Shaozhen Zhao
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View article: Exploring Machine Learning Models for Vault Safety in ICL Implantation: A Comparative Analysis of Regression and Classification Models
Exploring Machine Learning Models for Vault Safety in ICL Implantation: A Comparative Analysis of Regression and Classification Models Open
Classification models, particularly gradient boosting and random forest, demonstrated strong potential for predicting clinically significant vault categories, enabling personalized surgical planning and improved risk management. While regr…
View article: Efficacy of 3% diquafosol sodium eye drops at different frequencies in the treatment of dry eye after FS-LASIK
Efficacy of 3% diquafosol sodium eye drops at different frequencies in the treatment of dry eye after FS-LASIK Open
AIM: To compare the efficacy of 3% diquafosol sodium (DQS) eye drops at different frequencies in dry eye (DE) after femtosecond laser-assisted in situ keratomileusis (FS-LASIK). METHODS: In this prospective study, DE patients after FS-LASI…
View article: The impact of glycemic control and duration of diabetes on clinical manifestation of ocular surface in middle-aged and elderly type 2 diabetic population
The impact of glycemic control and duration of diabetes on clinical manifestation of ocular surface in middle-aged and elderly type 2 diabetic population Open
Purpose To investigate the impact of glycemic control and duration of diabetes on clinical manifestation of dry eye in middle-aged and elderly type 2 diabetic population of Tianjin, Northern China. Methods Participants aged over 50 years w…
View article: Clinical characteristics and risk factors for readmission after deep anterior lamellar keratoplasty: a nationwide, cross-sectional, multicenter study
Clinical characteristics and risk factors for readmission after deep anterior lamellar keratoplasty: a nationwide, cross-sectional, multicenter study Open
View article: Efficacy of a simple intravitreal perfluoropropane injection in treating unclosed idiopathic macular holes following vitrectomy
Efficacy of a simple intravitreal perfluoropropane injection in treating unclosed idiopathic macular holes following vitrectomy Open
For patients with unclosed MHs after primary PPV, the presence of the 'cuff' sign on OCT suggests that retreatment can be effectively achieved through a simple intravitreal gas injection. This approach is straightforward, practical, and ef…
View article: Impact of tear film stability on corneal refractive power measurement and surgical planning for cataract
Impact of tear film stability on corneal refractive power measurement and surgical planning for cataract Open
This study highlights that tear film instability can lead to deviations in corneal refractive power and astigmatism measurements, contributing to increased prediction errors in IOL power calculation, particularly with the SRK-T formula.
View article: Impact of corneal sub-basal nerve plexus on epithelial thickness after small incision lenticule extraction (SMILE): a quantitative assessment using in vivo confocal microscopy and optical coherence tomography
Impact of corneal sub-basal nerve plexus on epithelial thickness after small incision lenticule extraction (SMILE): a quantitative assessment using in vivo confocal microscopy and optical coherence tomography Open
Uneven epithelial thickness changes were observed after SMILE, regional epithelial thickening increased corneal oblateness. Non-uniform SNP regeneration was also observed, positive correlation between epithelial thickness and nerve paramet…
View article: Effects of corneal epithelial remodeling on corneal asphericity after FS-LASIK and Trans-PRK: A prospective study
Effects of corneal epithelial remodeling on corneal asphericity after FS-LASIK and Trans-PRK: A prospective study Open
Purpose: To observe the changes in corneal epithelial thickness after FS-LASIK and Trans-PRK surgery and to investigate the impact of corneal epithelial remodeling on Q-value and HOA. Methods: In this prospective cohort study, 50 patients …
View article: Water-Free Cyclosporine Ophthalmic Solution vs Vehicle for Dry Eye Disease
Water-Free Cyclosporine Ophthalmic Solution vs Vehicle for Dry Eye Disease Open
Importance Dry eye disease (DED) is a prevalent eye disorder. Cyclosporine is an effective immunomodulator that is widely used in DED; however, due to its highly hydrophobic nature, delivery of cyclosporine to the ocular surface is challen…
View article: Varenicline solution nasal spray for dry eye disease in Chinese patients: a randomized phase 3 trial
Varenicline solution nasal spray for dry eye disease in Chinese patients: a randomized phase 3 trial Open
Jixing Pharmaceutical Co. Ltd.
