Sijia Tian
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View article: Dual Roles of Hypoxia-Inducible Factor 1 in Acute Lung Injury: Tissue-Specific Mechanisms and Therapeutic Modulation
Dual Roles of Hypoxia-Inducible Factor 1 in Acute Lung Injury: Tissue-Specific Mechanisms and Therapeutic Modulation Open
Acute lung injury (ALI), a life-threatening clinical syndrome with multifactorial origins, is characterized by uncontrolled pulmonary inflammation and disrupted alveolar–capillary barrier integrity, leading to progressive hypoxemia and res…
View article: Traumatic brain injury: Bridging pathophysiological insights and precision treatment strategies
Traumatic brain injury: Bridging pathophysiological insights and precision treatment strategies Open
Blood–brain barrier disruption and the neuroinflammatory response are significant pathological features that critically influence disease progression and treatment outcomes. This review systematically analyzes the current understanding of …
View article: EGFR and MUC1 as dual-TAA drug targets for lung cancer and colorectal cancer
EGFR and MUC1 as dual-TAA drug targets for lung cancer and colorectal cancer Open
Background Epidermal growth factor receptor (EGFR) is a key protein in cellular signaling that is overexpressed in many human cancers, making it a compelling therapeutic target. On-target severe skin toxicity has limited its clinical appli…
View article: Bidirectional modulation of extracellular vesicle-autophagy axis in acute lung injury: Molecular mechanisms and therapeutic implications
Bidirectional modulation of extracellular vesicle-autophagy axis in acute lung injury: Molecular mechanisms and therapeutic implications Open
Acute lung injury (ALI), a multifactorial pathological condition, manifests through heightened inflammatory responses, compromised lung epithelial-endothelial barrier function, and oxidative stress, potentially culminating in respiratory f…
View article: Nanocarrier-mediated siRNA delivery: a new approach for the treatment of traumatic brain injury–related Alzheimer’s disease
Nanocarrier-mediated siRNA delivery: a new approach for the treatment of traumatic brain injury–related Alzheimer’s disease Open
Traumatic brain injury and Alzheimer’s disease share pathological similarities, including neuronal loss, amyloid-β deposition, tau hyperphosphorylation, blood–brain barrier dysfunction, neuroinflammation, and cognitive deficits. Furthermor…
View article: Virtual impedance control of double-fed induction generator for damping enhancement in hvdc collection system
Virtual impedance control of double-fed induction generator for damping enhancement in hvdc collection system Open
Wind power has become the focus of new energy generation by its abundant resources and clean and environmentally friendly features. However, as the proportion of wind power connected to the grid rises, there is a risk of causing sub-synchr…
View article: Analysis and Reflection on the Operation Status of Residential Special Maintenance Funds
Analysis and Reflection on the Operation Status of Residential Special Maintenance Funds Open
Residential special maintenance funds are large in volume and play an important role in safeguarding people's livelihood. In recent years, many problems have been exposed in the operation of maintenance funds: in management, the funds are …
View article: Radiation-Induced Intestinal Injury: Injury Mechanism and Potential Treatment Strategies
Radiation-Induced Intestinal Injury: Injury Mechanism and Potential Treatment Strategies Open
Radiation-induced intestinal injury (RIII) is one of the most common intestinal complications caused by radiotherapy for pelvic and abdominal tumors and it seriously affects the quality of life of patients. However, the treatment of acute …
View article: Tailor‐Made Autophagy Cascade Amplification Polymeric Nanoparticles for Enhanced Tumor Immunotherapy (Small 24/2023)
Tailor‐Made Autophagy Cascade Amplification Polymeric Nanoparticles for Enhanced Tumor Immunotherapy (Small 24/2023) Open
Enhanced Tumor Immunotherapies Tailor-made polymeric nanoparticles with the function of autophagy cascade amplification due to the co-delivery of autophagy inducer STF-62247 and antitumor drug epirubicin, which could assist cell uptake and…
View article: Effects of a closed-loop system against SARS-CoV-2 at the Beijing 2022 Olympic Winter Games: a descriptive and modeling study
Effects of a closed-loop system against SARS-CoV-2 at the Beijing 2022 Olympic Winter Games: a descriptive and modeling study Open
Imported cases are considered the main risk factor for SARS-CoV-2 transmission during mass gatherings, but a comprehensive closed-loop system could minimize transmission among attendees and general personnel.
