Sifan Guo
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View article: Multi‐Omics Decoding of <i>Dendrobium huoshanense</i> 's Dual‐Target Mechanism: Modulating Purine and Ether Lipid Metabolism for Type 2 Diabetes Therapy
Multi‐Omics Decoding of <i>Dendrobium huoshanense</i> 's Dual‐Target Mechanism: Modulating Purine and Ether Lipid Metabolism for Type 2 Diabetes Therapy Open
As a medicinal‐food homologous species, Dendrobium huoshanense (DH) exhibits promising antidiabetic properties; however, its underlying molecular mechanisms and bioactive components require further systematic investigation. This study inve…
View article: From traditional medicinal use to functional food: The pharmacological activity, hepatotoxicity mechanism and detoxification strategies of gardenia fructus
From traditional medicinal use to functional food: The pharmacological activity, hepatotoxicity mechanism and detoxification strategies of gardenia fructus Open
Gardenia fructus (GF), a medicinal and edible herb with over 2,000 years of use, possesses diverse bioactive compounds including iridoids, crocins, and organic acids. Herein, we summarize the ethnomedicinal applications, phytochemistry, ph…
View article: The metformin mediated MAPK signaling pathway influences D-Xylose regulation during diabetic kidney disease therapy
The metformin mediated MAPK signaling pathway influences D-Xylose regulation during diabetic kidney disease therapy Open
Metformin alleviates DKD through multi-modal mechanisms, modulating the MAPK signaling pathway and carbohydrate metabolites-notably D-xylose. As far as we are aware, these findings provide new mechanistic insights and suggest potential bio…
View article: Spatial Multi-Omics Dissection of Astragaloside IV in Diabetic Kidney Zonation: A Food-Derived Bioactive Regulator of Metabolic and Proteomic Landscapes
Spatial Multi-Omics Dissection of Astragaloside IV in Diabetic Kidney Zonation: A Food-Derived Bioactive Regulator of Metabolic and Proteomic Landscapes Open
View article: Identification and Genetic Characterization of a Strain of African Horse Sickness Virus Serotype 1 and Its Safety Evaluation in a Mouse Model
Identification and Genetic Characterization of a Strain of African Horse Sickness Virus Serotype 1 and Its Safety Evaluation in a Mouse Model Open
African horse sickness (AHS) is an arthropod-borne, severe equid disease caused by African horse sickness virus (AHSV). AHSV has high mortality and is endemic to sub-Saharan Africa. It has been classified into nine distinct serotypes (AHSV…
View article: Metabolite‐Guided Acetylation Therapy: Astragaloside IV Reverses Diabetic Nephropathy via Gna13‐Driven Purine Metabolic Reprogramming
Metabolite‐Guided Acetylation Therapy: Astragaloside IV Reverses Diabetic Nephropathy via Gna13‐Driven Purine Metabolic Reprogramming Open
Diabetic nephropathy (DN) exhibits profound metabolic dysregulation, yet the spatial organization and posttranslational control of pathogenic pathways remain poorly understood. This study integrates high‐resolution MALDI mass spectrometry …
View article: Integrated Omics Reveal Dendrobium nobile Lindl.’s Anti-Diabetic Mechanisms via Arginine/Proline and Glycerophospholipid Pathways
Integrated Omics Reveal Dendrobium nobile Lindl.’s Anti-Diabetic Mechanisms via Arginine/Proline and Glycerophospholipid Pathways Open
Background/Objectives: Dendrobium nobile Lindl. (DNL), a traditional dietary supplement, exhibits therapeutic potential for type 2 diabetes mellitus (T2DM), yet its mechanisms remain unclear. Methods: T2DM was induced in db/db mice. DNL (1…
View article: Spatially segregated multiomics decodes metformin-mediated functional-specific metabolic characteristics in diabetic kidney disease
Spatially segregated multiomics decodes metformin-mediated functional-specific metabolic characteristics in diabetic kidney disease Open
Understanding the specific metabolic changes in multiple regions of the kidney is crucial to revealing the underlying mechanism and developing effective targets for diabetic nephropathy (DN). In this study, integrated spatially resolved me…
View article: Single cell sequencing and spatial multiomics of diabetic kidney segmentation insights zonation-specific therapeutic metabolic pathways
Single cell sequencing and spatial multiomics of diabetic kidney segmentation insights zonation-specific therapeutic metabolic pathways Open
View article: Metabolic phenotypes: Molecular bridges between health homeostasis and disease imbalance
