Sid E. O’Bryant
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View article: Harmonizing 10,000 connectomes: site-invariant representation learning for multi-site analysis of network connectivity and cognitive impairment
Harmonizing 10,000 connectomes: site-invariant representation learning for multi-site analysis of network connectivity and cognitive impairment Open
The proposed model yields reproducible precision across 15 data configurations. This approach demonstrates the effectiveness of representation learning in enhancing biological signals by mitigating acquisition-specific confounding factors …
View article: Examination of metabolic syndrome in Down syndrome and association with dementia
Examination of metabolic syndrome in Down syndrome and association with dementia Open
INTRODUCTION In the neurotypical population, metabolic syndrome (MetS) is associated with Alzheimer's disease (AD). However, this has not been well studied in adults with Down syndrome (DS). METHODS The prevalence of MetS and its subcompon…
View article: Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome
Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome Open
INTRODUCTION Despite having few vascular risk factors, people with Down syndrome (DS) have MRI evidence of cerebrovascular disease (CVD) and neuroinflammation that worsens with Alzheimer's disease (AD) severity. We investigated whether mar…
View article: Networks and clusters of immunometabolic biomarkers and depression-associated features in middle-aged and older community-dwelling US adults with and without depression
Networks and clusters of immunometabolic biomarkers and depression-associated features in middle-aged and older community-dwelling US adults with and without depression Open
View article: Chronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population
Chronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population Open
The study highlights a further aspect of the pathophysiological mechanisms involved in the brain-body communication. While IL-6 partially explains statistical associations between chronic emotional stress and major cardiometabolic disorder…
View article: Rates of clinical progression according to biological Alzheimer's disease stages
Rates of clinical progression according to biological Alzheimer's disease stages Open
INTRODUCTION Predicting the rate of cognitive decline and the likelihood of progression to dementia remains a critical unmet need in clinical settings. METHODS We assessed progression to mild cognitive impairment (MCI) and all‐cause dement…
View article: Neuroimaging markers of dementia across race/ethnicity and sex/gender using an intersectional approach within the HABS‐HD cohort
Neuroimaging markers of dementia across race/ethnicity and sex/gender using an intersectional approach within the HABS‐HD cohort Open
INTRODUCTION Racial/ethnic and sex/gender differences in neuroimaging markers of dementia have been previously explored, but rarely with an intersectional approach. METHODS Using data from the Health and Aging Brain Study–Health Disparitie…
View article: White Matter Tract Vulnerability to Amyloid Pathology on the Alzheimer’s Disease Continuum
White Matter Tract Vulnerability to Amyloid Pathology on the Alzheimer’s Disease Continuum Open
Alzheimer’s disease (AD) is marked by progressive cognitive decline and memory loss, due to the abnormal accumulation of amyloid-beta ( Aβ ) plaques, which facilitate the spread of tau pathology, and a gradually spreading pattern of neuron…
View article: Scalable quality control on processing of large diffusion-weighted and structural magnetic resonance imaging datasets
Scalable quality control on processing of large diffusion-weighted and structural magnetic resonance imaging datasets Open
Thorough quality control (QC) can be time consuming when working with large-scale medical imaging datasets, yet necessary, as poor-quality data can lead to erroneous conclusions or poorly trained machine learning models. Most efforts to re…
View article: Preliminary Investigation of Obstructive Sleep Apnea and Alzheimer’s Disease in Down Syndrome
Preliminary Investigation of Obstructive Sleep Apnea and Alzheimer’s Disease in Down Syndrome Open
This study provided a preliminary examination of indices of obstructive sleep apnea (OSA) and sleep disruptions in adults with Down syndrome (DS), and their associations with Alzheimer’s disease (AD) pathology and symptomatology. Ninety-th…
View article: Revisiting Centiloids using AI
Revisiting Centiloids using AI Open
