Siddharth Singh
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View article: Lower Cranial Nerve Palsy Following Occipital Condylar Fracture
Lower Cranial Nerve Palsy Following Occipital Condylar Fracture Open
Lower cranial nerve palsy is a rare condition, and various causes attributed are malignant skull base lesions, internal carotid dissection, and rarely caused by trauma. We report a case of a road traffic accident presenting as lower crania…
View article: KAT5-mediated acetylation of PC4 facilitates DNA repair by promoting chromatin reorganization
KAT5-mediated acetylation of PC4 facilitates DNA repair by promoting chromatin reorganization Open
Human positive coactivator 4 (PC4) is a highly abundant non-histone chromatin protein involved in diverse cellular processes, including transcription regulation, genome organization, autophagy, B-cell differentiation, neurogenesis, DNA rep…
View article: Diagnostic Accuracy of Noninvasive Biomarkers and Imaging for Evaluating Postoperative Recurrence in Crohn’s Disease
Diagnostic Accuracy of Noninvasive Biomarkers and Imaging for Evaluating Postoperative Recurrence in Crohn’s Disease Open
The high sensitivity of fecal calprotectin (<50 μg/g) and cross-sectional imaging can help reduce the need for invasive and costly colonoscopy monitoring for CD recurrence after surgery. Applying optimal definitions of sonographic recurren…
View article: An International Consensus on Appropriate Management of Corticosteroids in Clinical Trials in Inflammatory Bowel Disease
An International Consensus on Appropriate Management of Corticosteroids in Clinical Trials in Inflammatory Bowel Disease Open
These recommendations will serve to optimize trial design and facilitate appropriate, acceptable, and standardized RCT corticosteroid handling practices.
View article: Treat-to-target of endoscopic remission in patients with inflammatory bowel disease in symptomatic remission on advanced therapies (QUOTIENT): rationale, design and protocol for an open-label, multicentre, pragmatic, randomised controlled trial
Treat-to-target of endoscopic remission in patients with inflammatory bowel disease in symptomatic remission on advanced therapies (QUOTIENT): rationale, design and protocol for an open-label, multicentre, pragmatic, randomised controlled trial Open
Introduction Targeted immunomodulators (eg, advanced therapies) effectively achieve symptomatic remission in patients with inflammatory bowel disease (IBD). However, ~25%–50% of patients with IBD achieving symptomatic remission with an adv…
View article: Corrigendum to “Differential efficacy of medical therapies for ulcerative colitis according to disease extent: patient-level analysis from multiple randomized controlled trials” volume 72, 102621
Corrigendum to “Differential efficacy of medical therapies for ulcerative colitis according to disease extent: patient-level analysis from multiple randomized controlled trials” volume 72, 102621 Open
[This corrects the article DOI: 10.1016/j.eclinm.2024.102621.].
View article: Interventions for Adjunctive Care in Patients With Inflammatory Bowel Disease and Permanent Ileostomy: A Systematic Review
Interventions for Adjunctive Care in Patients With Inflammatory Bowel Disease and Permanent Ileostomy: A Systematic Review Open
Background The evidence for the management of patients with Crohn’s disease (CD) and permanent ileostomy (PI) is limited. We aimed to summarize the interventional studies related to the provision of adjunctive ostomy care in this populatio…
View article: Predictive Model for Outcomes in Inflammatory Bowel Disease Patients Receiving Maintenance Infliximab Therapy
Predictive Model for Outcomes in Inflammatory Bowel Disease Patients Receiving Maintenance Infliximab Therapy Open
Background No models predict future outcomes in inflammatory bowel disease (IBD) patients receiving maintenance infliximab therapy. We created a predictive model for unfavorable outcomes. Methods Adult patients with IBD receiving maintenan…
View article: Oral Myiasis in Anterior Palate - A Rare Case Report & Review of Literature
Oral Myiasis in Anterior Palate - A Rare Case Report & Review of Literature Open
Oral myiasis was coined by Reverend F. William Hope in 1840. It is a rare pathology and risk to the patients in humans suffering from myiasis. It has a higher incidence in rural areas and in developing countries having hot climatic conditi…
View article: Chiral Electrokinetic Phenomena in Single Nanopores
Chiral Electrokinetic Phenomena in Single Nanopores Open
The arrangement of solvent molecules and ions at solid–liquid interfaces determines electrochemical properties that are important in separations platforms, sensing technologies, and energy‐storage systems. Here we show that single glass an…
View article: Red Flag Signs and Symptoms for Patients With Early-Onset Colorectal Cancer
Red Flag Signs and Symptoms for Patients With Early-Onset Colorectal Cancer Open
Importance Early-onset colorectal cancer (EOCRC), defined as a diagnosis at younger than age 50 years, is increasing, and so-called red flag signs and symptoms among these individuals are often missed, leading to diagnostic delays. Improve…
View article: Differential efficacy of medical therapies for ulcerative colitis according to disease extent: patient-level analysis from multiple randomized controlled trials
Differential efficacy of medical therapies for ulcerative colitis according to disease extent: patient-level analysis from multiple randomized controlled trials Open
This study did not receive any financial support.
