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View article: Targeting brain networks: a review of multi-site TMS techniques and applications
Targeting brain networks: a review of multi-site TMS techniques and applications Open
Transcranial magnetic stimulation (TMS) has evolved from a focal brain stimulation method to a network-level neuromodulation tool. This review examines the emerging field of multi-site TMS—approaches that target two or more brain regions t…
View article: Pulmonary alveolar proteinosis complicated by pulmonary and intracranial cryptococcal infection: A case report
Pulmonary alveolar proteinosis complicated by pulmonary and intracranial cryptococcal infection: A case report Open
Rationale: Pulmonary alveolar proteinosis (PAP) is a rare interstitial lung disease. Superimposed opportunistic Cryptococcus gattii infection can significantly complicate clinical management. Patient concerns: A 34-year-old male patient pr…
View article: Personalized whole-brain Ising models with heterogeneous nodes capture differences among brain regions
Personalized whole-brain Ising models with heterogeneous nodes capture differences among brain regions Open
Multiple lines of research have studied how complex brain dynamics emerge from underlying connectivity by using Ising models as simplified neural mass models. However, limitations on parameter estimation have prevented their use with indiv…
View article: Experience of implementing metagenomic next-generation sequencing in patients with suspected pulmonary infection in clinical practice
Experience of implementing metagenomic next-generation sequencing in patients with suspected pulmonary infection in clinical practice Open
Pulmonary infections remain a leading cause of infectious disease-related hospitalizations. Metagenomic next-generation sequencing (mNGS) has emerged as a promising diagnostic tool for identifying pathogens responsible for pulmonary infect…
View article: Risk of All-Cause Mortality in US Adults With Preserved Ratio Impaired Spirometry: An Observational Study
Risk of All-Cause Mortality in US Adults With Preserved Ratio Impaired Spirometry: An Observational Study Open
Our finding revealed that PRISm was significantly associated with increased risk of all-cause mortality in the general population compared with normal spirometry. Further research is needed to explore the intervention effect of PRISm.
View article: Interfacial phase regulation of flexible single-ion conducting block copolymer electrolytes ensuring ultra-stable lithium metal batteries
Interfacial phase regulation of flexible single-ion conducting block copolymer electrolytes ensuring ultra-stable lithium metal batteries Open
An SIPE with synergistically optimized mechanical properties and ionic conductivity is designed in this work and the transport mechanism of Li + is revealed by MD simulations. The formation of a stable SEI layer promotes uniform Li + depos…
View article: Achieving precipitation strengthening and retained austenite thinning via strain induced precipitation to improve fatigue wear resistance of bainitic steel
Achieving precipitation strengthening and retained austenite thinning via strain induced precipitation to improve fatigue wear resistance of bainitic steel Open
Precipitate phases provide precipitation strengthening effects but worsen fatigue properties. A Solid Solution-Forging-Austempering (SFA) process was presented aimed at breaking the trade-off between fatigue performance and hardness of Ti-…
View article: Circular RNA circ-CARD8 regulates alveolar macrophage pyroptosis through the miR-580-3p/CARD8 pathway in acute lung injury
Circular RNA circ-CARD8 regulates alveolar macrophage pyroptosis through the miR-580-3p/CARD8 pathway in acute lung injury Open
Pyroptosis is linked to the development of acute lung injury (ALI), and circular RNAs (circRNAs) play a role in ALI-related inflammation. However, the mechanisms by which circRNAs contribute to macrophage pyroptosis in ALI remain unclear. …
View article: Wear behavior dominated by strain partitioning between retained austenite and α-Fe in bainitic steel
Wear behavior dominated by strain partitioning between retained austenite and α-Fe in bainitic steel Open
The strains in α-Fe (bainite) and retained austenite (RA) exhibit an apparent discrepancy during deformation, namely strain partitioning, which can determine the tensile behavior of bainitic steels. Due to the involvement of plastic deform…
View article: Experience of implementing metagenomic next-generation sequencing in patients with suspected pulmonary infection in clinical practice
Experience of implementing metagenomic next-generation sequencing in patients with suspected pulmonary infection in clinical practice Open
Background Pulmonary infection remains one of the leading infectious diseases of hospitalization. Metagenomic next-generation sequencing (mNGS) has been proven to be a promising diagnostic technology in etiological identification for pulmo…
View article: Exploring the Application of Metagenomic Next-Generation Sequencing in the Diagnosis of Unexplained Pulmonary Infection
Exploring the Application of Metagenomic Next-Generation Sequencing in the Diagnosis of Unexplained Pulmonary Infection Open
Sida Chen, Ling Wen, Jintao Ou, Yuting Lai, Yan Shen Department of Respiratory, Shenzhen Longgang Central Hospital, Shenzhen, Guangdong, 518000, Peopleâs Republic of ChinaCorrespondence: Yan Shen, Shenzhen Longgang Central Hospital 6082 …
View article: M2b macrophages protect against doxorubicin induced cardiotoxicity via alternating autophagy in cardiomyocytes
M2b macrophages protect against doxorubicin induced cardiotoxicity via alternating autophagy in cardiomyocytes Open
