Shyam Joshi
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View article: 365. Amoxicillin Direct Oral Challenge in Patients with High-Risk Allergic Reaction
365. Amoxicillin Direct Oral Challenge in Patients with High-Risk Allergic Reaction Open
Background Historically, penicillin skin testing (PST) has been the first step in allergy evaluation, followed by an oral challenge (OC). Recently, there have been studies looking at the safety of direct OC in patients without a prior PST,…
View article: Endotypes, phenotypes, and biomarkers in chronic spontaneous urticaria
Endotypes, phenotypes, and biomarkers in chronic spontaneous urticaria Open
Chronic spontaneous urticaria (CSU) is an inflammatory disorder that manifests with hives, angioedema, or both and lasts more than or equal to 6 weeks. Although certain elements of CSU pathogenesis are well defined, others remain unclear. …
View article: Rate of dupilumab use and symptom severity of patients with chronic rhinosinusitis with nasal polyposis after Draf 3 frontal sinusotomy
Rate of dupilumab use and symptom severity of patients with chronic rhinosinusitis with nasal polyposis after Draf 3 frontal sinusotomy Open
Background The indications for endoscopic modified Lothrop procedure (Draf 3) in patients with refractory chronic rhinosinusitis with nasal polyposis (CRSwNP) remain unclear. This study evaluates the effectiveness of Draf 3 for refractory …
View article: 1229. Outpatient Penicillin and Sulfonamide Antibiotic Allergy E-Consult Service in Prospective Solid Organ Transplant Recipients
1229. Outpatient Penicillin and Sulfonamide Antibiotic Allergy E-Consult Service in Prospective Solid Organ Transplant Recipients Open
Background Solid organ transplant recipients (SOTr) are at increased risk for infections post-transplantation. A penicillin allergy incidence of 12% and sulfonamide antibiotic allergy incidence of 9% has been reported in transplant recipie…
View article: 2738. Two-step sulfonamide antibiotic challenges in patients who require treatment with trimethoprim-sulfamethoxazole at an academic medical center: Outcomes in a largely immunocompromised population
2738. Two-step sulfonamide antibiotic challenges in patients who require treatment with trimethoprim-sulfamethoxazole at an academic medical center: Outcomes in a largely immunocompromised population Open
Background Sulfonamide antibiotic allergy is the second most reported medication allergy. The allergy label limits the use of trimethoprim-sulfamethoxazole (TMP-SMX), the antibiotic of choice for pneumocystis jirovecii pneumonia (PJP), Tox…
View article: International consensus statement on allergy and rhinology: Allergic rhinitis – 2023
International consensus statement on allergy and rhinology: Allergic rhinitis – 2023 Open
Background In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR‐A…
View article: Management paradigms for chronic rhinosinusitis in individuals with asthma: An evidence‐based review with recommendations
Management paradigms for chronic rhinosinusitis in individuals with asthma: An evidence‐based review with recommendations Open
Background Despite the significant morbidity associated with chronic rhinosinusitis (CRS) in individuals with asthma (CRSwA), there is a paucity of codified, evidence‐based management strategies for CRS in this population. Methods Using Pu…
View article: Efficacy and safety of an e-consult program for COVID-19 vaccine allergy concerns
Efficacy and safety of an e-consult program for COVID-19 vaccine allergy concerns Open
Background: Although severe allergic reactions to coronavirus disease 2019 (COVID-19) vaccines are rare, fear of allergic reactions remains a major source of vaccine hesitancy. For concerned patients and providers alike, allergist consulta…
View article: 1093. Bypassing Penicillin Skin Testing in favor of Direct Oral Challenge: A Pharmacy-driven Inpatient Program
1093. Bypassing Penicillin Skin Testing in favor of Direct Oral Challenge: A Pharmacy-driven Inpatient Program Open
Background Patient interview, penicillin skin testing (PST) and/or an oral challenge can be used to evaluate penicillin allergies. Programs favor PST prior to oral challenge, but there is interest in bypassing PST and directly oral challen…
View article: Safety and efficacy of direct two-step penicillin challenges with an inpatient pharmacist-driven allergy evaluation
Safety and efficacy of direct two-step penicillin challenges with an inpatient pharmacist-driven allergy evaluation Open
Background: Penicillin allergy is commonly reported and has clinical and financial consequences for patients and hospitals. A penicillin evaluation program can safely delabel patients and optimize antibiotic therapy. Pharmacists who perfor…
View article: 177. Implementation of Pharmacist-Driven Penicillin Allergy Evaluation and Testing with a Focus on Bypassing Penicillin Skin Testing at an Academic Medical Center
177. Implementation of Pharmacist-Driven Penicillin Allergy Evaluation and Testing with a Focus on Bypassing Penicillin Skin Testing at an Academic Medical Center Open
Background Penicillin allergies are reported by approximately 10% of the US population; however, studies reveal that >90% of those patients can tolerate penicillins. Penicillin allergies are associated with negative health outcomes, bot…
View article: Prospective Cohort Study of Breastfeeding and the Risk of Childhood Asthma
Prospective Cohort Study of Breastfeeding and the Risk of Childhood Asthma Open
AK Lossius, MC Magnus, J Lunde, K Stordal. J Pediatr. 2018;195:182–189.e2
To investigate the association between breastfeeding duration and age of complementary food introduction with the development of childhood asthma. Previous studies …
View article: Perceived Exercise Limitations in Asthma: The Role of Disease Severity, Overweight, and Physical Activity in Children
Perceived Exercise Limitations in Asthma: The Role of Disease Severity, Overweight, and Physical Activity in Children Open
To determine if perceived exercise limitation (EL) in asthmatic children was associated with lung function, demographic factors, and/or other medical comorbidities.The study included 302 Norwegian children (64% male) with asthma from the E…