Siamak Haghdoost
YOU?
Author Swipe
View article: “Hadrontherapy for Life” Symposium, Caen, March 10/11, 2025–Strategy for the Future–Pediatric Tumors
“Hadrontherapy for Life” Symposium, Caen, March 10/11, 2025–Strategy for the Future–Pediatric Tumors Open
View article: ROLES OF NRF2 SIGNALING AND PARP IN THE RADIORESISTANCE OF CANCER STEM CELLS EXPOSED IN-VITRO TO PHOTONS, PROTONS OR C-IONS
ROLES OF NRF2 SIGNALING AND PARP IN THE RADIORESISTANCE OF CANCER STEM CELLS EXPOSED IN-VITRO TO PHOTONS, PROTONS OR C-IONS Open
View article: Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) as a Biomarker for Radiation Dosimetry and Health Risk Assessment: A Review
Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) as a Biomarker for Radiation Dosimetry and Health Risk Assessment: A Review Open
Nuclear factor erythroid 2-related factor 2 (NRF2) is a key transcription factor that controls the antioxidant response to oxidative stress, especially after exposure to ionizing radiation (IR). This review examines NRF2’s emerging role as…
View article: Clinical white paper from the “Hadrontherapy for Life” symposium. Clinical expansion of Carbon Ion Facilities worldwide
Clinical white paper from the “Hadrontherapy for Life” symposium. Clinical expansion of Carbon Ion Facilities worldwide Open
View article: EDITORIAL. A milestone in the technological development of hadrontherapy, in France
EDITORIAL. A milestone in the technological development of hadrontherapy, in France Open
View article: Combined Radiations: Biological Effects of Mixed Exposures Across the Radiation Spectrum
Combined Radiations: Biological Effects of Mixed Exposures Across the Radiation Spectrum Open
Combined radiation exposures—pairings of ionizing and non-ionizing radiation—are increasingly relevant in medical, spaceflight, and environmental contexts. This systematic review evaluates their radiobiological effects and therapeutic appl…
View article: Combined Radiations: Biological Effects of Mixed Exposures Across the Radiation Spectrum
Combined Radiations: Biological Effects of Mixed Exposures Across the Radiation Spectrum Open
Combined radiation exposures—pairings of ionizing and non-ionizing radiation—are increasingly relevant in medical, spaceflight, and environmental contexts. This systematic review evaluates their radiobiological effects and therapeutic appl…
View article: An Update on Role of Ionizing Radiation to Enhance Proliferation and Differentiation of Normal Stem Cells via Activation of NRF2 Pathway: Review
An Update on Role of Ionizing Radiation to Enhance Proliferation and Differentiation of Normal Stem Cells via Activation of NRF2 Pathway: Review Open
Ionizing radiation (IR) as a stress inducer has a significant impact on various normal stem cells differentiation through activation of various signaling pathways. Low levels of oxidative stress of IR may preserve or even enhance cell diff…
View article: Combined Radiations: Biological Effects of Mixed Exposures Across the Radiation Spectrum
Combined Radiations: Biological Effects of Mixed Exposures Across the Radiation Spectrum Open
The growing use of mixed radiation exposures in medicine, space exploration, and environmental contexts has emphasized the need to understand their biological effects. This review compiles and analyzes findings from over 170 studies examin…
View article: Particle Therapy to Overcome Cancer Radiation Resistance: “ARCHADE” Consortium Updates in Radiation Biology
Particle Therapy to Overcome Cancer Radiation Resistance: “ARCHADE” Consortium Updates in Radiation Biology Open
Radiation therapy is a medical treatment that uses high doses of radiation to kill or damage cancer cells. It works by damaging the DNA within the cancer cells, ultimately causing cell death. Radiotherapy can be used as a primary treatment…
View article: Synergistic Effects of UVB and Ionizing Radiation on Human Non-Malignant Cells: Implications for Ozone Depletion and Secondary Cosmic Radiation Exposure
Synergistic Effects of UVB and Ionizing Radiation on Human Non-Malignant Cells: Implications for Ozone Depletion and Secondary Cosmic Radiation Exposure Open
The ozone layer in the Earth’s atmosphere filters solar radiation and limits the unwanted effects on humans. A depletion of this ozone shield would permit hazardous levels of UV solar radiation, especially in the UVB range, to bombard Eart…
View article: Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors
Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors Open
View article: Role of Oxidative Stress Signaling, Nrf2, on Survival and Stemness of Human Adipose-Derived Stem Cells Exposed to X-rays, Protons and Carbon Ions
Role of Oxidative Stress Signaling, Nrf2, on Survival and Stemness of Human Adipose-Derived Stem Cells Exposed to X-rays, Protons and Carbon Ions Open
Some cancers have a poor prognosis and often lead to local recurrence because they are resistant to available treatments, e.g., glioblastoma. Attempts have been made to increase the sensitivity of resistant tumors by targeting pathways inv…
View article: THE ROLE OF NRF2 SIGNALING IN SURIVAL AND DIFFERENTIATION OF PRIMARY STEM CELLS EXPOSED TO PARTICLE RADIATION
THE ROLE OF NRF2 SIGNALING IN SURIVAL AND DIFFERENTIATION OF PRIMARY STEM CELLS EXPOSED TO PARTICLE RADIATION Open
View article: Oxidative Stress Levels and DNA Repair Kinetics in Senescent Primary Human Fibroblasts Exposed to Chronic Low Dose Rate of Ionizing Radiation
Oxidative Stress Levels and DNA Repair Kinetics in Senescent Primary Human Fibroblasts Exposed to Chronic Low Dose Rate of Ionizing Radiation Open
Background: Exposure to low dose rate (LDR) radiation may accelerate aging processes. Previously, we identified numerous LDR-induced pathways involved in oxidative stress (OS) and antioxidant systems, suggesting that these pathways protect…
View article: Assessing late outcomes of advances in radiotherapy for paediatric cancers: Study protocol of the “HARMONIC-RT” European registry (NCT 04746729)
