Siddhartha Sharma
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View article: Non-pyroptotic caspase-11 activity regulates osteoclastogenesis and pathological bone loss
Non-pyroptotic caspase-11 activity regulates osteoclastogenesis and pathological bone loss Open
Osteoclasts are essential for bone remodeling; however, their hyperactivity leads to pathological bone loss. While inflammasome-activated caspases are known to influence osteoclastogenesis, the role of caspase-11, beyond its conventional f…
View article: Critical Care Medical Expenses And Affordability: An AI-Based Prediction Model
Critical Care Medical Expenses And Affordability: An AI-Based Prediction Model Open
Background: The advances in the medical field and pharmaceutical sciences year on year have enhanced the human life span in developed and developing countries. A major factor that has contributed is the advancements in medical technologies…
View article: Effect of Distal Fragment Length on Construct Stability in an Extra-articular Distal Tibial Fracture Model Fixed With Locked Intramedullary Nailing: A Biomechanical Study
Effect of Distal Fragment Length on Construct Stability in an Extra-articular Distal Tibial Fracture Model Fixed With Locked Intramedullary Nailing: A Biomechanical Study Open
Introduction Fractures of the distal tibia are complex injuries with high complication rates, which include delayed union, non-union, and wound complications like dehiscence and infection. The two commonly employed definite internal fixati…
View article: Postoperative Complications After Acute Achilles Tendon Rupture Repair: A Survival Analysis of Minimally Invasive vs Open Techniques
Postoperative Complications After Acute Achilles Tendon Rupture Repair: A Survival Analysis of Minimally Invasive vs Open Techniques Open
Background: The complication rates after surgical repair of acute Achilles tendon ruptures (ATRs) using open repair or minimally invasive surgical techniques (MIS) have been debated extensively. Despite significant research, a literature h…
View article: Non-pyroptotic caspase-11 activity regulates osteoclastogenesis and pathological bone loss
Non-pyroptotic caspase-11 activity regulates osteoclastogenesis and pathological bone loss Open
Osteoclasts are essential for bone remodeling; however, their hyperactivity leads to pathological bone loss. While inflammasome-activated caspases are known to influence osteoclastogenesis, the role of caspase-11, beyond its conventional f…
View article: Predicting Mortality in Polytrauma Patients with Open Fractures: A Review
Predicting Mortality in Polytrauma Patients with Open Fractures: A Review Open
View article: Prevalence of Thalassemic Arthropathy in Transfusion Dependent β-Thalassemia Patients: An Observational Study
Prevalence of Thalassemic Arthropathy in Transfusion Dependent β-Thalassemia Patients: An Observational Study Open
View article: Congruent Weber-B ankle fractures do not alter tibiotalar contact mechanics
Congruent Weber-B ankle fractures do not alter tibiotalar contact mechanics Open
View article: Research on Determining Bony Landmarks for Accurate Tibiofibular Syndesmotic Fixation: Cadaveric Validity and Safety Analysis of Angle Bisector Method
Research on Determining Bony Landmarks for Accurate Tibiofibular Syndesmotic Fixation: Cadaveric Validity and Safety Analysis of Angle Bisector Method Open
Category: Trauma; Ankle Introduction/Purpose: Syndesmosis fixation, a common procedure, is vital for restoring ankle biomechanics, but malreduction occurs in up to 52% of cases, necessitating precise anatomic reduction. While AO guidelines…
View article: Survey of encoding techniques for quantum machine learning
Survey of encoding techniques for quantum machine learning Open
Quantum computing is a field of computation that processes information in a fundamentally different way compared to classical computers. Quantum computing is a rapidly expanding research field with ongoing investigations regarding applicat…
View article: Ipsilateral fractures of the ulnar styloid with distal radius fractures; to fix or not? A systematic review and meta-analysis
Ipsilateral fractures of the ulnar styloid with distal radius fractures; to fix or not? A systematic review and meta-analysis Open
View article: Parameters That Can Be Used to Quantify Reduction Accuracy in Talar Neck Fractures and Malunions: A PRISMA-Compliant Scoping Review and Meta-Analysis
Parameters That Can Be Used to Quantify Reduction Accuracy in Talar Neck Fractures and Malunions: A PRISMA-Compliant Scoping Review and Meta-Analysis Open
View article: Evaluation of the Stability of Internal Fixation Constructs in a Low Distal Tibia Extra-articular Cadaveric Fracture Model: A Comparative Biomechanical Study
Evaluation of the Stability of Internal Fixation Constructs in a Low Distal Tibia Extra-articular Cadaveric Fracture Model: A Comparative Biomechanical Study Open
Introduction Despite the recent advances in implant design, the choice of an internal fixation modality for extra-articular distal tibia fractures remains controversial, and there is sparse literature comparing the stability of intramedull…
View article: Utility of three-dimensional printing in the surgical management of intra-articular distal humerus fractures: a systematic review and meta-analysis of randomized controlled trials
Utility of three-dimensional printing in the surgical management of intra-articular distal humerus fractures: a systematic review and meta-analysis of randomized controlled trials Open
Background: Clinical outcomes after fixation of distal humerus intraarticular fractures are directly related to the quality of reduction. The use of three-dimensional (3D)-printed fracture models can benefit preoperative planning to ensure…
View article: Unveiling Syndesmotic Malreduction: A Proof-of-Concept towards Portable Ultrasound Detection.
