Siddhartha Jaiswal
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View article: Environmental Pollution Triggers Inflammation In Vivo and is Associated With Higher Risk <scp>MDS</scp> in an Urban Cohort
Environmental Pollution Triggers Inflammation In Vivo and is Associated With Higher Risk <span>MDS</span> in an Urban Cohort Open
View article: Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations
Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations Open
Clonal hematopoiesis (CH) is defined by the expansion of a lineage of genetically identical cells in blood. Genetic lesions that confer a fitness advantage, such as leukemogenic point mutations or mosaic chromosomal alterations (mCAs), are…
View article: Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations
Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations Open
Clonal hematopoiesis (CH) is defined by the expansion of a lineage of genetically identical cells in blood. Genetic lesions that confer a fitness advantage, such as leukemogenic point mutations or mosaic chromosomal alterations (mCAs), are…
View article: Clonal hematopoiesis of indeterminate potential and the risk of cognitive impairment in the Women's Health Initiative Memory Study
Clonal hematopoiesis of indeterminate potential and the risk of cognitive impairment in the Women's Health Initiative Memory Study Open
INTRODUCTION Clonal hematopoiesis of indeterminate potential (CHIP) confers an increased risk of several chronic aging‐related diseases. Paradoxically, CHIP was associated with lower risk of dementia in recent studies. METHODS We examined …
View article: In silico approach for kinetic profiling of Piper nigrum extract to understand its therapeutic potential.
In silico approach for kinetic profiling of Piper nigrum extract to understand its therapeutic potential. Open
View article: Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease
Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease Open
Background and Aims Clonal haematopoiesis of indeterminate potential (CHIP) has been associated with cardiovascular risk, but its prognostic relevance and mechanistic role in coronary artery disease (CAD) remains incompletely understood. T…
View article: EnrichMET: R Package for Integrated Pathway and Network Analysis for Metabolomics
EnrichMET: R Package for Integrated Pathway and Network Analysis for Metabolomics Open
Advances in metabolomics have significantly improved our understanding of cellular processes by enabling the identification of hundreds of metabolites in a single experiment. These developments provide valuable insights into complex metabo…
View article: Clonal Hematopoiesis and Cardiovascular Outcomes in Older Women
Clonal Hematopoiesis and Cardiovascular Outcomes in Older Women Open
In an older female cohort, key CHIP subtypes (TET2, ASXL1, and JAK2) were associated with incident CVD, with associations that appeared to differ by CVD outcome. These findings suggest that CHIP remains associated with cardiovascular healt…
View article: Clonal Hematopoiesis of Indeterminate Potential and the Risk of Cognitive Impairment in the Women’s Health Initiative Memory Study
Clonal Hematopoiesis of Indeterminate Potential and the Risk of Cognitive Impairment in the Women’s Health Initiative Memory Study Open
INTRODUCTION Clonal hematopoiesis of indeterminate potential (CHIP) confers an increased risk of several chronic aging-related diseases. Paradoxically, CHIP was associated with lower risk of dementia in recent studies. METHODS We examined …
View article: TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice Open
View article: TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice Open
Clonal hematopoiesis (CH) is associated with many age-related diseases, but its interaction with Alzheimer's disease (AD) remains unclear. Here, we show that TET2-mutant CH is associated with a 47% reduced risk of late-onset AD (LOAD) in t…
View article: Correlates and consequences of clonal hematopoiesis expansion rate: a 16-year longitudinal study of 6976 women
Correlates and consequences of clonal hematopoiesis expansion rate: a 16-year longitudinal study of 6976 women Open
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased mortality and malignancy risk, yet the determinants of clonal expansion remain poorly understood. We performed sequencing at a depth of coverage of >400…
View article: Clonal hematopoiesis: elements associated with clonal expansion and diseases
Clonal hematopoiesis: elements associated with clonal expansion and diseases Open
View article: Correlates and Consequences of Clonal Hematopoiesis Expansion Rate: A 15-Year Longitudinal Study of 6,986 Women
Correlates and Consequences of Clonal Hematopoiesis Expansion Rate: A 15-Year Longitudinal Study of 6,986 Women Open
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased mortality and malignancy risk, yet the determinants of clonal expansion remain poorly understood. We performed sequencing at >4,000x depth of coverage for …
View article: Increased local DNA methylation disorder in AMLs with DNMT3A-destabilizing variants and its clinical implication
Increased local DNA methylation disorder in AMLs with DNMT3A-destabilizing variants and its clinical implication Open
The mechanistic link between the complex mutational landscape of de novo methyltransferase DNMT3A and the pathology of acute myeloid leukemia (AML) has not been clearly elucidated so far. Motivated by a recent discovery of the significance…
View article: Radon Exposure, Clonal Hematopoiesis, and Stroke Susceptibility in the Women's Health Initiative.
