Shanshan Sun
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Advancing Cardiorenal Interaction: From Pathophysiological Paradigms to Novel Therapeutic Strategies Open
Background: The frequent co-occurrence of kidney and heart diseases stems from complex, bidirectional pathophysiological interactions, which contribute to elevated morbidity and mortality and present significant challenges in clinical mana…
Five years of biochar amendment combined with reduced fertilization and irrigation improved the soil organic carbon composition and structure in a solonchak Open
Biochar application can increase cultivated soil organic carbon (SOC) and fertility, especially in saline‒alkali soils facing climate change and salinization. To evaluate the effects of biochar application on SOC composition and structure,…
Experimental validation of virtual strain sensing methods for offshore jacket platforms Open
The offshore jacket platform is prone to stress concentration issues under the influence of long-term environmental loads and human factors, making strain monitoring at key locations crucial for assessing the structure's lifespan. To addre…
View article: MetaGP: A generative foundation model integrating electronic health records and multimodal imaging for addressing unmet clinical needs
MetaGP: A generative foundation model integrating electronic health records and multimodal imaging for addressing unmet clinical needs Open
Artificial intelligence makes strides in specialized diagnostics but faces challenges in complex clinical scenarios, such as rare disease diagnosis and emergency condition identification. To address these limitations, we develop Meta Gener…
Growth Arrest-specific 1 Inhibits Keap1/Nrf2 Signaling Transduction in the Activation of the Ferroptosis Program in Retinal Müller Cells Open
Background: Diabetes retinopathy (DR) represents a microvascular disease in diabetes. Growth arrest-specific 1 (GAS1) is differentially expressed in rat retinal Müller cells under high glucose (HG) conditions, and its promotion of ferropto…
View article: [Retracted] Role of the EZH2/miR‑200 axis in STAT3‑mediated OSCC invasion
[Retracted] Role of the EZH2/miR‑200 axis in STAT3‑mediated OSCC invasion Open
Following the publication of the above paper, and a corrigendum that has already been published (doi.org/10.3892/ijo.2023.5528) to attend to errors that were made in the assembly of Figs. 2 and 8, it was drawn to the Editor's attention by …
View article: Simultaneous determination of twelve microcystins in algal supplements on the Chinese market and possible risks to exposed populations
Simultaneous determination of twelve microcystins in algal supplements on the Chinese market and possible risks to exposed populations Open
Algae supplements are widely recognized for their nutritional benefits and are commonly marketed as natural health products. However, concerns regarding contamination with cyanobacterial toxins have been raised. Moreover, there is very lit…
Enhancing anti-tumor therapy with agmatine-cholesterol conjugate liposomes: in vitro and in vivo evidence Open
In this study, we synthesized a novel compound, agmatine-cholesterol conjugate (AG-Chol), to enhance the anti-tumor activity of liposomes. We used AG-Chol to replace cholesterol in preparing doxorubicin hydrochloride (DOX) liposomes by an …
Age-related elevation of O-GlcNAc causes meiotic arrest and subfertility in male mice Open
In recent years, the postponement of childbearing has become a critical social issue. Male fertility is negatively associated with age because of testis aging. Spermatogenesis is impaired with age, but the molecular mechanism remains unkno…
View article: Irigenin inhibits glioblastoma progression through suppressing YAP/β-catenin signaling
Irigenin inhibits glioblastoma progression through suppressing YAP/β-catenin signaling Open
Glioblastoma (GBM) is the most malignant glioma in brain tumors with low survival and high recurrence rate. Irigenin, as an isoflavone compound extracted from Shegan, has shown many pharmacological functions such as antioxidant, anti-infla…
Fraxinellone inhibits progression of glioblastoma via regulating the SIRT3 signaling pathway Open
Glioblastoma (GBM) is the most prevalent type of adult primary brain tumor and chemotherapy of GBM was limited by drug-resistance. Fraxinellone is a tetrahydro-benzofuranone derivative with various pharmacological activities. However, the …
GLP-1R Agonist Exendin-4 Protects Against Hemorrhagic Transformation Induced by rtPA After Ischemic Stroke via the Wnt/β-Catenin Signaling Pathway Open
Tissue plasminogen activator (tPA) is recommended by the FDA to dissolve intravascular clots after acute ischemic stroke (AIS). However, it may contribute to hemorrhagic transformation (HT). The Wnt/β-catenin signaling pathway plays an imp…
An HDAC9-associated immune-related signature predicts bladder cancer prognosis Open
Background The close relationship between histone deacetylase 9 (HDAC9) and immunity has attracted attention. We constructed an immune signature for HDAC9, a vital epigenetic modification, to predict the survival status and treatment benef…
EZH2, a prominent orchestrator of genetic and epigenetic regulation of solid tumor microenvironment and immunotherapy Open
Immune checkpoint blockade (ICB) is regarded as a promising strategy for cancer therapy. The histone methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), has been implicated in the carcinogenesis of numerous solid tumors. However, the un…
An RNA-binding protein-related risk signature can predict the prognosis and tumor immunity of patients with testicular germ cell tumors. Open
The established risk signature including four selected RBPs in TGCTs could predict the prognosis, tumor-related immunity and treatment benefits of patients with TGCTs. Utilization of this signature could help clinicians make personalized t…
Rapid Identification of Adulteration in Edible Vegetable Oils Based on Low-Field Nuclear Magnetic Resonance Relaxation Fingerprints Open
Most current approaches applied for the essential identification of adulteration in edible vegetable oils are of limited practical benefit because they require long analysis times, professional training, and costly instrumentation. The pre…
A novel immune-related gene pair prognostic signature for predicting overall survival in bladder cancer Open
Background Bladder cancer (BC) is the ninth most common malignant tumor. We constructed a risk signature using immune-related gene pairs (IRGPs) to predict the prognosis of BC patients. Methods The mRNA transcriptome, simple nucleotide var…
DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway Open
Breast cancer (BRCA) is one of the most deadly cancers worldwide, with poor survival rates that could be due to its high proliferation. Human all-alpha dCTP pyrophosphatase 1 (DCTPP1) is implicated in numerous diseases, including cancers. …
Construction and analysis of a ceRNA network and patterns of immune infiltration in bladder cancer Open
TTLL7, DSC2, ELN, hsa-miR-29c-3p, resting mast cells, and M0 macrophages may play an important role in the development of BC. However, additional studies are needed to confirm this hypothesis.
A Perspective on Accelerated Aging Caused by the Genetic Deficiency of the Metabolic Protein, OPA1 Open
Autosomal Dominant Optic Atrophy (ADOA) is an ophthalmological condition associated primarily with mutations in the OPA1 gene. It has variable onset, sometimes juvenile, but in other patients, the disease does not manifest until adult midd…
Expression patterns and prognostic value of m6A RNA methylation regulators in adrenocortical carcinoma Open
Adrenocortical carcinoma (ACC) is considered a rare cancer with poor prognosis. We used public datasets from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases to assess the relationships between N6-methyladenos…