View article: Challenges in IBD Research 2024: Pragmatic Clinical Research
Challenges in IBD Research 2024: Pragmatic Clinical Research Open
Pragmatic clinical research is 1 of the 5 focus areas of the Challenges in IBD Research 2024, a multidisciplinary effort by scientists, clinicians, patients, and funders to identify priorities for patient-centric research. This summary pro…
View article: Disrupting the interaction between a p53 gain‐of‐function mutant and the transcriptional co‐activator <scp>PC</scp>4 reverses drug resistance in cancer cells
Disrupting the interaction between a p53 gain‐of‐function mutant and the transcriptional co‐activator <span>PC</span>4 reverses drug resistance in cancer cells Open
PC4 is a chromatin‐associated protein and transcriptional coactivator whose role in gene regulation by wild‐type p53 is now well known. Little is known about the roles of PC4 in tumor cells bearing mutant p53 genes. We show that PC4 associ…
View article: Does Combined Medical and Surgical Treatment Improve Perianal Fistula Outcomes in Patients With Crohn’s Disease? A Systematic Review and Meta-Analysis
Does Combined Medical and Surgical Treatment Improve Perianal Fistula Outcomes in Patients With Crohn’s Disease? A Systematic Review and Meta-Analysis Open
Background The optimal treatment of perianal fistulizing Crohn’s disease [PFCD] is unknown. We performed a systematic review with meta-analysis to compare combined surgical intervention and anti-tumour necrosis factor [anti-TNF] therapy [c…
View article: PATTERNS AND ASSOCIATED FACTORS OF OBJECTIVE INFLAMMATION ASSESSMENT TO TREAT-TO-TARGET: DATA FROM THE IBD QORUS COLLABORATIVE
PATTERNS AND ASSOCIATED FACTORS OF OBJECTIVE INFLAMMATION ASSESSMENT TO TREAT-TO-TARGET: DATA FROM THE IBD QORUS COLLABORATIVE Open
BACKGROUND A Treat-to-Target (T2T) strategy for inflammatory bowel disease (IBD) improves clinical outcomes. The cornerstone of T2T is the routine assessment of objective markers of inflammation to determine treatment efficacy. Despite thi…
View article: EXPLORING THE RELATIONSHIP BETWEEN PATIENT SYMPTOMS AND PROVIDER GOALS FOR MUCOSAL HEALING IN IBD: INSIGHTS FROM THE IBD QORUS SURVEY DATA
EXPLORING THE RELATIONSHIP BETWEEN PATIENT SYMPTOMS AND PROVIDER GOALS FOR MUCOSAL HEALING IN IBD: INSIGHTS FROM THE IBD QORUS SURVEY DATA Open
INTRODUCTION Patients with inflammatory bowel disease (IBD) often experience symptoms such as abdominal pain, diarrhea, and bloody bowel movements. While these symptoms traditionally guided treatment, their predictive value for disease pro…