Radon Exposure, Clonal Hematopoiesis, and Stroke Susceptibility in the Women's Health Initiative. Open
BACKGROUND AND OBJECTIVES: Studies suggest that clonal hematopoiesis of indeterminate potential (CHIP) may increase risk of hematologic malignancy and cardiovascular disease, including stroke. However, few studies have investigated plausib…
View article: Modeling Sociohistorical Epigenetics in Parasite Evolution
Modeling Sociohistorical Epigenetics in Parasite Evolution Open
View article: A blueprint for pursuing therapeutic interventions and early phase clinical trials in clonal haematopoiesis
A blueprint for pursuing therapeutic interventions and early phase clinical trials in clonal haematopoiesis Open
Summary The age‐associated mutational state of clonal haematopoiesis (CH) is linked to multiple adverse health outcomes. As higher risk CH can lead to progressive neoplastic or vascular disease, there is interest in developing clinical tri…
View article: Determinants of mosaic chromosomal alteration fitness
Determinants of mosaic chromosomal alteration fitness Open
View article: The Genetic Determinants and Genomic Consequences of Non-Leukemogenic Somatic Point Mutations
The Genetic Determinants and Genomic Consequences of Non-Leukemogenic Somatic Point Mutations Open
Clonal hematopoiesis (CH) is defined by the expansion of a lineage of genetically identical cells in blood. Genetic lesions that confer a fitness advantage, such as point mutations or mosaic chromosomal alterations (mCAs) in genes associat…
View article: Impact of Clonal Hematopoiesis on the Carcinogenic Process of Multiple Myeloma
Impact of Clonal Hematopoiesis on the Carcinogenic Process of Multiple Myeloma Open
Clonal hematopoiesis (CH), a phenomenon linked to aging, correlates with inflammation and myeloid malignancies. Here, we explore the interaction of CH, with terminally differentiated lymphoid malignancy, and multiple myeloma (MM). Analysis…
View article: Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate
Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate Open
View article: Determinants of mosaic chromosomal alteration fitness
Determinants of mosaic chromosomal alteration fitness Open
Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion. These driver mutations can be single nucleotide variants in cancer driver genes or larger …
View article: Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease
Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease Open
Age-related changes to the genome-wide DNA methylation (DNAm) pattern observed in blood are well-documented. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age-related acquisition and expansion of leukemogenic…
View article: Clonal hematopoiesis associated with epigenetic aging and clinical outcomes
Clonal hematopoiesis associated with epigenetic aging and clinical outcomes Open
Clonal hematopoiesis of indeterminate potential (CHIP) is a common precursor state for blood cancers that most frequently occurs due to mutations in the DNA-methylation modifying enzymes DNMT3A or TET2. We used DNA-methylation array and wh…
View article: Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics
Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics Open
Background: Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of mutant hematopoietic stem cells, confers risk for multiple diseases of aging including hematologic cancer and cardiovascular disease. Whole-ex…
View article: Clonal Hematopoiesis Is Associated with Higher Risk of Stroke
Clonal Hematopoiesis Is Associated with Higher Risk of Stroke Open
Background and Purpose: Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease-related morbidity and mortality. The association of CHIP with risk of incident ischemic stroke was…
View article: Radon Exposure, Clonal Hematopoiesis, and Stroke Susceptibility in the Women's Health Initiative
Radon Exposure, Clonal Hematopoiesis, and Stroke Susceptibility in the Women's Health Initiative Open
The robust elevation of radon-related risk of CHIP among postmenopausal women who develop incident cardioembolic stroke is consistent with a potential role of somatic genomic mutation in this societally burdensome form of cerebrovascular d…
View article: Individual and Neighborhood-level Socioeconomic Status and Somatic Mutations Associated With Increased Risk of Cardiovascular Disease and Mortality: A Cross-Sectional Analysis in the Women's Health Initiative
Individual and Neighborhood-level Socioeconomic Status and Somatic Mutations Associated With Increased Risk of Cardiovascular Disease and Mortality: A Cross-Sectional Analysis in the Women's Health Initiative Open
View article: CHIP is associated with cardiovascular disease in the UK Biobank
CHIP is associated with cardiovascular disease in the UK Biobank Open
Clonal hematopoiesis (CH) is a form of age-related somatic mosaicism. CH encompasses both clonal events with recognizable leukemic driver mutations, such as CH of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs), as…