Sibo Jiang
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View article: Cardiac patch treatment alleviates ischemic cardiomyopathy correlated with reverting Piezo1/2 expression by unloading left ventricular myocardium
Cardiac patch treatment alleviates ischemic cardiomyopathy correlated with reverting Piezo1/2 expression by unloading left ventricular myocardium Open
Pathologically elevated mechanical load promotes the adverse remodeling of left ventricle (LV) post myocardial infarction, which results in the progression from ischemic cardiomyopathy to heart failure. Cardiac patches could attenuate adve…
View article: Novel Selenium-modified Nucleic Acids For Structural and Functional Studies
Novel Selenium-modified Nucleic Acids For Structural and Functional Studies Open
Nucleic acids, as one of the most important macromolecules in living systems, play critical roles in storing, transferring, regulating genetic information, directing proteins synthesis, and catalysis. Understanding the structure of nucleic…
View article: Physiologically‐based pharmacokinetics modeling to investigate formulation factors influencing the generic substitution of dabigatran etexilate
Physiologically‐based pharmacokinetics modeling to investigate formulation factors influencing the generic substitution of dabigatran etexilate Open
The exposure‐response relationship of direct acting oral anti‐coagulants (DOACs) for bleeding risk is steep relative to ischemic stroke reduction. As a result, small changes in exposure may lead to bleeding events. The overall goal of this…
View article: ClpP participates in stress tolerance, biofilm formation, antimicrobial tolerance, and virulence of Enterococcus faecalis
ClpP participates in stress tolerance, biofilm formation, antimicrobial tolerance, and virulence of Enterococcus faecalis Open
Background ClpP is important for bacterial growth and plays an indispensable role in cellular protein quality control systems by refolding or degrading damaged proteins, but the physiological significance of ClpP in Enterococcus faecalis r…
View article: ClpP participates in stress tolerance, biofilm formation, antimicrobial tolerance, and virulence of Enterococcus faecalis
ClpP participates in stress tolerance, biofilm formation, antimicrobial tolerance, and virulence of Enterococcus faecalis Open
Background ClpP is important for bacterial growth and plays an indispensable role in cellular protein quality control systems by refolding or degrading damaged proteins, but the physiological significance of ClpP in Enterococcus faecalis r…
View article: Population Pharmacokinetic Modeling of Acetaminophen Protein Adducts in Adults and Children
Population Pharmacokinetic Modeling of Acetaminophen Protein Adducts in Adults and Children Open
Acetaminophen protein adducts (adducts) are a well‐established biomarker to diagnose acetaminophen toxicity. To date, the quantitative relationship between acetaminophen exposure, which drives adduct formation, and adduct exposure remains …
View article: Issue Information
Issue Information Open
Aims and Scope: For more than 50 years, clinical pharmacologists, clinical and pharmaceutical researchers, drug development specialists, physicians, nurses, and other medical professionals have relied on The Journal of Clinical Pharmacolog…
View article: Physiological significance of ClpP in Enterococcus faecalis and its regulating proteins were identified by Tandem Mass Tag Mass Spectrometry
Physiological significance of ClpP in Enterococcus faecalis and its regulating proteins were identified by Tandem Mass Tag Mass Spectrometry Open
Background ClpP is important for bacterial growth and plays an indispensable role in cellular protein quality control systems by refolding or degrading damaged proteins, but the physiological significance of ClpP in Enterococcus faecalis i…
View article: In Vitro Activities of Daptomycin Combined with Fosfomycin or Rifampin on Planktonic and Adherent Linezolid-resistant <i>Enterococcus faecalis</i>
In Vitro Activities of Daptomycin Combined with Fosfomycin or Rifampin on Planktonic and Adherent Linezolid-resistant <i>Enterococcus faecalis</i> Open
This study aimed to explore daptomycin combined with fosfomycin or rifampin against the planktonic and adherent linezolid-resistant isolates of Enterococcus faecalis . Four linezolid-resistant isolates of E. faecalis which formed biofilms …
View article: Nanotechnology in retinal drug delivery
Nanotechnology in retinal drug delivery Open
Retinal diseases, including age-related macular degeneration (AMD) and diabetic retinopathy (DR) are the leading causes of blindness in adults over the age of 50 years in the US. While most of those conditions do not have a cure, currently…
View article: A novel antimicrobial and remineralizing toothpaste containing CaCl₂/chitosan microspheres.
A novel antimicrobial and remineralizing toothpaste containing CaCl₂/chitosan microspheres. Open
Antibacterial chitosan could be used to encapsulate CaCl₂ and then formulated into toothpaste for caries control through in-situ formed amorphous calcium phosphate (ACP) during brushing.
View article: Nucleic acid crystallization and phase determination facilitated by selenium functionalization
Nucleic acid crystallization and phase determination facilitated by selenium functionalization Open
Selenium atom-specific functionalization can offer nucleic acids with many unique and novel properties (such as facilitated crystallization and phase determination) without significant perturbation of 3D structures of nucleic acids and the…
View article: Nucleic Acid Crystallography via Direct Selenium Derivatization: RNAs Modified with Se-Nucleobases
Nucleic Acid Crystallography via Direct Selenium Derivatization: RNAs Modified with Se-Nucleobases Open