Sibo Zhao
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View article: The Protective Effects of Membrane‐Separated Ripe Pu‐Erh Tea Extracts Against Chronic Alcoholic Liver Injury
The Protective Effects of Membrane‐Separated Ripe Pu‐Erh Tea Extracts Against Chronic Alcoholic Liver Injury Open
Excessive alcohol consumption in contemporary society induces alcoholic liver disease (ALD). Previous laboratory studies demonstrated hepatoprotective and gut microbiota–modulating effects of ripe Pu‐erh tea. To identify the key bioactive …
View article: PTHP-15. Enhancing Medulloblastoma Classification: Integrating IHC and DNA Methylation Data from the SJMB12 Clinical Trial
PTHP-15. Enhancing Medulloblastoma Classification: Integrating IHC and DNA Methylation Data from the SJMB12 Clinical Trial Open
The SJMB12 trial used immunohistochemistry (IHC)-based molecular grouping to separate medulloblastoma (MB) into WNT, SHH, and non-WNT/non-SHH (NWNS) groups for risk and treatment stratification. IHC was selected due to its rapid turnaround…
View article: Research on the Impact of Educational Investment on Regional Economic Growth
Research on the Impact of Educational Investment on Regional Economic Growth Open
This paper aims to explore the impact of educational investment on regional economic growth. By applying econometric models and regression analysis methods, an in-depth analysis was conducted on the relationship between edu-cational invest…
View article: Research on the Quantum Leap Path of Digital Transformation in Manufacturing Enterprises from the Perspective of Dynamic Capabilities — A Case Study of Ailebo Robot
Research on the Quantum Leap Path of Digital Transformation in Manufacturing Enterprises from the Perspective of Dynamic Capabilities — A Case Study of Ailebo Robot Open
This study takes Ailebo Robot Co., Ltd. as a case to analyze the dynamic capabil-ity evolution mechanism of digital transformation in SMEs. Through an embed-ded single-case research method, it reveals the enterprise's transformation path a…
View article: Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors
Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors Open
RNA therapeutics have recently shown significant promise in treating a variety of diseases, including cancers, infectious diseases, and genetic disorders. However, their potential in addressing neuropsychiatric disorders has been limited b…
View article: Does trade policy uncertainty reduce household consumption-based carbon emissions? Evidence from Chinese family panel data
Does trade policy uncertainty reduce household consumption-based carbon emissions? Evidence from Chinese family panel data Open
View article: Data-Driven Discovery of Novel Additives for Superconformal Cobalt Electrodeposition in 3D Interconnects
Data-Driven Discovery of Novel Additives for Superconformal Cobalt Electrodeposition in 3D Interconnects Open
View article: MDB-92. EFFECT OF REDUCED-DOSE CRANIOSPINAL IRRADIATION AND REDUCED-DOSE ADJUVANT CHEMOTHERAPY ON CHILDREN AND ADOLESCENTS WITH WNT MEDULLOBLASTOMA WITHOUT RESIDUAL OR METASTATIC DISEASE: RESULTS FROM THE SJMB12 CLINICAL TRIAL
MDB-92. EFFECT OF REDUCED-DOSE CRANIOSPINAL IRRADIATION AND REDUCED-DOSE ADJUVANT CHEMOTHERAPY ON CHILDREN AND ADOLESCENTS WITH WNT MEDULLOBLASTOMA WITHOUT RESIDUAL OR METASTATIC DISEASE: RESULTS FROM THE SJMB12 CLINICAL TRIAL Open
BACKGROUND In response to studies showing medulloblastoma (MB) survival is not only contingent on clinical factors (e.g. metastases, residual disease) but also on molecular factors (e.g. molecular group, gene aberrations), we launched the …
View article: Pu-erh tea partly improved liver cholesterol metabolism disorders in colitis mice via the gut-liver axis
Pu-erh tea partly improved liver cholesterol metabolism disorders in colitis mice via the gut-liver axis Open
