Explanipedia

Elevated levels of peripheral and central nervous system immune markers reflect innate immune dysregulation in autism spectrum disorder Open

Attila Szabó, Kevin S. O’Connell, Ibrahim A. Akkouh, Thor Ueland, Ida E. Sønderby , et al. · 2024

Our results suggest a role for inflammasome dysregulation in ASD pathophysiology.

Bidirectional genetic overlap between autism spectrum disorder and cognitive traits Open

Sigrun Hope, Alexey Shadrin, Aihua Lin, Shahram Bahrami, Linn Rødevand , et al. · 2023

Autism spectrum disorder (ASD) is a highly heritable condition with a large variation in cognitive function. Here we investigated the shared genetic architecture between cognitive traits (intelligence (INT) and educational attainment (EDU)…

Systemic immune profile in Prader-Willi syndrome: elevated matrix metalloproteinase and myeloperoxidase and reduced macrophage inhibitory factor Open

Sigrun Hope, Terje Nærland, Svein O. Kolset, Thor Ueland, Ole A. Andreassen , et al. · 2023

Sex as a Moderator Between Parent Ratings of Executive Dysfunction and Social Difficulties in Children and Adolescents with Autism Spectrum Disorder Open

Tonje Torske, Terje Nærland, Daniel Quintana, Ruth Elizabeth Hypher, Anett Kaale , et al. · 2022

Girls and boys might differ in autistic symptoms and associated cognitive difficulties such as executive function (EF). We investigated sex differences in the relationship between parent rated EF and autistic symptoms in 116 children and a…

Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation Open

Mashhood Ahmed Sheikh, Kevin S. O‘Connell, Tove Lekva, Attila Szabó, Ibrahim A. Akkouh , et al. · 2022

Our results support a systemic and cerebral dysregulation of soluble ICAM-1 expression in SMI and especially in patients with SCZ.

Bidirectional genetic overlap between autism spectrum disorder and cognitive traits Open

Sigrun Hope, Aihua Lin, Shahram Bahrami, Linn Rødevand, Oleksandr Frei , et al. · 2022

Objective Autism Spectrum Disorder (ASD) is a highly heritable condition with a large variation in cognitive function. Here we investigated the shared genetic architecture between cognitive traits (intelligence (INT) and educational attain…

Correction to: Attitudes among parents of persons with autism spectrum disorder towards information about genetic risk and future health Open

J. S. Johannessen, Terje Nærland, Sigrun Hope, Tonje Torske, Anett Kaale , et al. · 2021

Attitudes among parents of persons with autism spectrum disorder towards information about genetic risk and future health Open

J. S. Johannessen, Terje Nærland, Sigrun Hope, Tonje Torske, Anett Kaale , et al. · 2021

Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation Open

Attila Szabó, Kevin S. O’Connell, Thor Ueland, Mashhood Ahmed Sheikh, Ingrid Agartz , et al. · 2021

Based on these results, we suggest a role for inflammasome activation/dysregulation in SMI. Our findings further the understanding of possible underlying inflammatory mechanisms and may expose important therapeutic targets in SMI.

Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study Open

John Abel Engh, Thor Ueland, Ingrid Agartz, Dimitrios Andreou, Pål Aukrust , et al. · 2021

Background Immune dysfunction has been implicated in the pathogenesis of schizophrenia and other nonaffective psychosis (SCZ), bipolar spectrum disorder (BIP) and major depressive disorder (MDD). The cytokines B cell-activating factor (BAF…

Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation Open

Attila Szabó, Kevin S. O’Connell, Thor Ueland, Mashhood Ahmed Sheikh, Ingrid Agartz , et al. · 2021

Background Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their pathophysiology. Howeve…

Treatment experience in two adults with creatinfe transporter deficiency Open

Jack Schjelderup, Sigrun Hope, Christian Vatshelle, Clara van Karnebeek · 2021

Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders Open

Elina J. Reponen, Ingrid Dieset, Martin Tesli, Ragni H. Mørch, Monica Aas , et al. · 2020

Our findings suggest that low-grade inflammation and abnormal neutrophil activation may cause increased CVD risk in patients with psychotic disorders. These mechanisms should be further examined to determine the potential for development o…

Nutritional challenges in children and adolescents with Down syndrome Open

Marianne Nordstrøm, Kjetil Retterstøl, Sigrun Hope, Svein O. Kolset · 2020

T8. ATHEROGENIC LIPID RATIOS RELATED TO MYELOPEROXIDASE AND C-REACTIVE PROTEIN LEVELS IN PSYCHOTIC DISORDERS Open

Elina J. Reponen, Ingrid Dieset, Martin Tesli, Ragni H. Mørch, Nils Eiel Steen , et al. · 2019

Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders. The interaction between lipid accumulation, inflammation and vascular remodeling promotes atherogenesis and adverse CVD outcomes. We hyp…

Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders Open

Nils Eiel Steen, Ingrid Dieset, Sigrun Hope, Trude Seselie Jahr Vedal, Olav B. Smeland , et al. · 2019

Background We aimed at exploring potential pathophysiological processes across psychotic disorders, applying metabolomics in a large and well-characterized sample of patients and healthy controls. Methods Patients with schizophrenia and bi…

Intellectual Disability Associated With Pyridoxine-Responsive Epilepsies: The Need to Protect Cognitive Development Open

Bjørnar Hassel, Ane Gretesdatter Rogne, Sigrun Hope · 2019

Pyridoxine (vitamin B6)-responsive epilepsies are severe forms of epilepsy that manifest as seizures immediately after birth, sometimes in utero, sometimes months, or years after birth. Seizures may be treated efficiently by life-lo…

Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors – ERRATUM Open

Ragni H. Mørch, Ingrid Dieset, Ann Færden, Elina J. Reponen, Sigrun Hope , et al. · 2019

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Identification of common genetic risk variants for autism spectrum disorder Open

Jakob Grove, Stephan Ripke, Thomas D. Als, Manuel Mattheisen, Raymond K. Walters , et al. · 2019

Sex differences in the relationship between social difficulties and executive dysfunction in children and adolescents with autism spectrum disorder Open

Tonje Torske, Terje Nærland, Daniel Quintana, Ruth Elizabeth Hypher, Anett Kaale , et al. · 2018

The prevalence of autism spectrum disorder (ASD) in boys is nearly four times higher than in girls, and the causes of this sex difference are not fully known. Difficulties in executive function may be involved in development of autistic sy…

An association between <span>YKL</span>‐40 and type 2 diabetes in psychotic disorders Open

Ingrid Dieset, Ragni H. Mørch, Sigrun Hope, Eva Hoseth, Elina J. Reponen , et al. · 2018

Objective This study examines if YKL ‐40 is increased in individuals with psychotic disorders and if elevated YKL ‐40 levels at baseline is associated with subsequent development of type 2 diabetes. Method A total of 1383 patients with a d…

Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders Open

Monica Aas, Ingrid Dieset, Ragni H. Mørch, Nils Eiel Steen, Sigrun Hope , et al. · 2018

Securing rights and nutritional health for persons with intellectual disabilities – a pressing challenge Open

Svein O. Kolset, Marianne Nordstrøm, Sigrun Hope, Kjetil Retterstøl, Per Ole Iversen · 2018

Persons with intellectual disabilities (ID) are dependent on nutritional policies that have so far not been addressed in a systematic and health-promoting manner in Norway and other nations with a high socioeconomic standard. In many poor …

Attenuated Notch signaling in schizophrenia and bipolar disorder Open

Eva Z. Hoseth, Florian Krull, Ingrid Dieset, Ragni H. Mørch, Sigrun Hope , et al. · 2018

Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder Open

Eva Z. Hoseth, Florian Krull, Ingrid Dieset, Ragni H. Mørch, Sigrun Hope , et al. · 2018

The right to a health-promoting diet for people with intellectual disabilities Open

Sigrun Hope, Marianne Nordstrøm, Kjetil Retterstøl, Per Ole Iversen, Svein O. Kolset · 2018

Common risk variants identified in autism spectrum disorder Open

Jakob Grove, Stephan Ripke, Thomas D. Als, Manuel Mattheisen, Raymond K. Walters , et al. · 2017

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no ind…

Event-Related Potentials in a Cued Go-NoGo Task Associated with Executive Functions in Adolescents with Autism Spectrum Disorder; A Case-Control Study Open

Anne Lise Høyland, Geir Øgrim, Stian Lydersen, Sigrun Hope, Morten Engstrøm , et al. · 2017

Executive functions are often affected in autism spectrum disorders (ASD). The underlying biology is however not well known. In the DSM-5, ASD is characterized by difficulties in two domains: Social Interaction and Repetitive and Restricte…

Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses Open

Monica Aas, Ingrid Dieset, Sigrun Hope, Eva Hoseth, Ragni H. Mørch , et al. · 2017

Dose-dependent social-cognitive effects of intranasal oxytocin delivered with novel Breath Powered device in adults with autism spectrum disorder: a randomized placebo-controlled double-blind crossover trial Open

Daniel Quintana, Lars T. Westlye, Sigrun Hope, Terje Nærland, Torbjørn Elvsåshagen , et al. · 2017

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