Shyam Natarajan
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View article: Evolution of Active Surveillance of Prostate Cancer: Impact of Magnetic Resonance Imaging, Magnetic Resonance Imaging–Guided Biopsy, and Focal Therapy
Evolution of Active Surveillance of Prostate Cancer: Impact of Magnetic Resonance Imaging, Magnetic Resonance Imaging–Guided Biopsy, and Focal Therapy Open
Durability of AS may be linked to baseline MRGB. In men starting AS with MRGB and low-risk prostate cancer, subsequent MRI exhibits high negative predictive value, indicating routine follow-up biopsy is avoidable. In some men, FT may allow…
View article: Focal therapy of prostate cancer: Use of artificial intelligence to define tumour volume and predict treatment outcomes
Focal therapy of prostate cancer: Use of artificial intelligence to define tumour volume and predict treatment outcomes Open
Objectives The aim of this study is to evaluate new software (Unfold AI) in the estimation of prostate tumour volume (TV) and prediction of focal therapy outcomes. Subjects/patients and methods Subjects were 204 men with prostate cancer (P…
View article: Extracapsular extension risk assessment using an artificial intelligence prostate cancer mapping algorithm
Extracapsular extension risk assessment using an artificial intelligence prostate cancer mapping algorithm Open
Objective The objective of this study is to compare detection rates of extracapsular extension (ECE) of prostate cancer (PCa) using artificial intelligence (AI)‐generated cancer maps versus MRI and conventional nomograms. Materials and met…
View article: Artificial Intelligence Improves the Ability of Physicians to Identify Prostate Cancer Extent
Artificial Intelligence Improves the Ability of Physicians to Identify Prostate Cancer Extent Open
AI-assisted cancer contours reduce underestimation of prostate cancer extent, significantly improving contouring accuracy and negative margin rate achieved by physicians. This technology can potentially improve outcomes, as accurate contou…
View article: Prediction and Mapping of Intraprostatic Tumor Extent with Artificial Intelligence
Prediction and Mapping of Intraprostatic Tumor Extent with Artificial Intelligence Open
View article: Data from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer
Data from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer Open
Purpose: To determine whether MRI/ultrasound (MRI/US) fusion biopsy facilitates longitudinal resampling of the same clonal focus of prostate cancer and to determine whether high-grade cancers can evolve from low-grade clones.Expe…
View article: Data from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer
Data from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer Open
Purpose: To determine whether MRI/ultrasound (MRI/US) fusion biopsy facilitates longitudinal resampling of the same clonal focus of prostate cancer and to determine whether high-grade cancers can evolve from low-grade clones.Expe…
View article: Supplementary Figure 1 from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer
Supplementary Figure 1 from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer Open
Supplementary Figure 1. Study overview to determine the ability of MRI/ultrasound fusion guided biopsy to resample the same prostate cancer foci using molecular markers of clonality.
View article: Supplementary material from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer
Supplementary material from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer Open
Supplementary methods
View article: Supplementary Figure 1 legend from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer
Supplementary Figure 1 legend from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer Open
Legend to for supplementary Figure 1
View article: Supplementary material from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer
Supplementary material from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer Open
Supplementary methods
View article: Supplementary Figure 1 legend from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer
Supplementary Figure 1 legend from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer Open
Legend to for supplementary Figure 1
View article: Supplementary Figure 1 from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer
Supplementary Figure 1 from Molecular Profiling to Determine Clonality of Serial Magnetic Resonance Imaging/Ultrasound Fusion Biopsies from Men on Active Surveillance for Low-Risk Prostate Cancer Open
Supplementary Figure 1. Study overview to determine the ability of MRI/ultrasound fusion guided biopsy to resample the same prostate cancer foci using molecular markers of clonality.