Pu-erh tea has been shown to reduce gut infl ammation in dextran sulfate sodium (DSS)-induced mice. Also, we found abnormal liver cholesterol metabolism in DSS-induced mice. However, it’s not clear how Pu-erh tea improves DSS-induced impai…
View article: Understanding Family Dynamics in a Cross-Cultural Sample: A Multi-National Study
Understanding Family Dynamics in a Cross-Cultural Sample: A Multi-National Study Open
The Family Systems Circumplex Model posits that balanced levels of cohesion and adaptability are associated with positive familial outcomes, whereas extremely high or low levels of these factors are associated with deleterious outcomes. De…
View article: Data from Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models
Data from Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models Open
Purpose: Pediatric glioblastoma multiforme (pGBM) is a highly aggressive tumor in need of novel therapies. Our objective was to demonstrate the therapeutic efficacy of MLN8237 (alisertib), an orally available selective inhibitor of …
View article: Data from Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models
Data from Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models Open
Purpose: Pediatric glioblastoma multiforme (pGBM) is a highly aggressive tumor in need of novel therapies. Our objective was to demonstrate the therapeutic efficacy of MLN8237 (alisertib), an orally available selective inhibitor of …
View article: Supplementary Figure S1-S3 from Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models
Supplementary Figure S1-S3 from Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models Open
Supplementary Figure S1-S3 Figure S1. Anti-proliferative effects of MLN8237 on pGBM cell lines. Paired monolayer (Mono) and neurosphere (NS) of IC-4687GBM, IC-3752GBM and ICR0315GBM were seeded at 2,000 cells/well and exposed to MLN8237 (1…
View article: Supplementary Figure S1-S3 from Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models
Supplementary Figure S1-S3 from Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX Models Open
Supplementary Figure S1-S3 Figure S1. Anti-proliferative effects of MLN8237 on pGBM cell lines. Paired monolayer (Mono) and neurosphere (NS) of IC-4687GBM, IC-3752GBM and ICR0315GBM were seeded at 2,000 cells/well and exposed to MLN8237 (1…
View article: Pu-erh tea intake enhances the anti-obesity effect of intermittent fasting via modulating follicle-stimulating hormone and gut dysbacteriosis in female high-fat-diet mice
Pu-erh tea intake enhances the anti-obesity effect of intermittent fasting via modulating follicle-stimulating hormone and gut dysbacteriosis in female high-fat-diet mice Open
Intermittent fasting (IF) could not work well in females indicating that additional interventions might be necessary to improve outcomes. We here investigated whether Pu-erh tea extract (PTE) intake could enhance anti-obesity effect of IF …
View article: Gut-brain axis in depression: Crosstalk between neuroinflammation and gut microbiota
Gut-brain axis in depression: Crosstalk between neuroinflammation and gut microbiota Open
Depression is the most common mental disorder and the leading cause of disability and suicide worldwide. Recently, during the COVID-19 pandemic, there has been a dramatic increase in the number of patients with depression on a global scale…
View article: Correction: Long-term Pu-erh tea consumption improves blue light-induced depression-like behaviors
Correction: Long-term Pu-erh tea consumption improves blue light-induced depression-like behaviors Open
Correction for ‘Long-term Pu-erh tea consumption improves blue light-induced depression-like behaviors’ by Sibo Zhao et al. , Food Funct. , 2023, https://doi.org/10.1039/d2fo02780a.
