Explanipedia

Engineered metallic hybrid nanozyme for advanced inflammatory disease therapy Open

Xi‐Ming Xia, Xuwen Liu, Yue Gao, Jiatong Lin, Shiyang Pan , et al. · 2025

An assessment of molecular diagnosis of tuberculosis and multi-drug resistant tuberculosis testing and quality assessment: findings of an international survey Open

Jim F. Huggett, Daniel Evans, Denise M. O’Sullivan, Katell Peoc’h, Helia Bakhshi-Nejad , et al. · 2025

Molecular ‘ in vitro diagnostic’ (IVD) tests are established for the diagnosis of tuberculosis (TB) and multi-drug resistant TB (MDR-TB). What is less clear is how the use of TB or MDR-TB molecular IVD results differ across regions, whethe…

Phenotypic Age and Neutrophil-to-Lymphocyte Ratio mediate the association between the triglyceride glucose-body mass index and the cardiovascular mortality risk in hypertensive patients Open

Yu Pan, X.J. LIU, Shiyang Pan, Shuang Yin, Xu Zhao , et al. · 2025

Background The triglyceride glucose-body mass index (TyG-BMI) has emerged as a novel marker for insulin resistance and metabolic syndrome. However, its relationship with prognosis in hypertensive patients remains uncertain. This study inve…

Bimetallic Plasmonic Nanozyme‐Based Microneedle for Synergistic Ferroptosis Therapy of Melanoma Open

Wei Duan, Keying Xu, Yue Gao, Sheng Huang, Xi‐Ming Xia , et al. · 2025

Melanoma is the most common malignant skin tumor, characterized by complexity, invasiveness, and heterogeneity. Conventional therapies often yield poor outcomes, posing significant clinical challenges. Here, a microneedle (MN) patch that i…

A global perspective on smoking’s impact on peptic ulcer disease: DALY trends and projections Open

Chang Li, Kun Jiang, Shiyang Pan, Chi‐Chung Tang, Kai Wang · 2025

Objective This study aims to analyze global trends in smoking-attributable peptic ulcer disease (PUD) disability-adjusted life years (DALYs) from 1990 to 2021 and project future trends to 2046. Methods Data were obtained from the Global Bu…

Liquid biopsy in oncology: navigating technical hurdles and future transition for precision medicine Open

Mengxiao Xie, Shiyang Pan, Mario Plebani · 2025

DA-DRD5 signaling reprograms B cells to promote CD8+ T cell-mediated antitumor immunity Open

Yuqing Wu, Lei Zhu, Sheng Li, Lu Liu, Yaman Wang , et al. · 2025

Neuronal signals have emerged as pivotal regulators of B cells that regulate antitumor immunity and tumor progression. However, the functional relevance and mechanistic basis of the effects of the neurotransmitter dopamine (DA) on tumor im…

P-1557. Using cefazolin and ceftriaxone via automated susceptibility predicts susceptibility to oral cefpodoxime but not cefuroxime in Enterobacterales Open

Joseph Sassine, Cindy B. McCloskey, Bryan P. White, Nayle Ibragimova, Denise Robison , et al. · 2025

Background Current CLSI recommendations suggest using cefazolin to predict susceptibilities of oral cephalosporins for uncomplicated UTI (uUTI) due to Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis. Most laboratories do not …

Establishment and Validation of a Risk Prediction Model for Sepsis-Associated Liver Injury in ICU Patients: A Retrospective Cohort Study Open

Chang Li, Jinling Ji, Ting Shi, Shiyang Pan, Kun Jiang , et al. · 2024

This novel nomogram effectively predicts SALI risk in sepsis patients by integrating readily available clinical parameters. While external validation is needed, the model shows promise as a practical tool for early risk stratification, pot…

Pan‐cancer analysis identifies the IRF family as a biomarker for survival prognosis and immunotherapy Open

Hua‐Guo Xu, C Chen, Lin‐Yuan Chen, Shiyang Pan · 2023

IRF family genes have been shown to be crucial in tumorigenesis and tumour immunity. However, information about the role of IRF in the systematic assessment of pan‐cancer and in predicting the efficacy of tumour therapy is still unknown. I…

Cellular crosstalk of macrophages and therapeutic implications in non-small cell lung cancer revealed by integrative inference of single-cell transcriptomics Open

