
UDP-Glucose Dehydrogenases: Identification, Expression, and Function Analyses in Upland Cotton (Gossypium hirsutum) Open
UDP-glucose dehydrogenase (UGD; EC1.1.1.22) is a NAD + -dependent enzyme that catalyzes the two-fold oxidation of UDP-glucose (UDP-Glc) to produce UDP-glucuronic acid and plays an important role in plant cell wall synthesis. A total of 42 …
View article: Downregulated miR‑21 mediates matrine‑induced apoptosis via the PTEN/Akt signaling pathway in FTC‑133 human follicular thyroid cancer cells
Downregulated miR‑21 mediates matrine‑induced apoptosis via the PTEN/Akt signaling pathway in FTC‑133 human follicular thyroid cancer cells Open
Matrine is an alkaloid extracted from the leguminous plant Sophora flavescens. Matrine has clinical effects in the treatment of tumors, including those in lung cancer, nasopharyngeal cancer and liver cancer. However, the effect of m…
View article: Genome-Wide Identification and Expression Analysis of the Metacaspase Gene Family in Gossypium Species
Genome-Wide Identification and Expression Analysis of the Metacaspase Gene Family in Gossypium Species Open
Metacaspases (MCs) are cysteine proteases that are important for programmed cell death (PCD) in plants. In this study, we identified 89 MC genes in the genomes of four Gossypium species (Gossypium raimondii, Gossypium barbadense, Gossypium…