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View article: Revolutionizing Early Chronic Kidney Disease Detection: The Potential of Kidney Functional Reserve and Biomarker Integration
Revolutionizing Early Chronic Kidney Disease Detection: The Potential of Kidney Functional Reserve and Biomarker Integration Open
This paper focuses on the importance of early diagnosis of chronic kidney disease (CKD) before the development of prob lems that are used to diagnose the disease currently, especially in high-risk patients with diabetes mellitus, obesity, …
View article: A Rare Agent in Blood: Rothia kristinae
A Rare Agent in Blood: Rothia kristinae Open
Rothia kristinae, a Gram-positive coccus often regarded as a harmless commensal, is emerging as a potential pathogen, especially in immunocompromised patients. We hereby present a case involving R. kristinae bacteremia in a 66-year-old fem…
View article: Effects of plant-based diet on metabolic parameters, liver and kidney steatosis: a prospective interventional open-label study
Effects of plant-based diet on metabolic parameters, liver and kidney steatosis: a prospective interventional open-label study Open
This interventional single-centre prospective open-label study aims to evaluate the effects of a vegan diet, compared with a vegetarian and omnivorous diet, on metabolic parameters, insulin sensitivity, and liver and kidney steatosis in he…
View article: Community-Acquired Human Bocavirus Infection in an Immunocompetent Adult
Community-Acquired Human Bocavirus Infection in an Immunocompetent Adult Open
Human bocavirus 1 (HBoV1) is a recognized pathogen in respiratory infections among children; however, its prevalence and clinical implications in immunocompetent adults are unclear. We present a case of HBoV1 infection in a 61-year-old imm…
View article: Acute kidney injury following CAR-T cell therapy: a nephrologist’s perspective
Acute kidney injury following CAR-T cell therapy: a nephrologist’s perspective Open
Chimeric antigen receptor T (CAR-T) cell therapy, an emerging personalized immunotherapy for various haematologic malignancies, autoimmune diseases and other conditions, involves the modification of patients’ T cells to express a chimeric …
View article: Effect of Bimagrumab on body composition: a systematic review and meta-analysis
Effect of Bimagrumab on body composition: a systematic review and meta-analysis Open
Background Sarcopenia, a condition marked by progressive muscle mass and function decline, presents significant challenges in aging populations and those with chronic illnesses. Current standard treatments such as dietary interventions and…
View article: The association between klotho and kidney and cardiovascular outcomes: a comprehensive systematic review and meta-analysis
The association between klotho and kidney and cardiovascular outcomes: a comprehensive systematic review and meta-analysis Open
Background Chronic kidney disease (CKD) and end-stage renal disease (ESKD) are significant global health challenges associated with progressive kidney dysfunction and numerous complications, including cardiovascular disease and mortality. …
View article: SGLT2 inhibitors and nephrolithiasis risk: a meta-analysis
SGLT2 inhibitors and nephrolithiasis risk: a meta-analysis Open
Background Sodium–glucose co-transporter 2 (SGLT2) inhibitors are novel anti-diabetic medications with potential beneficial effects on cardiovascular and renal outcomes, metabolic parameters and body weight. In addition to the beneficial e…
View article: Proximal tubule hypertrophy and hyperfunction: a novel pathophysiological feature in disease states
Proximal tubule hypertrophy and hyperfunction: a novel pathophysiological feature in disease states Open
The role of proximal tubules (PTs), a major component of the renal tubular structure in the renal cortex, has been examined extensively. Along with its physiological role in the reabsorption of various molecules, including electrolytes, am…
View article: An update review of post‐transplant diabetes mellitus: Concept, risk factors, clinical implications and management
An update review of post‐transplant diabetes mellitus: Concept, risk factors, clinical implications and management Open
Objective Kidney transplantation is the gold standard therapeutic alternative for patients with end‐stage renal disease; nevertheless, it is not without potential complications leading to considerable morbidity and mortality such as post‐t…
View article: Imlifidase in kidney transplantation
Imlifidase in kidney transplantation Open
Kidney transplantation, the gold-standard therapeutic approach for patients with end-stage kidney disease, offers improvement in patient survival and quality of life. However, broad sensitization against human leukocyte antigens often resu…
View article: Glomerular hyperfiltration as a therapeutic target for CKD
Glomerular hyperfiltration as a therapeutic target for CKD Open
The global burden of chronic kidney disease (CKD) is high and increasing. Early diagnosis and intervention are key to improve outcomes. Single-nephron glomerular hyperfiltration is an early pathophysiologic manifestation of CKD that may re…
View article: Management of <i>de novo</i> nephrolithiasis after kidney transplantation: a comprehensive review from the European Renal Association CKD-MBD working group
Management of <i>de novo</i> nephrolithiasis after kidney transplantation: a comprehensive review from the European Renal Association CKD-MBD working group Open
The lifetime incidence of kidney stones is 6%–12% in the general population. Nephrolithiasis is a known cause of acute and chronic kidney injury, mediated via obstructive uropathy or crystal-induced nephropathy, and several modifiable and …
View article: A Survey-Based Study on Attitudes of The Clinicians Toward Contrast-Induced Nephropathy: Which Drugs to Discontinue?
