Explanipedia

Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection Open

Ieva Bagdonaite, Irina N. Marinova, Asha M. Rudjord-Levann, Emil M.H. Pallesen, Sarah L. King‐Smith , et al. · 2023

Structure and Role of O-Linked Glycans in Viral Envelope Proteins Open

Sigvard Olofsson, Marta Bally, Edward Trybala, Tomas Bergström · 2023

N- and O-glycans are both important constituents of viral envelope glycoproteins. O-linked glycosylation can be initiated by any of 20 different human polypeptide O-acetylgalactosaminyl transferases, resulting in an important functional O-…

Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection Open

Ieva Bagdonaite, Irina N. Marinova, Asha M. Rudjord-Levann, Emil MH Pallesen, Sarah L. King‐Smith , et al. · 2022

Viral and host glycans represent an understudied aspect of host-pathogen interactions, despite potential implications for treatment of viral infections. This is due to lack of easily accessible tools for analyzing glycan function in a mean…

Cellular Chondroitin Sulfate and the Mucin-like Domain of Viral Glycoprotein C Promote Diffusion of Herpes Simplex Virus 1 While Heparan Sulfate Restricts Mobility Open

Yara Abidine, Lifeng Liu, Oskar Wallén, Edward Trybala, Sigvard Olofsson , et al. · 2022

The diffusion of viruses at the cell membrane is essential to reach a suitable entry site and initiate subsequent internalization. Although many viruses take advantage of glycosaminoglycans (GAG) to bind to the cell surface, little is know…

Recombinant Glycoprotein E of Varicella Zoster Virus Contains Glycan-Peptide Motifs That Modulate B Cell Epitopes into Discrete Immunological Signatures Open

Rickard Nordén, Jonas Nilsson, Ebba Samuelsson, Christian Risinger, Carina Sihlbom , et al. · 2019

A recombinant subunit vaccine (Shingrix®) was recently licensed for use against herpes zoster. This vaccine is based on glycoprotein E (gE) of varicella zoster virus (VZV), the most abundantly expressed protein of VZV, harboring sites for …

Regulatory Mechanisms of the Mucin-Like Region on Herpes Simplex Virus during Cellular Attachment Open

Martin Delguste, Nadia Peerboom, Grégoire Le Brun, Edward Trybala, Sigvard Olofsson , et al. · 2019

Mucin-like regions, characterized by a local high density of O-linked glycosylation, are found on the viral envelope glycoproteins of many viruses. Herpes simplex virus type 1 (HSV-1), for example, exhibits a mucin-like region on its glyco…

Linear Multiepitope (Glyco)peptides for Type-Specific Serology of Herpes Simplex Virus (HSV) Infections Open

Christian Risinger, Kasper K. Sørensen, Knud J. Jensen, Sigvard Olofsson, Tomas Bergström , et al. · 2017

Detection of type-specific antibodies is an important and essential part of accurate diagnosis, even in silent carriers of herpes simplex virus (HSV)-1 (oral) and HSV-2 (genital) infections. Serologic assays that identify HSV-1 and HSV-2 t…

Global Mapping of O-Glycosylation of Varicella Zoster Virus, Human Cytomegalovirus, and Epstein-Barr Virus Open

Ieva Bagdonaite, Rickard Nordén, Hiren J. Joshi, Sarah L. King, Sergey Y. Vakhrushev , et al. · 2016

Herpesviruses are among the most complex and widespread viruses, infection and propagation of which depend on envelope proteins. These proteins serve as mediators of cell entry as well as modulators of the immune response and are attractiv…

Elongation of O-linked glycans affects HSV-1 secretion/infectivity. Open

Ieva Bagdonaite, Rickard Nordén, J. Joshi Hiren, Dabelsteen Sally, Kristina Nystrôm , et al. · 2015

(A) HaCaT wild-type or HaCaT mutant keratinocytes, lacking elongation of mucin-type O-liked glycosylation (HaCaT sc D5 and HaCaT sc E5) were infected with MOI of 10 of HSV-1 Syn17+ produced in HaCaT wt. Medium was harvested at 12 and 20 ho…

A Strategy for O-Glycoproteomics of Enveloped Viruses—the O-Glycoproteome of Herpes Simplex Virus Type 1 Open

Ieva Bagdonaite, Rickard Nordén, Hiren J. Joshi, Sally Dabelsteen, Kristina Nystrôm , et al. · 2015

Glycosylation of viral envelope proteins is important for infectivity and interaction with host immunity, however, our current knowledge of the functions of glycosylation is largely limited to N-glycosylation because it is difficult to pre…

Published sequences do not support transfer of oseltamivir resistance mutations from avian to human influenza A virus strains Open

Peter Norberg, Magnus Lindh, Sigvard Olofsson · 2015

The results indicate that resistance in influenza viruses infecting humans is due to the selection pressure posed by the global OE administration in humans rather than transfer from avian influenza A virus strains carrying mutations induce…

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