Siham Al‐Sinani
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View article: Hepatitis C Direct-Acting Antivirals in the Immunosuppressed Host: Mechanisms, Interactions, and Clinical Outcomes
Hepatitis C Direct-Acting Antivirals in the Immunosuppressed Host: Mechanisms, Interactions, and Clinical Outcomes Open
Direct-acting antivirals (DAAs) have transformed hepatitis C virus (HCV) management, offering high cure rates, favorable safety, and simplified regimens. Management in immunosuppressed patients remains challenging due to drug–drug interact…
View article: The Seroprevalence, Risk Factors, and Clinical Profile of Hepatitis D in Omani Patients with Chronic Hepatitis B: A Multicenter Cross-Sectional Study
The Seroprevalence, Risk Factors, and Clinical Profile of Hepatitis D in Omani Patients with Chronic Hepatitis B: A Multicenter Cross-Sectional Study Open
Background: Since the introduction of the hepatitis B virus (HBV) vaccination program in Oman in 1990, the HBV prevalence has markedly decreased. However, hepatitis D virus (HDV) infection, which is associated with progressive liver diseas…
View article: The Seroprevalence, Risk Factors, and Clinical Profile of Hepatitis D in Patients with Chronic Hepatitis B in Oman: A Multicenter Cross-Sectional Study
The Seroprevalence, Risk Factors, and Clinical Profile of Hepatitis D in Patients with Chronic Hepatitis B in Oman: A Multicenter Cross-Sectional Study Open
Background: Since the introduction of the hepatitis B virus (HBV) vaccination program in Oman in 1990, the HBV prevalence has markedly decreased. However, hepatitis D virus (HDV) infection, which is associated with progressive liver diseas…
View article: Association of the Magnitude of Anti-SARS-CoV-2 Vaccine Side Effects with Sex, Allergy History, Chronic Diseases, Medication Intake, and SARS-CoV-2 Infection
Association of the Magnitude of Anti-SARS-CoV-2 Vaccine Side Effects with Sex, Allergy History, Chronic Diseases, Medication Intake, and SARS-CoV-2 Infection Open
Vaccination provides the best protection against the increasing infections of SARS-CoV-2. The magnitude and type of anti-SARS-CoV-2 vaccine side effects (SEs) depend on parameters that are not fully understood. In this cross-sectional stud…
View article: Hepatitis B Related Liver Cirrhosis in Oman
Hepatitis B Related Liver Cirrhosis in Oman Open
Objectives: An estimated 887 000 deaths were due to chronic hepatitis B (CHB) related complications in 2015 worldwide. Most of these deaths were related to decompensated liver cirrhosis and hepatocellular carcinoma (HCC). Oman is a country…
View article: Programmatic Evaluation: A Prospect in Program Evaluation Design
Programmatic Evaluation: A Prospect in Program Evaluation Design Open
Improving the provision of health care is the ultimate goal of health profession education (HPE) programs. Therefore, a well-founded evaluation program is fundamental in the effective planning and implementation of HPE to achieve quality h…
View article: Graduate Medical Education Accreditation Across Borders: Toward a Remote Alternative
Graduate Medical Education Accreditation Across Borders: Toward a Remote Alternative Open
Preparing for accreditation involves months of planning, heaps of documentation, and multiple meetings with stakeholders. The groundwork may vary according to the program and local context; however, the fundamentals remain the same.1Until …
View article: Medical research during the COVID-19 pandemic
Medical research during the COVID-19 pandemic Open
The current pandemic of coronavirus disease 2019 (COVID-19) which was first detected in Wuhan, China in December 2019 is caused by the novel coronavirus named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The virus has quic…
View article: Navigating the ‘Next Normal’ in Medical Education Post COVID-19
Navigating the ‘Next Normal’ in Medical Education Post COVID-19 Open
In Graduate Medical Education (GME), disaster management plans are put in place to navigate possible disasters or closures in training sites to ensure continuity. However, what happens when all training sites are facing the disaster such a…
View article: Hepatocellular Carcinoma in Oman: An analysis of 284 cases
Hepatocellular Carcinoma in Oman: An analysis of 284 cases Open
The majority of Omani HCC patients were male and had cirrhosis due to viral hepatitis. In addition, few patients were identified by the national surveillance programme and presented with advanced disease precluding therapeutic or even pall…
View article: Cystic Fibrosis Liver Disease: Know More
Cystic Fibrosis Liver Disease: Know More Open
Cystic fibrosis (CF) is a multisystem disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. CFTR is expressed in the apical surface of cholangiocytes. Homozygous CFTR gene mutation results in viscous and ac…
View article: Characteristics, Trends, and Factors Associated With Publication Among Residents of Oman Medical Specialty Board Programs
Characteristics, Trends, and Factors Associated With Publication Among Residents of Oman Medical Specialty Board Programs Open
Background Research during residency is associated with better clinical performance, improved critical thinking, and increased interest in an academic career. Objective We examined the rate, characteristics, and factors associated with res…