Metabolic phenotypes: Molecular bridges between health homeostasis and disease imbalance Open
Metabolic phenotypes represent the overall characterization of an individual's metabolites at a specific point in time. They precisely reflect the complex interactions among genetic background, environmental factors, lifestyle, and gut mic…
View article: Integrated metabolomics and proteomics revealed astragaloside IV inhibiting Pdxk-mediated vitamin B6 metabolism based on liquid chromatography-tandem mass spectrometry combined with pattern recognition and correlation analysis
Integrated metabolomics and proteomics revealed astragaloside IV inhibiting Pdxk-mediated vitamin B6 metabolism based on liquid chromatography-tandem mass spectrometry combined with pattern recognition and correlation analysis Open
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Unique metabolic needs of cells highlight the potential for fruitful drug and t…
View article: Berberine Mediates Exosomes Regulating the Lipid Metabolism Pathways to Promote Apoptosis of RA-FLS Cells
Berberine Mediates Exosomes Regulating the Lipid Metabolism Pathways to Promote Apoptosis of RA-FLS Cells Open
Objectives: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint damage and commonly linked to symptoms such as inflammation, swelling, and pain. Traditional Chinese Medicine offers complementary and integrative…
View article: Lipoprotein transport system Lol may be a selective target for Gram-negative bacteria
Lipoprotein transport system Lol may be a selective target for Gram-negative bacteria Open
View article: The communication mechanism of the gut-brain axis and its effect on central nervous system diseases: A systematic review
The communication mechanism of the gut-brain axis and its effect on central nervous system diseases: A systematic review Open
Gut microbiota is involved in intricate and active metabolic processes the host's brain function, especially its role in immune responses, secondary metabolism, and symbiotic connections with the host. Gut microbiota can promote the produc…
View article: Metabolomics for Clinical Biomarker Discovery and Therapeutic Target Identification
Metabolomics for Clinical Biomarker Discovery and Therapeutic Target Identification Open
As links between genotype and phenotype, small-molecule metabolites are attractive biomarkers for disease diagnosis, prognosis, classification, drug screening and treatment, insight into understanding disease pathology and identifying pote…
View article: Decoding immune interactions of gut microbiota for understanding the mechanisms of diseases and treatment
Decoding immune interactions of gut microbiota for understanding the mechanisms of diseases and treatment Open
OPINION article Front. Microbiol., 07 December 2023Sec. Microorganisms in Vertebrate Digestive Systems Volume 14 - 2023 | https://doi.org/10.3389/fmicb.2023.1238822
View article: Localization analysis of metabolites from complex biological samples-recent analytical technique of mass spectrometry imaging
Localization analysis of metabolites from complex biological samples-recent analytical technique of mass spectrometry imaging Open
OPINION article Front. Mol. Biosci., 21 April 2023Sec. Metabolomics Volume 10 - 2023 | https://doi.org/10.3389/fmolb.2023.1169449
View article: Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine
Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine Open
Natural products derived from herbal medicine are a fruitful source of lead compounds because of their structural diversity and potent bioactivities. However, despite the success of active compounds derived from herbal medicine in drug dis…
View article: Innovation in identifying metabolites from complex metabolome—Highlights of recent analytical platforms and protocols
Innovation in identifying metabolites from complex metabolome—Highlights of recent analytical platforms and protocols Open
Metabolites are closely intertwined genotypes that can provide clear information about the final phenotype. The high-throughput analysis platform used to identify candidate metabolites and describe their contributions can help to quickly d…
View article: Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy
Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy Open
Diabetic retinopathy (DR) is a universal microvascular complication of diabetes mellitus (DM), which is the main reason for global sight damage/loss in middle-aged and/or older people. Current clinical analyses, like hemoglobin A1c, posses…