View article: Efficacy of simple intravitreal gas injection for treating unclosed idiopathic macular holes after vitrectomy
Efficacy of simple intravitreal gas injection for treating unclosed idiopathic macular holes after vitrectomy Open
Background This study aimed to observe the efficacy of simple intravitreal injection of C3F8 in the treatment of unclosed idiopathic macular holes (IMH) in patients after primary pars plana vitrectomy (PPV). Methods T…
View article: Morphological features of the eyelid margin in relation to conjunctival goblet cells and MUC5AC in tear film and clinical tests of dry eye
Morphological features of the eyelid margin in relation to conjunctival goblet cells and MUC5AC in tear film and clinical tests of dry eye Open
Purpose This study aimed to investigate the morphological features of eyelid margin in dry eye patients and determine their correlations with conjunctival goblet cells, MUC5AC secretion, and clinical tests of tear film. Methods Patients di…
View article: Functional role of translocator protein and its ligands in ocular diseases (Review)
Functional role of translocator protein and its ligands in ocular diseases (Review) Open
The 18 kDa translocator protein (TSPO) is an essential outer mitochondrial membrane protein that is responsible for mitochondrial transport, maintenance of mitochondrial homeostasis and normal physiological cell function. The role of TSPO …
View article: Identification of key genes modules linking diabetic retinopathy and circadian rhythm
Identification of key genes modules linking diabetic retinopathy and circadian rhythm Open
Background Diabetic retinopathy (DR) is a leading cause of vision loss worldwide. Recent studies highlighted the crucial impact of circadian rhythms (CR) on normal retinopathy in response to the external light cues. However, the role of ci…
View article: A deep learning-based model for automatic segmentation and evaluation of corneal neovascularization using slit-lamp anterior segment images
A deep learning-based model for automatic segmentation and evaluation of corneal neovascularization using slit-lamp anterior segment images Open
The fully automated network model IterNet provides a time-saving and efficient method to make a quantitative evaluation of CoNV using slit-lamp anterior segment images. This method demonstrates great value and clinical application potentia…
View article: Clinical and in vivo confocal microscopy characteristics of Candida keratitis following keratoplasty
Clinical and in vivo confocal microscopy characteristics of Candida keratitis following keratoplasty Open
View article: Effect of preoperative pupil offset on corneal higher-order aberrations after femtosecond laser-assisted in situ keratomileusis
Effect of preoperative pupil offset on corneal higher-order aberrations after femtosecond laser-assisted in situ keratomileusis Open
Background This study aimed to investigate the relationship between multiple higher-order aberrations (HOAs) subgroups and pupil offset, as well as to analyze the factors affecting postoperative corneal HOAs in patients with different degr…
View article: Overcoming the Stromal Barrier of the Cornea with a Peptide Conjugate Nano‐Assembly to Combat Fungal Keratitis (Adv. Healthcare Mater. 10/2023)
Overcoming the Stromal Barrier of the Cornea with a Peptide Conjugate Nano‐Assembly to Combat Fungal Keratitis (Adv. Healthcare Mater. 10/2023) Open
Fungal Keratitis In article 2202409, Shaozhen Zhao, Zhongwei Niu, Ruibo Yang, and co-workers report a peptide conjugate nano-assembly (PCNA) that permeates corneal stroma and kills the hyphae without irritating the ocular cornea. PCNA with…
View article: Perfluorohexyloctane Eye Drops for Dry Eye Disease Associated With Meibomian Gland Dysfunction in Chinese Patients
Perfluorohexyloctane Eye Drops for Dry Eye Disease Associated With Meibomian Gland Dysfunction in Chinese Patients Open
Importance Meibomian gland dysfunction (MGD) is a leading cause of evaporative dry eye disease (DED). Medical and surgical management for DED is limited; therefore, new treatment options are sought. Objective To evaluate the efficacy and s…
View article: ICL Postimplantation Decentration and Tilt in Myopic Patients with Primary Iridociliary Cysts
ICL Postimplantation Decentration and Tilt in Myopic Patients with Primary Iridociliary Cysts Open
Purpose . To observe the decentration and tilt of implantable collamer lens (ICL) as well as possible visual effects postimplantation in primary iridociliary cysts. Methods . The present investigation was a retrospective cohort study. All …
