Jennifer Morgan
YOU?
Author Swipe
View article: Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth
Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth Open
Oligonucleotide therapeutics are a new class of drugs that enable robust and sustained modulation of gene expression. However, achieving efficient delivery of siRNAs to tumors is a challenge for therapy. Here, we demonstrate that fully che…
View article: Interaction of IRS2 with PLK1 protects cells from mitotic stress
Interaction of IRS2 with PLK1 protects cells from mitotic stress Open
In this study we identify a role for IRS2 in the protection of cells from mitotic stress through its interaction with PLK1. IRS2 is an adaptor protein for the insulin and IGF-1 receptors that mediates their signaling functions. In this cap…
View article: Quality Improvement training to improve care for critically ill children with cancer: Our global experience
Quality Improvement training to improve care for critically ill children with cancer: Our global experience Open
View article: Characteristics and Associated Survival of Patients Diagnosed With Non–Small Cell Lung Cancer in a Designated Lung Cancer Program in Western Kenya
Characteristics and Associated Survival of Patients Diagnosed With Non–Small Cell Lung Cancer in a Designated Lung Cancer Program in Western Kenya Open
PURPOSE Although lung cancer is a major cause of cancer incidence and mortality worldwide, lung cancer studies in sub-Saharan Africa are scarce. Here, we present outputs from a designated lung cancer program in western Kenya, part of the M…
View article: Real-world breast cancer treatment patterns and guideline-concordant treatment completion among Malawian women
Real-world breast cancer treatment patterns and guideline-concordant treatment completion among Malawian women Open
While curative-intent GCT was associated with improved survival in this Malawian cohort, treatment completion rates were suboptimal. Resource-stratified guidelines must be paired with locally relevant, multilevel implementation strategies …
View article: Global Equity in Clinical Trials: A Pragmatic Approach
Global Equity in Clinical Trials: A Pragmatic Approach Open
View article: Fluorescent tagging of endogenous IRS2 with an auxin-dependent degron to assess dynamic intracellular localization and function
Fluorescent tagging of endogenous IRS2 with an auxin-dependent degron to assess dynamic intracellular localization and function Open
View article: Expanding Myeloma Training and Care in Western Kenya Through the ECHO Model: The Pilot Phase
Expanding Myeloma Training and Care in Western Kenya Through the ECHO Model: The Pilot Phase Open
PURPOSE Multiple myeloma (MM) in rural western Kenya is characterized by under and late diagnosis with poor long-term outcomes. Inadequate skilled rural health care teams are partly to blame. The Extension for Community Healthcare Outcomes…
View article: Uptake and Outcomes of a Clinical Breast Exam Program in Western Kenya
Uptake and Outcomes of a Clinical Breast Exam Program in Western Kenya Open
View article: Evolution of pharmacogenomic services and implementation of a multi-state pharmacogenomics clinic across a large rural healthcare system
Evolution of pharmacogenomic services and implementation of a multi-state pharmacogenomics clinic across a large rural healthcare system Open
Introduction: Pharmacogenomics (PGx) aims to maximize drug benefits while minimizing risk of toxicity. Although PGx has proven beneficial in many settings, clinical uptake lags. Lack of clinician confidence and limited availability of PGx …
View article: Invited commentary on: Mentoring approaches in a safe surgery program in Tanzania: Lessons learned during Covid-19 and recommendations for the future
Invited commentary on: Mentoring approaches in a safe surgery program in Tanzania: Lessons learned during Covid-19 and recommendations for the future Open
View article: Breast Cancer Germline Genetic Counseling and Testing for Populations of African Heritage Globally: A Scoping Review on Research, Practice, and Bioethical Considerations
Breast Cancer Germline Genetic Counseling and Testing for Populations of African Heritage Globally: A Scoping Review on Research, Practice, and Bioethical Considerations Open
PURPOSE Despite the disproportionately high risk of breast cancer among women of African heritage, little is known about the facilitators and barriers to implementing germline genetic testing and counseling (GT/C). METHODS This scoping rev…
View article: The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC Open
View article: Reinventing the Clinical Audit in a Pediatric Oncology Network
Reinventing the Clinical Audit in a Pediatric Oncology Network Open
