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View article: Supplementary Table S1 from Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function
Supplementary Table S1 from Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function Open
Supplementary Table S1
View article: Supplementary Table S5 from Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function
Supplementary Table S5 from Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function Open
Supplementary Table S5
View article: Supplementary Table S3 from Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function
Supplementary Table S3 from Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function Open
Supplementary Table S3
View article: Supplementary Table S4 from Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function
Supplementary Table S4 from Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function Open
Supplementary Table S4
View article: Supplementary Table S8 from Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function
Supplementary Table S8 from Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function Open
Supplementary Table S8
View article: Supplementary Figures from Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function
Supplementary Figures from Immunogenetic Metabolomics Reveals Key Enzymes That Modulate CAR T-cell Metabolism and Function Open
Supplementary Figures 1-10
View article: Brain-wide Genome Editing via STEP-RNPs for Treatment of Angelman Syndrome
Brain-wide Genome Editing via STEP-RNPs for Treatment of Angelman Syndrome Open
Brain-wide genome-editing remains a major hurdle for the treatment of neurogenetic disorders. Here, we report a non-viral, non-nanoparticle, chemical modification-based method, called Stimuli-Responsive Traceless Engineering Platform (STEP…
View article: Berberine Hydrochloride Reduces the Intracellular Survival of Salmonella Typhimurium by Enhancing Host Autophagic Flux Through the Inhibition of the Type III Secretion System
Berberine Hydrochloride Reduces the Intracellular Survival of Salmonella Typhimurium by Enhancing Host Autophagic Flux Through the Inhibition of the Type III Secretion System Open
Salmonella Typhimurium, a significant intracellular foodborne pathogen, regulates host cell autophagy to achieve its own survival by injecting effector proteins into host cells via its type III secretion system (T3SS). Berberine hydrochlor…
View article: Identification of NAE1-dependent β-catenin neddylation as selective vulnerability in B-cell malignancies
Identification of NAE1-dependent β-catenin neddylation as selective vulnerability in B-cell malignancies Open
Background and Significance. In epithelial cells, β-catenin promotes canonical WNT signaling and expression of MYC. Mutations that stabilize β-catenin protein expression function as oncogenic drivers in solid tumors and myeloid leukemia. I…
View article: The Impact of Orthopoxvirus Vaccination and Mpox Infection on Cross-Protective Immunity 2402
The Impact of Orthopoxvirus Vaccination and Mpox Infection on Cross-Protective Immunity 2402 Open
Description Immunological memory provides rapid protection post-infection or vaccination, yet cross-reactive memory in humans is not well understood. We examined cross-protective responses to orthopoxviruses via smallpox/mpox vaccination a…
View article: Study on the Mechanism of Action of Nourishing Blood Diuretic Formula in the Treatment of Chronic Renal Failure and Anti-Renal Fibrosis Through TGF-β/Smad Signaling Pathway
Study on the Mechanism of Action of Nourishing Blood Diuretic Formula in the Treatment of Chronic Renal Failure and Anti-Renal Fibrosis Through TGF-β/Smad Signaling Pathway Open
Background Nourishing Blood Diuretic Formula (NBDF) is derived from the empirical formula of Prof. Fan Heng in the Department of Traditional Chinese Medicine (TCM), Union Hospital, Tongji Medical College, Huazhong University of Science and…
View article: Analyzing Teacher-Student Interaction Patterns Through Deep Learning: Implications for Classroom Management and Teaching Effectiveness
Analyzing Teacher-Student Interaction Patterns Through Deep Learning: Implications for Classroom Management and Teaching Effectiveness Open
This study employed a multimodal deep learning architecture to analyze teacher-student interaction patterns across 432 class hours in diverse educational settings. The model successfully identified five distinct interaction patterns with 8…
View article: Spatially Resolved Panoramic in vivo CRISPR Screen via Perturb-DBiT
Spatially Resolved Panoramic in vivo CRISPR Screen via Perturb-DBiT Open
Spatially resolved in vivo CRISPR screening integrates gene editing with spatial transcriptomics to examine how genetic perturbations alter gene expression within native tissue environments. However, current methods are limited to small p…
View article: The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study
The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study Open
Yale University and Stavros Niarchos Foundation Institute for Global Infectious Disease.
View article: Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering
Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering Open
View article: Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairs
Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairs Open
View article: TCPGdb: A comprehensive T cell perturbation genomics database for identification of critical T cell regulators
TCPGdb: A comprehensive T cell perturbation genomics database for identification of critical T cell regulators Open
CAR-T therapies utilizing T cells engineered with chimeric antigen receptors (CARs) have revolutionized the treatment of hematologic and immune-related malignancies. However, the anti-tumor capability of engineered CAR-T cells are often no…
View article: Spatially Resolved<i>in vivo</i>CRISPR Screen Sequencing via Perturb-DBiT
Spatially Resolved<i>in vivo</i>CRISPR Screen Sequencing via Perturb-DBiT Open
SUMMARY Perturb-seq enabled the profiling of transcriptional effects of genetic perturbations in single cells but lacks the ability to examine the impact on tissue environments. We present Perturb-DBiT for simultaneous co- sequencing of sp…
View article: PTX3 exacerbates hepatocyte pyroptosis in hepatic ischemia–reperfusion injury by promoting macrophage M1 polarization
PTX3 exacerbates hepatocyte pyroptosis in hepatic ischemia–reperfusion injury by promoting macrophage M1 polarization Open
PTX3 regulates macrophage polarization during hepatic IRI, consequently influencing hepatocellular pyroptosis.
View article: 65 High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics
65 High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics Open
View article: Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission
Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission Open
View article: Supplementary Table S8 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function
Supplementary Table S8 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function Open
Supplementary Table S8
View article: Supplementary Table S7 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function
Supplementary Table S7 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function Open
Supplementary Table S7
View article: Supplementary Table S4 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function
Supplementary Table S4 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function Open
Supplementary Table S4
View article: Supplementary Table S3 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function
Supplementary Table S3 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function Open
Supplementary Table S3
View article: Supplementary Table S9 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function
Supplementary Table S9 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function Open
Supplementary Table S9
View article: Supplementary Table S8 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function
Supplementary Table S8 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function Open
Supplementary Table S8
View article: Supplementary Table S1 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function
Supplementary Table S1 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function Open
Supplementary Table S1
View article: Supplementary Table S7 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function
Supplementary Table S7 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function Open
Supplementary Table S7
View article: Supplementary Table S6 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function
Supplementary Table S6 from Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function Open
Supplementary Table S6