Yang‐Hu Sima
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The <span>JNK</span> signalling pathway gene <i>BmJun</i> is involved in the regulation of egg quality and production in the silkworm, <i>Bombyx mori</i> Open
The Jun N‐terminal kinase (JNK) signalling pathway has a key role in tissue remodelling during insect metamorphosis by regulating programmed cell death. However, multiple members of the JNK pathway in Lepidoptera remain uncharacterized. In…
Effects of Habitual Dietary Change on the Gut Microbiota and Health of Silkworms Open
Diet plays a crucial role in shaping the gut microbiota and overall health of animals. Traditionally, silkworms are fed fresh mulberry leaves, and artificial diets do not support good health. The aim of this study was to explore the relati…
Inhibition of Expression of the Circadian Clock Gene Cryptochrome 1 Causes Abnormal Glucometabolic and Cell Growth in Bombyx mori Cells Open
Cryptochrome is the earliest discovered photoreceptor protein in organisms. However, the effect of CRY (BmCRY), the clock protein in Bombyx mori, on the body or cell metabolism remains unclear. In this study, we continuously interfered wit…
Sericin Ser3 Ectopic Expressed in Posterior Silk Gland Affects Hemolymph Immune Melanization Response via Reducing Melanin Synthesis in Silkworm Open
The transgenesis of silkworms is an important way to innovate genetic resources and silk function. However, the silk-gland (SG) of transgenic silkworms, which is the most concerned target tissue of sericulture, often suffers from low vital…
Circadian clock regulates developmental time through ecdysone and juvenile hormones in <i>Bombyx mori</i> Open
The circadian clock plays an integral role in hormone biosynthesis and secretion. However, how the circadian clock precisely coordinates hormonal homeostasis to maintain normal animal development remains unclear. Here, we show that knockin…
The LIM Domain Protein BmFHL2 Inhibits Egg Production in Female Silkworm, Bombyx mori Open
The female Bombyx mori accumulates a large amount of egg proteins, mainly Vg and 30K, during egg formation to provide nutrition for embryo development. The synthesis and transport of Vg have been extensively studied, particularly the regul…
Black soldier fly larvae replace traditional iced trash fish diet to enhance the delicious flavor of Chinese mitten crab (Eriocheir sinensis) Open
Chinese mitten crabs ( Eriocheir sinensis ) are traditionally fed iced trash fish, but the industry is facing problems such as low breeding safety. Black soldier fly ( Hermetia illucens ) is an alternative protein source in animal diets, i…
Ectopic expression of sericin enables efficient production of ancient silk with structural changes in silkworm Open
Bombyx mori silk is a super-long natural protein fiber with a unique structure and excellent performance. Innovative silk structures with high performance are in great demand, thus resulting in an industrial bottleneck. Herein, the outer l…
Relationship between Changes in Intestinal Microorganisms and Effect of High Temperature on the Growth and Development of Bombyx mori Larvae Open
Temperature is an important environmental factor affecting the growth and development of silkworm (Bombyx mori). To analyze the effect of intestinal microbes on silkworm in response to a high-temperature environment, this study used a comb…
Combined analysis of silk synthesis and hemolymph amino acid metabolism reveal key roles for glycine in increasing silkworm silk yields Open
Rearing silkworms (Bombyx mori) using formula feed has revolutionized traditional mulberry feed strategies. However, low silk production efficiencies persist and have caused bottlenecks, hindering the industrial application of formula feed…
Ectopic expression of sericin enables efficient production of ancient silk with structural changes in silkworm Open
Bombyx mori silk is a super-long natural protein fiber with a unique structure and excellent performance. Innovative silk structures with high performance are in great demand, thus resulting in an industrial bottleneck. Herein, a transgeni…
Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model Open
Hyperproteinemia is a metabolic disorder associated with increased plasma protein concentration (PPC) and is often clinically complicated by malignant diseases or severe infections. At present, however, research on the molecular mechanism …
Circadian Clock Gene Period Contributes to Diapause via GABAeric-Diapause Hormone Pathway in Bombyx mori Open
Diapause is a developmental transition in insects based on seasonal adaptation to adversity; it is regulated by a circadian clock system and the endocrine system. However, the molecular node and its mechanism underlying the effects of thes…
Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model Open
Hyperproteinemia is a metabolic disorder associated with increased plasma protein concentration (PPC). It is often clinically complicated by malignant diseases or severe infections. Research on the molecular mechanism of High PPC (HPPC) is…
Influence of Hyperproteinemia on Insect Innate Immune Function of the Circulatory System in Bombyx mori Open
Metabolic disorders of the circulatory system of animals (e.g., hyperglycemia and hyperlipidemia) can significantly affect immune function; however, since there is currently no reliable animal model for hyperproteinemia, its effects on imm…
Inhibition of Period Gene Expression Causes Repression of Cell Cycle Progression and Cell Growth in the Bombyx mori Cells Open
Circadian clock system disorders can lead to uncontrolled cell proliferation, but the molecular mechanism remains unknown. We used a Bombyx mori animal model of single Period gene (BmPer) expression to investigate this mechanism. A slow gr…
Influence of hyperproteinemia on reproductive development in an invertebrate model Open
Hyperproteinemia is a severe metabolic disease characterized by abnormally elevated plasma protein concentrations (PPC). However, there is currently no reliable animal model for PPC, and the pathological mechanism of hyperproteinemia thus …
Induced Hyperproteinemia and Its Effects on the Remodeling of Fat Bodies in Silkworm, Bombyx mori Open
Hyperproteinemia, which is characterized by an abnormally elevated plasma protein concentration (PPC), is a high-mortality, metabolic complication associated with severe liver and kidney disease. It is difficult to clinically distinguish t…
Differences in gut microbiota between silkworms (<i>Bombyx mori</i>) reared on fresh mulberry (<i>Morus alba</i>var. multicaulis) leaves or an artificial diet Open
Artificial diets for silkworms have many potential applications and they are important in sericulture.
Inhibition of expression of the circadian clock gene Period causes metabolic abnormalities including repression of glycometabolism in Bombyx mori cells Open
Abnormalities in the circadian clock system are known to affect the body’s metabolic functions, though the molecular mechanisms responsible remain uncertain. In this study, we achieved continuous knockdown of B. mori Period (BmPer) gene ex…
Different toxicity of cadmium telluride, silicon, and carbon nanomaterials against hemocytes in silkworm, Bombyx mori Open
Exposure to CdTe QDs, SiNPs, or C–NCDs exerted different toxic effects on silkworm hemocytesviathe induction of different PCD processes.