Siham Boumhaouad
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View article: Altered striatal dopamine regulation in <i>ADGRL3</i> knockout mice
Altered striatal dopamine regulation in <i>ADGRL3</i> knockout mice Open
Dopaminergic signaling is essential for regulating movement, learning, and reward. Disruptions in this system are linked to neuropsychiatric disorders such as ADHD. ADGRL3, an adhesion G protein-coupled receptor highly expressed in the bra…
View article: Regulation of dopamine release by tonic activity patterns in the striatal brain slice
Regulation of dopamine release by tonic activity patterns in the striatal brain slice Open
Voluntary movement, motivation, and reinforcement learning depend on the activity of ventral midbrain neurons that extend axons to release dopamine (DA) in the striatum. These neurons exhibit two patterns of action potential activity: a lo…
View article: Decreased Dorsomedial Striatum Direct Pathway Neuronal Activity Is Required for Learned Motor Coordination
Decreased Dorsomedial Striatum Direct Pathway Neuronal Activity Is Required for Learned Motor Coordination Open
It has been suggested that the dorsomedial striatum (DMS) is engaged in the early stages of motor learning for goal-directed actions, whereas at later stages, control is transferred to the dorsolateral striatum (DLS), a process that enable…