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The American Federation for Medical Research maintains commitment to decades of support of vaccine and vaccination research to improve public health Open

Zanthia Wiley, Sidharth Mahapatra, Gaurav Agarwal, Stephanie L. Baer, Syed Bukhari , et al. · 2025

Supplementary Figure S5 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open

Shailendra Kumar Maurya, Jenny A. Jaramillo-Gómez, Asad Ur Rehman, Shailendra K. Gautam, Mahek Fatima , et al. · 2025

Supplementary Figure 5. MUC5AC silencing inhibits cMET and CD44v6 expression and Astrocytes induce MUC5AC expression in breast cancer cells. A-B. Western blots showing knockdown of MUC5AC in MDA-231BR HER2 (A) and MUC5AC knockout in HCC195…

Supplementary Figure S6 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open

Shailendra Kumar Maurya, Jenny A. Jaramillo-Gómez, Asad Ur Rehman, Shailendra K. Gautam, Mahek Fatima , et al. · 2025

Supplementary Figure 6. PLB1001 inhibit cMET and CD44v6 expression. A. Representative IHC images showing MUC5AC expression in G5-3 PDXs B. Representative fluorescence microscopy images showing GFP+ in G5-3 PDXs C. Representative IHC images…

Supplementary Figure S4 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open

Shailendra Kumar Maurya, Jenny A. Jaramillo-Gómez, Asad Ur Rehman, Shailendra K. Gautam, Mahek Fatima , et al. · 2025

Supplementary Figure 4. MUC5AC silencing inhibits brain metastasis. A. Fluorescence microscopy images showing Cytokeratin 8/18 and MUC5AC in the brain tissue sections of the mice intracardially injected with shSCR and shMUC5AC KD MDA-231BR…

Data from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open

Shailendra Kumar Maurya, Jenny A. Jaramillo-Gómez, Asad Ur Rehman, Shailendra K. Gautam, Mahek Fatima , et al. · 2025

Purpose:Breast cancer brain metastasis remains a significant clinical problem. Mucins have been implicated in metastasis; however, whether they are also involved in breast cancer brain metastasis remains unknown. We queried databases of pa…

Supplementary Figure S1 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open

Shailendra Kumar Maurya, Jenny A. Jaramillo-Gómez, Asad Ur Rehman, Shailendra K. Gautam, Mahek Fatima , et al. · 2025

Supplementary Figure 1. Expression of MUC5AC is high in breast cancer brain metastasis. A. Heatmap showing the expression of upregulated genes in BC BrM cells as compared to primary BC cells (MDA-231BR vs MDA-231P). B. Comparison of MUC5AC…

Supplementary Figure S3 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open

Shailendra Kumar Maurya, Jenny A. Jaramillo-Gómez, Asad Ur Rehman, Shailendra K. Gautam, Mahek Fatima , et al. · 2025

Supplementary Figure 3. MUC5AC promotes brain metastasis. A. Western blot for HER2 expression in MDA-231BR HER2 cells. B. Western blot showing knockout of MUC5AC in the HCC1954BR cells. C-F. Wound healing assay and quantification showing r…

Supplementary Figure S2 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open

Shailendra Kumar Maurya, Jenny A. Jaramillo-Gómez, Asad Ur Rehman, Shailendra K. Gautam, Mahek Fatima , et al. · 2025

Supplementary Figure 2. MUC5AC IHC staining using Aperio Digital Imaging revealed MUC5AC strong to medium scores in BrM patient samples. Tumor areas were defined by annotations (green color) and necrotic areas or areas not corresponding to…

MDB-93. A TRANSCRIPTOME-BASED APPROACH TO DRUG REPURPOSING FOR AGGRESSIVE GROUP 3 MEDULLOBLASTOMAS Open

David Doss, Ranjana Kanchan, Naveenkumar Perumal, Surinder K. Batra, Sidharth Mahapatra · 2024

BACKGROUND Medulloblastoma (MB) is the most common malignant brain tumor in children, representing 20% of pediatric brain tumors. International consensus has identified molecular subgroups: WNT, SHH, group 3 (G3), and group 4 (G4). Current…

MDB-15. INHIBITING THE IRON-SULFUR CLUSTER TRANSPORTER ABCB7 CAN POTENTIATE CISPLATIN RESPONSE IN PEDIATRIC GROUP 3 MEDULLOBLASTOMAS BY TRIGGERING FERROPTOSIS Open

Sidharth Mahapatra, Ranjana Kanchan, David Doss, Parvez Κhan, Mohd W. Nasser , et al. · 2024