Providing equal access to pediatric cancer patients regardless of their geographic location is a major goal of the Affiliate Program at St. Jude Children’s Research Hospital (St. Jude). Thirty-five percent of new cancer patients enrolled o…
View article: A Ten-Year Experience of Treating Chronic Myeloid Leukemia in Rural Rwanda: Outcomes and Insights for a Changing Landscape
A Ten-Year Experience of Treating Chronic Myeloid Leukemia in Rural Rwanda: Outcomes and Insights for a Changing Landscape Open
PURPOSE In describing our ten-year experience with treating chronic myeloid leukemia (CML) as part of the Glivec Patient Assistance Program (GIPAP) in rural Rwanda, we evaluate (1) patient characteristics and treatment outcomes, (2) resour…
View article: Visualisation and optimisation of alcohol-related hospital admissions ICD-10 codes in Welsh e-cohort data
Visualisation and optimisation of alcohol-related hospital admissions ICD-10 codes in Welsh e-cohort data Open
IntroductionThe excessive consumption of alcohol is detrimental to long term health and increases the likelihood of hospital admission. However, definitions of alcohol-related hospital admission vary, giving rise to uncertainty in the effe…
View article: Reply to D.A. Goldman and K.S. Panageas
Reply to D.A. Goldman and K.S. Panageas Open
View article: Handoff Communication between Remote Healthcare Facilities
Handoff Communication between Remote Healthcare Facilities Open
Introduction: Handoffs and transitions of care are common weak points in healthcare provider communication as patients move between sites. With no consistent pattern of communication between St. Jude Children’s Research Hospital (St. Jude)…
View article: From Creation to Evaluation: A Comprehensive Global Health Scholars Program for Graduate Medical Education Trainees
From Creation to Evaluation: A Comprehensive Global Health Scholars Program for Graduate Medical Education Trainees Open
Introduction: Recently, participation in clinical global health rotations has significantly increased among graduate medical education (GME) trainees. Despite the many benefits these experiences provide, many ethical challenges exist. Well…
View article: ACKNOWLEDGMENTS
ACKNOWLEDGMENTS Open
us to learn about the city and its history.Shelley and Jay were also our landlords, providing the small apartment on the fi rst fl oor of their Camden home.Drew and Leah Hood spent several weeks photographing the fathers and children who a…
View article: An unusual presentation of ACE inhibitor-induced visceral angioedema
An unusual presentation of ACE inhibitor-induced visceral angioedema Open
ACE inhibitors (ACEi) are common anti-hypertensive drugs that can cause angioedema. Though classic, or facial angioedema is rare, visceral angioedema is even less common. When angioedema occurs, it typically presents early, within 30 days …
View article: Epidemiology of alcohol-related emergency hospital admissions in children and adolescents: An e-cohort analysis in Wales in 2006-2011
Epidemiology of alcohol-related emergency hospital admissions in children and adolescents: An e-cohort analysis in Wales in 2006-2011 Open
Female children and adolescents were more likely to be admitted to hospital for alcohol-related reasons. These data illustrate the significant burden of alcohol-related harm in young people and highlight the need for interventions and poli…
View article: Chemotherapy Wait Times in a Network of Pediatric Oncology Clinics
Chemotherapy Wait Times in a Network of Pediatric Oncology Clinics Open
Patient satisfaction with medical care delivery is an important aspect of value-based health care. Providers strive to provide optimal patient satisfaction. Among a network of ambulatory pediatric oncology affiliate clinics, we conducted p…
View article: Quality Improvement Interventions across a Network of Pediatric Hematology–Oncology Clinics
Quality Improvement Interventions across a Network of Pediatric Hematology–Oncology Clinics Open
Introduction: Achieving improvement in quality among different institutions is challenging. Immunocompromised children with febrile neutropenia are at high risk of severe infection. Pediatric hematology–oncology patients frequently experie…
View article: TRIM5α Resistance Escape Mutations in the Capsid Are Transferable between Simian Immunodeficiency Virus Strains
TRIM5α Resistance Escape Mutations in the Capsid Are Transferable between Simian Immunodeficiency Virus Strains Open
TRIM5α polymorphism limits and complicates the use of simian immunodeficiency virus (SIV) for evaluation of human immunodeficiency virus (HIV) vaccine strategies in rhesus macaques. We previously reported that the TRIM5α-sensitive SIV from…