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Exploring the impact of metabolic comorbidities on epicardial adipose tissue in heart failure with preserved ejection fraction Open

Nassiba Menghoum, Maria Chiara Badii, Martin Leroy, M. Parra, Clotilde Roy , et al. · 2025

ClinicalTrials.gov. Identifier: NCT03197350; NCT02599480.

Plasma myo-inositol elevation in heart failure: clinical implications and prognostic significance. Results from the BElgian and CAnadian MEtabolomics in HFpEF (BECAME-HF) research project Open

Anne‐Catherine Pouleur, Nassiba Menghoum, Julien Cumps, Alice Marino, Maria Chiara Badii , et al. · 2024

Effectiveness of left bundle branch area pacing to restore narrow QRS in patients with right bundle branch block Open

J.‐H. Küpper, Sibille Lejeune, Quentin Garnir, Aurélien Wauters · 2024

Background/Introduction Left bundle branch area pacing (LBBaP) is an innovative technique used to capture conduction tissue and maintain ventricular synchrony during pacing. There are few data about the efficacy of LBBaP in right bundle br…

Carbohydrate antigen 125: a useful marker of congestion, fibrosis, and prognosis in heart failure with preserved ejection fraction Open

Nassiba Menghoum, Maria Chiara Badii, Matthieu Deltombe, Sibille Lejeune, Clotilde Roy , et al. · 2024

Aims Heart failure (HF) with preserved ejection fraction (HFpEF) is a disease associated with high morbidity and mortality, for which it is difficult to identify patients with the poorest prognosis in routine clinical practice. Carbohydrat…

Dual antiplatelet therapy is associated with high α-tubulin acetylation in circulating platelets from coronary artery disease patients Open

Valentine Robaux, Shakeel Kautbally, Audrey Ginion, Mélanie Dechamps, Sibille Lejeune , et al. · 2023

Platelet inhibition is the main treatment strategy to prevent atherothrombotic complications after acute coronary syndrome or percutaneous coronary intervention. Despite dual antiplatelet therapy (DAPT) combining aspirin and a P2Y₁₂

Mean platelet volume: a prognostic marker in heart failure with preserved ejection fraction Open

Nassiba Menghoum, Christophe Beauloye, Sibille Lejeune, Maria Chiara Badii, Damien Gruson , et al. · 2023

Heart failure (HF) with preserved ejection fraction (HFpEF) is associated with high burden of comorbidities known to increase the mean platelet volume (MPV). This parameter has been associated with morbidity and mortality in HF. However, t…

Association of Plasma Myeloperoxidase with Inflammation and Diabetic status in HFpEF Open

Sibille Lejeune, Audrey Ginion, Nassiba Menghoum, David Vancraeynest, Agnès Pasquet , et al. · 2023

Background: Inflammation and oxidative stress are thought to play an important role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF) through the development of endothelial dysfunction. Myeloperoxidase (MPO) …

Clinical use of mean platelet volume and neutrophil-to-lymphocyte ratio to predict prognosis in heart failure with preserved ejection fraction patients Open

N Menghoum, Christophe Beauloye, Sibille Lejeune, Didier Gruson, Agnès Pasquet , et al. · 2022

Background Over the last decade, a new paradigm for heart failure with preserved ejection (HFpEF) development has been proposed. High burden of comorbidities would lead to a systemic inflammatory state and enhanced platelet activation. Hig…

Myeloperoxidase as therapeutic target in HFpEF Open

Sibille Lejeune, A Ginion, N Menghoum, S Horman, Christophe Beauloye , et al. · 2022

Background Inflammation and oxidative stress are thought to play an important role in the pathophysiology of HFpEF through the development of endothelial dysfunction. Myeloperoxidase (MPO), a leukocyte-derived enzyme, functions as a link b…

Review of: "Defining the reference range for right ventricular systolic strain by echocardiography in healthy subjects: A meta-analysis" Open

Sibille Lejeune, Anne‐Catherine Pouleur · 2021

Potential competing interests: The author(s) declared that no potential competing interests exist.The meta-analysis "Defining the reference range for right ventricular systolic strain by echocardiography in healthy subjects" reports the po…

Diabetic phenotype and prognosis of patients with heart failure and preserved ejection fraction in a real life cohort Open

Sibille Lejeune, Clotilde Roy, Alisson Slimani, Agnès Pasquet, David Vancraeynest , et al. · 2021

When residents work less, they feel better: Lessons learned from an unprecedent context of lockdown Open

Amandine Degraeve, Sibille Lejeune, Tim Muilwijk, Filip Poelaert, M Piraprez , et al. · 2020

Fibroblast growth factor 23: a biomarker of fibrosis and prognosis in heart failure with preserved ejection fraction Open

Clotilde Roy, Sibille Lejeune, Alisson Slimani, Christophe de Meester, Sylvie A. Ahn AS , et al. · 2020

Aims Besides regulating calcium‐phosphate metabolism, fibroblast growth factor 23 (FGF‐23) has been associated with incident heart failure (HF) and left ventricular hypertrophy. However, data about FGF‐23 in HF and preserved ejection fract…

Right Ventricular Global Longitudinal Strain and Outcomes in Heart Failure with Preserved Ejection Fraction Open

Sibille Lejeune, Clotilde Roy, Victor Ciocea, Alisson Slimani, Christophe de Meester , et al. · 2020

Impact of paced left ventricular dyssynchrony on left ventricular reverse remodeling after cardiac resynchronization therapy Open

Anaïs Gauthey, Erik Willemen, Joost Lumens, Sylvain Ploux, Pierre Bordachar , et al. · 2020

Introduction We investigated whether pacing‐induced electrical dyssynchrony at the time of cardiac resynchronization therapy (CRT) device implantation was associated with chronic CRT response. Methods and Results We included a total of 69 …