Shaomeng Wang
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View article: Balance between STAT5 and STAT3 determines dendritic cell function and tumor immunity 2337
Balance between STAT5 and STAT3 determines dendritic cell function and tumor immunity 2337 Open
Description Immune checkpoint blockade (ICB) has transformed cancer therapy. Immunotherapy efficacy depends on dendritic cell (DC)-mediated tumor antigen presentation, T-cell priming and activation. However, the relationship between the ke…
View article: Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance 2251
Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance 2251 Open
Description Immune checkpoint blockade (ICB) triggers tumor ferroptosis. However, most patients are unresponsive to ICB. Tumors might evade ferroptosis in the tumor microenvironment (TME). Here, we discover SLC13A3 is an itaconate transpor…
View article: RAS Mutation–Specific Responses to Paralog- and State-Selective RAS Inhibitors
RAS Mutation–Specific Responses to Paralog- and State-Selective RAS Inhibitors Open
A high therapeutic index, defined as potent inhibition of oncogenic signaling in tumor cells with minimal effects on normal cells, is critical for effective cancer therapies. Recent advances have introduced diverse RAS-targeting inhibitors…
View article: The effects of transfusion load on renal function in intraoperative salvage autotransfusion: a retrospective cohort study for 200 patients
The effects of transfusion load on renal function in intraoperative salvage autotransfusion: a retrospective cohort study for 200 patients Open
Objectives This study aimed to investigate the effect of transfusion load on renal function during intraoperative salvage auto-transfusion. Methods A total of 200 patients were assigned to five groups based on the transfusion load: 0–200 m…
View article: PROTACs therapeutically target the polyglutamine androgen receptor in spinal and bulbar muscular atrophy models
PROTACs therapeutically target the polyglutamine androgen receptor in spinal and bulbar muscular atrophy models Open
Spinal and bulbar muscular atrophy (SBMA) is a CAG/polyglutamine (polyQ) repeat expansion disorder in which the mutant androgen receptor (AR) protein triggers progressive degeneration of the neuromuscular system in men. As the misfolded po…
View article: Streptococcus pneumoniae synchronizes the states of cell wall peptidoglycan acetylation and genome methylation by programmed DNA inversions
Streptococcus pneumoniae synchronizes the states of cell wall peptidoglycan acetylation and genome methylation by programmed DNA inversions Open
Bacterial cell wall peptidoglycan (PG) consists of alternating β-(1,4) linked N- acetylmuramic acid (NAM) and N- acetylglucosamine (NAG). The C-6 hydroxyl group of NAM is acetylated by transmembrane O -acetyltransferases post PG biosynthes…
View article: Cellular and molecular mechanisms of arenobufagin in cancer therapy: a systematic review
Cellular and molecular mechanisms of arenobufagin in cancer therapy: a systematic review Open
The search for effective and safe therapeutic options is the goal of clinical treatment for cancer patients. In recent years, natural products have received increasing attention in order to develop new drugs with good antitumor effects and…
View article: Ph+B-ALL is defined by BCR::ABL1-induced enhancer reprogramming and hypersensitivity to enhancer-targeting drugs
Ph+B-ALL is defined by BCR::ABL1-induced enhancer reprogramming and hypersensitivity to enhancer-targeting drugs Open
Cancer is driven by genomic lesions and malignancy-promoting transcriptional programs. In blood cancers, both are often directly linked as lesions frequently affect transcription factor (TF) or epigenetic co-factor-encoding genes. Transcri…
View article: Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy
Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy Open
IKZF2 (Helios) is a transcription factor that is selectively expressed by Tregs and is essential for preserving the function and stability of Tregs in the tumor microenvironment (TME), where it suppresses the anti-tumor immune response. Ta…
View article: RAS mutation-specific signaling dynamics in response to paralog- and state- selective RAS inhibitors
RAS mutation-specific signaling dynamics in response to paralog- and state- selective RAS inhibitors Open
A high therapeutic index (TI), balancing potent oncogenic signaling inhibition in tumor cells with minimal effects on normal cells, is critical for effective cancer therapies. Recent advances have introduced diverse RAS-targeting inhibitor…