View article: Publisher Correction: Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas
Publisher Correction: Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas Open
View article: Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas
Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas Open
View article: EPCO-39. ADAPTIVE CONVERGENCE OF METHYLOMES REVEALS EPIGENETIC DRIVERS AND BOOSTERS OF REPEATED RELAPSES IN PATIENT-MATCHED CHILDHOOD EPENDYMOMAS AND IDENTIFIES TARGETS FOR ANTI-RECURRENCE THERAPIES
EPCO-39. ADAPTIVE CONVERGENCE OF METHYLOMES REVEALS EPIGENETIC DRIVERS AND BOOSTERS OF REPEATED RELAPSES IN PATIENT-MATCHED CHILDHOOD EPENDYMOMAS AND IDENTIFIES TARGETS FOR ANTI-RECURRENCE THERAPIES Open
Ependymoma (EPN) is the third most common brain tumor in children and frequently recurs. Here, we report an integrated longitudinal analysis of epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses obtained fr…
View article: EPEN-02. Adaptive Convergence of Methylomes Reveals Epigenetic Drivers and Boosters of Repeated Relapses in Patient-matched Childhood Ependymomas and Identifies Targets for Anti-Recurrence Therapies
EPEN-02. Adaptive Convergence of Methylomes Reveals Epigenetic Drivers and Boosters of Repeated Relapses in Patient-matched Childhood Ependymomas and Identifies Targets for Anti-Recurrence Therapies Open
Ependymoma (EPN) is the third most common brain tumor in children and frequently recurs. Here, we report an integrated longitudinal analysis of epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses obtained fr…
View article: Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma
Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma Open
Clinical outcomes in patients with WHO grade II/III astrocytoma, oligodendroglioma or secondary glioblastoma remain poor. Isocitrate dehydrogenase 1 (IDH1) is mutated in > 70% of these tumors, making it an attractive therapeutic target. To…
View article: Static and modal analysis of industrial robots
Static and modal analysis of industrial robots Open
As an important automation equipment in contemporary manufacturing industry, 5-axis industrial robot is an important part of automated production. It improves the quality of work and production efficiency, reduces the workload of workers a…
View article: Mental Health Outcomes among Chinese College Students over a Decade
Mental Health Outcomes among Chinese College Students over a Decade Open
Background: Economic growth in China has brought about significant social and psychological changes in society. Objective: This study aims to explore how the mental and psychological health of college students has changed over the past dec…
View article: Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies
Evaluation of an EZH2 inhibitor in patient-derived orthotopic xenograft models of pediatric brain tumors alone and in combination with chemo- and radiation therapies Open
View article: Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion
Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion Open
Diffuse invasion is the primary cause of treatment failure of glioblastoma (GBM). Previous studies on GBM invasion have long been forced to use the resected tumor mass cells. Here, a strategy to reliably isolate matching pairs of invasive …
View article: Adaptive Convergence of Methylomes Reveals Epigenetic Drivers and Boosters of Repeated Relapses in Patient-matched Childhood Ependymomas and Identifies Targets for Anti-Recurrence Therapies
Adaptive Convergence of Methylomes Reveals Epigenetic Drivers and Boosters of Repeated Relapses in Patient-matched Childhood Ependymomas and Identifies Targets for Anti-Recurrence Therapies Open
Ependymoma (EPN) is the third most common brain tumor in children and frequently recurs. Here, we report an integrated longitudinal analysis of epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses obtained fr…
View article: Feeling matters: perceived social support moderates the relationship between personal relative deprivation and depressive symptoms
Feeling matters: perceived social support moderates the relationship between personal relative deprivation and depressive symptoms Open
View article: Reliability and Validity of the Chinese General Social Capital Scale and Its Effect on Physical Disease and Psychological Distress among Chinese Medical Professionals
Reliability and Validity of the Chinese General Social Capital Scale and Its Effect on Physical Disease and Psychological Distress among Chinese Medical Professionals Open
The study was designed with two objectives. The first was to assess the factor structure, internal consistency reliability, and preliminary psychometric properties of the Chinese version of the Chinese-translated General Social Capital Sca…
View article: Feeling matters: Perceived Social Support Moderate the Relationship between Personal Relative Deprivation and Depressive Symptoms
Feeling matters: Perceived Social Support Moderate the Relationship between Personal Relative Deprivation and Depressive Symptoms Open
Background Little research describes the mechanisms underlying depressive symptoms and personal relative deprivation in Chinese populations. Methods In this study, the respondents were (N = 938) residents of Beijing (17-59 years old) and r…