View article: Domain generalization for prostate segmentation in transrectal ultrasound images: A multi-center study
Domain generalization for prostate segmentation in transrectal ultrasound images: A multi-center study Open
View article: Domain Generalization for Prostate Segmentation in Transrectal Ultrasound Images: A Multi-center Study
Domain Generalization for Prostate Segmentation in Transrectal Ultrasound Images: A Multi-center Study Open
Prostate biopsy and image-guided treatment procedures are often performed under the guidance of ultrasound fused with magnetic resonance images (MRI). Accurate image fusion relies on accurate segmentation of the prostate on ultrasound imag…
View article: Focal Laser Ablation of Prostate Cancer: An Office Procedure
Focal Laser Ablation of Prostate Cancer: An Office Procedure Open
In this article, we describe and illustrate an outpatient procedure for focal laser ablation (FLA) of prostate cancer (PCa). The procedure is conceptually similar to a fusion biopsy and is performed under local anesthesia in a clinic setti…
View article: Serial Molecular Profiling of Low-grade Prostate Cancer to Assess Tumor Upgrading: A Longitudinal Cohort Study
Serial Molecular Profiling of Low-grade Prostate Cancer to Assess Tumor Upgrading: A Longitudinal Cohort Study Open
View article: Monitoring Focal Laser Ablation with Interstitial Fluence Probes: Monte Carlo Simulation and Phantom Validation
Monitoring Focal Laser Ablation with Interstitial Fluence Probes: Monte Carlo Simulation and Phantom Validation Open
Focal laser ablation offers a minimally invasive method of treating solid organ tumors via hyperthermia. Real-time monitoring of the induced tissue damage is critical for clinical success, and is typically accomplished using thermal measur…
View article: Multicenter analysis of clinical and MRI characteristics associated with detecting clinically significant prostate cancer in PI-RADS (v2.0) category 3 lesions
Multicenter analysis of clinical and MRI characteristics associated with detecting clinically significant prostate cancer in PI-RADS (v2.0) category 3 lesions Open
View article: Using spatial tracking with magnetic resonance imaging/ultrasound‐guided biopsy to identify unilateral prostate cancer
Using spatial tracking with magnetic resonance imaging/ultrasound‐guided biopsy to identify unilateral prostate cancer Open
Objectives To create reliable predictive metrics of unilateral disease using spatial tracking from a fusion device, thereby improving patient selection for hemi‐gland ablation of prostate cancer. Patients and Methods We identified patients…
View article: Prostate Cancer Detection Rate of Freehand versus 3-Dimensional Template Mapping Biopsy Using a Magnetic Resonance Imaging-Ultrasound Fusion Device in Biopsy Naïve Men
Prostate Cancer Detection Rate of Freehand versus 3-Dimensional Template Mapping Biopsy Using a Magnetic Resonance Imaging-Ultrasound Fusion Device in Biopsy Naïve Men Open
Template mapping systematic biopsy detected more prostate cancer than conventional sampling in biopsy naïve men. It is a promising cost-effective alternative to magnetic resonance imaging-ultrasound fusion biopsy as an upfront screening to…
View article: Comparison of Targeted vs Systematic Prostate Biopsy in Men Who Are Biopsy Naive
Comparison of Targeted vs Systematic Prostate Biopsy in Men Who Are Biopsy Naive Open
An MRI-visible lesion in men undergoing first-time prostate biopsy identifies those with a heightened risk of clinically significant prostate cancer. Combining targeted and systematic biopsy offers the best chances of detecting the cancer.