Objective Doxorubicin (DOX) is an anthracycline antibiotic which is widely used for the treatment of various cancers, while the dose-related cardiotoxicity limits its potential therapeutic application. The underlying mechanism of DOX induc…
View article: Performance of Liquid Biopsy for Diagnosis and Surveillance of Human Papillomavirus–Associated Oropharyngeal Cancer
Performance of Liquid Biopsy for Diagnosis and Surveillance of Human Papillomavirus–Associated Oropharyngeal Cancer Open
Importance There is growing interest in the use of circulating plasma tumor human papillomavirus (HPV) DNA for diagnosis and surveillance of patients with HPV-associated oropharyngeal squamous cell carcinoma (OPSCC). Recent advances in the…
View article: Investigation of retained austenite morphology-dominated hardening and fatigue behavior in bainitic steel during wear process
Investigation of retained austenite morphology-dominated hardening and fatigue behavior in bainitic steel during wear process Open
This study aims to revealing the relationship between retained austenite (RA) morphology, deformation-induced transformation (DIPT) behavior and surface wear behavior. The hardening and fatigue behavior during wear of continuous film-like …
View article: High-throughput metagenomics analysis in early and precise diagnosis of eosinophilic meningoencephalitis complicated with respiratory failure: A case report
High-throughput metagenomics analysis in early and precise diagnosis of eosinophilic meningoencephalitis complicated with respiratory failure: A case report Open
Rationale: Human infection with Angiostrongylus cantonensis is uncommon and has only been sporadically reported in the literature. Patients infected with A cantonensis usually have a delayed diagnosis and sometimes a poor prognosis. Patien…
View article: Supplementary Methods and Figure Legends from Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms
Supplementary Methods and Figure Legends from Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms Open
Supplementary Methods and Figure Legends
View article: Supplementary Methods and Figure Legends from Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms
Supplementary Methods and Figure Legends from Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms Open
Supplementary Methods and Figure Legends
View article: Supplementary Figures 1-9 from Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms
Supplementary Figures 1-9 from Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms Open
Supplementary Figures 1-9. Figure S1: Auto-phosphorylation of EGFR-A289V and EGFR-G598V can be inhibited by EGFR TKIs. Figure S2: EGFR* expression is strongly induced in hGFAP-tTA tetO-EGFR* off-Dox mouse brains. Figure S3: Gfap and Nestin…
View article: Supplementary Figures 1-9 from Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms
Supplementary Figures 1-9 from Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms Open
Supplementary Figures 1-9. Figure S1: Auto-phosphorylation of EGFR-A289V and EGFR-G598V can be inhibited by EGFR TKIs. Figure S2: EGFR* expression is strongly induced in hGFAP-tTA tetO-EGFR* off-Dox mouse brains. Figure S3: Gfap and Nestin…
View article: Prediction and control of focal seizure spread: Random walk with restart on heterogeneous brain networks
Prediction and control of focal seizure spread: Random walk with restart on heterogeneous brain networks Open
Whole-brain models offer a promising method of predicting seizure spread, which is critical for successful surgical treatment of focal epilepsy. Existing methods are largely based on structural connectome, which ignores the effects of hete…
View article: Erratum: lncRNA FTX promotes asthma progression by sponging miR-590-5p and upregulating JAK2.
Erratum: lncRNA FTX promotes asthma progression by sponging miR-590-5p and upregulating JAK2. Open
[This corrects the article on p. 8833 in vol. 13, PMID: 34539998.].
View article: Research on Big Data Computing Model based on Spark and Big Data Application
Research on Big Data Computing Model based on Spark and Big Data Application Open
Under the background of the information age, with the rapid development of cloud computing and Internet of things technology, all kinds of data information grow rapidly. How to transform massive data information into effective resources is…
View article: Association of Post-operative Systolic Blood Pressure Variability With Mortality After Coronary Artery Bypass Grafting
Association of Post-operative Systolic Blood Pressure Variability With Mortality After Coronary Artery Bypass Grafting Open
Background: Blood pressure variability (BPV) has long been considered a risk factor for cardiovascular events. We aimed to investigate whether post-operative systolic BPV was associated with early and late all-cause mortality in patients u…
View article: lncRNA FTX promotes asthma progression by sponging miR-590-5p and upregulating JAK2.
lncRNA FTX promotes asthma progression by sponging miR-590-5p and upregulating JAK2. Open
The increased proliferation and migration of airway smooth muscle cells (ASMCs) are essential factors in the development of asthma. Long noncoding RNAs (lncRNAs) play key roles in the pathogenesis of various diseases, including asthma. A g…
View article: Correlation between level of autophagy and frequency of CD8<sup>+</sup> T cells in patients with chronic obstructive pulmonary disease
Correlation between level of autophagy and frequency of CD8<sup>+</sup> T cells in patients with chronic obstructive pulmonary disease Open
Objective The pathogenesis of chronic obstructive pulmonary disease (COPD) remains elusive. Here, we assessed the correlation between CD8 + T cell frequencies and autophagy in COPD patients. Methods Subjects were divided into three groups …