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View article: Secondary Perianal Paget’s Disease Originating From Adenocarcinoma of the Anorectal Junction: A Case Report
Secondary Perianal Paget’s Disease Originating From Adenocarcinoma of the Anorectal Junction: A Case Report Open
Secondary extramammary Paget's disease (EMPD), originating from the cutaneous dissemination of malignant cells, represents a rare subtype prone to misdiagnosis. This study presents a case of secondary perianal Paget's disease (PPD) associa…
View article: GmFTIP09 regulated flowering time and seed weight
GmFTIP09 regulated flowering time and seed weight Open
Soybean is highly sensitive to photoperiod, which influences the growth period including flowering time (R1) and maturity (R8), ultimately affecting yield. In this study, we used a chromosome segment substitution lines population (CSSLs), …
View article: Identification and whole genome sequencing analysis of Bacillus subtilis K35-1, a highly efficient cellulose in forage degrading bacterium
Identification and whole genome sequencing analysis of Bacillus subtilis K35-1, a highly efficient cellulose in forage degrading bacterium Open
This study reports the isolation and characterization of Bacillus subtilis K35-1, a novel cellulolytic strain with exceptional forage degradation capabilities. From eight B. subtilis isolates obtained from yak rumen fluid through Congo red…
View article: Role of dietary energy and protein proportions on serum inflammatory factors, antioxidant capacity, and rumen microbiota in postpartum weaned female yak
Role of dietary energy and protein proportions on serum inflammatory factors, antioxidant capacity, and rumen microbiota in postpartum weaned female yak Open
Our study provides recommendations for improving the physical health of postpartum weaned female yaks, reducing the time from calving to estrus, and enhancing the reproductive capacity of yaks in Tibetan areas.
View article: Discovery of Small Molecules Against Foot-and-Mouth Disease Virus Replication by Targeting 2C Helicase Activity
Discovery of Small Molecules Against Foot-and-Mouth Disease Virus Replication by Targeting 2C Helicase Activity Open
Background: The 2C protein of foot-and-mouth disease virus (FMDV), a member of helicase superfamily 3 (SF3), drives viral genome replication and serves as a critical target for antiviral drug development. Methods: A fluorescence resonance …
View article: Algorithms to minimize the effect of maternal contamination in non-invasive chromosome screening
Algorithms to minimize the effect of maternal contamination in non-invasive chromosome screening Open
The CNV correction algorithm could be used to minimize the effect of maternal contamination in culture medium and enhance the accuracy of non-invasive chromosome screening.
View article: Evaluating the Effect of Dietary Protein–Energy Ratios on Yak Intestinal Microbiota Using High-Throughput 16S rRNA Gene Sequencing
Evaluating the Effect of Dietary Protein–Energy Ratios on Yak Intestinal Microbiota Using High-Throughput 16S rRNA Gene Sequencing Open
This study investigated the impact of varying dietary protein–energy ratios on the intestinal microbiota composition in postpartum weaned female yak. For this study, forty yaks were divided into four groups and provided with different diet…
View article: Overexpression of Suaeda salsa SsDHN Gene Enhances Salt Resistance in Tobacco by Improving Photosynthetic Characteristics and Antioxidant Activity
Overexpression of Suaeda salsa SsDHN Gene Enhances Salt Resistance in Tobacco by Improving Photosynthetic Characteristics and Antioxidant Activity Open
Salt stress is a major abiotic stress that interferes with plant growth and affects crop production. Dehydrin (DHN), a member of the late embryogenesis abundant (LEA) protein family, was considered to be a stress protein involved in the pr…
View article: Gut Barrier Dysfunction and Microbiota Variations in Cryptosporidiosis: A Comprehensive Review
Gut Barrier Dysfunction and Microbiota Variations in Cryptosporidiosis: A Comprehensive Review Open
Cryptosporidiosis is a zoonotic protozoan parasite-born disease, equally significant in both animals and humans, especially affecting immunocompromised individuals (e.g., AIDS patients) and neonates. The prime concerns of this review artic…
View article: Joint exploration of network pharmacology and metabolomics on the effects of traditional Chinese medicine compounds in weaned yaks
Joint exploration of network pharmacology and metabolomics on the effects of traditional Chinese medicine compounds in weaned yaks Open
Introduction Chinese herbal medicines are relatively inexpensive and have fewer side effects, making them an effective option for improving health and treating diseases. As a result, they have gained more attention in recent years. The wea…
View article: Cost-effective and Flexible Preimplantation Genetic Testing (PGT) Using Adaptive Sampling-based Targeted Nanopore Sequencing (ASTN-seq)
Cost-effective and Flexible Preimplantation Genetic Testing (PGT) Using Adaptive Sampling-based Targeted Nanopore Sequencing (ASTN-seq) Open
Genetic diseases encompass a spectrum of disorders resulting from DNA variations. Preimplantation genetic testing (PGT) is a critical strategy for preventing recurrent miscarriage, foetal malformations, and the birth of children affected b…
View article: Rapid and minimally invasive preimplantation genetic testing for aneuploidies (PGT-A) based on polar body and nanopore sequencing: a viable alternative to conventional trophectoderm-based PGT-A?