View article: Do contemporary imaging and biopsy techniques reliably identify unilateral prostate cancer? Implications for hemiablation patient selection
Do contemporary imaging and biopsy techniques reliably identify unilateral prostate cancer? Implications for hemiablation patient selection Open
Background Hemiablation is a less morbid treatment alternative for appropriately selected patients with unilateral prostate cancer (PCa). However, to the authors’ knowledge, traditional diagnostic techniques inadequately identify appropria…
View article: MP78-07 DO CONTEMPORARY IMAGING AND BIOPSY TECHNIQUES RELIABLY IDENTIFY UNILATERAL PROSTATE CANCER? IMPLICATIONS FOR HEMIABLATION PATIENT SELECTION
MP78-07 DO CONTEMPORARY IMAGING AND BIOPSY TECHNIQUES RELIABLY IDENTIFY UNILATERAL PROSTATE CANCER? IMPLICATIONS FOR HEMIABLATION PATIENT SELECTION Open
You have accessJournal of UrologyProstate Cancer: Localized: Ablative Therapy (MP78)1 Apr 2019MP78-07 DO CONTEMPORARY IMAGING AND BIOPSY TECHNIQUES RELIABLY IDENTIFY UNILATERAL PROSTATE CANCER? IMPLICATIONS FOR HEMIABLATION PATIENT SELECTI…
View article: LBA-11 PAIREDCAP TRIAL: PROSPECTIVE ASSESSMENT OF IMAGE REGISTRATION IN DIAGNOSIS OF PROSTATE CANCER
LBA-11 PAIREDCAP TRIAL: PROSPECTIVE ASSESSMENT OF IMAGE REGISTRATION IN DIAGNOSIS OF PROSTATE CANCER Open
You have accessJournal of UrologySunday Next Frontier (LBA)1 Apr 2019LBA-11 PAIREDCAP TRIAL: PROSPECTIVE ASSESSMENT OF IMAGE REGISTRATION IN DIAGNOSIS OF PROSTATE CANCER Rajiv Jayadevan*, Fuad Elkhoury, Ely Felker, Lorna Kwan, Anthony Sisk…
View article: PD64-05 A MACHINE LEARNING MODEL FOR PREDICTING CANCER PRESENCE IN PROSTATE BIOPSY TARGETS USING MRI
PD64-05 A MACHINE LEARNING MODEL FOR PREDICTING CANCER PRESENCE IN PROSTATE BIOPSY TARGETS USING MRI Open
You have accessJournal of UrologyProstate Cancer: Detection & Screening VIII (PD64)1 Apr 2019PD64-05 A MACHINE LEARNING MODEL FOR PREDICTING CANCER PRESENCE IN PROSTATE BIOPSY TARGETS USING MRI Alex G. Raman*, Karthik V. Sarma, Wen Shi, St…
View article: MP78-04 PREDICTING PROSTATE CANCER FOCAL THERAPY ELIGIBILITY WITH MACHINE LEARNING
MP78-04 PREDICTING PROSTATE CANCER FOCAL THERAPY ELIGIBILITY WITH MACHINE LEARNING Open
You have accessJournal of UrologyProstate Cancer: Localized: Ablative Therapy (MP78)1 Apr 2019MP78-04 PREDICTING PROSTATE CANCER FOCAL THERAPY ELIGIBILITY WITH MACHINE LEARNING Steve Zhou*, Alan Priester, Rajiv Jayadevan, Jason Yang, David…
View article: V08-07 PROSTATE CANCER: USE OF TARGETED BIOPSY INFORMATION FOR PLANNING PARTIAL GLAND ABLATION WITH HIGH-INTENSITY FOCUSED ULTRASOUND
V08-07 PROSTATE CANCER: USE OF TARGETED BIOPSY INFORMATION FOR PLANNING PARTIAL GLAND ABLATION WITH HIGH-INTENSITY FOCUSED ULTRASOUND Open
You have accessJournal of UrologyRenal and Prostate II: Techniques (V08)1 Apr 2019V08-07 PROSTATE CANCER: USE OF TARGETED BIOPSY INFORMATION FOR PLANNING PARTIAL GLAND ABLATION WITH HIGH-INTENSITY FOCUSED ULTRASOUND Alan Priester*, Rajiv J…
View article: A tissue-mimicking prostate phantom for 980 nm laser interstitial thermal therapy
A tissue-mimicking prostate phantom for 980 nm laser interstitial thermal therapy Open
Purpose: To develop a phantom with optical and thermal properties matched to human prostate. This phantom will provide a platform for the development and characterization of 980 nm laser interstitial thermal therapy (LITT) systems. …
View article: A system using patient‐specific 3D‐printed molds to spatially align in vivo MRI with ex vivo MRI and whole‐mount histopathology for prostate cancer research
A system using patient‐specific 3D‐printed molds to spatially align in vivo MRI with ex vivo MRI and whole‐mount histopathology for prostate cancer research Open
Background Patient‐specific 3D‐printed molds and ex vivo MRI of the resected prostate have been two important strategies to align MRI with whole‐mount histopathology (WMHP) for prostate cancer (PCa) research, but the combination of these t…