The Centiloid scale is the standard for Amyloid (Aβ) PET quantification, widely used in research, clinical settings, and trial stratification. However, variability between tracers and scanners remains a challenge. This study introduces Dee…
View article: Low premorbid IQ may exacerbate the cognitive effects of apolipoprotein ε4 (APOE ε4): a multi-ethnic cross-sectional study from HABS-HD
Low premorbid IQ may exacerbate the cognitive effects of apolipoprotein ε4 (APOE ε4): a multi-ethnic cross-sectional study from HABS-HD Open
Introduction Apolipoprotein allele 4 (APOE ε4) is associated with lower IQ scores during childhood and adolescence, but the influence of APOE ε4 and low IQ on late-life cognition is unknown. This study examines the association between APOE…
View article: Health and Aging Brain Study–Health Disparities (HABS‐HD) methods and partner characteristics
Health and Aging Brain Study–Health Disparities (HABS‐HD) methods and partner characteristics Open
INTRODUCTION The Health and Aging Brain Study–Health Disparities (HABS‐HD) is an ongoing prospective study aimed at understanding brain health and aging. The current work provides a description of the cohort baseline characteristics and ou…
View article: Amyloid PET and clinical management in a diverse, cognitively impaired population: The New IDEAS Study
Amyloid PET and clinical management in a diverse, cognitively impaired population: The New IDEAS Study Open
INTRODUCTION The New Imaging Dementia–Evidence for Amyloid Scanning (IDEAS) study (NCT04426539) evaluated the association between amyloid positron emission tomography (PET) and changes in clinical management among ethnoracially diverse, cl…
View article: Brain-derived extracellular vesicle microRNAs in Lewy body and Alzheimer’s disease
Brain-derived extracellular vesicle microRNAs in Lewy body and Alzheimer’s disease Open
INTRODUCTION Robust plasma-based biomarkers to distinguish Lewy body disease (LBD) and Alzheimer’s disease (AD) are currently lacking. We applied track-etch magnetic nanopore (TENPO) sorting for enrichment of brain-derived extracellular ve…
View article: The Alzheimer's Biomarker Consortium–Down Syndrome (ABC‐DS): A 10‐year report
The Alzheimer's Biomarker Consortium–Down Syndrome (ABC‐DS): A 10‐year report Open
INTRODUCTION Virtually all adults with Down syndrome (DS) will accumulate the neuropathologies associated with Alzheimer's disease (AD) by age 40, with the majority having a clinical dementia diagnosis by their middle 50s. METHODS This pap…
View article: Enhancing participation of historically minoritized groups in Alzheimer disease and related dementias research: National Conference Report
Enhancing participation of historically minoritized groups in Alzheimer disease and related dementias research: National Conference Report Open
This paper reports on a Conference organized by the Washington University School of Medicine's (WUSM) Knight Alzheimer Disease Research Center (Knight ADRC), entitled “Enhancing Participation by Minoritized Groups in Alzheimer Disease and …
View article: Alzheimer's disease genetic risk: Top African American risk allele frequencies and genetic architecture among Mexican‐, African‐, and non‐Hispanic White Americans
Alzheimer's disease genetic risk: Top African American risk allele frequencies and genetic architecture among Mexican‐, African‐, and non‐Hispanic White Americans Open
INTRODUCTION Alzheimer's disease (AD) continues to be the sixth leading cause of death in the United States. Significant efforts are spent researching etiology and potential management strategies. Although minorities face a higher disease …
View article: Psychosocial behavioral phenotypes of racially/ethnically minoritized older adults enrolled in HABS‐HD differ on neuroimaging measures of brain age gap, hippocampal volume, and cortical thickness
Psychosocial behavioral phenotypes of racially/ethnically minoritized older adults enrolled in HABS‐HD differ on neuroimaging measures of brain age gap, hippocampal volume, and cortical thickness Open
INTRODUCTION This study examined whether previously identified psychosocial behavioral phenotypes differed on structural neuroimaging markers. METHODS Latent profile analysis (LPA) employed in a sample of 1820 community‐dwelling older adul…
View article: <i>APOE</i> and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos
<i>APOE</i> and Alzheimer's disease and related dementias risk among 12,221 Hispanics/Latinos Open
BACKGROUND Effect of apolipoprotein E ( APOE ) on Alzheimer's disease and related dementias (ADRD) risk is heterogeneous across populations, with scarce data on Hispanics/Latinos. METHODS APOE genotype was studied in 12,221 Hispanics/Latin…
View article: Diabetes and cortical thickness in ethnically diverse cognitively normal older adults
