Si Eun Kim
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View article: Physical Activity, Alzheimer Plasma Biomarkers, and Cognition
Physical Activity, Alzheimer Plasma Biomarkers, and Cognition Open
Importance Physical activity (PA) is a nonpharmacological intervention for dementia prevention. The association between PA and Alzheimer disease (AD) plasma biomarkers remains underexplored. Objective To investigate the associations among …
View article: LSTM-Autoencoder Based Detection of Time-Series Noise Signals for Water Supply and Sewer Pipe Leakages
LSTM-Autoencoder Based Detection of Time-Series Noise Signals for Water Supply and Sewer Pipe Leakages Open
The efficient management of urban water distribution networks is crucial for public health and urban development. One of the major challenges is the quick and accurate detection of leaks, which can lead to water loss, infrastructure damage…
View article: Distinct effects of blood pressure parameters on Alzheimer’s and vascular markers in 1,952 Asian individuals without dementia
Distinct effects of blood pressure parameters on Alzheimer’s and vascular markers in 1,952 Asian individuals without dementia Open
Background Risk factors for cardiovascular disease, including elevated blood pressure, are known to increase risk of Alzheimer’s disease. There has been increasing awareness of the relationship between long-term blood pressure (BP) pattern…
View article: Deep learning model for individualized trajectory prediction of clinical outcomes in mild cognitive impairment
Deep learning model for individualized trajectory prediction of clinical outcomes in mild cognitive impairment Open
Objectives Accurately predicting when patients with mild cognitive impairment (MCI) will progress to dementia is a formidable challenge. This work aims to develop a predictive deep learning model to accurately predict future cognitive decl…
View article: Factors associated with caregiver burden in early onset dementia: the LEAF study
Factors associated with caregiver burden in early onset dementia: the LEAF study Open
Background Early‐onset dementia is often predicted to have a greater care burden than late‐onset dementia. Indeed, previous studies have reported that caregivers of early‐onset dementia suffer more than those of late‐onset dementia. We exp…
View article: Baseline demographic and clinical characteristics of Longitudinal study of Early onset dementia And Family members
Baseline demographic and clinical characteristics of Longitudinal study of Early onset dementia And Family members Open
Background Patients with early‐onset dementia (EOD) tend to be different from patients with late‐onset dementia in their rarities, atypical presentations, higher genetic predisposition and diverse etiologies. Although EOD has devastating i…
View article: Classification and prediction of cognitive trajectories of cognitively unimpaired individuals
Classification and prediction of cognitive trajectories of cognitively unimpaired individuals Open
Objectives Efforts to prevent Alzheimer’s disease (AD) would benefit from identifying cognitively unimpaired (CU) individuals who are liable to progress to cognitive impairment. Therefore, we aimed to develop a model to predict cognitive d…
View article: Polyether-based waterborne synergists: effect of polymer topologies on pigment dispersion
Polyether-based waterborne synergists: effect of polymer topologies on pigment dispersion Open
In this study, we studied the effect of polymer topologies on pigment dispersion. This study suggests the widespread potential application of the topology-controlled polyglycidol based water-borne synergists for various dispersion applicat…
View article: Transferability of Alzheimer Disease Polygenic Risk Score Across Populations and Its Association With Alzheimer Disease-Related Phenotypes
Transferability of Alzheimer Disease Polygenic Risk Score Across Populations and Its Association With Alzheimer Disease-Related Phenotypes Open
Importance Polygenic risk scores (PRSs), which aggregate the genetic effects of single-nucleotide variants identified in genome-wide association studies (GWASs), can help distinguish individuals at a high genetic risk for Alzheimer disease…
View article: Interaction between Alzheimer’s Disease and Cerebral Small Vessel Disease: A Review Focused on Neuroimaging Markers
Interaction between Alzheimer’s Disease and Cerebral Small Vessel Disease: A Review Focused on Neuroimaging Markers Open
Alzheimer’s disease (AD) is characterized by the presence of β-amyloid (Aβ) and tau, and subcortical vascular cognitive impairment (SVCI) is characterized by cerebral small vessel disease (CSVD). They are the most common causes of cognitiv…
View article: Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population
Identifying novel genetic variants for brain amyloid deposition: a genome-wide association study in the Korean population Open
Background Genome-wide association studies (GWAS) have identified a number of genetic variants for Alzheimer’s disease (AD). However, most GWAS were conducted in individuals of European ancestry, and non-European populations are still unde…
View article: One-pot synthesis for gradient copolymers <i>via</i> concurrent tandem living radical polymerization: mild and selective transesterification of methyl acrylate through Al(acac)<sub>3</sub> with common alcohols
One-pot synthesis for gradient copolymers <i>via</i> concurrent tandem living radical polymerization: mild and selective transesterification of methyl acrylate through Al(acac)<sub>3</sub> with common alcohols Open
The acrylate based gradient copolymers were successfully synthesized by concurrent tandem living radical polymerization using Al(acac)3 as cocatalyst with common alcohols.