View article: Association between duration of return of spontaneous circulation and outcomes after out-of-hospital cardiac arrest
Association between duration of return of spontaneous circulation and outcomes after out-of-hospital cardiac arrest Open
Background Return of spontaneous circulation (ROSC) is a core outcome element of cardiopulmonary resuscitation (CPR); however, the definition or criterion of ROSC is disputed and varies in resuscitation for out-of-hospital cardiac arrest (…
View article: Medical services for sports injuries and illnesses in the Beijing 2022 Olympic Winter Games
Medical services for sports injuries and illnesses in the Beijing 2022 Olympic Winter Games Open
Background：It is well recognized that the Beijing 2022 Olympics will be the second Games held amid the COVID-19 pandemic, a condition that has impacted millions of lives from every nation, moreover, to a certain extent, it has altered the …
View article: National survey of do not attempt resuscitation decisions on out-of-hospital cardiac arrest in China
National survey of do not attempt resuscitation decisions on out-of-hospital cardiac arrest in China Open
Background To investigate and understand the determinants of decisions not to attempt resuscitation following out-of-hospital cardiac arrest, to contribute to establishing rules that are appropriate to China. Methods We recruited participa…
View article: Medical services for sports injuries and illnesses in the Beijing 2022 Olympic Winter Games
Medical services for sports injuries and illnesses in the Beijing 2022 Olympic Winter Games Open
Overall, 11% of athletes incurred at least one injury during the Games, which is similar to the findings during the Olympic Winter Games in 2014 and 2018. Regarding illness, 2% of athletes were affected, which is approximately one-third of…
View article: Marathon and Disaster: Lessons From the 2021 Gansu Marathon
Marathon and Disaster: Lessons From the 2021 Gansu Marathon Open
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View article: Cardiopulmonary resuscitation and termination of resuscitation on out-of-hospital cardiac arrest in China
Cardiopulmonary resuscitation and termination of resuscitation on out-of-hospital cardiac arrest in China Open
To the Editor: Out-of-hospital cardiac arrest (OHCA) is a major public health challenge. Early initiation, good quality cardiopulmonary resuscitation (CPR), and the use of an automated external defibrillator (AED) have been reported to sig…
View article: MicroRNA‑218 inhibits the malignant phenotypes of glioma by modulating the TNC/AKT/AP‑1/TGFβ1 feedback signaling loop
MicroRNA‑218 inhibits the malignant phenotypes of glioma by modulating the TNC/AKT/AP‑1/TGFβ1 feedback signaling loop Open
Gliomas are the most malignant and common tumors of the human brain, and the prognosis of glioma patients is extremely poor. MicroRNAs (miRNAs or miRs) play critical roles in different types of cancer by performing post‑transcriptional reg…
View article: Association Between Duration of Return of Spontaneous Circulation and Favorable Outcomes After Out-of-Hospital Cardiac Arrest
Association Between Duration of Return of Spontaneous Circulation and Favorable Outcomes After Out-of-Hospital Cardiac Arrest Open
Background: Return of spontaneous circulation (ROSC) is a core outcome element of cardiopulmonary resuscitation (CPR), but the definition or criterion of ROSC is disputed and varies in resuscitation for out-of-hospital cardiac arrest (OHCA…
View article: Perception of Telephone-assisted Cardiopulmonary Resuscitation Among Emergency Medical Personnel in China: a Web-based Survey
Perception of Telephone-assisted Cardiopulmonary Resuscitation Among Emergency Medical Personnel in China: a Web-based Survey Open