BACKGROUND Medulloblastoma (MB) is the most common malignant pediatric brain tumor, with group 3 tumors (G3MB) being the most aggressive. Uniquely, their aggressiveness is inversely proportional to ferroptosis activation. Intracellularly, …

A National Meeting for the American Federation for Medical Research: Decades in the Making Open

Sidharth Mahapatra · 2024

Cover Image, Volume 50, Issue 1 Open

Sage Green, Travis Hoover, David Doss, Kimberly Davidow, Andrew W. Walter , et al. · 2024

WNT‐activated, <i>MYC</i> ‐amplified medulloblastoma displaying intratumoural heterogeneity Open

Sage Green, Travis Hoover, David Doss, Kimberly Davidow, Andrew W. Walter , et al. · 2023

Medulloblastomas (MB) are the most commonly occurring malignant brain tumour in childhood. The mainstay of therapy incorporates gross total resection followed by craniospinal irradiation (CSI) and chemotherapy. To guide post-surgical treat…

MDB-45. SELECTIVE B7-H3 INHIBITORS NI1 AND NI4 REDUCE AGGRESSIVENESS OF GROUP 3 MEDULLOBLASTOMA Open

Prakadeeswari Gopala Krishnan, Ranjana Kanchan, David Doss, Hamdan Alfrefaei, Prachi Agarwal , et al. · 2023

Medulloblastoma (MB) is a primary childhood malignancy of the central nervous system (CNS). Clinically heterogenous MB are sub-grouped into four molecular subgroups, i.e. Wingless (WNT), Sonic Hedgehog (SHH), Group 3, and Group 4. Among al…

MDB-40. TRANSCRIPTOME-BASED DRUG REPURPOSING IN GROUP 3 MEDULLOBLASTOMA Open

David Doss, Ranjana Kanchan, Naveenkumar Perumal, Surinder K. Batra, Sidharth Mahapatra · 2023

Medulloblastoma (MB) is the most common malignant pediatric brain tumor. MB is divided into four molecular subgroups (SHH, WNT, Group 3 [G3], and Group 4 [G4]), each defined by unique genetic and molecular features. G3MB is the most aggres…

MDB-34. “INDUCING IRON IMBALANCE BY TARGETING THE ABCB7/GPX4 AXIS ACCELERATES FERROPTOSIS IN MEDULLOBLASTOMA” Open

Ranjana Kanchan, Naveenkumar Perumal, David Doss, Parvez Κhan, Ramakanth Chirravuri Venkata , et al. · 2023

Medulloblastomas (MB), the most common malignant pediatric brain tumor and a leading cause of childhood mortality, are stratified into four primary subgroups. Deletions within chromosomal locus 17p13.3, which houses multiple tumor suppress…

To kill a cancer: Targeting the immune inhibitory checkpoint molecule, B7-H3 Open

Ranjana Kanchan, David Doss, Parvez Κhan, Mohd W. Nasser, Sidharth Mahapatra · 2022

Targeting the anti-tumor immune response via the B7 family of immune-regulatory checkpoint proteins has revolutionized cancer treatment and resulted in punctuated responses in patients. B7-H3 has gained recent attention given its prominent…

Comparative Effectiveness of Diversion of Cerebrospinal Fluid for Children With Severe Traumatic Brain Injury Open

Michael J. Bell, Bedda L. Rosario, Patrick M. Kochanek, P. David Adelson, Kevin Morris , et al. · 2022

In this comparative effectiveness study, CSF diversion was not associated with improved outcome at 6 months after TBI, but a decrease in ICP was observed. Given the higher quality of evidence generated by this study, current evidence-based…

MEDB-89. Elucidation of the Oncogenic role of Nuclear Factor I/B (NFIB) in group 3 medulloblastoma Open

Naveenkumar Perumal, Ranjana Kanchan, David Doss, Ishwor Thapa, Mohd W. Nasser , et al. · 2022

Amongst the 4 subgroups of medulloblastoma (MB), tumors falling into group 3 are the most aggressive and associated with increased incidence of aberrations on chromosome 17p, c-Myc amplification, metastases at diagnosis, and rapid tumor re…

MEDB-87. Transcriptome-driven drug repurposing in group 3 medulloblastoma Open

David Doss, Ranjana Kanchan, Naveenkumar Perumal, Surinder K. Batra, Sidharth Mahapatra · 2022

Across the molecular spectrum of medulloblastoma (MB), group 3 (G3) tumors are the most aggressive with <50% five-year survival, the lowest of all MB subgroups. G3 MB tumors are characterized by frequent metastases at diagnosis, unique …

MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis Open

Parvez Κhan, Jawed A. Siddiqui, Prakash Kshirsagar, Ramakanth Chirravuri Venkata, Shailendra Kumar Maurya , et al. · 2022

Background: Small cell lung cancer (SCLC) is an aggressive lung cancer subtype that is associated with high recurrence and poor prognosis. Due to a lack of potential drug targets, SCLC patients have few therapeutic options. MicroRNAs (miRN…

Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury Open

Patrick M. Kochanek, P. David Adelson, Bedda L. Rosario, James S. Hutchison, Nikki Miller Ferguson , et al. · 2022

In this comparative effectiveness research study, bolus HTS was associated with lower ICP and higher CPP, whereas mannitol was associated only with higher CPP. After adjustment for confounders, both therapies showed no association with ICP…

Repressing ABCB7 Potentiates Cisplatin Response in Pediatric Group 3 Medulloblastoma by Triggering Ferroptosis Open

Ranjana Kanchan, Naveenkumar Perumal, Parvez Κhan, David Doss, Prakadeeshwari Gopalakrishnan , et al. · 2022

Medulloblastomas (MB) are the most common malignant pediatric brain tumor and a leading cause of childhood mortality. Aggressive tumors belonging to group 3 (G3MB) are distinguished by a marked reduction in programmed cell death by ferropt…

Risk Factors Associated with Mechanical Ventilation in Critical Bronchiolitis Open

Rachel K. Marlow, Sydney Brouillette, Vannessa Williams, Ariann Lenihan, Nichole Nemec , et al. · 2021

The American Academy of Pediatrics (AAP) recommends supportive care for the management of bronchiolitis. However, patients admitted to the intensive care unit with severe (critical) bronchiolitis define a unique group with varying needs fo…

Clinical Characteristics Distinguishing Bronchiolitis Patients Requiring Mechanical Ventilation Open

Rachel K. Marlow, Sydney Brouillette, Vannessa Williams, Ariann Lenihan, Nichole Nemec , et al. · 2021

The AAP recommends supportive care for the management of bronchiolitis. However, patients progressing to critical bronchiolitis define a unique group with varying needs for both non-invasive and invasive respiratory support. Currently, no …

Antipsychotics, versatility in action Open

Sidharth Mahapatra, Tiago Reis Marques · 2021

In PNAS Patergnani et al. elucidate tantalizing mechanisms by which neurodegeneration occurs in the context of multiple sclerosis (MS) in their paper entitled “Antipsychotic drugs counteract autophagy and mitophagy in multiple sclerosis” (…

BIOL-07. MIR-212 FUNCTIONS AS A TUMOR SUPPRESSOR GENE IN GROUP 3 MEDULLOBLASTOMA VIA TARGETING NUCLEAR FACTOR I/B (NFIB) Open

Naveenkumar Perumal, Ranjana Kanchan, David Doss, Pranita Atri, Ramakanth Chirravuri Venkata , et al. · 2021

Medulloblastoma (MB), the most frequent malignant pediatric brain tumor is subdivided into four primary subgroups, i.e. wingless-type (WNT), sonic hedgehog (SHH), group 3, and group 4. Haploinsufficiency of chromosome 17p13.3 and c-myc amp…

A Retrospective Analysis of Feeding Practices and Complications in Patients with Critical Bronchiolitis on Non-Invasive Respiratory Support Open

Ariann Lenihan, Vannessa Ramos, Nichole Nemec, Joseph Lukowski, Junghyae Lee , et al. · 2021

Limited data exist regarding feeding pediatric patients managed on non-invasive respiratory support (NRS) modes that augment oxygenation and ventilation in the setting of acute respiratory failure. We conducted a retrospective cohort study…

A Retrospective Analysis of Feeding Practices and Complications in Patients with Critical Bronchiolitis on Non-invasive Respiratory Support Open

Ariann Lenihan, Vannessa Ramos, Nichole Nemec, Joseph Lukowski, Junghyae Lee , et al. · 2021

Limited data exist regarding feeding pediatric patients managed on non-invasive respiratory support (NRS) modes that augment oxygentation and ventilation in the setting of respiratory failure. We conducted a retrospective cohort study to e…

MiR-212-3p functions as a tumor suppressor gene in group 3 medulloblastoma via targeting Nuclear Factor I/B (NFIB) Open

Naveenkumar Perumal, Ranjana Kanchan, David Doss, Noah Bastola, Pranita Atri , et al. · 2021

Background Medulloblastoma (MB), the most frequent malignant pediatric brain tumor, is subdivided into four primary subgroups, wingless-type (WNT), sonic hedgehog (SHH), group 3, and group 4. Haploinsufficiency of chromosome 17p13.3 and c-…

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