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View article: P0671 Supporting vedolizumab treatment throughout pregnancy: Insights from a population pharmacokinetic model
P0671 Supporting vedolizumab treatment throughout pregnancy: Insights from a population pharmacokinetic model Open
Background The pharmacokinetic (PK) profile of vedolizumab during pregnancy is not fully characterised, though concentrations have been reported to drop1.To minimise transplacental transfer, discontinuation in the 3rd trimester has been su…
View article: P0984 Treatment with allopurinol and low-dose azathioprine during pregnancy in patients with Inflammatory Bowel Disease. A Danish single center experience
P0984 Treatment with allopurinol and low-dose azathioprine during pregnancy in patients with Inflammatory Bowel Disease. A Danish single center experience Open
Background Low-dose azathioprine in combination with allopurinol (LD-AZA/ALLO) is a widely used treatment option in inflammatory bowel disease (IBD). Data on pregnancy and birth outcomes from exposure to combination therapy are sparse. The…
View article: Risk of cancer in patients with bile acid diarrhoea: a Danish nationwide matched cohort study
Risk of cancer in patients with bile acid diarrhoea: a Danish nationwide matched cohort study Open
Objective Bile acid diarrhoea is a common cause of chronic diarrhoea. Increased levels of potentially carcinogenic bile acids in faeces, theoretically, may increase the risk of colorectal cancer in particular, but the long-term disease cou…
View article: DOP79 Promising efficacy of biologicals and small molecules for microscopic colitis: results from a large real-life multicenter cohort
DOP79 Promising efficacy of biologicals and small molecules for microscopic colitis: results from a large real-life multicenter cohort Open
Background Microscopic colitis (MC) is a chronic inflammatory condition of the colon, resulting in an impaired quality of life due to debilitating watery diarrhea. First-line therapy consists of budesonide, though a subset of patients is r…
View article: Prospective comparison of diagnostic tests for bile acid diarrhoea
Prospective comparison of diagnostic tests for bile acid diarrhoea Open
Summary Background Bile acid diarrhoea is often missed because gold standard nuclear medicine tauroselcholic [75‐Se] acid (SeHCAT) testing has limited availability. Empirical treatment effect has unknown diagnostic performance, whereas pla…
View article: Low-dose azathioprine and allopurinol versus azathioprine monotherapy in patients with ulcerative colitis (AAUC): An investigator-initiated, open, multicenter, parallel-arm, randomised controlled trial
Low-dose azathioprine and allopurinol versus azathioprine monotherapy in patients with ulcerative colitis (AAUC): An investigator-initiated, open, multicenter, parallel-arm, randomised controlled trial Open
Funding for AAUC was provided by The Capital Region of Denmark (Regionernes Medicinpulje (6062/16)).
View article: The Process of Developing a Disease Activity Index in Microscopic Colitis
The Process of Developing a Disease Activity Index in Microscopic Colitis Open
Background and Aims Patient-reported outcome measures [PROMs] aim to measure patients’ perception of how their disorder influences everyday functioning. The objective of this study was to develop a PROM to assess disease activity in micros…
View article: Vedolizumab clearance in neonates, susceptibility to infections and developmental milestones: a prospective multicentre population‐based cohort study
Vedolizumab clearance in neonates, susceptibility to infections and developmental milestones: a prospective multicentre population‐based cohort study Open
Summary Background Little is known about the consequences of intrauterine exposure to, and the post‐natal clearance of, vedolizumab. Aims To investigate the levels of vedolizumab in umbilical cord blood of newborns and rates of clearance a…
View article: Effect of cholecystectomy on bile acid diarrhoea biomarkers: A prospective clinical study
Effect of cholecystectomy on bile acid diarrhoea biomarkers: A prospective clinical study Open
Background The pathophysiological mechanisms of bile acid diarrhoea after cholecystectomy are unknown. Therefore, we aimed to explore the effects of cholecystectomy on the plasma biomarkers of bile acid diarrhoea: fibroblast growth factor …
View article: P347 Vedolizumab as first line biologic therapy in elderly patients with contraindications against anti-TNF therapy - A real-world nationwide cohort of patients with inflammatory bowel diseases
P347 Vedolizumab as first line biologic therapy in elderly patients with contraindications against anti-TNF therapy - A real-world nationwide cohort of patients with inflammatory bowel diseases Open
Background Data regarding the efficacy and safety of vedolizumab as the first line of biologic therapy for elderly patients with ulcerative colitis (UC) and Crohn’s disease (CD) or patients with contraindications against anti-tumor necrosi…
View article: European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations
European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations Open
Introduction Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost normal endoscopic appearance of the colon, chronic watery, nonbloody diarrhoea and distinct histological abnormalities, which identi…
View article: Biochemical Diagnosis of Bile Acid Diarrhea: Prospective Comparison With the 75Seleno-Taurohomocholic Acid Test
Biochemical Diagnosis of Bile Acid Diarrhea: Prospective Comparison With the 75Seleno-Taurohomocholic Acid Test Open
INTRODUCTION: The diagnosis of bile acid diarrhea is often missed because the availability of the 75 seleno-taurohomocholic acid (SeHCAT) test is limited. We aimed to compare the biomarkers 7α-hydroxy-4-cholesten-3-one (C4) and fibroblast …
View article: P524 Administration and monitoring of biologic therapy in patients with inflammatory bowel disease: A national Danish survey
P524 Administration and monitoring of biologic therapy in patients with inflammatory bowel disease: A national Danish survey Open
Background Administration and monitoring of biologic therapy to patients with inflammatory bowel disease (IBD) is an increasing burden in gastroenterology outpatient clinics. The aim of this study was to compare the present organisation of…
View article: Anti-TNF Therapy in Pregnant Women With Inflammatory Bowel Disease: Effects of Therapeutic Strategies on Disease Behavior and Birth Outcomes
Anti-TNF Therapy in Pregnant Women With Inflammatory Bowel Disease: Effects of Therapeutic Strategies on Disease Behavior and Birth Outcomes Open
Discontinuation of anti-TNF before gestational week 30 did not increase the risk of relapse in the third trimester. Relapse and continuation of anti-TNF throughout pregnancy were each independently associated with lower birth weight, a mar…
View article: Fecal Calprotectin Is Not Affected by Pregnancy
Fecal Calprotectin Is Not Affected by Pregnancy Open
The physiological changes that occur during pregnancy do not affect FC, in contrast to CRP and HBI/SCCAI. The combined use of FC and PGA seems optimal to assess disease activity in IBD during pregnancy.
View article: Chenodeoxycholic acid stimulated fibroblast growth factor 19 response – a potential biochemical test for bile acid diarrhoea.
Chenodeoxycholic acid stimulated fibroblast growth factor 19 response – a potential biochemical test for bile acid diarrhoea. Open
Summary Background Bile acid diarrhoea is underdiagnosed and better diagnostic tests are needed. Fasting serum fibroblast growth factor‐19 ( FGF 19) has insufficient diagnostic value, but this may be improved by stimulation. Aim To explore…
View article: The Danish National Registry for Biological Therapy in Inflammatory Bowel Disease
The Danish National Registry for Biological Therapy in Inflammatory Bowel Disease Open
The database will be available for research during 2016. Data will be made available by The Danish Clinical Registries (www.rkkp.dk).