Diabetes and cortical thickness in ethnically diverse cognitively normal older adults Open
INTRODUCTION Mechanisms linking type 2 diabetes mellitus (T2DM) with dementia are poorly understood. We examined T2DM associations with cortical thickness and hippocampal volume in ethnoracially diverse, cognitively unimpaired older adults…
View article: Association of Alzheimer’s disease biomarkers with low premorbid intellectual functioning in a multi-ethnic community-dwelling cohort: A cross-sectional study of HABS-HD
Association of Alzheimer’s disease biomarkers with low premorbid intellectual functioning in a multi-ethnic community-dwelling cohort: A cross-sectional study of HABS-HD Open
Background: Individuals with intellectual disability (ID) may have a five-fold increased risk for developing Alzheimer's disease (AD). However, studies investigating brain aging among individuals with ID without Down syndrome (DS) are lack…
View article: Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer’s disease and related neurodegenerative pathologies using 7T postmortem MRI
Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer’s disease and related neurodegenerative pathologies using 7T postmortem MRI Open
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC), is common in elderly brains and often seen in conjunction with Alzheimer’s disease neuropathologic change (ADNC). LATE-NC typically begins in the amygda…
View article: Chronic stress, social support, and Alzheimer's blood‐based biomarkers in the HABS‐HD study
Chronic stress, social support, and Alzheimer's blood‐based biomarkers in the HABS‐HD study Open
INTRODUCTION High levels of chronic stress and low social support have been associated with worse cognition among older adults, but the underlying mechanisms remain unclear. METHODS We included 2117 older adults (mean age 65.5 years) enrol…
View article: Rethinking the residual approach: leveraging statistical learning to operationalize cognitive resilience in Alzheimer’s disease
Rethinking the residual approach: leveraging statistical learning to operationalize cognitive resilience in Alzheimer’s disease Open
Cognitive resilience (CR) describes the phenomenon of individuals evading cognitive decline despite prominent Alzheimer's disease neuropathology. Operationalization and measurement of this latent construct is non-trivial as it cannot be di…
View article: Cross‐Sectional Comparison of Structural <scp>MRI</scp> Markers of Impairment in a Diverse Cohort of Older Adults
Cross‐Sectional Comparison of Structural <span>MRI</span> Markers of Impairment in a Diverse Cohort of Older Adults Open
Neurodegeneration is presumed to be the pathological process measure most proximal to clinical symptom onset in Alzheimer Disease (AD). Structural MRI is routinely collected in research and clinical trial settings. Several quantitative MRI…
View article: Preliminary investigation of obstructive sleep apnea and Alzheimer’s disease in down syndrome
Preliminary investigation of obstructive sleep apnea and Alzheimer’s disease in down syndrome Open
This study provided a preliminary examination of indices of obstructive sleep apsnea (OSA) and sleep disruptions in adults with Down syndrome (DS), and their associations with Alzheimer’s disease (AD) pathology and symptomatology. A total …
View article: Establishing tau-PET cut-points for cognitive diagnosis with 18F-PI-2620 in a multi-ethnoracial cohort
Establishing tau-PET cut-points for cognitive diagnosis with 18F-PI-2620 in a multi-ethnoracial cohort Open
18F-PI-2620 is a newer tau-PET tracer with minimal off-target binding in the choroid plexus. Defining tau cut-points to differentiate between cognitively unimpaired and impaired individuals is crucial for both biomarker validation and clin…
View article: A comparison of multiple amyloid PET radiotracers for Down syndrome clinical trials
A comparison of multiple amyloid PET radiotracers for Down syndrome clinical trials Open
Adults with Down syndrome carry high risk of developing Alzheimer’s disease and efforts to include this population in clinical trials remain limited. A barrier to recruitment for anti-amyloid trials includes the availability of the same am…
View article: Alzheimer's disease plasma biomarkers and physical functioning in a diverse sample of adults
Alzheimer's disease plasma biomarkers and physical functioning in a diverse sample of adults Open
INTRODUCTION The relationship between Alzheimer's disease (AD) plasma biomarkers, and physical functioning (PF) across diverse races and ethnicities remains unclear. This study aims to explore this association in an ethno‐racially diverse …