Lei Wu, Wenying Xia, Yiting Hua, Kun Fan, Yanfei Lu , et al. · 2023

Introduction: Non-small cell lung cancer (NSCLC) exhibits heterogeneity with diverse immune cell infiltration patterns that can influence tumor cell behavior and immunotherapy. A comprehensive characterization of the tumor microenvironment…

P2.09-02 Impact of Co-mutations on the Prognosis of Targeted Therapy in EGFR-Mutant Advanced NSCLC: a Result of Real-World Study Open

Shiyang Pan, Ning Wang, Min Tian, Xia Song · 2023

Novel insights into IL-37: an anti-inflammatory cytokine with emerging roles in anti-cancer process Open

Min Gu, Yuexinzi Jin, Xun Gao, Wenying Xia, Ting Xu , et al. · 2023

Interleukin-37 (IL-37) is a newly discovered member of IL-1 family. The cytokine was proved to have extensive protective effects in infectious diseases, allergic diseases, metabolic diseases, autoimmune diseases and tumors since its discov…

Determination of Geographic Origin of Turquoise by Combining Laser Ablation Inductively Coupled Plasma Mass Spectrometry Analysis and Chemometrics Open

Shuoyun Tong, Guodong Chen, Weikang Hu, Shiyang Pan, Dan Zhu , et al. · 2023

Microsampling elemental analysis is widely used for gemstone and mineralogy traceability. Using laser ablation inductively coupled plasma mass spectrometry combined with chemometrics, the contents of 56 elements in turquoise samples from 5…

860MO MRG003: A novel EGFR-targeted antibody-drug conjugant (ADC) for recurrent/metastatic nasopharyngeal carcinoma Open

Fei Han, Fei Wang, Y-R. Shi, Ye Guo, X-L. shu , et al. · 2023

Clinical Characteristics of Severe COVID-19 Patients During Omicron Epidemic and a Nomogram Model Integrating Cell-Free DNA for Predicting Mortality: A Retrospective Analysis Open

Yanfei Lu, Wenying Xia, Shuxian Miao, Min Wang, Lei Wu , et al. · 2023

There was a high mortality rate among patients with severe COVID-19. cfDNA levels ≥97.67 ng/mg can significantly increase mortality. When predicting mortality in patients with severe COVID-19, a nomogram based on age, tracheal intubation, …

PD-1+ IFN-γ+ subset of CD8+ T cell in circulation predicts response to anti–PD-1 therapy in NSCLC Open

Wenxiu Chen, Yiting Hua, Conghui Shan, Jia Wei, Yutong Zhou , et al. · 2023

Background Treatment with programmed cell death protein-1 (PD-1) antibodies has minimal response rates in patients with non–small cell lung cancer (NSCLC), and, actually, they are treated with chemotherapy combined with anti–PD-1 therapy c…

SP70 is a novel biomarker of hepatocellular carcinoma Open

Lin Wang, Hui Shi, Wei Jia, Wenxiu Chen, Yuexinzi Jin , et al. · 2023

Background Tumor-specific protein 70 (SP70) was identified as a new biomarker associated with the proliferation and invasion of cancer cells. This study aimed to investigate the expression of SP70 in hepatocellular carcinoma (HCC) and asse…

Molecular identification, antifungal susceptibility, and resistance mechanisms of pathogenic yeasts from the China antifungal resistance surveillance trial (CARST-fungi) study Open

Qiqi Wang, Xuan Cai, Yun Li, Jianhong Zhao, Xiaogang Li , et al. · 2022

To have a comprehensive understanding of epidemiology and antifungal susceptibilities in pathogenic yeasts, the China Antifungal Resistance Surveillance Trial (CARST-fungi) study was conducted. All yeast isolates were identified by ribosom…

P059 The overexpression of efflux pump gene cdr1B resulting in voriconazole- and isavuconazole- resistance in Aspergillus fumigatus recovered from a patient with chronic pulmonary aspergillosis in China Open

Tianyu Liang, Qiqi Wang, Shiyang Pan, Fang Ni, Ruoyu Li , et al. · 2022

Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Objectives Triazole resistance in the pathogenic Aspergillus fumigatus has been increasing worldwide, posing a growing therapeutic challenge. To date, triazole resistance in clinical…

