Sieger Henke
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View article: Single particle identification and automated classification of small (<10µm) microplastics using cathodoluminescence
Single particle identification and automated classification of small (<10µm) microplastics using cathodoluminescence Open
View article: Investigations regarding the influence of particle shape on the numerical simulation of air pluviation using the dem method
Investigations regarding the influence of particle shape on the numerical simulation of air pluviation using the dem method Open
View article: Experimental Validation of the Microplastic Index—Two Approaches to Understanding Microplastic Formation
Experimental Validation of the Microplastic Index—Two Approaches to Understanding Microplastic Formation Open
The Microplastic Index (MPI) was presented in a previous paper as a method to assess the formation of microplastics during the application of impact and wear stresses, based on selected mechanical and physical properties of polymers. In th…
View article: Microplastic Index—How to Predict Microplastics Formation?
Microplastic Index—How to Predict Microplastics Formation? Open
The presence of microplastics in environmental compartments is generally recognized as a (potential) health risk. Many papers have been published on the abundance of microplastics at various locations around the globe, but only limited kno…
View article: Protocol for the production of micro- and nanoplastic test materials
Protocol for the production of micro- and nanoplastic test materials Open
Micro- and nanoplastics (MNP) are ubiquitous, but little is known about the risks they pose to human health. Currently available data are of limited use for developing relevant risk assessments due to poor quality control, the lack of a st…
View article: Protocol for the production of micro- and nanoplastic test materials
Protocol for the production of micro- and nanoplastic test materials Open
Micro- and nanoplastics (MNP) are ubiquitous, but little is known about the risks they pose to human health. Currently available data are of limited use for developing relevant risk assessments due to poor quality control, the lack of a st…
View article: Classification of (micro)plastics using cathodoluminescence and machine learning
Classification of (micro)plastics using cathodoluminescence and machine learning Open
Microplastics are a growing environmental and toxicological concern, having been found in the remotest locations of the earth and within multiple organs of the human body. However, the scale of the problem is not yet fully known as the sma…
View article: Classification of (Micro)Plastics Using Cathodoluminescence and Machine Learning
Classification of (Micro)Plastics Using Cathodoluminescence and Machine Learning Open
View article: Tethering Cells via Enzymatic Oxidative Crosslinking Enables Mechanotransduction in Non‐Cell‐Adhesive Materials (Adv. Mater. 42/2021)
Tethering Cells via Enzymatic Oxidative Crosslinking Enables Mechanotransduction in Non‐Cell‐Adhesive Materials (Adv. Mater. 42/2021) Open
Cell–Material Tethering Cells need to sense their environment in order to survive and function. In article number 2102660, Tom Kamperman, Jeroen Leijten, and co-workers present an enzymatic crosslinking strategy that can tether non-cell-ad…
View article: Tethering Cells via Enzymatic Oxidative Crosslinking Enables Mechanotransduction in Non‐Cell‐Adhesive Materials
Tethering Cells via Enzymatic Oxidative Crosslinking Enables Mechanotransduction in Non‐Cell‐Adhesive Materials Open
Cell–matrix interactions govern cell behavior and tissue function by facilitating transduction of biomechanical cues. Engineered tissues often incorporate these interactions by employing cell‐adhesive materials. However, using constitutive…
View article: Enzymatic outside-in cross-linking enables single-step microcapsule production for high-throughput three-dimensional cell microaggregate formation
Enzymatic outside-in cross-linking enables single-step microcapsule production for high-throughput three-dimensional cell microaggregate formation Open
Cell-laden hydrogel microcapsules enable the high-throughput production of cell aggregates, which are relevant for three-dimensional tissue engineering and drug screening applications. However, current microcapsule production strategies ar…
View article: On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials
On-the-fly exchangeable microfluidic nozzles for facile production of various monodisperse micromaterials Open
Exchangeable microfluidic nozzles enable the facile production of a wide variety of micromaterials using a single cleanroom-free manufactured microfluidic device.
View article: An important step towards a prevascularized islet microencapsulation device: in vivo prevascularization by combination of mesenchymal stem cells on micropatterned membranes
An important step towards a prevascularized islet microencapsulation device: in vivo prevascularization by combination of mesenchymal stem cells on micropatterned membranes Open
View article: Microgels: Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape (Small 22/2017)
Microgels: Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape (Small 22/2017) Open
In article number 1603711, Marcel Karperien, Jeroen Leijten, and co-workers present the first microfluidic approach that enables long-term 3D single cell culture by centering cells in microgels in a facile, modular, and widely applicable m…
View article: Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape
Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape Open
Single-cell-laden microgels support physiological 3D culture conditions while enabling straightforward handling and high-resolution readouts of individual cells. However, their widespread adoption for long-term cultures is limited by cell …
View article: Biofabrication: Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro‐ and Macroenvironments (Adv. Healthcare Mater. 3/2017)
Biofabrication: Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro‐ and Macroenvironments (Adv. Healthcare Mater. 3/2017) Open
Modular bioinks based on single-cell-laden microgels are engineered using droplet microfluidics and leveraged to uncouple micro- and macroenvironments of biomaterials by Marcel Karperien and co-workers in article 1600913. These inks enable…
View article: Nanoemulsion-induced enzymatic crosslinking of tyramine-functionalized polymer droplets
Nanoemulsion-induced enzymatic crosslinking of tyramine-functionalized polymer droplets Open
Nanoemulsified crosslinker enables the facile enzymatic crosslinking of tyramine-functionalized polymer droplets into hydrogel particles that span multiple length scales for numerous applications including 3D cell culture.
View article: Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro‐ and Macroenvironments
Single Cell Microgel Based Modular Bioinks for Uncoupled Cellular Micro‐ and Macroenvironments Open
Modular bioinks based on single cell microgels within distinct injectable prepolymers enable uncoupling of biomaterials' micro- and macroenvironments. These inks allow biofabrication of 3D constructs that recapitulate the multiscale modula…
View article: Microgel technology for improved beta cell transplantation
Microgel technology for improved beta cell transplantation Open
Type 1 diabetes affects approximately 11-22 million people worldwide and cannot be cured. In this thesis, we have explored various strategies to encapsulate (beta) cells in micro hydrogels, with the special aim of contributing to curing di…
View article: Enzymatic Crosslinking of Polymer Conjugates is Superior over Ionic or UV Crosslinking for the On‐Chip Production of Cell‐Laden Microgels
Enzymatic Crosslinking of Polymer Conjugates is Superior over Ionic or UV Crosslinking for the On‐Chip Production of Cell‐Laden Microgels Open
Cell‐laden micrometer‐sized hydrogels (microgels) hold great promise for improving high throughput ex‐vivo drug screening and engineering biomimetic tissues. Microfluidics is a powerful tool to produce microgels. However, only a limited am…
View article: Abstracts
Abstracts Open
View article: Optimizing cell viability in droplet-based cell deposition
Optimizing cell viability in droplet-based cell deposition Open