Sidney M. Morris
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View article: Analysis of genotype effects and inter-individual variability in iPSC-derived trisomy 21 neural progenitor cells
Analysis of genotype effects and inter-individual variability in iPSC-derived trisomy 21 neural progenitor cells Open
Trisomy of human chromosome 21 (T21) gives rise to Down syndrome (DS), the most frequent live-born autosomal aneuploidy. T21 triggers genome-wide transcriptomic alterations that result in multiple atypical phenotypes with highly variable p…
View article: Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy
Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy Open
Endothelial dysfunction, characterized by reduced bioavailability of nitric oxide and increased oxidative stress, is a hallmark characteristic in diabetes and diabetic nephropathy (DN). High levels of asymmetric dimethylarginine (ADMA) are…
View article: <scp>l</scp> ‐Homoarginine supplementation prevents diabetic kidney damage
<span>l</span> ‐Homoarginine supplementation prevents diabetic kidney damage Open
l-homoarginine is an endogenous, non-proteinogenic amino acid that has emerged as a new player in health and disease. Specifically, low l-homoarginine levels are associated with cardiovascular diseases, stroke, and reduced kidney function.…
View article: Arginase-2 mediates renal ischemia-reperfusion injury
Arginase-2 mediates renal ischemia-reperfusion injury Open
Novel therapeutic interventions for preventing or attenuating kidney injury following ischemia-reperfusion injury (IRI) remain a focus of significant interest. Currently, there are no definitive therapeutic or preventive approaches availab…
View article: Distinct roles of arginases 1 and 2 in diabetic nephropathy
Distinct roles of arginases 1 and 2 in diabetic nephropathy Open
Diabetes is the leading cause of end-stage renal disease, resulting in a significant health care burden and loss of economic productivity by affected individuals. Because current therapies for progression of diabetic nephropathy (DN) are o…
View article: Phosphorylation of zinc channel ZIP7 drives MAPK, PI3K and mTOR growth and proliferation signalling
Phosphorylation of zinc channel ZIP7 drives MAPK, PI3K and mTOR growth and proliferation signalling Open
Zinc is an essential trace element participating in diverse biological processes. Cellular zinc levels are strictly controlled by two families of transport proteins: ZIP channels (SLC39A) and ZnT transporters (SLC30A). ZIP channels increas…