Unveiling Syndesmotic Malreduction: A Proof-of-Concept towards Portable Ultrasound Detection. Open
We introduced a novel sign, the "gap penetrance sign", best measured from the posterior ankle, which can accurately detect syndesmotic malreduction using P-US in a manner that does not require specific quantitative measurements and is read…
View article: Concurrent avulsion of posterior cruciate ligament and semimembranosus: a case-based discussion and literature review
Concurrent avulsion of posterior cruciate ligament and semimembranosus: a case-based discussion and literature review Open
A 30-year-old male sustained a road traffic accident and presented to our trauma centre with injuries to his pelvis and right knee. Radiology showed closed fractures of the right posterior wall and posterior column of the acetabulum and PC…
View article: Irreducible Complex Posterior Elbow Dislocation with Varus Posteromedial Rotary Instability – A Case Report
Irreducible Complex Posterior Elbow Dislocation with Varus Posteromedial Rotary Instability – A Case Report Open
Introduction: Elbow dislocations, particularly those associated with varus posteromedial rotary instability, are relatively uncommon. We present the case of a 25-year-old male initially managed nonoperatively for a posterior elbow dislocat…
View article: Inter- and Intra-observer Reliability of a New Classification System for Calcaneus Fracture Malunions: The ADEINS Classification
Inter- and Intra-observer Reliability of a New Classification System for Calcaneus Fracture Malunions: The ADEINS Classification Open
View article: Should all Small Shell Posterior Malleolar Fractures be Considered for Fixation? Results from a 3D Fracture Mapping Study
Should all Small Shell Posterior Malleolar Fractures be Considered for Fixation? Results from a 3D Fracture Mapping Study Open
Category: Ankle; Trauma Introduction/Purpose: Approximately 10-15% of posterior malleolar fractures (PMFs) are "small shell," extra-articular fragments. Current classification systems present difficulties to perform a uniform typification …
View article: Clinical Outcomes of Insertional Achilles Tendinopathy Patients Treated with Reattachment and Dorsal Closing Wedge Calcaneal Osteotomy: A Meta-analysis
Clinical Outcomes of Insertional Achilles Tendinopathy Patients Treated with Reattachment and Dorsal Closing Wedge Calcaneal Osteotomy: A Meta-analysis Open
Category: Hindfoot; Sports Introduction/Purpose: Posterior heel pain at the Achilles tendon insertion is a prevalent and debilitating condition that is not yet fully understood. It results from a combination of bony and soft tissue abnorma…
View article: Talar Neck Malunions: Evaluation of Kinematics, Pedobarographic Changes and Patient Reported Outcome Measures
Talar Neck Malunions: Evaluation of Kinematics, Pedobarographic Changes and Patient Reported Outcome Measures Open
Category: Trauma; Hindfoot Introduction/Purpose: Malunion is a disabling complication of talar neck fractures and is prevalent in approximately 17% of cases. The impact of talar neck malunions (TNM) on foot biomechanics and functional outc…
View article: Do Syndesmotic Injury Patterns Influence Functional and Radiological Outcomes in Complex Ankle Fractures? A Retrospective Cohort Study
Do Syndesmotic Injury Patterns Influence Functional and Radiological Outcomes in Complex Ankle Fractures? A Retrospective Cohort Study Open
Category: Ankle; Trauma Introduction/Purpose: Syndesmosis injury can be of a varying magnitude; little information exists about the influence of degree of initial syndesmotic injury/instability on functional outcomes in ankle fractures, no…
View article: Congruent Weber-B Ankle Fractures do not affect Tibiotalar Contact Mechanics: No Need for the Scalpel?