Single‐cell RNA sequencing reveals the characteristics of cerebrospinal fluid tumour environment in breast cancer and lung cancer leptomeningeal metastases Open

Haoyu Ruan, Zhe Wang, Ziwei Sun, Jia Wei, Lei Zhang , et al. · 2022

Leptomeningeal metastases (LM) occur in patients with breast cancer (BC) and lung cancer (LC) showing exceptionally poor prognosis. The cerebrospinal fluid (CSF) tumour microenvironment (TME) of LM patients is not well defined at a single‐…

Molecular diagnostics of SARS-CoV-2: Findings of an international survey Open

Aldo Vacaflores Salinas, Tester F. Ashavaid, Deborah Payne, Mark W. Linder, Katarina Baluchova , et al. · 2022

Construction of Novel Prognostic Nomogram for Mucinous and Signet Ring Cell Colorectal Cancer Patients with a Survival Longer Than 5 Years Open

Juan Xu, Ziwei Sun, Huanyu Ju, Erfu Xie, Mu Yuan , et al. · 2022

Juan Xu,1,2,* Ziwei Sun,1,2,* Huanyu Ju,1,2 Erfu Xie,1,2 Yuan Mu,1,2 Jian Xu,1,2 Shiyang Pan1,2 1Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 2Branch o…

Cell-Free DNA Variables including Gene Mutations in CA15-3 Normal Breast Cancer Reflect Prognosis Open

Juan Xu, Wenxiu Chen, Ziwei Sun, Hailin Peng, Chenglin Zhou , et al. · 2022

Background. Cell-free DNA (cfDNA) has attracted considerable attention in precision medicine. However, few data are available regarding to the prognostic value of cfDNA variables in CA15-3 normal breast cancer (BC) patients. Here, we aimed…

Development and validation of a prediction model for malignant pulmonary nodules Open

Zhen Ren, Hongmei Ding, Zhenzhen Cai, Mu Yuan, Lin Wang , et al. · 2021

This study is to develop and validate a preoperative prediction model for malignancy of solitary pulmonary nodules. Data from 409 patients who underwent solitary pulmonary nodule resection at the First Affiliated Hospital of Nanjing Medica…

Clinical utility of procalcitonin and its association with pathogenic microorganisms Open

Hua‐Guo Xu, Tian Meng, Shiyang Pan · 2021

In this review, we summarize the relationship of PCT with pathogens, evaluate the clinical utility of PCT in the diagnosis of clinical diseases, condition monitoring and evaluation, and guiding medical decision-making, and explore current …

Serum miR-27a is a biomarker for the prognosis of non-small cell lung cancer patients receiving chemotherapy Open

Erfu Xie, Mingxin Lin, Ziwei Sun, Yuexinzi Jin, Shi-Chang Zhang , et al. · 2021

Collectively, our results suggest that miR-27a is involved in the apoptosis of lung cancer cells and that serum miR-27a levels are related to the prognosis of NSCLC patients. The expression levels of miR-27a in the serum may be an independ…

Chinese Expert Consensus on the Nucleic Acid Detection of SARS-CoV-2 Open

Zijie Liu, Yongqing Tong, Jun Wu, Lutao Du, Chaojun Wei , et al. · 2020

The coronavirus disease 2019 (COVID-19) has already become a pandemic wherein the infection's timely diagnosis has proven beneficial to patient treatment and disease control. Nucleic acid detection has been the primary laboratory diagnosti…

Serum miR-27a is a biomarker for prognosis of non-small cell lung cancer patients receiving chemotherapy Open

Erfu Xie, Yazhou Ji, Mingxin Lin, Yuexinzi Jin, Shi-Chang Zhang , et al. · 2020

Background: Lung cancer has a high incidence and a 5-year survival rate of less than 15%. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer cases. Chemotherapy and immunotherapy are the most frequently used a…

MAb NJ001 inhibits lung adenocarcinoma invasiveness by directly regulating TIMP‐3 promoter activity via FOXP1 binding sites Open

Chunrong Gu, Ying Luo, Shi-Chang Zhang, Jian Xu, Jiexin Zhang , et al. · 2020

Background Previously, we developed a monoclonal antibody (mAb) NJ001 that binds to the antigen SP70 in human non‐small cell lung cancer (NSCLC) cells and showed it could inhibit lung adenocarcinoma (AD) growth. Here, we investigated the e…

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