Rapid and minimally invasive preimplantation genetic testing for aneuploidies (PGT-A) based on polar body and nanopore sequencing: a viable alternative to conventional trophectoderm-based PGT-A? Open
STUDY QUESTION Can third-generation sequencing (TGS)-based polar body (PB) analysis serve as a viable alternative to conventional trophectoderm (TE) biopsy for preimplantation genetic testing for aneuploidy (PGT-A)? SUMMARY ANSWER This stu…
View article: Parental and cell-division origin analysis to reduce false-positives in mosaic embryos for preimplantation genetic testing
Parental and cell-division origin analysis to reduce false-positives in mosaic embryos for preimplantation genetic testing Open
STUDY QUESTION Can parental and cell-division origin analysis identify the false-positive chromosomal aberrations in mosaic embryos detected during preimplantation genetic testing for aneuploidy (PGT-A)? SUMMARY ANSWER Parental origin anal…
View article: LEAFY1 and 2 are required for floral organ development in soybean
LEAFY1 and 2 are required for floral organ development in soybean Open
View article: Genetic risk stratification and risk factors of early menopause in women: a multi-center study utilizing polygenic risk scores
Genetic risk stratification and risk factors of early menopause in women: a multi-center study utilizing polygenic risk scores Open
Objective This study aims to evaluate the utility of polygenic risk scores (PRS) in women with early menopause (EM) and to investigate the clinical characteristics and risk factors associated with EM based on genetic risk. Study design Gen…
View article: Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy
Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy Open
In summary, our study demonstrates that HPF targets a novel mechanism for promoting adipose thermogenesis and exhibits potent and safe anti-obesity efficacy.
View article: Effect of allelic combinations of soybean maturity loci E1/E2/E3/E4 on latitude adaptation
Effect of allelic combinations of soybean maturity loci E1/E2/E3/E4 on latitude adaptation Open
View article: Effects of decapitation on yield-related traits of total node number per plant in soybean
Effects of decapitation on yield-related traits of total node number per plant in soybean Open
View article: Non-invasive Preimplantation Genetic Testing of Embryonic Genome in Spent Culture Medium
Non-invasive Preimplantation Genetic Testing of Embryonic Genome in Spent Culture Medium Open
Traditionally, preimplantation genetic testing (PGT) for in vitro fertilization (IVF) requires invasive trophectoderm (TE) biopsy, which might be detrimental to the embryo. Recently proposed non-invasive PGT (ni-PGT) utilizing cell-free DN…
View article: Comparative Analysis of Microbiota in Jiani Yaks with Different Rib Structures
Comparative Analysis of Microbiota in Jiani Yaks with Different Rib Structures Open
The Jiani yak is a nationally renowned species that is known for its meat which is rich in various minerals, amino acids, and proteins. The rumen microbiota plays a critical role in gastrointestinal health and feed degradation, contributin…
View article: Post-Flowering Photoperiod Sensitivity of Soybean in Pod-Setting Responses
Post-Flowering Photoperiod Sensitivity of Soybean in Pod-Setting Responses Open
The development of soybean (Glycine max) is regulated by the photoperiod, with genes related to photoperiod sensitivity primarily focused on the flowering time. However, their roles in post-flowering reproductive development and the mechan…
View article: Multi-omics PGT: re-evaluation of euploid blastocysts for implantation potential based on RNA sequencing
Multi-omics PGT: re-evaluation of euploid blastocysts for implantation potential based on RNA sequencing Open