View article: Multidimensional analyses identify genes of high priority for pancreatic cancer research
Multidimensional analyses identify genes of high priority for pancreatic cancer research Open
Pancreatic ductal adenocarcinoma (PDAC) is a drug-resistant and lethal cancer. Identification of the genes that consistently show altered expression across patient cohorts can expose effective therapeutic targets and strategies. To identif…
View article: Terahertz Amplification Induced by Electron–Phonon Interactions in Gated Graphene Plasmonic System
Terahertz Amplification Induced by Electron–Phonon Interactions in Gated Graphene Plasmonic System Open
Terahertz (THz) amplification presents promising potential for various innovative applications. Here, we achieve an ultra-broadband and high-gain THz amplification from 0.1 to 25 THz with a saturated electric field peaking at 10 7 V/m by l…
View article: The SpxA1-TenA toxin-antitoxin system regulates epigenetic variations of Streptococcus pneumoniae by targeting protein synthesis
The SpxA1-TenA toxin-antitoxin system regulates epigenetic variations of Streptococcus pneumoniae by targeting protein synthesis Open
Human pathogen Streptococcus pneumoniae forms multiple epigenetically and phenotypically distinct intra-populations by invertase PsrA-driven inversions of DNA methyltransferase hsdS genes in the colony opacity-determinant ( cod ) locus. As…
View article: Harsh Parenting and Problematic Smartphone Use: The Chain Mediating Effects of Attention to Negative Information and Social Anxiety
Harsh Parenting and Problematic Smartphone Use: The Chain Mediating Effects of Attention to Negative Information and Social Anxiety Open
Harsh parenting (HP) has been shown to be associated with problematic smartphone use (PSU) among adolescents. However, few studies have explored the relationship between HP and PSU through a dual-system framework that integrates both emoti…
View article: Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia
Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia Open
MDM2 has been pursued as an attractive therapeutic target for human cancers. Herein, we describe our discovery of MD-265 as a promising PROTAC MDM2 degrader and extensive in vitro and in vivo evaluations of its therapeutic potential and me…
View article: Enhancing heat transfer in X-ray tube by van der heterostructures-based thermionic emission
Enhancing heat transfer in X-ray tube by van der heterostructures-based thermionic emission Open
Van der Waals (vdW) heterostructures have attracted much attention due to their distinctive optical, electrical, and thermal properties, demonstrating promising potential in areas such as photocatalysis, ultrafast photonics, and free elect…
View article: Proteolysis-targeting vaccines (PROTAVs) for robust combination immunotherapy of melanoma
Proteolysis-targeting vaccines (PROTAVs) for robust combination immunotherapy of melanoma Open
Protein/peptide subunit vaccines are promising to promote the tumor therapeutic efficacy of immune checkpoint blockade (ICB). However, current protein/peptide vaccines elicit limited antitumor T cell responses, leading to suboptimal therap…
View article: <scp>SHP2</scp> ablation mitigates osteoarthritic cartilage degeneration by promoting chondrocyte anabolism through <scp>SOX9</scp>
<span>SHP2</span> ablation mitigates osteoarthritic cartilage degeneration by promoting chondrocyte anabolism through <span>SOX9</span> Open
Articular cartilage phenotypic homeostasis is crucial for life‐long joint function, but the underlying cellular and molecular mechanisms governing chondrocyte stability remain poorly understood. Here, we show that the protein tyrosine phos…
View article: Discovery of CW-3308 as a Potent, Selective, and Orally Efficacious PROTAC Degrader of BRD9
Discovery of CW-3308 as a Potent, Selective, and Orally Efficacious PROTAC Degrader of BRD9 Open
The bromodomain-containing protein BRD9 has emerged as an attractive therapeutic target. In the present study, we successfully identified a number of highly potent BRD9 degraders by using two different cereblon ligands developed in our lab…
View article: Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers
Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers Open
Aberrant activation of RAS/MAPK signaling is common in cancer, and efforts to inhibit pathway components have yielded drugs with promising clinical activities. Unfortunately, treatment-provoked adaptive resistance mechanisms inevitably dev…