View article: Safety and Efficacy of the Phototherapeutic Keratectomy for Treatment of Recurrent Corneal Erosions: A Systematic Review and Meta-Analysis
Safety and Efficacy of the Phototherapeutic Keratectomy for Treatment of Recurrent Corneal Erosions: A Systematic Review and Meta-Analysis Open
Background: Phototherapeutic keratectomy (PTK) has been increasingly used to treat severe recurrent corneal erosion syndrome (RCES) patients who do not respond to other treatments. However, the efficacy and complication of ea…
View article: Effect of Preoperative Pupil Offset on Corneal Higher-Order Aberrations after Femtosecond Laser-Assisted In Situ Keratomileusis
Effect of Preoperative Pupil Offset on Corneal Higher-Order Aberrations after Femtosecond Laser-Assisted In Situ Keratomileusis Open
Background This study aimed to investigate the relationship between multiple higher-order aberrations (HOAs) subgroups and pupil offset, as well as to analyze the factors affecting postoperative corneal HOAs in patients with different degr…
View article: Impact of Dry Eye Disease on Visual Function and Quality after Femtosecond LaserAssisted In-Situ Keratomileusis
Impact of Dry Eye Disease on Visual Function and Quality after Femtosecond LaserAssisted In-Situ Keratomileusis Open
Purpose: The purpose of this study was to determine how objective and subjective parameters of dry eye disease correlate with objective vision quality changes following femtosecond laser in-situ keratomileusis (FS-LASIK) surgery in low and…
View article: The correlation between Demodex infestation and meibomian gland dysfunction at different ages
The correlation between Demodex infestation and meibomian gland dysfunction at different ages Open
Background This study aimed to explore the associations between Demodex infestation and the ocular surface characteristics of meibomian gland dysfunction (MGD) in different age groups, to further understand the effect of Demodex on MGD. Me…
View article: Clinical observations of EVO-ICL implantation and changes in corneal astigmatism using a modified technique
Clinical observations of EVO-ICL implantation and changes in corneal astigmatism using a modified technique Open
Background Implantable collamer lens (ICL) surgery techniques are constantly progressing. The purpose of this study was to investigate the application effect of the modified technique and its impact on the change in corneal astigmatism in …
View article: Acute Foggy Corneal Epithelial Disease: Seeking Clinical Features and Risk Factors
Acute Foggy Corneal Epithelial Disease: Seeking Clinical Features and Risk Factors Open
(1) Purpose: Here, we describe the clinical characteristics and predisposing factors of acute foggy corneal epithelial disease, a rare disease newly found during COVID-19 pandemic; (2) Methods: In this single-arm, ambispective case series …
View article: Characteristics of Pupil Offset in Young Asian Adults With Mild-Moderate and High Myopia
Characteristics of Pupil Offset in Young Asian Adults With Mild-Moderate and High Myopia Open
Subjects with high myopia with a larger pupil offset should be considered for better postoperative visual quality during refractive surgery.
View article: A novel analysis of Scheimpflug total corneal refractive power following corneal cross-linking in mild to moderate keratoconus
A novel analysis of Scheimpflug total corneal refractive power following corneal cross-linking in mild to moderate keratoconus Open
AIM: To detect an earlier improvement in mild to moderate keratoconus following corneal cross-linking (CXL) with total corneal refractive power (TCRP) using ray tracing method. METHODS: A total of 40 eyes of 30 consecutive patients who und…
View article: Mesenchymal stem cell derived exosomes-based immunological signature in a rat model of corneal allograft rejection therapy
Mesenchymal stem cell derived exosomes-based immunological signature in a rat model of corneal allograft rejection therapy Open
Background: Mesenchymal stem cells (MSCs) are promising candidates for immunomodulatory therapy that are currently being tested in corneal allograft rejection. In this study, we tested the effects of Mesenchymal stem cells derived exosomes…
View article: Comparative study of objective visual quality between FS-LASIK and SMART in myopia
Comparative study of objective visual quality between FS-LASIK and SMART in myopia Open
AIM: To compare the changes in the objective visual quality of patients with low and moderate myopia postoperatively after transepithelial photorefractive keratectomy using the smart pulse technology (SMART) and femtosecond laser in situ k…