Background: To investigate the perception of telephone-assisted cardiopulmonary resuscitation (T-CPR) after out-of-hospital cardiac arrest (OHCA) among emergency medical service (EMS) providers in China. Methods: A multicentre, cross-secti…
View article: Epidemiological and clinical characteristics of COVID-19 infection outside Wuhan, China: a multicentre study
Epidemiological and clinical characteristics of COVID-19 infection outside Wuhan, China: a multicentre study Open
Numerous cases of coronavirus disease 2019 (COVID-19) have been confirmed worldwide. Herein, we report the epidemiological and clinical features of 478 confirmed cases from a multicenter study in four cities in China, excluding Wuhan. We e…
View article: Data associated with the article: Epidemiological and clinical characteristics of imported cases with COVID-19 infection: a multicentre study
Data associated with the article: Epidemiological and clinical characteristics of imported cases with COVID-19 infection: a multicentre study Open
This dataset consists of a single .xlsx spreadsheet with two tabs. The first tab contains the epidemiological and clinical features of 478 confirmed cases of COVID-19 from a multicentre study outside of Wuhan, China. It contains 21 measure…
View article: Transmission of SARS-CoV-2 during air travel: a descriptive and modelling study
Transmission of SARS-CoV-2 during air travel: a descriptive and modelling study Open
We found that the universal use of face masks on the flight, together with the plane's ventilation system, significantly decreased the infectivity of COVID-19.KEY MESSAGESThe COVID-19 pandemic is changing the lifestyle in the world, especi…
View article: Effective Inhibition of MYC-Amplified Group 3 Medulloblastoma Through Targeting EIF4A1
Effective Inhibition of MYC-Amplified Group 3 Medulloblastoma Through Targeting EIF4A1 Open
Yang Zhao,1,* Tiantian Li,2,* Shuaiwei Tian,1,* Wei Meng,1 Yi Sui,2 Jian Yang,1 Baocheng Wang,1 Zhuangzhuang Liang,1 Heng Zhao,1 Yipeng Han,1 Yujie Tang,1,2 Lei Zhang,2 Jie Ma1 1Department of Pediatric Neurosurgery, Xin Hua Hospital Affili…
View article: Transmission of SARS-CoV-2 During Air Travel: A Descriptive and Modelling Study
Transmission of SARS-CoV-2 During Air Travel: A Descriptive and Modelling Study Open
Background Millions of cases of the novel coronavirus disease 2019 (COVID-19) have been reported in the world. Although it is known that the air travel has the potential to spread SARS-CoV-2, the risk of in-flight transmission is unknown.M…
View article: A competing-risk-based score for predicting twenty-year risk of incident diabetes: the Beijing Longitudinal Study of Ageing study
A competing-risk-based score for predicting twenty-year risk of incident diabetes: the Beijing Longitudinal Study of Ageing study Open
Few risk tools have been proposed to quantify the long-term risk of diabetes among middle-aged and elderly individuals in China. The present study aimed to develop a risk tool to estimate the 20-year risk of developing diabetes while incor…
View article: Health-seeking behavior of patients with COVID-19 infection
Health-seeking behavior of patients with COVID-19 infection Open
Background: Corona Virus Disease 2019 (COVID-19) emerged across the world, and the disease course can be affected by health-seeking behavior of patients. This study aimed to explore the influence of the health-seeking behavior of patients …
View article: MiR-218 inhibits malignant phenotypes of glioma by targeting TNC/AKT/AP-1/TGFβ1 feedback signaling loop
MiR-218 inhibits malignant phenotypes of glioma by targeting TNC/AKT/AP-1/TGFβ1 feedback signaling loop Open
Background: Gliomas are the most malignant and common tumors in human brains, and the prognosis of glioma patient is very poor. MicroRNAs (miRNAs) play critical roles in different types of cancer by performing posttranscriptional regulatio…