Assessing late outcomes of advances in radiotherapy for paediatric cancers: Study protocol of the “HARMONIC-RT” European registry (NCT 04746729) Open
View article: Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors
Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors Open
Long-term toxicities caused by cancer treatments have recently gained increasing recognition due to a steadily growing population of cancer survivors. Radiotherapy (RT) is a common treatment known to unintentionally harm surrounding normal…
View article: Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy
Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy Open
The coordinating role of nuclear factor erythroid-2-related factor 2 (Nrf2) in cellular function is undeniable. Evidence indicates that this transcription factor exerts massive regulatory functions in multiple signaling pathways concerning…
View article: A Longitudinal Study of Individual Radiation Responses in Pediatric Patients Treated with Proton and Photon Radiotherapy, and Interventional Cardiology: Rationale and Research Protocol of the HARMONIC Project
A Longitudinal Study of Individual Radiation Responses in Pediatric Patients Treated with Proton and Photon Radiotherapy, and Interventional Cardiology: Rationale and Research Protocol of the HARMONIC Project Open
The Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy (photon and proton) in Pediatrics (HARMONIC) is a five-year project funded by the European Commission that aimed to improve the understanding of the long-term ionizing radia…
View article: Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)
Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project) Open
The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potenti…
View article: A systems radiation biology approach to unravel the role of chronic low-dose-rate gamma-irradiation in inducing premature senescence in endothelial cells
A systems radiation biology approach to unravel the role of chronic low-dose-rate gamma-irradiation in inducing premature senescence in endothelial cells Open
Purpose The aim of this study was to explore the effects of chronic low-dose-rate gamma-radiation at a multi-scale level. The specific objective was to obtain an overall view of the endothelial cell response, by integrating previously publ…
View article: Sensitization of chondrosarcoma cells with PARP inhibitor and impact on cancer stem cells
Sensitization of chondrosarcoma cells with PARP inhibitor and impact on cancer stem cells Open
View article: Impact of Hypoxia and Hadrontherapy on Radioresistant Chondrosarcoma Cancer Stem Cells
Impact of Hypoxia and Hadrontherapy on Radioresistant Chondrosarcoma Cancer Stem Cells Open
International audience
View article: A Proteomic Study Suggests Stress Granules as New Potential Actors in Radiation-Induced Bystander Effects
A Proteomic Study Suggests Stress Granules as New Potential Actors in Radiation-Induced Bystander Effects Open
Besides the direct effects of radiations, indirect effects are observed within the surrounding non-irradiated area; irradiated cells relay stress signals in this close proximity, inducing the so-called radiation-induced bystander effect. T…
View article: Effect of dose and dose rate of gamma irradiation on the formation of micronuclei in bone marrow cells isolated from whole‐body‐irradiated mice
Effect of dose and dose rate of gamma irradiation on the formation of micronuclei in bone marrow cells isolated from whole‐body‐irradiated mice Open
It is well‐known that the cytotoxicity and mutagenic effects of high dose rate (HDR) ionizing radiation (IR) are increased by increasing the dose but less is known about the effects of chronic low dose rate (LDR). In vitro, we have shown t…
View article: Exposure to Low to Moderate Doses of Ionizing Radiation Induces A Reduction of Pro-Inflammatory Ly6chigh Monocytes and a U-Curved Response of T Cells in APOE -/- Mice
Exposure to Low to Moderate Doses of Ionizing Radiation Induces A Reduction of Pro-Inflammatory Ly6chigh Monocytes and a U-Curved Response of T Cells in APOE -/- Mice Open
Low dose ionizing radiation (LDIR) is known to have a protective effect on atherosclerosis in rodent studies, but how it impacts different cells types involved in lesion formation remains incompletely understood. We investigated the immuno…
View article: Proteomic analysis of bystander effects in chondrosarcoma cells
Proteomic analysis of bystander effects in chondrosarcoma cells Open
View article: Targeting NRF2, Regulator of Antioxidant System, to Sensitize Glioblastoma Neurosphere Cells to Radiation-Induced Oxidative Stress
Targeting NRF2, Regulator of Antioxidant System, to Sensitize Glioblastoma Neurosphere Cells to Radiation-Induced Oxidative Stress Open
The presence of glioma stem cells (GSCs), which are enriched in neurospheres, may be connected to the radioresistance of glioblastoma (GBM) due to their enhanced antioxidant defense and elevated DNA repair capacity. The aim was to evaluate…
View article: Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer
Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer Open
Nearly half of all cancers are treated with radiotherapy alone or in combination with other treatments, where damage to normal tissues is a limiting factor for the treatment. Radiotherapy-induced adverse health effects, mostly of importanc…
View article: Effects of Tomato Juice Intake on Salivary 8-Oxo-dG Levels as Oxidative Stress Biomarker after Extensive Physical Exercise
Effects of Tomato Juice Intake on Salivary 8-Oxo-dG Levels as Oxidative Stress Biomarker after Extensive Physical Exercise Open
Reactive oxygen species (ROS) at a normal level are important molecules involved in several cellular processes including immune response and cell signalling. Overproduction of ROS may lead to elevated oxidative stress and consequently to a…