View article: Preparing for ACGME-I Accreditation: An International Perspective
Preparing for ACGME-I Accreditation: An International Perspective Open
The Oman Medical Specialty Board (OMSB) sponsors graduate medical education programs that comprise 560 residents and approximately 600 faculty, distributed among 6 major centers and multiple local health centers (such as family medicine ce…
View article: <i>Helicobacter Pylori</i> infection in Omani children
<i>Helicobacter Pylori</i> infection in Omani children Open
Sharef W. Sharef appeared as the author's name when the article was published in issue 19:4 of Helicobacter, and the author would like to have it corrected to Sharef Waadallah Al-Mulaabed.1 The authors would like to apologize for any confu…
View article: Supplementary Material for: Liver Disease and Other Comorbidities in Wolcott-Rallison Syndrome: Different Phenotype and Variable Associations in a Large Cohort
Supplementary Material for: Liver Disease and Other Comorbidities in Wolcott-Rallison Syndrome: Different Phenotype and Variable Associations in a Large Cohort Open
Background: Wolcott-Rallison syndrome (WRS) is caused by recessive EIF2AK3 mutations and characterized by early-onset diabetes and skeletal dysplasia. Hepatic dysfunction has been reported in 60% of patients. Aims: To describe a cohort of …
View article: Supplementary Material for: Liver Disease and Other Comorbidities in Wolcott-Rallison Syndrome: Different Phenotype and Variable Associations in a Large Cohort
Supplementary Material for: Liver Disease and Other Comorbidities in Wolcott-Rallison Syndrome: Different Phenotype and Variable Associations in a Large Cohort Open
Background: Wolcott-Rallison syndrome (WRS) is caused by recessive EIF2AK3 mutations and characterized by early-onset diabetes and skeletal dysplasia. Hepatic dysfunction has been reported in 60% of patients. Aims: To describe a cohort of …
View article: Congenital generalized lipodystrophy: identification of novel variants and expansion of clinical spectrum
Congenital generalized lipodystrophy: identification of novel variants and expansion of clinical spectrum Open
Congenital generalized lipodystrophy ( CGL ) is an autosomal recessive disorder with two major subtypes. Variants in AGPAT2 result in CGL type 1 with milder manifestations, whereas BSCL2 variants cause CGL type 2 with more severe features.…
View article: Adult Hepatoblastoma : What do we know?
Adult Hepatoblastoma : What do we know? Open
Hepatoblastoma (HB), despite being rare, is the most common malignant hepatic tumour in children. It is debatable whether adult HB occurs as an entity. Several features of the tumours described in adults are strikingly different from HB in…
View article: Incidence and Risk Factors of Parenteral Nutrition-Associated Cholestasis in Omani Neonates : Single centre experience
Incidence and Risk Factors of Parenteral Nutrition-Associated Cholestasis in Omani Neonates : Single centre experience Open
This study found a PNAC incidence of 39% in Omani neonates. There were several significant risk factors for PNAC in Omani neonates; however, after logistic regression analysis, only total PN duration remained statistically significant. Pre…
View article: 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography in the Management of Metastatic Colorectal Cancer : Are we there yet?
18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography in the Management of Metastatic Colorectal Cancer : Are we there yet? Open
Colorectal cancer (CRC) is the second most commonly diagnosed cancer in females and the third in males. More than 1.2 million cases around the globe are diagnosed every year and it is the estimated cause of death for more than half a milli…
View article: Novel Mutation in Wolcott–Rallison Syndrome with Variable Expression in Two Omani Siblings
Novel Mutation in Wolcott–Rallison Syndrome with Variable Expression in Two Omani Siblings Open
Wolcott-Rallison syndrome (WRS) is an autosomal recessive disease, characterized by neonatal or early-onset non-autoimmune insulin-dependent diabetes. WRS, although rare, is recognized to be the most frequent cause of neonatal-onset diabet…
View article: Prevalence of Hepatitis C among Multi-transfused Thalassaemic Patients in Oman : Single centre experience
Prevalence of Hepatitis C among Multi-transfused Thalassaemic Patients in Oman : Single centre experience Open
It is likely that the high prevalence of HCV among multi-transfused thalassaemic patients in Oman is due to blood transfusions dating from before the implementation of HCV screening in 1991 as the risk of HCV-associated transfusions has si…
View article: Liver Disease and Other Comorbidities in Wolcott-Rallison Syndrome: Different Phenotype and Variable Associations in a Large Cohort
Liver Disease and Other Comorbidities in Wolcott-Rallison Syndrome: Different Phenotype and Variable Associations in a Large Cohort Open
Background: Wolcott-Rallison syndrome (WRS) is caused by recessive EIF2AK3 mutations and characterized by early-onset diabetes and skeletal dysplasia. Hepatic dysfunction has been reported in 60% of patients. Aims: To describe a cohort of …