A Survey-Based Study on Attitudes of The Clinicians Toward Contrast-Induced Nephropathy: Which Drugs to Discontinue? Open
Objective: Contrast-induced nephropathy (CIN) is the third leading cause of iatrogenic acute kidney injury, affecting approximately 10% of patients. Multiple risk factors, including preexisting kidney disease, diabetes mellitus, and hypert…
View article: Supplementary Material for: Angiopoietin as A Novel Prognostic Marker in Kidney Disease
Supplementary Material for: Angiopoietin as A Novel Prognostic Marker in Kidney Disease Open
Renal injury is among the leading causes of morbidity and mortality, however, there are no reliable indicators for determining the likelihood of developing CKD, CKD progression or AKI events. Vascular growth factors called angiopoietins ha…
View article: Supplementary Material for: Angiopoietin as A Novel Prognostic Marker in Kidney Disease
Supplementary Material for: Angiopoietin as A Novel Prognostic Marker in Kidney Disease Open
Renal injury is among the leading causes of morbidity and mortality, however, there are no reliable indicators for determining the likelihood of developing CKD, CKD progression or AKI events. Vascular growth factors called angiopoietins ha…
View article: Supplementary Material for: Angiopoietin as A Novel Prognostic Marker in Kidney Disease
Supplementary Material for: Angiopoietin as A Novel Prognostic Marker in Kidney Disease Open
Renal injury is among the leading causes of morbidity and mortality, however, there are no reliable indicators for determining the likelihood of developing CKD, CKD progression or AKI events. Vascular growth factors called angiopoietins ha…
View article: Supplementary Material for: Angiopoietin as A Novel Prognostic Marker in Kidney Disease
Supplementary Material for: Angiopoietin as A Novel Prognostic Marker in Kidney Disease Open
Renal injury is among the leading causes of morbidity and mortality, however, there are no reliable indicators for determining the likelihood of developing CKD, CKD progression or AKI events. Vascular growth factors called angiopoietins ha…
View article: Predicting Chronic Kidney Disease Progression from Cardiac Fibrosis: An Interplay Between Two Major Organ Systems
Predicting Chronic Kidney Disease Progression from Cardiac Fibrosis: An Interplay Between Two Major Organ Systems Open
Objective: Cardiovascular disease and chronic kidney disease are two major medical conditions leading to significant morbidity, mortality, and medical spending globally; nevertheless, the exact underlying pathophysiological background link…
View article: Novel Biomarkers of Kidney Injury: Possibility Toward Preventive Strategies
Novel Biomarkers of Kidney Injury: Possibility Toward Preventive Strategies Open
Acute kidney injury is a common comorbidity especially observed in hospitalized patients with high morbidity and mortal- ity. However, biomarkers assessing the degree or etiology of acute kidney injury and predictive markers to detect the …
View article: Intrauterine life to adulthood: a potential risk factor for chronic kidney disease
Intrauterine life to adulthood: a potential risk factor for chronic kidney disease Open
Multiple risk factors for chronic kidney disease (CKD), one of the major causes of morbidity and mortality in the adult population globally, have been identified, including older age, male gender, family history, smoking, diabetes mellitus…
View article: Social isolation and loneliness: Undervalued risk factors for disease states and mortality
Social isolation and loneliness: Undervalued risk factors for disease states and mortality Open
Social isolation and loneliness are two common but undervalued conditions associated with a poor quality of life, decreased overall health and mortality. In this review, we aim to discuss the health consequences of social isolation and lon…
View article: The Mitochondrion: A Promising Target for Kidney Disease
The Mitochondrion: A Promising Target for Kidney Disease Open
Mitochondrial dysfunction is important in the pathogenesis of various kidney diseases and the mitochondria potentially serve as therapeutic targets necessitating further investigation. Alterations in mitochondrial biogenesis, imbalance bet…
View article: Intravenous fluid therapy in accordance with kidney injury risk: when to prescribe what volume of which solution
Intravenous fluid therapy in accordance with kidney injury risk: when to prescribe what volume of which solution Open
Acute kidney injury (AKI) is common in hospitalized patients while common risk factors for the development of AKI include postoperative settings, patients with baseline chronic kidney disease (CKD) or congestive heart failure. Intravenous …
View article: Donor obesity and weight gain after transplantation: two still overlooked threats to long-term graft survival
Donor obesity and weight gain after transplantation: two still overlooked threats to long-term graft survival Open
The effect of donor obesity on kidney transplantation success has long been an overlooked clinical research area. Even though there is no strict guideline in most countries prohibiting donation from obese individuals, most candidates with …
View article: Novel strategies in nephrology: what to expect from the future?
Novel strategies in nephrology: what to expect from the future? Open
Chronic kidney disease (CKD) will become the fifth global case of death by 2040. Its largest impact is on premature mortality but the number of persons with kidney failure requiring renal replacement therapy (RRT) is also increasing dramat…
View article: The association between acute kidney injury and outcomes in cancer patients receiving immune checkpoint inhibitor therapy: a systematic review and meta-analysis
The association between acute kidney injury and outcomes in cancer patients receiving immune checkpoint inhibitor therapy: a systematic review and meta-analysis Open
Background Immune checkpoint inhibitors (ICPIs) are a novel therapeutic approach to cancer treatment that have changed the landscape of cancer therapy but also have some considerable drawbacks. Acute kidney injury (AKI) is one of these pot…
View article: SGLT-2 inhibitors in nephrotic-range proteinuria: emerging clinical evidence
SGLT-2 inhibitors in nephrotic-range proteinuria: emerging clinical evidence Open
Sodium-glucose cotransporter-2 (SGLT-2) inhibitors are a class of novel oral anti-hyperglycemic agents which are increasingly used in clinical practice. SGLT-2 inhibitors improve glycemic control and cardiorenal outcomes, promote weight lo…