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View article: Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets
Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets Open
Age is a risk factor for hematologic malignancies. Attributes of the aging hematopoietic system include increased myelopoiesis, impaired adaptive immunity, and a functional decline of the hematopoietic stem cells (HSCs) that maintain hemat…
View article: Combination of CD49b and CD229 Reveals a Subset of Multipotent Progenitors With Short-Term Activity Within the Hematopoietic Stem Cell Compartment
Combination of CD49b and CD229 Reveals a Subset of Multipotent Progenitors With Short-Term Activity Within the Hematopoietic Stem Cell Compartment Open
Hematopoiesis is maintained by hematopoietic stem cells (HSCs) that replenish all blood lineages throughout life. It is well-established that the HSC pool is functionally heterogeneous consisting of cells differing in longevity, self-renew…
View article: Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets
Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets Open
Age is a risk factor for hematologic malignancies. Attributes of the aging hematopoietic system include increased myelopoiesis, impaired adaptive immunity, and a functional decline of the hematopoietic stem cells (HSCs) that maintain hemat…
View article: T-RHEX-RNAseq – a tagmentation-based, rRNA blocked, random hexamer primed RNAseq method for generating stranded RNAseq libraries directly from very low numbers of lysed cells
T-RHEX-RNAseq – a tagmentation-based, rRNA blocked, random hexamer primed RNAseq method for generating stranded RNAseq libraries directly from very low numbers of lysed cells Open
View article: The combination of CD49b and CD229 reveals a subset of multipotent progenitors with short-term activity within the hematopoietic stem cell compartment
The combination of CD49b and CD229 reveals a subset of multipotent progenitors with short-term activity within the hematopoietic stem cell compartment Open
Hematopoiesis is maintained by hematopoietic stem cells (HSCs) that replenish all blood lineages throughout life. It is well-established that the HSC pool is functionally heterogeneous consisting of cells differing in longevity, self-renew…
View article: T-RHEX-RNAseq – A tagmentation-based, rRNA blocked, random hexamer primed RNAseq method for generating stranded RNAseq libraries directly from very low numbers of lysed cells
T-RHEX-RNAseq – A tagmentation-based, rRNA blocked, random hexamer primed RNAseq method for generating stranded RNAseq libraries directly from very low numbers of lysed cells Open
Background RNA sequencing has become the mainstay for studies of gene expression. Still, analysis of rare cells with random hexamer priming – to allow analysis of a broader range of transcripts – remains challenging. Results We here descri…
View article: CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells
CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells Open
Hematopoiesis is maintained by functionally diverse lineage-biased hematopoietic stem cells (HSCs). The functional significance of HSC heterogeneity and the regulatory mechanisms underlying lineage bias are not well understood. However, ab…
View article: FOXO Dictates Initiation of B Cell Development and Myeloid Restriction in Common Lymphoid Progenitors
FOXO Dictates Initiation of B Cell Development and Myeloid Restriction in Common Lymphoid Progenitors Open
The development of B cells relies on an intricate network of transcription factors critical for developmental progression and lineage commitment. In the B cell developmental trajectory, a temporal switch from predominant Foxo3 to Foxo1 exp…
View article: FOXO dictate initiation of B cell development and myeloid restriction in common lymphoid progenitors
FOXO dictate initiation of B cell development and myeloid restriction in common lymphoid progenitors Open
The development of B cells relies on an intricate network of transcription factors critical for developmental progression and lineage commitment. In the B cell developmental trajectory, a temporal switch from predominant Foxo3 to Foxo1 exp…
View article: Strict in vivo specificity of the Bcl11a erythroid enhancer
Strict in vivo specificity of the Bcl11a erythroid enhancer Open
Key Points Deletion of the erythroid enhancer of Bcl11a from the mouse genome does not affect viability or Bcl11a expression in nonerythroid lineages. Elevated levels of γ-globin in Bcl11a enhancer–deleted mice are comparable to those in e…
View article: Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors
Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors Open
View article: Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype
Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype Open
B cell CLL/lymphoma 11A (BCL11A) is a transcription factor and regulator of hemoglobin switching that has emerged as a promising therapeutic target for sickle cell disease and thalassemia. In the hematopoietic system, BCL11A is required fo…
View article: BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis Open
Enhancers, critical determinants of cellular identity, are commonly recognized by correlative chromatin marks and gain-of-function potential, although only loss-of-function studies can demonstrate their requirement in the native genomic co…