STUDY QUESTION In addition to chromosomal euploidy, can the transcriptome of blastocysts be used as a novel predictor of embryo implantation potential? SUMMARY ANSWER This retrospective analysis showed that based on differentially expresse…
View article: Technically feasible solutions to challenges in preimplantation genetic testing for thalassemia: experiences of multiple centers between 2019 and 2022
Technically feasible solutions to challenges in preimplantation genetic testing for thalassemia: experiences of multiple centers between 2019 and 2022 Open
View article: Screening of Neutralizing Antibodies against FaeG Protein of Enterotoxigenic Escherichia coli
Screening of Neutralizing Antibodies against FaeG Protein of Enterotoxigenic Escherichia coli Open
The misuse of antibiotics in veterinary medicine presents significant challenges, highlighting the need for alternative therapeutic approaches such as antibody drugs. Therefore, it is necessary to explore the application of antibody drugs …
View article: Lactobacillus salivarius and Berberine Alleviated Yak Calves’ Diarrhea via Accommodating Oxidation Resistance, Inflammatory Factors, and Intestinal Microbiota
Lactobacillus salivarius and Berberine Alleviated Yak Calves’ Diarrhea via Accommodating Oxidation Resistance, Inflammatory Factors, and Intestinal Microbiota Open
Yaks are important food animals in China; however, bacterial diarrheal diseases frequently occur on the plateau, with limited effective therapies. The objective of this research was to evaluate the effectiveness of Lactobacillus salivarius…
View article: Efficacy of non-invasive chromosome screening, preimplantation genetic testing for aneuploidy, and morphological grading in selecting embryos of patients with advanced maternal age: a three-armed prospective cohort study
Efficacy of non-invasive chromosome screening, preimplantation genetic testing for aneuploidy, and morphological grading in selecting embryos of patients with advanced maternal age: a three-armed prospective cohort study Open
View article: Subfunctionalisation and self-repression of duplicated E1 homologues finetunes soybean flowering and adaptation
Subfunctionalisation and self-repression of duplicated E1 homologues finetunes soybean flowering and adaptation Open
Soybean is a photoperiod-sensitive staple crop. Its photoperiodic flowering has major consequences for latitudinal adaptation and grain yield. Here, we identify and characterise a flowering locus named Time of flower 4b ( Tof4b ), which en…
View article: Comparative analysis of intestinal microbiota composition between free-ranged captive yak populations in Nimu County
Comparative analysis of intestinal microbiota composition between free-ranged captive yak populations in Nimu County Open
The intestinal microbiota assumes a pivotal role in modulating host metabolism, immune responses, overall health, and additional physiological dimensions. The structural and functional characteristics of the intestinal microbiota may cause…
View article: Soybean hypocotyl elongation is regulated by a <scp>MYB33</scp>‐<scp>SWEET11</scp>/21‐<scp>GA2ox8c</scp> module involving long‐distance sucrose transport
Soybean hypocotyl elongation is regulated by a <span>MYB33</span>‐<span>SWEET11</span>/21‐<span>GA2ox8c</span> module involving long‐distance sucrose transport Open
Summary The length of hypocotyl affects the height of soybean and lodging resistance, thus determining the final grain yield. However, research on soybean hypocotyl length is scarce, and the regulatory mechanisms are not fully understood. …
View article: Post-flowering photoperiod sensitivity of soybean in pod-setting responses
Post-flowering photoperiod sensitivity of soybean in pod-setting responses Open
The development of soybean ( Glycine max ) is regulated by photoperiod, with genes related to photoperiod sensitivity primarily focused on flowering time. However, their roles in post-flowering reproductive development and the mechanisms b…