Congruent Weber-B Ankle Fractures do not affect Tibiotalar Contact Mechanics: No Need for the Scalpel? Open
Category: Trauma; Ankle Introduction/Purpose: Weber-B ankle fractures represent an increasingly common injury world-wide, and the decision for operative fixation often hinges on the stability and congruency of the ankle. While tibiotalar d…
View article: Three-Dimensional Mapping of Chaput Tubercle Fractures: Evaluation of Morphologic Characteristics and Anterior Inferior Tibiofibular Ligament Involvement
Three-Dimensional Mapping of Chaput Tubercle Fractures: Evaluation of Morphologic Characteristics and Anterior Inferior Tibiofibular Ligament Involvement Open
Category: Ankle; Trauma Introduction/Purpose: Chaput tubercle fractures, which are thought to represent tibial-sided avulsions of the anterior inferior tibiofibular ligament (AITFL), are prevalent in up to 30% of trimalleolar ankle fractur…
View article: Post-Operative Complications after Acute Achilles Tendon Rupture Repair: A Survival Analysis of Minimally Invasive vs Open Techniques
Post-Operative Complications after Acute Achilles Tendon Rupture Repair: A Survival Analysis of Minimally Invasive vs Open Techniques Open
Category: Sports; Ankle Introduction/Purpose: Acute Achilles tendon ruptures (ATRs) can be treated surgically through either open repair or minimally invasive surgical techniques (MIS). While the relative complication rates between these t…
View article: Chevron vs Oblique Medial Displacement Calcaneal Osteotomy - Which Is More Stable? Results From a Finite Element Analysis Study
Chevron vs Oblique Medial Displacement Calcaneal Osteotomy - Which Is More Stable? Results From a Finite Element Analysis Study Open
Category: Hindfoot; Ankle Introduction/Purpose: The medial displacement calcaneal osteotomy is used to correct hindfoot valgus in adult-acquired flatfoot disease(AAFD). This is done by means of an oblique cut, which is then translated medi…
View article: A Novel Ultrasonographic Method to Detect Intra-Operative Syndesmotic Malreduction – the “Gap Penetrance” Sign
A Novel Ultrasonographic Method to Detect Intra-Operative Syndesmotic Malreduction – the “Gap Penetrance” Sign Open
Category: Ankle; Other Introduction/Purpose: Anatomical reduction of the distal syndesmosis can be challenging. There is ongoing debate and variability in the methods used for evaluating the accuracy of reduction, including radiography, in…
View article: Effect of Dorsal Closing Wedge Calcaneal Osteotomy on Foot Alignment and Biomechanics in Patients with Insertional Achilles Tendinopathy
Effect of Dorsal Closing Wedge Calcaneal Osteotomy on Foot Alignment and Biomechanics in Patients with Insertional Achilles Tendinopathy Open
Category: Hindfoot; Sports Introduction/Purpose: The use of a dorsal closing wedge calcaneal osteotomy (DCWCO) in the treatment of insertional Achilles tendinopathy (IAT) has recently gained popularity. The anatomical changes imposed by th…
View article: Early-Onset Spastic Ataxia Due to a Novel Mutation of the SACS Gene – A Case Report from North India with a Review of Indian Literature
Early-Onset Spastic Ataxia Due to a Novel Mutation of the SACS Gene – A Case Report from North India with a Review of Indian Literature Open
Dear Sir, 21-year-old male (Bachelor of Arts student) born out of full-term normal delivery of non-consanguineous parentage, with normal developmental milestones in all four domains, presented to the neurology outpatient (OPD) for the eval…
View article: Beyond the Boundary: A Bibliometric Analysis of the Published Research on Injuries in Cricket
Beyond the Boundary: A Bibliometric Analysis of the Published Research on Injuries in Cricket Open