View article: Identification of and a Prediction Model for Cognitive Trajectories in Patients With Mild Cognitive Impairment Due to Alzheimer’s Disease
Identification of and a Prediction Model for Cognitive Trajectories in Patients With Mild Cognitive Impairment Due to Alzheimer’s Disease Open
Background: Few studies have investigated cognitive trajectories or developed a prediction model for amyloid beta-positive (Aβ+) mild cognitive impairment (MCI) patients. We aimed to identify distinct cognitive trajectories in Aβ+ MCI pati…
View article: Disease progression modeling of Alzheimer’s disease according to education level
Disease progression modeling of Alzheimer’s disease according to education level Open
To develop a disease progression model of Alzheimer’s disease (AD) that shows cognitive decline from subjective cognitive impairments (SCI) to the end stage of AD dementia (ADD) and to investigate the effect of education level on the whole…
View article: The Effects of Longitudinal White Matter Hyperintensity Change on Cognitive Decline and Cortical Thinning over Three Years
The Effects of Longitudinal White Matter Hyperintensity Change on Cognitive Decline and Cortical Thinning over Three Years Open
White matter hyperintensity (WMH) has been recognised as a surrogate marker of small vessel disease and is associated with cognitive impairment. We investigated the dynamic change in WMH in patients with severe WMH at baseline, and the eff…
View article: Head-to-Head Comparison of 18F-Florbetaben and 18F-Flutemetamol in the Cortical and Striatal Regions
Head-to-Head Comparison of 18F-Florbetaben and 18F-Flutemetamol in the Cortical and Striatal Regions Open
Our findings suggest that FMM might be better than FBB to detect amyloid burden in the striatum, although both ligands are comparable for imaging AD pathology in vivo.
View article: Disease progression modelling from preclinical Alzheimer’s disease (AD) to AD dementia
Disease progression modelling from preclinical Alzheimer’s disease (AD) to AD dementia Open
Background: To characterize the course of Alzheimer’s disease (AD) over a longer time interval, we aimed to construct a disease course model for the entire span of the disease using two separate cohorts ranging from preclinical AD to AD de…
View article: Disease progression modeling of Alzheimer’s disease according to education level
Disease progression modeling of Alzheimer’s disease according to education level Open
Background To develop a disease progression model of Alzheimer’s disease (AD) that shows cognitive decline from subjective cognitive impairments (SCI) to dementia and to investigate the effect of education level on the whole disease spectr…
View article: Sex-specific relationship of cardiometabolic syndrome with lower cortical thickness
Sex-specific relationship of cardiometabolic syndrome with lower cortical thickness Open
Our findings suggest that cortical thickness is more vulnerable to cardiometabolic risk factors in women than in men. Therefore, sex-specific prevention strategies may be needed to protect against accelerated brain aging.
View article: Usability Study of Basic File Management on a Shared Storage System: Usability Test on the Lifetime Library Web Interface
Usability Study of Basic File Management on a Shared Storage System: Usability Test on the Lifetime Library Web Interface Open
The purpose of this study is to understand usability of the web interface of the Lifetime Library, a shared storage system provided by the School of Information and Library Science at the University of North Carolina at Chapel Hill. Eight …
View article: P2‐383: <sup>18</sup>F‐FLORBETABEN AND <sup>18</sup>F‐FLUTEMETAMOL PET BETA‐AMYLOID BINDING EXPRESSED IN CENTILOIDS WITHOUT CONVERSION TO PIB
P2‐383: <sup>18</sup>F‐FLORBETABEN AND <sup>18</sup>F‐FLUTEMETAMOL PET BETA‐AMYLOID BINDING EXPRESSED IN CENTILOIDS WITHOUT CONVERSION TO PIB Open
The Centiloid (CL) method enables quantitative values from Aβ-amyloid (Aβ) imaging of multiple tracers and methods. We compare 18F-florbetaben (FBB) and 18F-flutemetamol (FMM) head to head using the Centiloid. We conducted head to head com…
View article: <p>Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment</p>
Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment Open
The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.
View article: Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease
Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease Open
Dementia was found to be an independent predictor for the risk of malnutrition compared with CU participants. Our findings further suggest that cortical thinning in left temporal regions is related to the nutritional status.
View article: A Nomogram for Predicting Amyloid PET Positivity in Amnestic Mild Cognitive Impairment
A Nomogram for Predicting Amyloid PET Positivity in Amnestic Mild Cognitive Impairment Open
Background: Most clinical trials focus on amyloid-β positive (Aβ+) amnestic mild cognitive impairment (aMCI), but screening failures are high because only a half of patients with aMCI are positive on Aβ PET. Therefore, it becomes necessary…
View article: IC‐P‐050: AMYLOID DEPOSITION IN THE SUBCORTICAL REGION PREDICTS COGNITIVE DECLINE
IC‐P‐050: AMYLOID DEPOSITION IN THE SUBCORTICAL REGION PREDICTS COGNITIVE DECLINE Open
As a result of amyloid PET, the quantification of uptakes in targeting cortical region has been widely used as a means of interpreting positivity on PET using cut-off until now. However, amyloid PET did not properly utilize the regional in…
View article: P2‐319: DISEASE COURSE MODELING OF ALZHEIMER'S DISEASE DEPENDING ON AMYLOID DEPOSITION: AN ACCELERATED LONGITUDINAL DESIGN
P2‐319: DISEASE COURSE MODELING OF ALZHEIMER'S DISEASE DEPENDING ON AMYLOID DEPOSITION: AN ACCELERATED LONGITUDINAL DESIGN Open
A disease progression model is essential to describe the disease state of degenerative diseases. We aimed to develop an Alzheimer's disease model showing cognitive decline from asymptomatic to clinical stages using accelerated longitudinal…